Researchers at the Cells-in-Motion Cluster of Excellence have developed a new method for visualizing the heartbeat of living fruit-fly pupae and automatically recording the pulse frequency. The study is the result of interdisciplinary cooperation between computer scientists and biologists.
Glutamate is known as an flavour enhancer. But without the body’s own glutamate, nerve cells cannot transmit any signals. Researchers at the Cells-in-Motion Cluster of Excellence have shown how glutamate gets into nerve cells to the right places, describing the key role played by chloride.
Researchers at the Cells-in-Motion Cluster of Excellence have gained new insights into the mechanisms behind regenerative processes. In flatworms and zebrafish, even small wounds can initiate complete regeneration of heads and bones. The study has been published in “Nature Communications”.
If new blood vessels sprout from an existing network of vessels, their endothelial cells migrate in order to rearrange themselves and form contacts with other cells. CiM researchers show which mechanisms take place in the process. The study has been published in “Nature Communications”.
In November, CiM researchers Prof. Michael Schäfers and Prof. Stefan Schlatt demonstrated experiments with mice to journalists and gave insights into how different animals are kept at Münster University. The University has compiled an experience report and a collection of links to press articles.
During the development of an organism, individual cells are directed to perform specific tasks within the body of the adult organism. Researchers at the Cells-in-Motion Cluster of Excellence show now that the function of a certain protein is responsible for the development of sperm and egg cells.
Double success: two "Consolidator Grants" from the European Research Council (ERC) go to professors at the Cells-in-Motion Cluster of Excellence. Prof. Andrea Rentmeister, a chemist, and physicist Prof. Timo Betz each receive one of the coveted fundings – in total, almost four million euros.
Two scientific publications by physicists at the Cells-in-Motion Cluster of Excellence have made it onto the 2017 list of the 30 best papers worldwide in the fields of optics and photonics. One of the publications resulted from an interdisciplinary project undertaken by junior CiM researchers.
The German Research Foundation approved funding for the new Collaborative Research Centre 1348 „Dynamic Cellular Interfaces“. The positive assessment of this initiative which is headed by Prof. Christian Klämbt and involves many researchers at the Cells-in-Motion Cluster of Excellence gives additional momentum to the submission of a new proposal within the Excellence Strategy.
In order to be able to move, some cells form protrusions in the form of blebs. How do these blebs form? Researchers at the Cells-in-Motion Cluster of Excellence have discovered that folds in the cell membrane play a decisive role. The study has been published in the journal “Developmental Cell”.
One part of the foundation of the Cells-in-Motion Cluster of Excellence celebrates its tenth anniversary: the European Institute for Molecular Imaging. How has the institute developed over the past ten years? What were special moments? In an interview, the EIMI Directors look back.
At the Cells-in-Motion Cluster of Excellence there are lots of scientists doing work on and with zebrafish. These fish are perfect for research work because they grow outside the mother’s body and are transparent in the first five days of their life. What the scientists study in the tiny fish embryos is, for example, how bones, blood vessels and lymphatic vessels develop.
Prof. Ralf Stanewsky, a group leader at the Cells-in-Motion Cluster of Excellence, speaks with the University’s newspaper „wissen|leben“ about the research on the circadian clock. In December, the nobel prize for medicine will be awarded for insights into this topic. (Interview in German)
Two researchers from the Cells-in-Motion Cluster of Excellence travelled to Buenos Aires at the end of October to share their knowledge with schoolchildren and students there. 80 students from two German schools learned for example about the role played by chemistry when using imaging methods.
Prof. Hans-Christian Pape will be head of the Alexander von Humboldt Foundation starting January 2018. The group leader at the Cells-in-Motion Cluster of Excellence is an expert on the neurophysiological underpinnings of emotional behaviour. Among others, he researches into anxiety and anxiety disorders.
Do chemicals that we take up from the environment impair the function of sperm? This is what Dr. Christian Schiffer, a junior researcher at the Cells-in-Motion Cluster of Excellence, is investigating. He has received the KlarText Prize for an easy-to-understand article about his research work.
The German Research Foundation has announced a preliminary decision in the Excellence Strategy: “Cells in Motion” is one of the 88 Cluster candidates which can submit a full proposal for a new period of funding starting 2019. 195 draft proposals were submitted and reviewed in the first round.
Interdisciplinary research: At the Cells-in-Motion Cluster of Excellence, ten new projects are receiving funding worth a total of around one million euros. Two team leaders from different disciplines work together on each project and contribute their creative ideas to it.
Researchers at the Cells-in-Motion Cluster of Excellence have developed a new method for producing digital 3D reconstructions of blood and lymphatic vessels from tissue samples and then creating images of them for analysis. The study has been published in the “JCI Insight” journal.
