Principal investigator: Stefanie Bobe, Cristian A. Strassert
Project number: CRC 1450 A02
Project term: 01/2021–12/2028
We will elucidate the role of capillary mesenteric lymph vessels in peritoneal lymph drainage and inflammatory disease progression. Hence, the coordination-chemical concepts established in the first funding period will be implemented towards small molecules as functional labels. Their biodistribution profiles will be tuned by the amphiphilicity or by specific targeting units; since the chelator can remain invariant, no modification of the localization is expected upon exchange of the central cation. Thus, multiple orthogonal readouts arising from a single label will be used to visualize the early pathogen transport of Y. pseudotuberculosis in mice bridging the gap between different scales and modalities.
| Englmaier VA, Bobe S, Rolf N, Kriegel MF, Barth P, Eter N, Baydoun L. Anterior segment optical coherence tomography enables repeat Descemet Membrane Endothelial Keratoplasty instead of penetrating keratoplasty in a patient with a prominent corneal opacity following DMEK failure: a case report. BMC Ophthalmol 2026;26Abstract
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| Klunder L, Maus B, Rivas Aiello MB, Drakonaki A, Holtkamp M, Karst U, Gatsogiannis C, Strassert C, Faber C. Monte Carlo simulations of transverse relaxation for characterization of physicochemical properties of superparamagnetic iron oxide nanoparticles. Magn Reson Imaging 2026;125: 110553. Abstract
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| Lederer T, Lehr K, Bobe S, Falkenberg K, Thon C, Hoffmann E, Roll W, Rennebaum F, Morgul H, Masthoff M, Ocal O, Trebicka J, Wildgruber M, Link A, Schindler P. Combining tissue-derived microRNAs with clinical risk models for prediction of HCC recurrence after liver transplantation: A proof-of-concept study. Sci Rep 2026;16Abstract
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| Schindler P, Brandt J, Bobe S, Krahling T, Ventura D, Plasger A, Gotte M, Kiesel L, Dorten PM, Witteler R, Liehn L, Hanker L, Schafers M, Eltrop S, Backhaus P. Initial Results of FAPI PET/MRI to Assess the Extent of Endometriosis. J Nucl Med 2026;67: 1232-1238. Abstract
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| Ventura D, Schafers M, Bobe S, Buther F, Brandt J, Stegger L, Bruggemann P, Roll W, Rahbar K, Schindler P, Backhaus P. FAP-targeted [(68)Ga]BED003-PET in different solid malignancies. Eur J Nucl Med Mol Imaging 2026;53: 4977-4987. Abstract |
| Buss S, Borsdorf L, Muschiol EC, Cappellari MV, Maisuls I, Weise TMA, Hepp A, Kosters J, Esselen M, Fernandez G, Strassert CA. Aggregation, Photoluminescence, and Cytotoxicity of Pt(II) and Re(I) Complexes Bearing Multimodal-Coordinating Luminophores. Chemistry 2025;31: e202404115. Abstract
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| Huber A, Schmidt L, Gatz T, Bublitz J, Rex T, Sailaja STN, Verheggen E, Hofmann L, Wolper C, Strassert CA, Knauer SK, Voskuhl J. Stepwise Modulation of Bridged Single-Benzene-Based Fluorophores for Materials Science. Chemistry 2025;31: e202404263. Abstract
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| Luke J, Maisuls I, Hepp A, Strassert CA. Rhenium(I) Complexes with 2-(1,2,4-Triazol-5-yl)-beta-Carboline-Based Bidentate Luminophores and Neutral Co-Ligands: Towards Tunable Phosphorescence and Efficient Singlet Dioxygen Photoproduction. Int J Mol Sci 2025;26Abstract
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| Rex T, Mosser T, Vilela RRC, Hepp A, Grashoff C, Strassert CA. Supramolecular Assembly of Water-Soluble Platinum(II) Complexes: From Emission Modulation to Cell Imaging in Specific Organelles. Chemistry 2025;31: e202404432. Abstract
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| Schmiedtchen M, Maisuls I, Siera H, Balszuweit J, Wolper C, Giese M, Haberhauer G, Strassert CA, Voskuhl J. In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent Dibenzothiophenes. Angew Chem Int Ed Engl 2025;64: e202414326. Abstract
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| Thale I, Massa J, Nass E, Vinnenberg L, Todesca LM, Budde T, Maisuls I, Strassert CA, Koch O, Schwab A, Wunsch B. Visualization of K(Ca)31 Channels in Tumor Cells by Optimized Senicapoc-Bodipy Conjugates. ACS Pharmacol Transl Sci 2025;8: 3371-3388. Abstract |
