The role of IL24 in development and resolution of acute kidney injury

Principal investigators: Verena Hörr, Stefan Reuter
Project number: CRC 1450 C05
Project term: 01/2021–12/2024

Graphical abstract
© CRC inSight

Acute kidney injury (AKI) is characterised by impaired perfusion, a metabolic shift towards anaerobic glucose consumption and the secretion of pro-inflammatory mediators. We hypothesize that interleukin 24, which we recently identified in kidneys with AKI, is a key mediator in AKI (1). This leads us to investigate the influence of interleukin 24 on the functional, metabolic and cellular response of kidney cells and leukocytes during all stages of AKI (2, 3, 4).

We will use a multiscale imaging approach with special emphasis on the development and application of novel magnetic resonance imaging (MRI) techniques, such as Chemical Exchange Saturation Transfer (CEST) MRI (5, 6).


Principal investigators

Project members


The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.


Nahardani A, Moradi S, Vo M, Reuter S, Hoerr V. 23Na Magnetic Resonance Imaging in Sepsis-Induced Acute Kidney Injury: A Preclinical Study 2024Abstract
Schache D, Peddi A, Nahardani A, Faber C, Hoerr V. Corrections for Rabi oscillations in cardiac chemical exchange saturation transfer MRI under the influence of very short preparation pulses. NMR Biomed 2024;37: e5081. Abstract


Hoffmann E, Schache D, Holtke C, Soltwisch J, Niland S, Krahling T, Bergander K, Grewer M, Geyer C, Groeneweg L, Eble JA, Vogl T, Roth J, Heindel W, Maus B, Helfen A, Faber C, Wildgruber M, Gerwing M, Hoerr V. Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy. J Transl Med 2023;21: 577. Abstract
Lippe C, Schache D, Hoerr V. Book of Abstracts ESMRMB 2023 Online 39th Annual Scientific Meeting 4–7 October 2023. Magn Reson Mater Phy 2023;36: 1-328. Abstract
Zhao W-T, Herrmann K-H, Sibgatulin R, Nahardani A, Kramer M, Heitplatz B, van Marck V, Reuter S, Reichenbach JR, Hoerr V. Perfusion and T(2) Relaxation Time as Predictors of Severity and Outcome in Sepsis-Associated Acute Kidney Injury: A Preclinical MRI Study. J Magn Reson Imaging 2023;58: 1954-1963. Abstract


Jehn U, Wiedmer N, Boeckel GR, Pavenstadt H, Tholking G, Reuter S. Fast Tacrolimus Metabolism Does Not Promote Post-Transplant Diabetes Mellitus after Kidney Transplantation. Int J Mol Sci 2022;23Abstract
Schache D, Bardin S, Ciobanu L, Faber C, Hoerr V. Ultrafast CEST line scanning as a method to quantify mutarotation kinetics. J Magn Reson 2022;342: 107270. Abstract
Schutte-Nutgen K, Edeling M, Kentrup D, Heitplatz B, Van Marck V, Zarbock A, Meersch-Dini M, Pavenstadt H, Reuter S. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury. Am J Transplant 2022;22: 2548-2559. Abstract


Buscher K, Heitplatz B, van Marck V, Song J, Loismann S, Rixen R, Huchtmann B, Kurian S, Ehinger E, Wolf D, Ley K, Pavenstadt H, Reuter S. Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery. J Am Soc Nephrol 2021;32: 1933-1945. Abstract


Margraf A, Germena G, Drexler HCA, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn PW, Haller H, Heitplatz B, Meyer Zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil beta2-integrin LFA-1. Blood 2020;136: 2200-2205. Abstract


Kohnke R, Kentrup D, Schutte-Nutgen K, Schafers M, Schnockel U, Hoerr V, Reuter S. Update on imaging-based diagnosis of acute renal allograft rejection. Am J Nucl Med Mol Imaging 2019;9: 110-126. Abstract
Margraf A, Ley K, Zarbock A. Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns. Trends Immunol 2019;40: 613-634. Abstract


Kentrup D, Bovenkamp P, Busch A, Schuette-Nuetgen K, Pawelski H, Pavenstadt H, Schlatter E, Herrmann K-H, Reichenbach JR, Loffler B, Heitplatz B, Van Marck V, Yadav NN, Liu G, van Zijl PCM, Reuter S, Hoerr V. GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection. Kidney Int 2017;92: 757-764. Abstract
Kramer M, Motaal AG, Herrmann K-H, Loffler B, Reichenbach JR, Strijkers GJ, Hoerr V. Cardiac 4D phase-contrast CMR at 94 T using self-gated ultra-short echo time (UTE) imaging. J Cardiovasc Magn Reson 2017;19: 39. Abstract