Chemists succeed in synthesis of aminoalcohols by utilizing light

New method for generating the least accessible form of vicinal aminoalcohols / Study published in “Nature Catalysis”
© WWU - Glorius Group

Whether in beta-blockers to treat high blood pressure or in natural products: So-called vicinal aminoalcohols are high-quality organic compounds that are found in many everyday products. However, their production is difficult. For a long time, chemists are trying to develop efficient methods of synthesizing them. In their recent study published in the journal Nature Catalysis, scientists led by Prof. Dr. Frank Glorius of Münster University have found a solution for the production of a special variant of aminoalcohols. "The new method helps to study the properties of the substance and to find applications for these new compounds in the future", emphasizes Frank Glorius from the Organic Chemistry Institute at Münster University.

Molecular swarm rearranges surface structures atom by atom

New study: Nano-scientists develop a molecular tool to change the structure of a metal surface
The study was chosen for the cover of the print version of the journal.
© Wiley-VCH, Angew. Chem. Int. Ed.

The surface of metals plays a key role in many technologically relevant areas, such as catalysis, sensor technology and battery research. For example, the large-scale production of many chemical compounds takes place on metal surfaces, whose atomic structure determines if and how molecules react with one another. At the same time, the surface structure of a metal influences its electronic properties. This is particularly important for the efficiency of electronic components in batteries. Researchers worldwide are therefore working intensively on developing new kinds of methods to tailor the structure of metal surfaces at the atomic level.

A team of researchers at the University of Münster, consisting of physicists and chemists and led by Dr. Saeed Amirjalayer and Prof. Frank Glorius, has now developed a molecular tool which makes it possible, at the atomic level, to change the structure of a metal surface. Using computer simulations, it was possible to predict that the restructuring of the surface by individual molecules – so-called N-heterocyclic carbenes – takes place similar to a zipper. During the process, at least two carbene molecules cooperate to rearrange the structure of the surface atom by atom. The researchers could experimentally confirm, as part of the study, this “zipper-type” mechanism in which the carbene molecules work together on the gold surface to join two rows of gold atoms into one row. The results of the work have been published in the journal "Angewandte Chemie International Edition". The study was chosen for the cover of the print version of the journal.

Battery Research Centre: new international research school opened

9.5 million euros of funding from Ministry of Science for BACCARA Graduate School
Baccara 2020
© Peter Leßmann, WWU

Longer ranges for electric vehicles and the effective storage of electricity from renewable energies – these are research topics for the future which PhD students in Münster will be working on in a new international Graduate School. The research centre for “Battery Chemistry, Characterization, Analysis, Recycling and Application” (BACCARA for short) was officially opened on August 5 at the MEET Battery Research Centre at the University of Münster. It was set up with the participation of Münster University’s Department of Chemistry and Pharmacy and the Helmholtz Institute Münster – an outstation of the Jülich Research Centre. The state of North Rhine-Westphalia (NRW) is providing 9.5 million euros of funding for the school over five years.

“Promoting junior researchers will be decisive for the future success of battery research at Münster and is therefore especially important for the NRW government,” said Isabel Pfeiffer-Poensgen, NRW’s Minister of Culture and Science, as she presented the confirmation of funding at the MEET Battery Research Centre. “I very much hope that the BACCARA research school will be included in the CVs of many young researchers developing high-performance batteries of the future,” she added. She expressed her thanks to Prof. Martin Winter, the scientific director of the Battery Research Centre, Prof. Frank Glorius from the Institute of Organic Chemistry at the University of Münster, and the technical and commercial director of MEET, Dr. Falko Schappacher, who, she said, “have developed this project with a high degree of commitment.”

Frank Glorius receives award for catalysis science

Expert committee selects the organic chemist of Münster University for the "2020 Mitsui Chemicals Catalysis Science Award"
© Prof. Dr. Frank Glorius

For his work in the field of catalysis science, Frank Glorius has received the "2020 Mitsui Chemicals Catalysis Science Award". The prize, endowed with 5 million yen (the equivalent of almost 41,000 euros), is awarded every two years to outstanding chemists under 47 years of age. This year's focus is sustainability, to highlight the social issues including plastic waste management to which the chemical industry could contribute.
The committee honoured Frank Glorius especially for the development of so-called chemo- and enantioselective arene hydrogenation and of additional tools for improving synthesis.
Press release by Mitsui Chemicals

WWU-Cast Spezial: Forschen in Zeiten von Corona

Podcast mit Maximilian Koy (in german)
Maximilian Koy Podcast
© privat

Wie kann Forschung während der Coronakrise funktionieren, wenn sich die Universität in einem eingeschränkten Betrieb befindet, Labore nicht zugänglich und Bibliotheken geschlossen sind? Maximilian Koy ist Doktorand in der Arbeitsgruppe von Prof. Frank Glorius am Organisch-Chemischen Institut. Im Podcast berichtet er, wie er die aktuelle Situation als Wissenschaftler erlebt, wie sich seine Arbeitsgruppe organisiert und wie er die Zeit für seine Promotion effektiv nutzt.

