The role of IL24 in development and resolution of acute kidney injury

Principal investigators: Verena Hörr, Stefan Reuter
Project number: CRC 1450 C05
Project term: 01/2021–12/2024

Graphical abstract
© CRC inSight

Acute kidney injury (AKI) is characterised by impaired perfusion, a metabolic shift towards anaerobic glucose consumption and the secretion of pro-inflammatory mediators. We hypothesize that interleukin 24, which we recently identified in kidneys with AKI, is a key mediator in AKI (1). This leads us to investigate the influence of interleukin 24 on the functional, metabolic and cellular response of kidney cells and leukocytes during all stages of AKI (2, 3, 4).

We will use a multiscale imaging approach with special emphasis on the development and application of novel magnetic resonance imaging (MRI) techniques, such as Chemical Exchange Saturation Transfer (CEST) MRI (5, 6).

Team

Principal investigators

Project members

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.

2022

Schwarz C, Buchholz R, Jawad M, Hoesker V, Terwesten-Sole C, Karst U, Linsen L, Vogl T, Hoerr V, Wildgruber M, Faber C. Fingerprints of Element Concentrations in Infective Endocarditis Obtained by Mass Spectrometric Imaging and t-Distributed Stochastic Neighbor Embedding. ACS Infect Dis 2022Abstract

2021

Buscher K, Heitplatz B, van Marck V, Song J, Loismann S, Rixen R, Huchtmann B, Kurian S, Ehinger E, Wolf D, Ley K, Pavenstadt H, Reuter S. Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery. J Am Soc Nephrol 2021;32: 1933-1945. Abstract

2019

Kohnke R, Kentrup D, Schutte-Nutgen K, Schafers M, Schnockel U, Hoerr V, Reuter S. Update on imaging-based diagnosis of acute renal allograft rejection. Am J Nucl Med Mol Imaging 2019;9: 110-126. Abstract

2017

Kentrup D, Bovenkamp P, Busch A, Schuette-Nuetgen K, Pawelski H, Pavenstadt H, Schlatter E, Herrmann K-H, Reichenbach JR, Loffler B, Heitplatz B, Van Marck V, Yadav NN, Liu G, van Zijl PCM, Reuter S, Hoerr V. GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection. Kidney Int 2017;92: 757-764. Abstract
Kramer M, Motaal AG, Herrmann K-H, Loffler B, Reichenbach JR, Strijkers GJ, Hoerr V. Cardiac 4D phase-contrast CMR at 94 T using self-gated ultra-short echo time (UTE) imaging. J Cardiovasc Magn Reson 2017;19: 39. Abstract

2016

Grabner A, Kentrup D, Pawelski H, Muhlmeister M, Biermann C, Edemir B, Heitplatz B, Van Marck V, Bettinger T, Pavenstadt H, Schlatter E, Stypmann J, Tiemann K, Reuter S. Renal Contrast-Enhanced Sonography Findings in a Model of Acute Cellular Allograft Rejection. Am J Transplant 2016;16: 1612-1619. Abstract

2015

Bovenkamp PR, Brix T, Lindemann F, Holtmeier R, Abdurrachim D, Kuhlmann MT, Strijkers GJ, Stypmann J, Hinrichs KH, Hoerr V. Velocity mapping of the aortic flow at 94 T in healthy mice and mice with induced heart failure using time-resolved three-dimensional phase-contrast MRI (4D PC MRI). Magma 2015;28: 315-327. Abstract

2013

Grabner A, Kentrup D, Edemir B, Sirin Y, Pavenstadt H, Schlatter E, Schober O, Schafers M, Schnockel U, Reuter S. PET with 18F-FDG-labeled T lymphocytes for diagnosis of acute rat renal allograft rejection. J Nucl Med 2013;54: 1147-1153. Abstract
Hoerr V, Nagelmann N, Nauerth A, Kuhlmann MT, Stypmann J, Faber C. Cardiac-respiratory self-gated cine ultra-short echo time (UTE) cardiovascular magnetic resonance for assessment of functional cardiac parameters at high magnetic fields. J Cardiovasc Magn Reson 2013;15: 59. Abstract
Wiesinger A, Peters W, Chappell D, Kentrup D, Reuter S, Pavenstadt H, Oberleithner H, Kumpers P. Nanomechanics of the endothelial glycocalyx in experimental sepsis. PLoS One 2013;8: e80905. Abstract

2012

Hoerr V, Zbytnuik L, Leger C, Tam PPC, Kubes P, Vogel HJ. Gram-negative and Gram-positive bacterial infections give rise to a different metabolic response in a mouse model. J Proteome Res 2012;11: 3231-3245. Abstract

2010

Reuter S, Schnöckel U, Edemir B, Schröter R, Kentrup D, Pavenstädt H, Schober O, Schlatter E, Gabriels G, Schäfers M. Potential of noninvasive serial assessment of acute renal allograft rejection by 18F-FDG PET to monitor treatment efficiency. J Nucl Med 2010;51: 1644-1652. Abstract