Project area A: immune cell targeting

In this project area, we will develop chemical, biochemical and bioorthogonal targeting strategies to label innate immune cells for image-based tracking and analyses of their activation and functional state and to image bacteria. Novel versatile labels for multiscale imaging will uniquely allow detection of identical target moieties in different imaging modalities, thereby providing chemical bridging for multiscale imaging. Furthermore, mathematical modelling will allow optimised motion compensation during intravital imaging of moving organs (e.g. cardiac and respiratory motion) and a quantitative description of immune cell dynamics from multiscale imaging data. Data from all modalities will be integrated into multiscale datasets.