Activating palladium catalysis by light: teaching an old transition metal new tricks

Chemists at Münster University develop method to produce π-allylpalladium complexes by radical chemistry / Study in “Nature Catalysis”
2020 Huang Nature Catalysis
© Bill Oxford/Unsplash

In the production of compounds, chemists have the fundamental goal of finding strategies that are most selective and avoid waste products. Breakthroughs in this area serve, among other things, to drive industrial innovation and drug development. In this context, allylic substitution reactions using catalysts made of so-called transition metals have already led to significant advances in science. The catalysts cause that in a molecule a functional group is replaced by another group in allylic position, i.e. in direct proximity to a carbon-carbon double bond.
In particular, the so-called allylic functionalization by means of a catalyst based on the transition metal palladium has become a well-established strategy for constructing carbon-carbon or carbon–heteroatom bonds, and its utility has been demonstrated in natural product synthesis, drug discovery and materials science. Nevertheless, there are still considerable challenges in practice, especially with regard to the sustainability of the substances and their ability to undergo chemical reactions.
Now a team of researchers led by Prof. Frank Glorius from the University of Münster has developed a new approach to allyl functionalization and generated π-allylpalladium complexes using radical chemistry. The study has been published in the journal “Nature Catalysis”.

Predicting reaction results: Machines learn chemistry

Chemists and computer scientists develop artificial intelligence / Study published in "Chem"
2020 Sandfort Chem
© Frederik Sandfort/WWU, pixabay

Everyday life without artificial intelligence is barely conceivable in today's world. Countless applications in areas such as autonomous driving, foreign language translations or medical diagnostics have found their way into our lives. In chemical research, too, great efforts are being made to apply artificial intelligence (AI), also known as machine learning, effectively. These technologies have already been used to predict the properties of individual molecules, making it easier for researchers to select the compound to be produced.
This production, known as synthesis, usually involves considerable effort as there are many possible synthesis routes to producing a target molecule. Since the success of each individual reaction depends on numerous parameters, it is not always possible, even for experienced chemists, to predict whether a reaction will take place – and even less how well it will work. In order to remedy this situation, an interdisciplinary team of chemists and computer scientists from the University of Münster has joined forces and developed an AI tool which has now been published in the journal “Chem”.
The team - consisting of members of the Glorius group from the Institute of Organic Chemistry, supported by the Institute of Business Informatics and the Institute of Informatics - will continue to develop their programme further and equip it with new functions in the future. Prof. Frank Glorius is confident: “When it comes to evaluating large amounts of complex data, computers are fundamentally superior to us. However, our goal is not to replace synthetic chemists with machines, but to support them as effectively as possible. Models based on artificial intelligence can significantly change the way we approach chemical syntheses. But we are still at the very beginning.”

Two chiral catalysts working hand in hand

New synthetic method developed providing access to different stereoisomers of a molecule / Study published in “Nature Catalysis”
Eloisa+santanu 11 2019
© Peter Dziemba/WWU, Barsu Nagaraju/MPI KoFo

Just as our left hand is not superposable to our right hand, the mirror image of certain molecules cannot be overlapped onto it, even when turned or twisted. These two mirror images are referred to by chemists as enantiomers and the molecule is said to be chiral. Chirality, which is a word derived from the ancient Greek word for hand, is important since it is present in our daily lives. For example, the stereoisomers of a molecule – i.e. compounds in which the binding pattern is the same but which differ in the spatial arrangement of the atoms – can produce different effects when interacting with a biological system.
The stereoisomers of a drug, for example, can have different or even opposite effects on the body making it crucial to produce certain stereoisomers of a pharmaceutical compound. A central task for chemists is to develop methods that are switchable and can selectively produce one or another stereoisomer, from simple and identical starting materials using tunable reaction conditions.
Eloisa and Santanu have succesfully developed a new synthetic method for the targeted synthesis of all four stereoisomers of so-called α,β-disubstituted γ-butyrolactones.
γ-Butyrolactones are widespread motifs in natural products that display a wide range of biological activities. One important example is pilocarpine, a drug used to treat glaucoma. The newly developed synthetic method is based on the combination of two chiral catalysts—an organocatalyst and a metal catalyst—which each independently activate one of the two reaction partners. Eloisa and Santanu use the different combinations of the two chiral catalysts to control the formation of only one of the four possible products, but are able to access any of the products. This is a quite rare feature that only few chemical processes exhibit.

Clarivate Highly Cited Researcher 2019

Frank Glorius 2017
© Dr. Peter Dziemba, WWU

For the sixth time in a row, Frank Glorius has been named Highly Cited Researcher, according to the Highly Cited Researchers 2019 list from the Web of Science Group, released today.
The highly anticipated list identifies scientists and social scientists who produced multiple papers ranking in the top 1% by citations for their field and year of publication, demonstrating significant research influence among their peers. The methodology that determines the who’s who of influential researchers draws on the data and analysis performed by bibliometric experts from the Institute for Scientific Information at the Web of Science Group.
In addition, Frank made it to the second place in this years nationwide "Professor of the year" competition (natural sciences & medicine). Congratulations!

