Multiscale imaging of mechanisms underlying mast cell-dependent inflammation

Principal investigators: Tim Lämmermann, Angelika Rambold
Project number: CRC 1450 C08
Project term: 01/2025–12/2028

Mast cells play pivotal roles in local and systemic forms of anaphylactic inflammation. Employing multifaceted imaging methodology, our study aims at (1) understanding the intracellular interplay of organelle systems upon mast cell activation, (2) investigating how mast cell-activating triggers disseminate inflammatory signal through the tissue, and (3) developing methodology to assess systemic anaphylactic reactions with whole body imaging.

Team

Principal investigators

• Lämmermann, Tim, Univ.-Prof. Dr. rer. nat.
  Institute of Medical Biochemistry, ZMBE
• Rambold, Angelika, Univ.-Prof. Dr. rer. nat.
  Institute of Medical Biochemistry, ZMBE

Project member

• Stecher, Manuel, Dr. rer. nat.
  Institute of Medical Biochemistry, ZMBE

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2025, when funding for the project commenced, represent previous project-related work.