Lulit Tilahun Wolde, a visiting academic from Ethiopia, is working in a research group at the Cells-in-Motion Cluster of Excellence. She brought microorganisms with her that can survive in one of the hottest regions on Earth. She wants to find out how modifications in RNA enable the microorganisms to survive.
During angiogenesis, new blood vessels are formed from existing ones. Research teams at the Cells-in-Motion Cluster of Excellence have shown that the Notch signalling pathway influences the sprouting of new blood vessels and the formation of arteries. Two studies have appeared in the latest issue of “Nature Cell Biology”.
The junior research groups at the Cells-in-Motion Cluster of Excellence have demonstrated convincing work with their research. After three and a half years, group leaders Dr. Milos Galic and Dr. Sebastian Rumpf are receiving financial support for a further two years.
The European Society of Microcirculation has granted its most prestigious award to Prof. Ralf Adams, a group leader at the Cells-in-Motion Cluster of Excellence. He investigates the development of the vascular system and stands out by high-ranking publications and scientific contribution in this field.
During development, some of the connections between nerve cells disappear. Researchers at the Cells-in-Motion Cluster of Excellence have discovered a physiological process that plays an important role in this. The study has been published in the current issue of “Embo Journal”.
What role does the correct size of endothelial cells play in the development of blood vessels? Researchers at the Cells-in-Motion Cluster of Excellence have been studying this and have identified a gene which enlarges endothelial cells and can lead to diseases. The study has been published in “Nature Cell Biology”.
Usually, interdisciplinary research is especially innovative. This is why the Cells-in-Motion Cluster of Excellence is funding five new pilot projects. Young researchers from several different disciplines have to apply for and implement the projects, for which they are themselves responsible.
“March for Science”: On April 22, scientists and citizens around the world will demonstrate for the vital role of science. CiM Prof. Stefan Luschnig knows that knowledge does not emerge overnight. He tells how he discovered a protein – years and years of systematic research work and discussions with colleagues.
When during development does the 3D organisation of the genom in the nucleus arise? A team of researchers around Dr. Juanma Vaquerizas, a group leader at the Cells-in-Motion Cluster of Excellence, and Clemens Hug, a CiM-IMPRS graduate student, have found new answers to this question. The study has been published in the journal "Cell".
Prof. Timo Betz is studying the mechanics of cells at the Cells-in-Motion Cluster of Excellence. For his research he has now received a prestigious research award from the “Human Frontier Science Program”. Together with colleagues from the USA and Canada he is receiving one million euros of funding.
“Four-dimensional imaging” is becoming increasingly important for the diagnosis and treatment of a variety of diseases. A new joint project funded by the German Ministry of Education and Science now aims to improve the methods of “4D-imaging”. Project coordinator is Prof. Martin Burger, a group leader at the Cells-in-Motion Cluster of Excellence.
In stem cell transplantation, new stem cells are transferred to the recipient’s bloodstream and find their own way to the bone marrow. A research team headed by the CiM group leaders Prof. Ralf Adams and Prof. Dietmar Vestweber identified the blood flow conditions under which blood stem cells migrate from the vessels and can seek a niche in the bone marrow.
Using an optical method, researchers at the Cells-in-Motion Cluster of Excellence have investigated the mechanical features of cells in living zebrafish embryos and manipulated, for the first time, several components in the cells simultaneously. The study appears in the Journal of Biophotonics.
Which molecular mechanisms are at work when, in the case of inflammation, immune cells migrate from the blood vessel into the tissue? Researchers at the Cells-in-Motion Cluster of Excellence have gained new insights into this question. The study has been published in the journal “Cell Reports”.
Next Monday sees the beginning of building work for the MIC research centre in Röntgenstraße, which will bring imaging experts from a variety of faculties even closer together. The new research building gives a structural basis for the long-term establishment of the Cells-in-Motion Cluster of Excellence research concept at Münster University.
If cells are under stress, for example in the case of injuries, they react to the stress and reorganize their cytoskeleton. This has been demonstrated by Prof. Roland Wedlich-Söldner and his team at the “Cells in Motion” Cluster of Excellence. Their study has been published in the journal “eLife”.
CiM group leader Prof. Wiebke Herzog is looking into the question of how cells in the blood vessels find their way to the right place in the tissue and thus make growth possible. She has now received a Heisenberg fellowship for her work from the German Research Foundation.
Researchers at the Cells-in-Motion Cluster of Excellence have succeeded in visualizing, for the first time, ongoing inflammation in the brain in patients suffering from multiple sclerosis. The study has been published in the prestigious journal "Science Translational Medicine".