Glorius group uses light to build biologically active compounds

Photocatalyst builds 3D scaffolds from flat aromatics / New method at Münster University
Glorius Ma Chem 2019
© Dr. Jiajia Ma

Some of the most biologically active molecules, including synthetic drugs, contain a central, nitrogen-containing chemical structure called an isoquinuclidine. This core has a three-dimensional shape which means it has the potential to interact more favourably with enzymes and proteins than flat, two-dimensional molecules. Unfortunately methods to make isoquinuclidines and the related dehyrdoisoquinuclidines suffer from a number of drawbacks which make it more difficult for scientists to discover new medicinal compounds. The team of Prof. Frank Glorius has now published a new method of enabling this reaction. The study was published in the journal “Chem”.

University Day 2019 - Chemistry is Cult(ure)

Astonishing Experiments with Prof. Frank Glorius
Chemie Ist Kult(Ur)_2019
© Dr. Mara Hobbold

10 o'clock in the morning - starting signal in the Department of Chemistry and Pharmacy: the pupil surged with big expectations into the lecture hall of chemistry - one hour of live experiments which are not belonging to the curriculum of a normal chemistry school lesson. With the motto "Chemistry is Cult(ure)" Prof. Frank Glorius easily achieved to incite the pupil to participate: he made them to be astonished, to laugh, to speculate, and even to hold their ears from time to time. After this great show lecture the students-to-be started to appreciate the numerous possibilities offered by the Department on this special day.

Symposium "ROCCAT-II: Rising Organic Chemists in CATalysis"

From Münster to the world as a professor
Roccat Ii Kathrin Nolte Wwu
© Kathrin Nolte, WWU

A special alumni reunion: Between 2007 and 2014, they worked as postdocs at the Organic Chemistry Institute of the University of Münster. The seven chemists now have their own research groups and are professors in China, India, France and Germany. The symposium "ROCCAT-II: Rising Organic Chemists in CATalysis" took them back to Münster. At the invitation of Prof. Frank Glorius from the Institute of Organic Chemistry, they exchanged information about their research projects and networked with current scientists at the University of Münster. The team spirit, the Mensa, the Aasee - the seven professors miss many things from their time in Münster.

Gay-Lussac Humboldt Prize for Prof. Frank Glorius

© Dr. Peter Dziemba, WWU

Prof. Frank Glorius has been awarded the Gay-Lussac Humboldt Prize for his outstanding research and his close links to France in his work. He received the prize in Paris on 7 May. The French Ministry of Higher Education and Research awards the prize to excellent German researchers, in all disciplines, who are seen as examples of special collaboration between the two countries. Once a year, two researchers are chosen who each receive 60,000 euros for the purpose of further extending the collaborations they have.
The Gay-Lussac prize has been awarded since 1981. It was initiated – on the recommendation of the German and French Ministers of Research – by the then President of France, Valéry Giscard d’Estaing, and the German Chancellor, Helmut Schmidt. On the German side, the Alexander von Humboldt Foundation awards a similar prize to French researchers who are proposed by German scientists.

Christmas Lecture on 13.12.2018 with Prof. Glorius and his Team

Fire & ice, scents and colors: This year's Christmas Lecture was a huge success, with 600 happy spectators being testament to it! This event, called "Chemie ist Kult(ur)" was jointly organized and run by Frank, Felix Strieth-Kalthoff and Peter Eggert and generously sponsored by BASF Coatings. For more information, see the photos below and also the following article:

Clarivate Highly Cited Researcher 2018

Frank Glorius
© Peter Grewer, WWU

Congratulations on being named a Highly Cited Researcher for 2018! Frank is again among an elite group recognized for exceptional research performance demonstrated by production of multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Science. The distinction he has earned derives not from Clarivate Analytics but from his peers, who have time and again acknowledged the influence of his research contributions in their publications and citations.

New Reaction Path Presented

Symmetrical cleavage of disulphides is fast and biocompatible
Glorius Guldi News
© Prof. Dr. Frank Glorius

A team of researchers led by Prof. Frank Glorius and Michael Teders from the University of Münster and by Prof. Dirk Guldi from the University of Erlangen-Nuremberg have presented a new chemical reaction path which may prove to be of interest both for research and for the production of active ingredients in medicines. The new reaction leads to a splitting of bonds between two sulphur atoms. The chemists use a light-driven catalysis method (photocatalysis) to enable it. The results of the researchers’ work have been published in the latest issue of the journal “Nature Chemistry”.
The team of researchers at WWU led by Frank Glorius uses photocatalysts and visible light for the selective cleavage of sulphur-sulphur bonds. The colour of the reaction mixture after the reaction can give a first indication of the products formed (the right photo shows a plate with different reaction mixtures).
Press release of the WWU Münster

„Merck, Sharp & Dohme Award 2018“ of the Royal Society of Chemistry for Frank Glorius

Frank Glorius
© DFG, David Ausserhofer

Frank Glorius was awarded from the Royal Society of Chemistry with the „Merck, Sharp & Dohme Award“ for pioneering contributions on the use of N-heterocyclic carbene ligands in selective arene hydrogenation. Press Release of the WWU Münster
His research program focuses on the development of new concepts for catalysis and their implementation in organic synthesis. The group is especially interested in the chemistry of N-heterocyclic carbenes (NHCs), C-H activation, asymmetric arene hydrogenation, (asymmetric) NHC organocatalysis, photocatalysis, heterogeneous catalysis with common and with tailor-made, surface-modified nanoparticles and, the development of useful screening methodology.