| Bauer N, Beckmann D, Reinhardt D, Frost N, Bobe S, Erapaneedi R, Risse B, Kiefer F. Therapy-induced modulation of tumor vasculature and oxygenation in a murine glioblastoma model quantified by deep learning-based feature extraction. Sci Rep 2024;14: 2034. Abstract
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| Ezquerra Riega SD, Gutierrez Suburu ME, Rodríguez HB, Lantaño B, Kleinschmidt M, Marian CM, Strassert CA. A case-study on the photophysics of chalcogen-substituted zinc(II) phthalocyanines. Chemistry – A European Journal 2024
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| Hoffmann E, Masthoff M, Kunz WG, Seidensticker M, Bobe S, Gerwing M, Berdel WE, Schliemann C, Faber C, Wildgruber M. Multiparametric MRI for characterization of the tumour microenvironment. Nat Rev Clin Oncol 2024;21: 428-448. Abstract
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| Kirse TM, Maisuls I, Cappellari MV, Niehaves E, Kösters J, Hepp A, Karst U, Wolcan E, Strassert CA. Neutral and Cationic Re(I) Complexes with Pnictogen-Based Coligands and Tunable Functionality: From Phosphorescence to Photoinduced CO Release. Inorg Chem 2024;63: 4132-4151. Abstract
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| Kirse TM, Maisuls I, Spierling L, Hepp A, Kosters J, Strassert CA. One Dianionic Luminophore with Three Coordination Modes Binding Four Different Metals: Toward Unexpectedly Phosphorescent Transition Metal Complexes. Adv Sci (Weinh) 2024;11: e2306801. Abstract
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| Kirse TM, Maisuls I, Denofrio MP, Hepp A, Cabrerizo FM, Strassert CA. Functional Pt(II) and Re(I) Complexes with CO- and β Carboline-Based Coligands: From Time-Resolved Photoluminescence Spectroscopy and Evaluation of 1O2 Photosensitization Efficiency toward in vitro (Photo)cytotoxicity. Organometallics 2024
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| Rassek P, Bobe S, Kies P, Roll W. The value of core needle biopsy in the diagnostic workup of a [18F]FDG-PET positive thyroid metastasis from colorectal cancer. Nuklearmedizin 2024;63: 43-44. Abstract
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| Rex T, Baumert S, Hepp A, Fernandez G, Strassert CA. Adaptive photoluminescence through a bioinspired antioxidative mechanism. Chem Sci 2024;15: 18881-18887. Abstract
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| Rivas Aiello MB, Kirse TM, Lavorato GC, Maus B, Maisuls I, Kuberasivakumaran S, Ostendorp S, Hepp A, Holtkamp M, Winkler EL, Karst U, Wilde G, Faber C, Vericat C, Strassert CA. Superparamagnetic Nanoparticles with Phosphorescent Complexes as Hybrid Contrast Agents: Integration of MRI and PLIM. Small Science 2024Abstract
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| Sailaja STN, Maisuls I, Hepp A, Brünink D, Doltsinis NL, Faust A, Hermann S, Strassert CA. Dual Emissive Zn(II) Naphthalocyanines: Synthesis, Structural and Photophysical Characterization with Theory-Supported Insights towards Soluble Coordination Compounds with Visible and Near-Infrared Emission. nt J Mol Sci 2024Abstract
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| Sheelakumari SP, Cappellari MV, Rivas Aiello MB, Hepp A, Strassert CA. Synthesis and Photophysical Evaluation of Isoleptic Pt(II) and Pd(II) Complexes Utilizing N^N^N Ligands as Luminophoric Chelators with Different Ancillary Ligands. Inorganics 2024;12: 58. Abstract
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| Sutar P, Maisuls I, Fernandez Z, Strassert CA, Fernandez G. Pathway-dependent Metallosupramolecular Polymerization Regulated by Ligand Geometry. Chemistry 2024;30: e202403287. Abstract |
| Bauer N, Maisuls I, Pereira da Graca A, Reinhardt D, Erapaneedi R, Kirschnick N, Schäfers M, Grashoff C, Landfester K, Vestweber D, Strassert CA, Kiefer F. Genetically encoded dual fluorophore reporters for graded oxygen-sensing in light microscopy. Biosens Bioelectron 2023;221: 114917. Abstract
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| Kirse TM, Maisuls I, Spierling L, Hepp A, Kösters J, Strassert CA. One Dianionic Luminophore with Three Coordination Modes Binding Four Different Metals: Toward Unexpectedly Phosphorescent Transition Metal Complexes. Adv Sci (Weinh) 2023: e2306801. Abstract
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| Thale I, Maskri S, Grey L, Todesca LM, Budde T, Maisuls I, Strassert CA, Koch O, Schwab A, Wünsch B. Imaging of K(Ca) 31 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes. ChemMedChem 2023;18: e202200551. Abstract
