Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum

Principal investigator: Lydia Sorokin
Project number: CRC 1450 C04
Project term: 01/2021–12/2024

To define routes and mechanisms of leukocyte infiltration into the peritoneum during peritonitis a multiscale imaging approach will be employed to analyse the temporo-spatial dynamics of the extravasation of different myeloid populations across the high endothelial venule (HEV)-like versus conventional postcapillary venules of the omentum in response to different sterile or infectious stimuli (1, 2).

Combined with single cell RNA sequencing of omental vessels, this will identify marker molecules (3) for the development of non-invasive imaging strategies (4) for assessing acute peritoneal inflammation and, potentially, also for its manipulation.

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.