ERC Advanced Grant for Frank Glorius

Frank Glorius 2017
© Dr. Peter Dziemba, WWU

One of our research fields is the hydrogenation of aromatic molecules. We would like to achieve the selective transformation of well available flat two-dimensional molecules of this type to valuable saturated three-dimensional molecules as they are found in natural products and active pharmaceutical drugs. One of the problems is the low reactivity of aromatic compounds in connection with sensitive functional groups in these molecules. The objective of this project therefore is to develop new and powerful catalyst systems, which will foster these transformation without effecting connected functional groups. With this ERC Advanced Grant we will be able to extend this research. This is the second ERC Grant for Frank Glorius after the ERC Starting Grant in 2010.

Evonik PhD Price for Mario Wiesenfeldt

Mario Wiesenfeld Evonik Preis 2018
© Mario Wiesenfeldt

Today Mario was awarded with the Evonik PhD price for his project on the hydrogenation of fluoro arenes. Congratulations!

Photocatalysis Symposium 2018

News Poster Photocatalysis Symposium 29.2018.png
© Lena Pitzer, Felix Strieth-Kalthoff, WWU

Photochemistry and photophysics got highlighted in the university magazine and online. Just in time for the photochemistry symposium that takes place today. Destinct speakers and leaders in the field are Eric Meggers, Licheng Sun and Stefan Hecht. We very much look forward to this event. Everybodies welcome!
Please read more on WWU News (in german).

2017 Clarivate Highly Cited Researcher

Frank Glorius 2017
© Dr. Peter Dziemba, WWU

For the fourth time in a row, the Glorius group is ranking in the top 1% by citations for chemistry and publication year. Clarivate Analytics has assembled an updated list of highly cited researchers (HCR, formerly by Thomson Reuters). This list is based on publication and citation figures drawn from Essential Science IndicatorsSM (ESI), a component of the Web of Science™. Among its assorted features and metrics, ESI tracks papers published in the last decade that by citations rank in the top 1% for their respective years of publication in each of 22 main subject fields. Congratulations!

Science Paper on the Hydrogenation of Fluoroarenes Online

© Dr. Peter Dziemba, WWU

Our Science paper on the hydrogenation of fluoroarenes was just published online on FirstRelease: This allows the ready synthesis of valuable fluorinated building blocks for pharma, agro and materials. Remarkably, the Carbon-Fluorine bond remains intact during this transformation. Congratulations Mario, Zack and Wei! Keep going!!!
(from left: Prof. Frank Glorius, Dr. Wei Li, Dr. Zackaria Nairoukh, Mario Wiesenfeldt)
Press release of the WWU Münster

Two birds, one stone?

Glorius Ernst
© Prof. Dr. Frank Glorius

Two birds, one stone? We are very happy and proud that Johannes Ernst (Students Award) and Frank Glorius (Faculty Advisor Award) were selected for two prestigious awards of the International Precious Metal Institute (IPMI). Both will attend the 41st IPMI Annual Conference in Orlando, Florida. Congratulations! 
Press Release of the WWU Münster

New Group Members

Many new group members (Max, Zack, Sara, Luca, Felix, Frederik, Marco and Tuhin) have recently joined the group: Welcome and enjoy!

50th Annual Catalysis Meeting in Weimar

© Johannes Ernst, Andreas Lerchen

Lena, Johannes, Andreas, Felix and Mirco attended the exciting 50th annual catalysis meeting in Weimar and had great fun. Johannes gave an excellent talk (on the main stage!) and Andreas was awarded a poster prize! Congratulations!

New Publications

This year is not only our official year of hydrogenation (keep going guys!), but will also become a very successful year with many significant breakthroughs. It is especially great to see that ALL our research fields are contributing to this success! Please, kindly check out our growing publication list.

Evonik Award for Best PhD Research Work

We just got the news: Andreas Rühling will receive the annual Evonik Award for best PhD research work in our Department! Congratulations!!! The award ceremony will be held on Monday the 6th of February, 17:15 and the award lecture will be given by Prof. Roth/FU Berlin on chocolate/Schokolade. We very much look forward to this!

Glorius Group Winter Party

© Dr. Peter Dziemba

We started the year with a really great Glorius group Winter party with a lot of wine, food, chatting, dancing and singing! Thanks everyone to make this a really enjoyable for everyone and a real group event. See you at the group's Summer party...

Synfact of the month

Congratulations to Johannes! His recent JACS paper was selected as Synfact of the month, a great honor!

Poster award at the "20th International Symposium on Homogeneous Catalysis" (ISHC)

Tobias Gensch wins a poster award at the "20th International Symposium on Homogeneous Catalysis" (ISHC) in Kyoto for his poster on "Cobalt-catalyzed Cross-Dehydrogenative C–H Thiolation". This work was done together with Felix Klauck. Congratulations!

Poster Award at the "1st Trans Pyrenean Meeting in Catalysis" (TraPCat)

Lena Rakers wins a poster award at the "1st Trans Pyrenean Meeting in Catalysis" (TraPCat) in Toulouse for her poster on "N-Heterocyclic Carbenes for Stabilisation of nanoparticles and their application in catalysis". In addition to Lena, this work was done by Angelique, Andreas, Kathryn, Christian and others. Congratulations everyone!

