Neurobiology of the Parental Brain
Robert S. Bridges
ISBN: 978-0-12-374285-8
Elsevier 2008, 549 Seiten

Neurobiology of the Parental Brain presents cutting edge research on the basic neurobiology of parental behavior as it relates to behavioral disorders, including postpartum depression, anxiety, and inadequate parental bonding to infants. Internationally recognized basic and clinical researchers present new research findings in humans and animals that elucidate the roles of the brain, physiological state, genes and environment in maternal and paternal care. By bridging the gap between basic and clinical research, new understandings of how the biology of the brain and the reproductive state of the parent impact their mental health and the successful rearing of young emerge.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Bücher des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

The Manual of Scientific Style: A Guide for Authors, Editors, and Researchers

Edited by: Harold Rabinowitz and Suzanne Vogel
ISBN: 978-0-12-373980-3
Copyright © 2008 Elsevier Inc. All rights reserved

Much like The Chicago Manual of Style, The Manual of Scientific Style addresses all stylistic matters in the relevant disciplines of physical and biological science, medicine, health, and technology. It presents consistent guidelines for text, data, and graphics, providing a comprehensive and authoritative style manual that can be used by the professional scientist, science editor, general editor, science writer, and researcher.

Audience:
Anyone working with scientific vocabulary including contributors to scientific journal articles; authors/editors to scientific monographs, serials, and reference works; editors, writers, and designers preparing publications at all levels of readership

Motor Vehicle Collisions: Medical, Psychosocial and Legal Consequences

Edited by: Melanie P. Duckworth, Tony Iezzi and William T. O’Donohue
ISBN: 978-0-08-045048-3
Copyright © 2008 Elsevier Ltd.

This book is a comprehensive review of the motor vehicle collision (MVC) experience and includes chapters relevant to the assessment and treatment of multiple consequences of MVC involvement, including medical, psychosocial, and legal difficulties. The book is designed to be accessible to both clinicians and researchers interested in the study of MVCs and in the management of MVC-related problems. The aim of this book is to capture the MVC experience from a multidisciplinary perspective, This book will serve as a necessary reference for physicians, rehabilitation specialists, allied medical professionals, psychologists, and lawyers.

Molecular Photofitting: Predicting ancestry and phenotype using DNA

Author(s): Tony N. Frudakis
ISBN: 978-0-12-088492-6
Copyright © 2008 Elsevier Inc.

In the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects. Molecular Photofitting provides an accessible roadmap for both the forensic scientist hoping to make use of the new tests becoming available, and for the human genetic researcher working to discover the panels of markers that comprise these tests. By implementing population structure as a practical forensics and clinical genomics tool, Molecular Photofitting serves to redefine the way science and history look at ancestry and genetics, and shows how these tools can be used to maximize the efficacy of our criminal justice system.

Microcirculation (Second Edition)

Edited by: Ronald F. Tuma, Walter N. Durán and Klaus Ley
ISBN: 978-0-12-374530-9
Copyright © 2008 Elsevier Inc.

Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous sub-disciplines and subspecialties. This volume pulls all of the critical information into one volume eliminating the need to search through numerous books and journals which can be exhaustive and demanding. It provides cardiovascular physiologists with an integrated, in-depth evaluation of the latest research developments and will aide in developing new pathways of research and scholarship. This book is meticulously edited and reviewed. It provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship.It highlights the explosive growth in the knowledge about microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume. (Amazon)

Microbial Glycobiology: Structures, Relevance and Applications

Edited by: Otto Holst, Patrick J. Brennan and Mark von Itzstein
ISBN: 978-0-12-374546-0
Copyright © 2009 Elsevier Inc.

