Tailored coordination compounds as multimodal labels for multiscale imaging

Principal investigator: Cristian A. Strassert
Project number: CRC 1450 A02
Project term: 01/2021–12/2024

Graphical abstract
© CRC inSight

We will develop new coordination chemical concepts towards chromophores able to irreversibly chelate diverse cations therefore acting as multiscale imaging labels (1). With this novel approach, no modification of the biodistribution of labelled ligands is expected upon exchange of the coordinated atom for different imaging modes providing information on identical targets at various temporo-spatial scales (2,3).

Together with the new targeting units and bioorthogonal labelling technologies proposed in this CRC, a universal multiscale labelling toolbox is envisaged. This will allow to interrogate living systems at various scales (4) and finally also merging identical information across scales.


Principal investigator

Project member


The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.


Baumer N, Tiemann J, Scheller A, Meyer T, Wittmann L, Suburu MEG, Greune L, Peipp M, Kellmann N, Gumnior A, Brand C, Hartmann W, Rossig C, Muller-Tidow C, Neri D, Strassert CA, Ruter C, Dersch P, Lenz G, Koeffler HP, Berdel WE, Baumer S. Targeted siRNA nanocarrier: a platform technology for cancer treatment. Oncogene 2022;41: 2210-2224. Abstract


Proetto MT, Sanning J, Peterlechner M, Thunemann M, Stegemann L, Sadegh S, Devor A, Gianneschi NC, Strassert CA. Phosphorescent Pt(ii) complexes spatially arrayed in micellar polymeric nanoparticles providing dual readout for multimodal imaging. Chem Commun (Camb) 2019;55: 501-504. Abstract
Ren J, Cnudde M, Brunink D, Buss S, Daniliuc CG, Liu L, Fuchs H, Strassert CA, Gao H-Y, Doltsinis NL. On-Surface Reactive Planarization of Pt(II) Complexes. Angew Chem Int Ed Engl 2019;58: 15396-15400. Abstract


Delcanale P, Galstyan A, Daniliuc CG, Grecco HE, Abbruzzetti S, Faust A, Viappiani C, Strassert CA. Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts. ACS Appl Mater Interfaces 2018;10: 24361-24369. Abstract
Duffy MJ, Planas O, Faust A, Vogl T, Hermann S, Schäfers M, Nonell S, Strassert CA. Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo. Photoacoustics 2018;9: 49-61. Abstract
Gruner MC, Niemann S, Faust A, Strassert CA. Axially Decorated Si(IV) -phthalocyanines Bearing Mannose- or Ammonium-conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation. Photochem Photobiol 2018;94: 890-899. Abstract
Wilde S, Ma D, Koch T, Bakker A, Gonzalez-Abradelo D, Stegemann L, Daniliuc CG, Fuchs H, Gao H, Doltsinis NL, Duan L, Strassert CA. Toward Tunable Electroluminescent Devices by Correlating Function and Submolecular Structure in 3D Crystals, 2D-Confined Monolayers, and Dimers. ACS Appl Mater Interfaces 2018;10: 22460-22473. Abstract


Galstyan A, Block D, Niemann S, Gruner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schafers M, Loffler B, Strassert CA, Faust A. Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry 2016;22: 5243-5252. Abstract
Galstyan A, Kauscher U, Block D, Ravoo BJ, Strassert CA. Silicon(IV) Phthalocyanine-Decorated Cyclodextrin Vesicles as a Self-Assembled Phototherapeutic Agent against MRSA. ACS Appl Mater Interfaces 2016;8: 12631-12637. Abstract
Sanning J, Stegemann L, Ewen PR, Schwermann C, Daniliuc CG, Zhang D, Lin N, Duan L, Wegner D, Doltsinis NL, Strassert CA. Colour-tunable asymmetric cyclometalated Pt(ii) complexes and STM-assisted stability assessment of ancillary ligands for OLEDs. J. Mater. Chem. C 2016;4: 2560-2565. Abstract


Sanning J, Ewen PR, Stegemann L, Schmidt J, Daniliuc CG, Koch T, Doltsinis NL, Wegner D, Strassert CA. Scanning-tunneling-spectroscopy-directed design of tailored deep-blue emitters. Angew Chem Int Ed Engl 2015;54: 786-791. Abstract