Frank Glorius
© Peter Grewer, WWU

Mukaiyama Award 2017 for Frank Glorius

The Society of Synthetic Organic Chemistry of Japan has selected Prof. Glorius as winner of the Mukaiyama Award 2017, together with Prof. Nakao. This award acknowledges outstanding contributions in the field of synthetic organic chemistry. Specifically, Glorius’ pioneering investigations in the fields of C-H activation, and design and use of N-heterocyclic carbenes in catalysis and on-surface chemistry are highlighted. The award lecture will be given in Japan in September 2017.

Münster (upm/ch)

"Carbenes on the run.” Sorry: “on the roll.”

"Carbenes on the run.” Sorry: “on the roll.” Finally, our collaborative work with Prof. Doltsinis, Prof. Fuchs and his group got published in Nature Chemistry. Surprising ballbot-type motion of the NHCs on a gold atom was observed, elucidating a step of the formation of carbene monolayers on metal surfaces. The high resolution STM images are really exciting, check them out! We are very excited about the continuation of this work. Congratulations everyone! Publication, Press release WWU, Chemistry World

Poster Award at the "9th Asian-European Symposium on Metal-Mediated Efficient Organic Synthesis” (AES2016)

Adrián Gómez Suárez wins a poster award at the "9th Asian-European Symposium on Metal-Mediated Efficient Organic Synthesis” (AES2016) for his poster on "Accelerated Discovery in Photocatalysis using a Mechanism-based Screening Method". This work was done by Matt, Adrian, Michael, Basudev and Lena. Congratulations everyone!

Thomson Highly Cited
© Thomson Reuters

2016 Thomson Reuters Highly Cited Researchers

Great news! Thomson Reuter has just announced the 2016 Thomson Reuters Highly Cited Researchers - based on data analysis of the 1% most highly cited papers. For the third time, the Glorius group has been included in this list, a great honor. Congratulations to everyone!!!

Exhibition "Art&Chemistry - co.labore" - a Successful Experiment

Co Labore Rakers 2
© Petra Noppeney, WN

Our Art&Chemistry collaboration co.labore was displayed in the Schloss of Muenster at the end of June - a great success! PhD students from the SFB 858 ("Synergetic effects in chemistry") at the WWU Muenster, together with art students from the Kunstakademie Muenster interacted for several months, got to know each other and came up with interesting ideas. At the exhibition, jointly created pieces of art were flanked by scientific posters - a stimulating mixture that was well received by the general public. Well done! Thanks everyone for participating in this special and extremely successful experiment!

Aldrich Lecture Award 2016

© Peter Grewer, WWU

Prof. Glorius was given the Aldrich Lecture Award 2016 at Imperial College, London. Congratulations!

Poster Award at the "Research of the Chemical Industry" (FoChIn) Symposium

Roman wins a poster award (1st place) at the "Research of the Chemical Industry" (FoChIn) symposium for his poster on "Trifluoromethylthiolation of N-Heteroarenes and Alkenes". The awardees were elected by representatives from leading companies of the chemical industry. The presented projects on the poster were done by Roman, Johannes, Aleyda and Matt. Congratulations!

Poster Award at the MS-CEC Meeting

© Dr. Matthew Hopkinson

Matt wins a poster award at the MS-CEC meeting for his poster on "Accelerated Discovery in Photocatalysis using a Mechanism-based Screening Method". This work was done by Matt, Adrian, Michael and Basudev. Congratulations everyone!

Springer Thesis Prize for PhD Thesis

© Basudev Sahoo

Dr. Basudev Sahoo was awarded a prestigous Springer Thesis Prize for his PhD thesis in our group with the title "Visible Light Photocatalyzed Redox-Neutral Organic Reactions and Synthesis of Novel Metal-Organic Frameworks (MOFs)". We are very proud and happy. Congratulations!

Invited Lectures

© Peter Grewer, WWU

In the last weeks, Prof. Glorius was giving the BMS Lecture at UPenn and the 3rd Ewha Distinguished Lectureship in Chemistry and Nano Science. Congratulations!

© Angewandte Chemie; Wiley-VCH

"Catalyst Speed Dating"

We are very proud on the development of a mechanism-based screening method for accelerated discovery - soon to appear in Angewandte Chemie. We predict that this fundamentally new screening approach will have an impact on (photo)catalysis research; please, take a close look! We are very happy that we were selected to illustrate the cover of Angewandte with this work, so also take a look at our "Catalyst Speed Dating" Front Cover. Enjoy!

SYNLETT Best Paper Award 2015

© Jędrzej Wysocki

Our work on the asymmetric hydrogenation of 2-pyridones was awarded the SYNLETT Best Paper Award 2015: J. Wysocki, C. Schlepphorst, F. Glorius, Asymmetric Homogeneous Hydrogenation of 2-Pyridones, Synlett 2015, 26, 1557-1562. This work is said "To provide an original solution to a significant synthetic problem. The work of the Glorius team represents a new approach to the asymmetric hydrogenation of 2-pyridiones and provides an elegant access to enantiopure 2-piperidones." by the editor. These are very kind words and we are grateful for this distinction. Congratulations everyone!

