The role of CSK in the regulation of immune cell recruitment and metabolism during acute kidney injury

Principal investigators: Verena Hörr, Andreas Margraf
Former principal investigator: Stefan Reuter
Project number: CRC 1450 C05
Project term: 01/2021–12/2028

Src-family kinases (SFKs) are central regulators of both immune cell functionality and metabolism. The c-terminal Src-Kinase CSK is an inhibitor of SFKs. Acute kidney injury (AKI) is a disease in which both immunoregulatory as well as metabolic alterations occur, evoking in organ failure. To understand the role of CSK in the setting of AKI, we will investigate different mouse models, integrating molecular analyses such as microscopy, flow cytometry, and sequencing, along with in vivo tracking of immune cells and metabolic changes using MRI.

Team

Principal investigators

• Hörr, Verena, Univ.-Prof. Dr. rer. nat.
  Department of Radiology
• Margraf, Andreas, Dr. med.
  Department of Anaesthesiology, Intensive Care and Pain Medicine

Project members

• Lippe, Chris
  Department of Radiology
• Susat, Kathleen
  Department of Anaesthesiology, Intensive Care and Pain Medicine

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.