Nanocarrier-based functional analysis of myeloid cells in inflammatory and autoimmune diseases

Principal investigators: Katharina Landfester, Kerstin Steinbrink
Project number: CRC 1450 C06
Project term: 01/2021–12/2028

A key feature of cutaneous inflammatory diseases is the infiltration of myeloid cells into the skin. However, the role and crosstalk of subpopulations of myeloid cells, their interaction and the role of ROS stress in myeloid cell biology are largely unknown in the pathogenesis of inflammatory skin disorder s. We will combine novel nanocarrier-based approaches with functional and multiscale imaging techniques in mouse models of acute (allergic contact dermatitis) and chronic (systemic sclerosis) cutaneous inflammation to unravel molecular mechanisms of myeloid cell biology and of ROS-mediated processes in inflammatory and autoimmune skin diseases in vitro and in vivo.

Team

Principal investigators

• Landfester, Katharina, Prof. Dr. rer. nat.
  Max Planck Institute for Polymer Research, Mainz
• Steinbrink, Kerstin, Univ.-Prof. Dr. med.
  Department of Dermatology

Project members

• Krancan, Luisa
  Max Planck Institute for Polymer Research, Mainz
• Burkard, Hannah, Dr. rer. nat.
  Department of Dermatology

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.