Springer "BestMasters" Award for Lena and Andreas

© Lena Rakers, Andreas Lerchen

This is great news! The Master theses of Lena Rakers and Andreas Lerchen were selected for inclusion in the Springer "BestMasters" program. With "BestMasters" the publisher Springer is featuring the best Master theses, prepared at renowned universities in Germany, Austria and Switzerland. These theses were given the best marks and were recommended by referees. Congratulations Lena and Andreas!!!

  • News Archive

    October 2015
    After women power, now power. Dr. Eric Standley (USA), Felix Klauck (Germany) and Santanu Singha (India) have just joined the group. All the best for your start and: Welcome!

    September 2015
    Great news! Thomson Reuter has just announced the 2015 Thomson Reuters Highly Cited Researchers - based on data analysis of the 1% most highly cited papers. Once again, the Glorius group has been included in this list, a great honor. Congratulations to everyone!!!

    August 2015
    Women power! Dr. Lisa Candish (welcome back!), Lena Pitzer and Satobhisha Mukherjee have just joined the group. All the best for your start and: Welcome!

    July 2015
    Recently, many exciting manuscripts have been accepted for publication. Please, take a look at the updated publication list. To mention only three highlights:
    - NHC-organocatalysis: our most recent highly enantioselective conjugate umpolung of α,β-unsaturated aldehydes will appear in Nature Chem. soon. Valuable product motifs result, the reaction proceeds by a challenging dearomatization and the reactivity can be switched (formation of 6-membered vs. 5-membered rings). What more do you want?
    - NHCs in membranes? Our first joint paper with Prof. Galla on tailormade NHCs for applications in membranes has appeared. This exciting development might lead to a new field of application of NHCs.
    - sp3-C-H activation! We have achieved the first Rh(III)-catalyzed C-H activation of an unactivated sp3-C-H bond, providing new opportunities!

    Congratulations everyone!

    July 2015
    "Win some, lose some." Hiroshi Osaki, a PhD student from Shigehiro Yamaguchi's group at Nagoya University, Japan, has joint us for two months - working on an exciting collaborative project involving fluorescent molecules. On the other hand, Fabian Lied, a second year PhD student from our group, has moved to Mark Lautens' group at the University of Toronto, Canada. As a member of the IRTG 2027, Fabian is working a joint project in the field of C-H activation for the next 4 months. For both of you, good luck and have fun!

    July 2015
    Our annual Summer party took place on 18th of July and was a great success! Perfect weather, a beautiful spot and fun people -  we had a great time. Thanks for all the many former group members and partners who made the party really special - and for all the many helping hands. THANK YOU!!!

    May 2015
    We are proud to announce the successful securing of two attractive academic positions by two group members, Dr. Angelique Ferry and Dr. Junlong Li. In a very competitive selection process, Angelique Ferry came out top and was offered a position as Maître de conférences at the University of Cergy-Pontoise (close to Paris). Congratulations! We will continue to enjoy the final weeks together with you and wish you all the best for the time back in France.

    Similarly, Dr. Junlong Li has recently moved on back to China in order to become a Full Professor at the Sichuan Industrial Institute of Antibiotics (SIIA) of the University of Chengdu! Congratulations once again!

    We look forward to your steep academic career and our continuing friendship!

    March 2015
    NaCl? Is it possible to use table salt as catalyst? It is! Please, check out our most recent direct functionalization. Simple NaCl allows the efficient trifluoromethylthiolation of aromatic N-heterocycles such as pyrroles and indoles - transition metal-free! This method should prove especially valuable for applications in the pharmaceutical and agrochemical industry. Well done, Roman and Johannes!

    February 2015
    Two great talents! Two former postdocs who are now full Professors back in China have been selected for the prestigous "Thousand Talents Program". Prof. Honggen Wang from the School of Pharmaceutical Sciences of Sun Yat-sen University and Prof. Da-Gang Yu from the College of Chemistry of Sichuan University have both been selected in a very competitive procedure. This is a great honor and makes all of us proud! The Thousand Talents support will help them to rapidly build up an internationally visible research program. Congratulations, so well deserved!!!

    February 2015
    C-H Functionalization rules! Please, take a look at our most recent manuscripts that were just accepted by Angewandte Chemie (Zhao et al. and Vásquez-Céspedes et al.), JACS (Schröder et al.) and Chem. Sci. (Collins et al.). All four papers focus on challenging C-H functionalization reactions: the Co(III)-catalyzed C-H activation to form exciting fluorescent molecules (Zhao et al.), the Rh(III)-catalyzed C-H halogenation of electron-rich heterocycles (Schröder et al.), revealing a surprising dual role of the catalyst. In addition,  two other valuable transformations were realized under heterogeneous conditions: the C-H arylation of pi-extented arenes (Collins et al.) and also the sulfenylation of heteroarenes (Vásquez-Céspedes et al.). We are excited about this work and hope that these transformations will prove to be synthetically helpful. Congratulations everyone!!!

    December 2014
    "Drei auf einen Streich!" Please, take a look at our three most recent manuscripts that have just appeared in Angewandte Chemie (Zhao et al.) and in JACS (Guo et al. / Yu et al.). We report on our most recent successful attempts of switchable, highly asymmetric organocatalysis, of Co(III)-catalyzed C-H activation and of the formation of valuable aminoindoline products by Rh(III)-catalyzed C-H activation. Congratulations everyone!

