Tailored coordination compounds as multimodal labels for multiscale imaging

Principal investigator: Cristian A. Strassert
Project number: CRC 1450 A02
Project term: 01/2021–12/2024

Graphical abstract
© CRC inSight

We will develop new coordination chemical concepts towards chromophores able to irreversibly chelate diverse cations therefore acting as multiscale imaging labels (1). With this novel approach, no modification of the biodistribution of labelled ligands is expected upon exchange of the coordinated atom for different imaging modes providing information on identical targets at various temporo-spatial scales (2,3).

Together with the new targeting units and bioorthogonal labelling technologies proposed in this CRC, a universal multiscale labelling toolbox is envisaged. This will allow to interrogate living systems at various scales (4) and finally also merging identical information across scales.


Principal investigator


The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.


Ezquerra Riega SD, Gutierrez Suburu ME, Rodríguez HB, Lantaño B, Kleinschmidt M, Marian CM, Strassert CA. A case-study on the photophysics of chalcogen-substituted zinc(II) phthalocyanines. Chemistry – A European Journal 2024
Kirse TM, Maisuls I, Cappellari MV, Niehaves E, Kosters J, Hepp A, Karst U, Wolcan E, Strassert CA. Neutral and Cationic Re(I) Complexes with Pnictogen-Based Coligands and Tunable Functionality: From Phosphorescence to Photoinduced CO Release. Inorg Chem 2024;63: 4132-4151. Abstract
Kirse TM, Maisuls I, Denofrio MP, Hepp A, Cabrerizo FM, Strassert CA. Functional Pt(II) and Re(I) Complexes with CO- and β Carboline-Based Coligands: From Time-Resolved Photoluminescence Spectroscopy and Evaluation of 1O2 Photosensitization Efficiency toward in vitro (Photo)cytotoxicity. Organometallics 2024
Rivas Aiello MB, Kirse TM, Lavorato GC, Maus B, Maisuls I, Kuberasivakumaran S, Ostendorp S, Hepp A, Holtkamp M, Winkler EL, Karst U, Wilde G, Faber C, Vericat C, Strassert CA. Superparamagnetic Nanoparticles with Phosphorescent Complexes as Hybrid Contrast Agents: Integration of MRI and PLIM. Small Science 2024Abstract
Sailaja STN Maisuls I Hepp A Brünink D Doltsinis N L Faust A Hermann S Strassert C A. Dual Emissive Zn(II) Naphthalocyanines: Synthesis, Structural and Photophysical Characterization with Theory-Supported Insights towards Soluble Coordination Compounds with Visible and Near-Infrared Emission. nt J Mol Sci 2024Abstract


Bauer N, Maisuls I, Pereira da Graca A, Reinhardt D, Erapaneedi R, Kirschnick N, Schafers M, Grashoff C, Landfester K, Vestweber D, Strassert CA, Kiefer F. Genetically encoded dual fluorophore reporters for graded oxygen-sensing in light microscopy. Biosens Bioelectron 2023;221: 114917. Abstract
Kirse TM, Maisuls I, Spierling L, Hepp A, Kosters J, Strassert CA. One Dianionic Luminophore with Three Coordination Modes Binding Four Different Metals: Toward Unexpectedly Phosphorescent Transition Metal Complexes. Adv Sci (Weinh) 2023: e2306801. Abstract
Thale I, Maskri S, Grey L, Todesca LM, Budde T, Maisuls I, Strassert CA, Koch O, Schwab A, Wunsch B. Imaging of K(Ca) 31 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes. ChemMedChem 2023;18: e202200551. Abstract
Theiss T, Buss S, Maisuls I, Lopez-Arteaga R, Brunink D, Kosters J, Hepp A, Doltsinis NL, Weiss EA, Strassert CA. Room-Temperature Phosphorescence from Pd(II) and Pt(II) Complexes as Supramolecular Luminophores: The Role of Self-Assembly, Metal-Metal Interactions, Spin-Orbit Coupling, and Ligand-Field Splitting. J Am Chem Soc 2023Abstract