Microbiologists Infectious disease specialists are trying to understand how certain microbial pathogens (protozoa, bacteria, fungi, viruses etc) cause disease in humans. With insights from microbial glycobiology new diagnostic methods can be designed to detect the infectious agent and also to determine if one bug is more virulent than another, thus, helping disease diagnosis. Microbial glycobiology allows them to examine the role that sugars play in the disease process and help them determine a way to prevent a pathogen causing disease. Hence, new insights will be gained that could aid boost the immune system, thereby new biotheraputics and vaccines are being developed. By determining the structure of glycosylated proteins, lipids and other natural products from microbes, researchers can reveal the location of the sugars. They then have the ability to modify and control which sugars are attached and exactly how they are attached. This is important as it enables them to modify glycosylated biomolecules that are important in disease processes and turn these into better drugs.

Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment

Author(s): Scott D. Mendelson, M.D., Ph.D.
ISBN: 978-0-12-374240-7
Copyright © 2008 Elsevier Inc.

Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven’s syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer’s Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, ‚bad fats‘, inflammation, oxidative damage, over-stimulation of the ‚fight or flight‘ system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

Medicinal Chemistry of Anticancer Drugs

Author(s): Carmen Avendaño and J. Carlos Menéndez
ISBN: 978-0-444-52824-7
Copyright © 2008 Elsevier B.V.

Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures.

Matlab for Neuroscientists

Author(s): Pascal Wallisch, Michael Lusignan, Marc Benayoun,
Tanya I. Baker, Adam S. Dickey and Nicholas G. Hatsopoulos
ISBN: 978-0-12-374551-4, Copyright © 2009 Elsevier Inc.

Matlab is the accepted standard for scientific computing, used globally in virtually all Neuroscience and Cognitive Psychology laboratories. For instance, SPM, the most used software for the analysis and manipulation of fMRI images in research and clinical practice is fully programmed in matlab, and its use of the possibility to allow for sophisticated software modules to be freely added to the software has established it as the by far dominant software in the field. Many universities now offer, or are beginning to offer matlab introductory courses in their neuroscience and psychology programs. Nevertheless, so far there hasn’t been a textbook specific to this market, and the use of the plethora of existing engineering focused Matlab textbooks is notoriously difficult for teaching the package in those environments. This is the first comprehensive teaching resource and textbook for the teaching of Matlab in the Neurosciences and in Psychology. Matlab is unique in that it can be used to learn the entire empirical and experimental process, including stimulus generation, experimental control, data collection, data analysis and modeling. Thus a wide variety of computational problems can be addressed in a single programming environment. The idea is to empower advanced undergraduates and beginning graduate students by allowing them to design and implement their own analytical tools. As students advance in their research careers, they will have achieved the fluency required to understand and adapt more specialized tools as opposed to treating them as „black boxes“. Virtually all computational approaches in the book are covered by using genuine experimental data that are either collected as part of the lab project or were collected in the labs of the authors, providing the casual student with the look and feel of real data. In some rare cases, published data from classical papers are used to illustrate important concepts, giving students a computational understanding of critically important research. The ability to effectively use computers in research is necessary in an academic environment that is increasingly focused on quantitative issues. Matlab represents an ideal language of scientific computing. It is based on powerful linear algebra structures which lend themselves to empirical problems on the one hand, while at the same time allowing the student to make rapid problem-oriented progress (particularly in terms of visualization of data points) without having to lose focus by worrying too much about memory allocation and other „plumbing“ minutiae as would be required in other, more low-level programming languages such as C or C++. Currently, there are several books that provide introductions to Matlab that are either too generic and fundamental or too irrelevant for neuroscientists and cognitive psychologists who typically face a very circumscribed range of problems in data collection, data analysis and signal processing. Some non-book tutorials and primers that are in use in the community are typically out of date. Matlab versions are usually not backwards compatible. Many commands and functions used in older tutorials and primers, such as „flops“ won’t work in current versions of Matlab, necessitating a book that is timely and up-to-date. The complete lack of a relevant resource in this area, combined with a clearly felt need for such a text provided the primary and initial impetus for this project. The authors provide such a dearly needed resource adapting and pooling materials that developed for and used in highly rated courses involving the use of Matlab in Neuroscience at the University of Chicago. Two co-authors (PW and NH) have presented their respective work on teaching Matlab at national meetings and two of the co-authors (PW and MB) were awarded the coveted University of Chicago’s Booth Prize for excellence in teaching these courses.