Since the “go-ahead” for the Cells-in-Motion Cluster of Excellence, announced in 2012, CiM has sparked many changes at the University of Münster. The Coordinators of the Cluster, Prof. Lydia Sorokin, Prof. Volker Gerke and Prof. Michael Schäfers, provide insights into some of these achievements.
Dr. Kerstin Bartscherer, who is a group leader at the Cells-in-Motion Cluster of Excellence, has been awarded a prestigious "ERC Starting Grant" by the European Research Council. Using planarian flatworms, she investigates how the regeneration of injured or lost body parts can be activated.
Researchers of the Cells-in-Motion Cluster of Excellence have succeeded in marking messenger RNA in living cells using click chemistry. A new study of CiM Professor Andrea Rentmeister and her team has been published in the specialist journal “Angewandte Chemie”.
CiM-scientists have found that three factors control progenitor cell positioning in zebrafish embryos
Chemical cues, physical barriers and cell adhesion control progenitor cell positioning. This is the result of a study by cell biologists Azadeh Paksa and Prof. Erez Raz, who worked with an international team of scientists from Israel, France and the USA. The study was published in the journal Nature Communications.
Researchers at the Max Planck Institute and Münster University have discovered how to increase blood-forming stem cells
Blood vessels play a decisive role in the growth of bone tissue and in blood formation, or haematopoiesis. The blood vessels form so-called vascular niches which ensure that the blood-forming stem cells are preserved. Researchers have now found out how they can enhance the function of vascular stem cell niches in bone marrow and, as a result, increase the number of stem cells.
“Cells in Motion“ funds twelve new interdisciplinary research projects
CiM is providing 1.1 million euros of funding for no fewer than twelve new so-called flexible funds projects. What is special about the projects is that the project partners unite laboratories and clinics from the Departments of Biology, Chemistry, Physics, Mathematics and Medicine. Objects of research are sperm, nano-capsules and high-performance scanners.
Researchers analyse potential of an approach to treating local infections
Bacterial infections can have serious consequences – for example, when they colonize an artificial heart valve. There is especially problematic when the bacteria are resistant to several antibiotics. Researchers are looking for new methods of treatment as well as for ways to find centres of infection in the body, for example by means of special sugar molecules. Chemists, physicists, biologists and physicians were all involved in the study.
Scientists from Münster developed a new method to indicate acute lack of oxygen in cells
Without oxygen, cells cannot survive. Until now, scientists could not observe the effect that a reduced oxygen supply can have on individual cells. This was technically not feasible before. Scientists from Münster have now developed a reporter, which allows them to see an acute lack of oxygen of cells using light microscopy.
Biophysicists measure for the first time what happens when red blood cells “wriggle”
For the first time, and using physical methods, scientists from Münster, Paris and Jülich have demonstrated how red blood cells move. There had been real fights between academics over the question of whether these cells are moved by external forces or whether they actively “wriggle”. CiM Junior Research Group Leader Dr. Timo Betz and an international team have now proven that both opinions are correct. The study was published in “Nature Physics”.
Research team from Münster develops innovative catalytic chemistry process
Doctoral student Jan Metternich and his disstertation supervisor have now succeeded in turning to their advantage a chemical reaction which takes place in the eye and enables us to see light and dark. This process could be used to create special variants (isomers) of important carbon compounds which need a lot of energy to be produced by other means.
Through CiM, these two disciplines grow closer together
CiM brings together scientists from different disciplines to perform novel multidisciplinary research. Through a so-called pilot project programme, physicist Robert Meißner and biologist Wade Sugden will work together to directly measure the forces in blood flow that affect blood cells and their viscoelasticity. Their collaboration has already produced measurable success.
It does not always need to be the most expensive high tech product to optimize medical technology. A scientist from a research group in the Cells-in-Motion Cluster of Excellence used the Xbox technology for an experiment. With the help of this affordable technology Mirco Heß shows scientists a way to better understand clinical images of the inside from the outside.
Prof. Dr. Georg Lenz works on treatment approaches to lymph gland cancer
Prof. Dr. Georg Lenz mainly treats patients who suffer from aggressive cancer of the lymphatic glands. But you will not only meet him in the hospital. Prof. Lenz spends a good share of his working time in his laboratory. Holding the first CiM Clinical Translation Professorship he should, wherever possible, directly apply his scientific findings to clinical therapy and take up and intern apply impulses from the clinic to his research.
Just recently the Cells-in-Motion Cluster of Excellence (CiM) obtained a new device for 'photoacoustic imaging'. Prof. Michael Schäfers from the team of CiM coordinators explains in an interview with Christina Heimken why this prototype is especially important.