    Frank Glorius was just awarded the "Goldener Brendel", the award for excellent teaching at the Department of Chemistry & Pharmacy. The award decision is based on the evaluation records of lectures and the decision is made by the students. Congratulations!

    November 2014
    This is great news! The Master thesis of Christoph Schlepphorst was selected for inclusion in the Springer "BestMasters" program. With "BestMasters" the publisher Springer is featuring the best Master theses, prepared at renowned universities in Germany, Austria and Switzerland. These theses were given the best marks and were recommended by referees. Congratulations Christoph!!!

    September 2014
    Dr. Wei Li and Dr. Xiaoming Wang started their research stay in the Glorius group, both awarded with a Humboldt-Fellowship. Congratulations, Wei and Xiaoming! Both will spend two months on a German language course in November/December 2014.

    September 2014
    In the last weeks, Lisa, Kim, Adrian, Wei and Xiaoming have arrived in order to join the group. All the best for your start and: Welcome!

    September 2014
    Frank Glorius has started his Novartis Chemistry Lecture Tour. The first two trips will bring him to the US sites of Novartis (San Diego, San Francisco, Boston). In addition he will also visit Scripps, UC Berkeley, Harvard University and MIT and other places, giving a total of nine talks. A great time to meet friends and to talk science!

    July 2014
    Summer time - conference time! You can meet members from the Glorius group at the following conferences: Trilateral symposium MS-SH-HK in Hong Kong/China; 2nd International Symposium on C-H Bond Activation (ISCHA) in Rennes/France; International Symposium on Homogeneous Catalysis (ISHC) in Ontario/Canada; 14th Belgian Organic Synthesis Symposium (BOSS) in Louvain-la-Neuve/Belgium; International Symposium for Advancing the Chemical Science ISACS14 (Challenges in Organic Chemistry) in Shanghai/China; 8th Asian European Symposium on Metal-Mediated Efficient Organic Synthesis (AES MMEOS) in Iztech/Turkey; ORCHEM in Weimar/Germany AND the Reaxys Inspiring Chemistry Conference in Grindelwald/Switzerland. Hope to see you!

    June 2014
    Thomson Reuters has selected Frank Glorius as one of the 2014 Highly Cited Researchers for ranking in the top 1% most cited papers in the field of chemistry. This distinction was determined after examining the top 1% cited papers published in Thomson Reuters Web of Science Core Collection during an 11-year period spanning from 2002 to 2012. In total, only about 3000 individuals worldwide from all disciplines were selected as 2014 Thomson Reuters Highly Cited Researchers. Congratulations to all former & present group members! Keep going!

    Congratulations to Michael Schedler for being selected as finalist for the 2014 Reaxys PhD Prize. Of nearly 540 submissions from around the world, 45 finalists were selected and will meet for the final selection at a Chemistry Conference in Switzerland in September. We keep our fingers crossed! Go NHC organocatalysis!

    March 2014
    Frank Glorius was selected for the prestigious Novartis Chemistry Lectureship Award 2014/15. Congratulations!

    Frank Glorius went on an exciting trip to China, in order to visit some of the worlds premier institutions for Chemical Research: the Shanghai Institute of Organic Chemistry-CAS (SIOC), Nankai University and Peking University (PKU). He will give talks and meet old and new friends.

    December 2013
    Dr. Mélissa Boultadakis-Arapinis has received the prestigious "Prix solennel de la Chancellerie des Universités de Paris" award for her PhD work! This is very well deserved and constitutes a big encouragement for the future. We are proud and very happy for her. Congratulations!!!

    November 2013
    Dr. Olga García Mancheño has become Associate Professor of Chemistry at the University of Regensburg: Congratulations!!! This is so well deserved and we are happy for you, but also miss you a lot! All the best for your future, Professor Garcia Mancheno!

    September 2013
    Dr. Honggen Wang successfully finished his postdoctoral stay in our group and has just started his new position as an Associate Professor at Sun Yat-sen University. Congratulations on your new position at this excellent University!!! With this, Honggen is following several other former group members, who have recently started their own independent academic careers: Raphael, Keiichi, Congyang, Ranganath, Tatiana, Biju, Xavier, Frederic, Joanna, ... Have fun and all the best for all of you!

    August 2013
    Dr. Olga García Mancheño has received an offer (Ruf) for an Associate Professorship at the Universität Regensburg! This is very well deserved and we are very happy for her. Congratulations to her and her team!!!

    July 2013
    Congratulations to Dr. Olga García Mancheño and Dr. Karl Collins, who both received prizes at the 2013 European Symposium of Organic Chemistry in Marseille.
    Olga received the ACS Catalysis Oral Communication Award for her excellent presentation, and Karl was awarded the Thieme Poster Prize.

    June 2013
    Please, check out our most recent publications: several quite exciting manuscripts on asymmetric hydrogenation, C-H activation chemistry and reaction methodology have recently been published. Congratulations everyone!
    In addition, we are very happy that our benzothiophene arylation work (J. Am. Chem. Soc. 2013, 135, 7450; Congratulations Daniel and Karl!) was the most accessed paper of JACS during the last month and that it was also highlighted by Nature (Nature 2013, 498, 275). Please, check it out!
    Finally, we are also very happy to have received so much positive feedback on our robustness screen (Nature Chem. 2013, 5, 597; Congratulation Karl!) and also to see it highlighted in the news & views section of Nature Chem. by an insightful article of Ian Churcher: Nature Chem. 2013, 5, 554.
    Congratulations everyone and: Keep on going!

