Metabolic priming of monocytes during inflammation in vivo

Principal investigators: Johannes Roth, Michael Schäfers
Project number: CRC 1450 C01
Project term: 01/2021–12/2028

During systemic inflammation, shifts in metabolism lead to a secondary immune tolerance with a life-threatening defective antimicrobial defence. We demonstrated significant metabolic alterations during tolerance in monocytes. We will now target specific metabolic pathways in monocytes to analyse functional consequences. We will use metabolic radiotracers and innovative tracking strategies to confirm their relevance in infections and sterile inflammation. Our final goal is the identification of metabolites which could be used as innovative tracers for imaging specific disease stages or therapeutic targets for inflammation.

Team

Principal investigators

• Roth, Johannes, Univ.-Prof. Dr. med.
  Institute of Immunology
• Schäfers, Michael, Univ.-Prof. Dr. med.
  European Institute for Molecular Imaging & Department of Nuclear Medicine

Project members

• Heiden, Nadine
  Department of Nuclear Medicine
  European Institute for Molecular Imaging
  
  Knörr, Lisa
  European Institute for Molecular Imaging
• Mittrowann, Ricarda, Dr. rer. nat.
  Institute of Immunology

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.