Backhaus P, Burg MC, Asmus I, Pixberg M, Buther F, Breyholz H-J, Yeh R, Weigel SB, Stichling P, Heindel W, Bobe S, Barth P, Tio J, Schafers M. Initial Results of FAPI-PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer. J Nucl Med 2022Abstract
Baumer N, Tiemann J, Scheller A, Meyer T, Wittmann L, Suburu MEG, Greune L, Peipp M, Kellmann N, Gumnior A, Brand C, Hartmann W, Rossig C, Muller-Tidow C, Neri D, Strassert CA, Ruter C, Dersch P, Lenz G, Koeffler HP, Berdel WE, Baumer S. Targeted siRNA nanocarrier: a platform technology for cancer treatment. Oncogene 2022;41: 2210-2224. Abstract
Kirse TM, Luke J, Maisuls I, Hepp A, Strassert CA. Comparison of Phosphorescent Pt(II) Complexes with C;N;N vs N;N;N Chelators and Caffeine-Based NHC-co-ligands(1). Photochem Photobiol 2022Abstract
Maisuls I, Kirse TM, Hepp A, Kosters J, Wolcan E, Strassert CA. Rhenium(I) Complexes with Neutral Monodentate Coligands and Monoanionic 2-(1,2,4-Triazol-5-yl)pyridine-Based Chelators as Bidentate Luminophores with Tunable Color and Photosensitized Generation of (1)O(2): An Integrated Case Study Involving Photophysics and Theory. Inorg Chem 2022;61: 13775-13791. Abstract
Matern J, Maisuls I, Strassert CA, Fernandez G. Luminescence and Length Control in Nonchelated d(8) -Metallosupramolecular Polymers through Metal-Metal Interactions. Angew Chem Int Ed Engl 2022;61: e202208436. Abstract


Maisuls I, Singh J, Salto IP, Steiner ST, Kirse TM, Niemann S, Strassert CA, Faust A. Conjugated Pt(II) Complexes as Luminescence-Switch-On Reporters Addressing the Microenvironment of Bacterial Biofilms. Inorg Chem 2021;60: 11058-11069. Abstract
Maisuls I, Wang C, Gutierrez Suburu ME, Wilde S, Daniliuc C-G, Brunink D, Doltsinis NL, Ostendorp S, Wilde G, Kosters J, Resch-Genger U, Strassert CA. Ligand-controlled and nanoconfinement-boosted luminescence employing Pt(ii) and Pd(ii) complexes: from color-tunable aggregation-enhanced dual emitters towards self-referenced oxygen reporters. Chem Sci 2021;12: 3270-3281. Abstract


Proetto MT, Sanning J, Peterlechner M, Thunemann M, Stegemann L, Sadegh S, Devor A, Gianneschi NC, Strassert CA. Phosphorescent Pt(ii) complexes spatially arrayed in micellar polymeric nanoparticles providing dual readout for multimodal imaging. Chem Commun (Camb) 2019;55: 501-504. Abstract
Ren J, Cnudde M, Brunink D, Buss S, Daniliuc CG, Liu L, Fuchs H, Strassert CA, Gao H-Y, Doltsinis NL. On-Surface Reactive Planarization of Pt(II) Complexes. Angew Chem Int Ed Engl 2019;58: 15396-15400. Abstract


Delcanale P, Galstyan A, Daniliuc CG, Grecco HE, Abbruzzetti S, Faust A, Viappiani C, Strassert CA. Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts. ACS Appl Mater Interfaces 2018;10: 24361-24369. Abstract
Duffy MJ, Planas O, Faust A, Vogl T, Hermann S, Schäfers M, Nonell S, Strassert CA. Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo. Photoacoustics 2018;9: 49-61. Abstract
Gruner MC, Niemann S, Faust A, Strassert CA. Axially Decorated Si(IV) -phthalocyanines Bearing Mannose- or Ammonium-conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation. Photochem Photobiol 2018;94: 890-899. Abstract
Wilde S, Ma D, Koch T, Bakker A, Gonzalez-Abradelo D, Stegemann L, Daniliuc CG, Fuchs H, Gao H, Doltsinis NL, Duan L, Strassert CA. Toward Tunable Electroluminescent Devices by Correlating Function and Submolecular Structure in 3D Crystals, 2D-Confined Monolayers, and Dimers. ACS Appl Mater Interfaces 2018;10: 22460-22473. Abstract