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| Theiss T, Buss S, Maisuls I, López-Arteaga R, Brünink D, Kösters J, Hepp A, Doltsinis NL, Weiss EA, Strassert CA. Room-Temperature Phosphorescence from Pd(II) and Pt(II) Complexes as Supramolecular Luminophores: The Role of Self-Assembly, Metal-Metal Interactions, Spin-Orbit Coupling, and Ligand-Field Splitting. J Am Chem Soc 2023Abstract |
| Backhaus P, Burg MC, Asmus I, Pixberg M, Büther F, Breyholz H-J, Yeh R, Weigel SB, Stichling P, Heindel W, Bobe S, Barth P, Tio J, Schäfers M. Initial Results of FAPI-PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer. J Nucl Med 2022Abstract
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| Bäumer N, Tiemann J, Scheller A, Meyer T, Wittmann L, Suburu MEG, Greune L, Peipp M, Kellmann N, Gumnior A, Brand C, Hartmann W, Rossig C, Müller-Tidow C, Neri D, Strassert CA, Rüter C, Dersch P, Lenz G, Koeffler HP, Berdel WE, Bäumer S. Targeted siRNA nanocarrier: a platform technology for cancer treatment. Oncogene 2022;41: 2210-2224. Abstract
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| Bobe S, Beckmann D, Klump DM, Dierkes C, Kirschnick N, Redder E, Bauer N, Schäfers M, Erapaneedi R, Risse B, van de Pavert SA, Kiefer F. Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice. Front Cell Dev Biol 2022;10: 949896. Abstract
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| Kirse TM, Lüke J, Maisuls I, Hepp A, Strassert CA. Comparison of Phosphorescent Pt(II) Complexes with C;N;N vs N;N;N Chelators and Caffeine-Based NHC-co-ligands(1). Photochem Photobiol 2022Abstract
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| Maisuls I, Kirse TM, Hepp A, Kösters J, Wolcan E, Strassert CA. Rhenium(I) Complexes with Neutral Monodentate Coligands and Monoanionic 2-(1,2,4-Triazol-5-yl)pyridine-Based Chelators as Bidentate Luminophores with Tunable Color and Photosensitized Generation of (1)O(2): An Integrated Case Study Involving Photophysics and Theory. Inorg Chem 2022;61: 13775-13791. Abstract
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| Matern J, Maisuls I, Strassert CA, Fernández G. Luminescence and Length Control in Nonchelated d(8) -Metallosupramolecular Polymers through Metal-Metal Interactions. Angew Chem Int Ed Engl 2022;61: e202208436. Abstract |
| Kong C, Bobe S, Pilger C, Lachetta M, Øie CI, Kirschnick N, Mönkemöller V, Hübner W, Förster C, Schüttpelz M, Kiefer F, Huser T, Schulte Am Esch J. Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies. Front Physiol 2021;12: 637136. Abstract
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| Maisuls I, Singh J, Salto IP, Steiner ST, Kirse TM, Niemann S, Strassert CA, Faust A. Conjugated Pt(II) Complexes as Luminescence-Switch-On Reporters Addressing the Microenvironment of Bacterial Biofilms. Inorg Chem 2021;60: 11058-11069. Abstract
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| Maisuls I, Wang C, Gutierrez Suburu ME, Wilde S, Daniliuc C-G, Brünink D, Doltsinis NL, Ostendorp S, Wilde G, Kösters J, Resch-Genger U, Strassert CA. Ligand-controlled and nanoconfinement-boosted luminescence employing Pt(ii) and Pd(ii) complexes: from color-tunable aggregation-enhanced dual emitters towards self-referenced oxygen reporters. Chem Sci 2021;12: 3270-3281. Abstract |
| Delcanale P, Galstyan A, Daniliuc CG, Grecco HE, Abbruzzetti S, Faust A, Viappiani C, Strassert CA. Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts. ACS Appl Mater Interfaces 2018;10: 24361-24369. Abstract
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| Duffy MJ, Planas O, Faust A, Vogl T, Hermann S, Schäfers M, Nonell S, Strassert CA. Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo. Photoacoustics 2018;9: 49-61. Abstract
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| Grüner MC, Niemann S, Faust A, Strassert CA. Axially Decorated Si(IV) -phthalocyanines Bearing Mannose- or Ammonium-conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation. Photochem Photobiol 2018;94: 890-899. Abstract
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| Wilde S, Ma D, Koch T, Bakker A, Gonzalez-Abradelo D, Stegemann L, Daniliuc CG, Fuchs H, Gao H, Doltsinis NL, Duan L, Strassert CA. Toward Tunable Electroluminescent Devices by Correlating Function and Submolecular Structure in 3D Crystals, 2D-Confined Monolayers, and Dimers. ACS Appl Mater Interfaces 2018;10: 22460-22473. Abstract |
