Project area C: immune cell and organ responses
This project area focuses on the development and application of multiscale imaging strategies to study organ-specific immune cell responses to distinct sterile and bacterial inflammatory triggers in ischemia-reperfusion (heart, kidney), autoimmune disease (rheumatoid arthritis, systemic sclerosis and lupus erythematosus) and infections (sepsis, enteritis, peritonitis). Specifically, the effect of metabolic priming on monocyte function, the role of phagocytes in acute versus chronic inflammation and apoptotic cell clearance, molecular mechanisms of myeloid infiltration in peritonitis, and the metabolic dynamics of immune and renal cells in acute kidney injury will be studied. Furthermore, the interplay of platelets, NET formation and degradation, and myeloid immune cells in lymphatic tissue response during enteritic acute versus chronic Yersinia infections will be analysed.
Projects
- C01 – Metabolic priming of monocytes during inflammation in vivo
Principal investigators: Johannes Roth, Michael Schäfers
Project term: 01/2021–12/2024 - C02 – Phagocyte responses during apoptotic cell clearance in resolution of inflammation
Principal investigator: Noelia Alonso Gonzalez
Project term: 01/2021–12/2024 - C03 – Imaging of inflammatory and regulatory mechanisms in arthritis
Principal investigators: Sven Hermann, Thomas Vogl
Project term: 01/2021–12/2024 - C04 – Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum
Principal investigator: Lydia Sorokin
Project term: 01/2021–12/2024 - C05 – The role of IL24 in development and resolution of acute kidney injury
Principal investigators: Verena Hörr, Stefan Reuter
Project term: 01/2021–12/2024 - C06 – Nanocapsule-based functional analysis of myeloid cells and platelets in autoimmune diseases
Principal investigators: Katharina Landfester, Kerstin Steinbrink
Project term: 01/2021–12/2024 - C07 – Imaging of immune cell dynamics and host-pathogen interactions in gut-associated lymphoid tissue during Yersinia pseudotuberculosis infections
Principal investigators: Petra Dersch, Jan Rossaint
Project term: 01/2021–12/2024
- PI-2023-01: Containing the infection – Visualization and analysis of the influence of innate immune cells on the intestinal barrier during a bacterial infection
Project leader: Christopher Margraf (Institute of Infectiology, ZMBE)
Project term: 01/2024 - 12/2024 - PEP-2022-05 – Functional analysis of cardiac resident hematopoietic cells during post-injury recovery in zebrafish
Principal investigator: Felix Gunawan (Institute of Cell Biology)
Project term: 01/2023–12/2023 - CS-Starter-2023-02 – The role of hyperphosphatemia in endothelial inflammation
Clinician scientist: Göran Ramin Boeckel (Department of Nephrology and Rheumatology)
Mentor: Marcus Brand
Project term: 05/2023–04/2024 - CS-2021-01 – Cellular and metabolic imaging of monocyte dynamics during arthritis in vivo
(related CRC project C01)
Clinician scientist: Nadine Heiden (Department of Nuclear Medicine & European Institute for Molecular Imaging)
Scientific and clinical mentors: Johannes Roth, Michael Schäfers
Project term: 01/2022 - 12/2024 - MedK MD project – Untersuchung des Immunzellmetabolismus mittels radioaktiver Substrate
(related to CRC project C01)
Medical doctoral researcher: Lea Jansen (European Institute for Molecular Imaging)
Mentor: Michael Schäfers
Project term: 02/2022 - 01/2023 -
PI-2022-01 – NEUTROMARROW – Multiplex imaging of neutrophil
development and maturation in the bone marrow
Project leader: Mathis Richter (Institute of Experimental Pathology, ZMBE)
Project term: 04/2022 - 03/2023 -
ST-2022-01 – Unravelling the dynamic interplay between neutrophils and
macrophages following Yersinia pseudotuberculosis infection
Project leader: Samriti Sharma (Institute of Infectiology, ZMBE)
Project term: 04/2022 - 03/2023