    May 2013
    Two of our manuscripts have made it into Angewandtes most recent "most cited" list. Articles on this list are the most frequently cited ones among those published in 2010 or 2011. They have contributed the most to the journal's impact factor in 2012.

    Thomas Dröge, Frank Glorius,
    The Measure of All Rings—N-Heterocyclic Carbenes [Minireview],
    Angew. Chem. Int. Ed. 2010, vol. 49, pp. 6940–6952.


    Frederic W. Patureau, Tatiana Besset, Frank Glorius,
    Rhodium-Catalyzed Oxidative Olefination of C-H Bonds in Acetophenones and Benzamides [Communication],
    Angew. Chem. Int. Ed. 2011, vol. 50, pp. 1064–1067.

    Congratulations everyone!!!

    May 2013
    For three months each, Dr. Dennis Köster (short postdoctoral stay; formerly PhD student in group of Prof. Werz) and Mr. Matthew Lindale (exchange PhD student from the group of Prof. Liebeskind) have joined our group. We are excited about their arrival. Good luck and have fun!

    May 2013
    Please, check out our most recent publications: several manuscripts, we are very excited about, just appeared online! Congratulations to all contributors!!! And four more exciting manuscripts are under minor revision at the moment, so please, keep your fingers crossed!

    April 2013
    Nils Schröder has just started a 6-month stay in the group of Prof. Kenichiro Itami at Nagoya University, Japan.

    January 2013
    A few days ago the Deutsche Forschungsgemeinschaft (DFG) announced the winners of the Leibniz-Award 2013, "Germanys most important research award."

    ....and the Leibniz goes to... us!

    This is a great honor for all present and past group members, CONGRATULATIONS!!!

    Dezember 2012
    Please check this out: Two of our recent Angewandte Chemie manuscripts already made it among the "25 Most Accessed" papers of the last 12 months (11/2011 - 10/2012), with the Asymmetric Hydrogenation paper even being at the top of the list(!):

    N. Ortega, S. Urban, B. Beiring, F. Glorius,
    Ruthenium-NHC Catalyzed Highly Asymmetric Hydrogenation of Benzofurans,
    Angew. Chem. Int. Ed. 2012, 51, 1710-1713; Angew. Chem. 2012, 124, 1742-1745.

    N. Kuhl, M. N. Hopkinson, J. Wencel-Delord, F. Glorius,
    Beyond Directing Groups: Transition Metal-Catalyzed C H Activation of Simple Arenes,
    Angew. Chem. Int. Ed. 2012, 51, 10236-10254; Angew. Chem. 2012, 124, 10382-10401.

    Similarly, our most recent Organic Letters paper made it among the top 5 "Most Read Articles" of the last 12 months:

    F. W. Patureau, C. Nimphius, F. Glorius,
    Rh Catalyzed C–H Activation and Oxidative Olefination without Chelate Assistance: On the Reactivity of Bromoarenes,
    Org. Lett. 2011, 13, 6346-6349.

    Congratulations to everyone!!! And, please, check them out!

    November 2012
    Dr. Da-Gang Yu and Dr. Dongbing Zhao were awarded as Humboldt-Fellows at the same day. Congratulations, Da-Gang and Dongbing! Both will spend 2 months on a German language course during the first weeks in 2013.

    November 2012
    Dr. Da-Gang Yu joined the Glorius group as postdoctoral research fellow. Welcome Da-Gang!

    Oktober 2012
    Dr. Dongbing Zhao joined the Glorius group as postdoctoral research fellow. Welcome Dongbing!

    Oktober 2012
    Dr. Matthew N. Hopkinson, who has recently started in the Glorius group as a postdoctoral research fellow, was awarded as Humboldt-Fellow, and is now spending 2 months on a German language course. Congratulations Matt!

    September 2012
    Michael Schedler was awarded with a price for his oral communication on the "International Conference Catalysis in Organic Synthesis" (ICCOS 2012) in Moscow, Russia. Congratulations!

    August 2012
    Dr. Karl Collins joined the Glorius group as postdoctoral research fellow. Welcome Karl!

    July 2012
    Science Watch: Our C-H activation work was kindly highlighted online. Please, take a look!

    February 2012
    Slawomir (Slawek) Urban was awarded with the Procter & Gamble Award of the JungChemikerForum Münster. The ceremonial lecture was given by Prof. Georg Schwedt, University of Bonn:
    "From Sugar to Spicery - Food Chemistry Experiments with Supermarket Products". Congratulations!

    November 2011
    Christoph Grohmann had recently finished a Japanese languague intensive course at the LSI Bochum and has started his 6-month stay in the Tatsumi group in Nagoya/Japan.

    November 2011
    Dr. Zhuangzhi Shi has recently started research in the Glorius group as a Humboldt fellow, after spending 2 months on a German language course. Welcome Zhuangzhi!

    July 2011
    Thomas Dröge was awarded with the Poster Prize of Catalysis Science & Technology at OMCOS 16 Conference (Shanghai, PR China). Congratulations!