Nanocapsule-based functional analysis of myeloid cells and platelets in autoimmune diseases

Principal investigators: Katharina Landfester, Kerstin Steinbrink
Project number: CRC 1450 C06
Project term: 01/2021–12/2024

Graphical abstract
© CRC inSight

A hallmark of cutaneous autoimmune diseases is the infiltration of myeloid cells into the skin and affected organs. However, the role of subpopulations of myeloid cells, in particular of inflammatory and patrolling monocytes, and their crosstalk with platelets remains largely unknown in the pathogenesis of systemic Lupus erythematosus (SLE) and systemic sclerosis (SSc).

To decipher molecular mechanisms (1, 2, 3) of myeloid cell and platelet function (4), their interaction and the role of ROS-mediated processes, we will combine novel nanocapsule-based approaches with multiscale imaging techniques in mouse models of SSc and SLE (5).


Principal investigators

Project members


The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.


Kaczmarek-Szczepanska B, Pin JM, Zasada L, Sonne MM, Reiter RJ, Slominski AT, Steinbrink K, Kleszczynski K. Assessment of Melatonin-Cultured Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials for Wound Healing. Antioxidants (Basel) 2022;11Abstract


Haub J, Roehrig N, Uhrin P, Schabbauer G, Eulberg D, Melchior F, Shahneh F, Probst HC, Becker C, Steinbrink K, Raker VK. Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis. J Invest Dermatol 2019;139: 2144-2153. Abstract


Schmidt T, Lorenz N, Raker VK, Schmidgen MI, Mahnke K, Enk A, Roth J, Steinbrink K. Allergen-Specific Low Zone Tolerance Is Independent of MRP8/14-, TLR4-, TLR7-, and TLR9-Mediated Immune Processes. J Invest Dermatol 2018;138: 452-455. Abstract
Tonigold M, Simon J, Estupinan D, Kokkinopoulou M, Reinholz J, Kintzel U, Kaltbeitzel A, Renz P, Domogalla MP, Steinbrink K, Lieberwirth I, Crespy D, Landfester K, Mailander V. Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona. Nat Nanotechnol 2018;13: 862-869. Abstract


Haeberle S, Raker V, Haub J, Kim YO, Weng S-Y, Yilmaz OK, Enk A, Steinbrink K, Schuppan D, Hadaschik EN. Regulatory T cell deficient scurfy mice exhibit a Th2/M2-like inflammatory response in the skin. J Dermatol Sci 2017;87: 285-291. Abstract


Filatov MA, Baluschev S, Landfester K. Protection of densely populated excited triplet state ensembles against deactivation by molecular oxygen. Chem Soc Rev 2016;45: 4668-4689. Abstract
Frick SU, Domogalla MP, Baier G, Wurm FR, Mailander V, Landfester K, Steinbrink K. Interleukin-2 Functionalized Nanocapsules for T Cell-Based Immunotherapy. ACS Nano 2016;10: 9216-9226. Abstract
Raker VK, Ook KY, Haub J, Lorenz N, Schmidt T, Stegemann A, Bohm M, Schuppan D, Steinbrink K. Myeloid cell populations and fibrogenic parameters in bleomycin- and HOCl-induced fibrosis. Exp Dermatol 2016;25: 887-894. Abstract


Kang B, Okwieka P, Schottler S, Seifert O, Kontermann RE, Pfizenmaier K, Musyanovych A, Meyer R, Diken M, Sahin U, Mailander V, Wurm FR, Landfester K. Tailoring the stealth properties of biocompatible polysaccharide nanocontainers. Biomaterials 2015;49: 125-134. Abstract
Kang B, Okwieka P, Schottler S, Winzen S, Langhanki J, Mohr K, Opatz T, Mailander V, Landfester K, Wurm FR. Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona. Angew Chem Int Ed Engl 2015;54: 7436-7440. Abstract


Wohnhaas C, Turshatov A, Mailander V, Lorenz S, Baluschev S, Miteva T, Landfester K. Annihilation upconversion in cells by embedding the dye system in polymeric nanocapsules. Macromol Biosci 2011;11: 772-778. Abstract