A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected in clinical trials by higher efficacy and success rates. However, they could only be produced at great expense or not at all using previous methods. Chemists led by Prof. Frank Glorius (University of Münster) and his colleagues Prof. M. Kevin Brown (Indiana University Bloomington, USA) and Prof. Kendall N. Houk (University of California, Los Angeles, USA) have now succeeded in converting several classes of flat nitrogen-containing molecules into the desired three-dimensional structures. Using more than 100 novel examples, they were able to demonstrate the broad applicability of the process. This study has now been published in the journal “Science”.
Dr. Manuel van Gemmeren, a chemist, convinced with his science: The German Research Foundation funds the junior scientist from the University of Münster with almost 1.7 million euros. This will enable him to set up his own research group at the Institute of Organic Chemistry over the next six years.
Münster (upm/sr) | 06.12.2019
Prof. Ryan Gilmour has been appointed "Prof. David Ginsburg Lecturer" at the Technion – Israel Institute of Technology for the academic year 2020/21.
Münster (upm/sr) | 29.11.2019
So far, instructors Karin Hassels and Peter Eggert have supervised 43 chemical lab assistants during their training.
In addition to providing facilities for studies and research, the University of Münster offers apprenticeships and vocational training in 19 different occupations – from gardener to IT systems technician. One example of this vocational training is that for chemical laboratory assistants at the Institute of Organic Chemistry, where the two people responsible for this training are Karin Hassels (since 2009) and Peter Eggert (since 2001). Kathrin Nolte spoke with the two instructors about educational requirements and about the development away from practical working towards a greater demand for specialist knowledge.
Pressure vessel (autoclave) for the hydrogenation of fluorinated pyridines. The reactions are carried out at a hydrogen pressure of 50 bar (normal atmospheric pressure is 1 bar).
Synthetic molecules are essential for many products in our lives: medicines, crop protection agents or special materials such as Teflon. These molecules have several components, which can be combined in a variety of ways, resulting in different properties. Both so-called piperidines and fluorinated groups are particularly important. Piperidines are small, ring-shaped chemical compounds. Since, as a result of their particular properties, fluorine atoms bring about dramatic changes in the properties of certain products –they are often integrated in pharmaceuticals. Hence around twenty percent of all medicines sold worldwide contain fluorine. Up to now, however, combining fluorine atoms and piperidines has always been an extremely laborious process. Now, for the first time, chemists at the University of Münster have developed a new, easy to do synthesis method for producing such fluorine-bearing piperidines. The study – written by Dr. Zackaria Nairoukh, Marco Wollenburg, Dr. Christoph Schlepphorst, Dr. Klaus Bergander and Prof. Frank Glorius – has just been published in the online edition of the Nature Chemistry journal.
On Tuesday evening (January 15th), the two outstanding junior scientists Manuel van Gemmeren and Raphael Wittkowski from the University of Münster have been welcomed by the North Rhine-Westphalian Academy of Sciences, Humanities and the Arts (AWK NRW) in Düsseldorf as new members of the Junges Kolleg. (see German press release here)
Münster (upm/ja) | 16.01.2019
Niels Petersen and Ryan Gilmour awarded Consolidator Grants by the European Research Council
Münster (upm/kk) | 03.12.2018
The new method has been described by a team of German and Chinese researchers headed by Prof. Bart Jan Ravoo, a chemist at the “Center for Soft Nanoscience” at the University of Münster.
Münster (upm) | 20.11.2018
Awarded for pioneering contributions on the use of N-heterocyclic carbene ligands in selective arene hydrogenation
Münster (upm/ch) | 08-05-2018
Two “Advanced Grants” from the European Research Council (ERC) go to researchers at the University of Münster and the Max Planck Institute (MPI) of Molecular Biomedicine in Münster.
Münster (upm) | 16.04.2018
Sought-after compounds readily accessible for the first time / Science publication as “breakthrough”
Münster (upm) | 11.08.2017
PhD student Johannes Ernst and his supervisor, Prof. Frank Glorius, from the Organic Chemistry Institute will receive two awards from the International Precious Metal Institute (IPMI) in Florida in June.
Glorius | 24.05.2017
The Chemical Society of Japan", CSJ, has named Prof. Erker as an honorary member
Münster (upm) | 07.04.2017
Within the Science magazine the Studer Research Group has published a unique concept for the transition metal-free formation of three C-C-bonds starting from vinylboron ate complexes.
Münster (upm/ch/lt) | 03.03.2017
Auszeichnung durch Max-Planck-Gesellschaft / Grundlagenforschung zur Kontrolle chemischer Reaktionen
Münster (upm/ch) | 17.01.2017
Starting Grant for Prof. Dr. Gustavo Fernández Huertas
(upper link to German press release)
Münster (upm) | 23.09.2016
The Society of Synthetic Organic Chemistry of Japan has selected Prof. Dr. Frank Glorius as the winner of the 2017 Mukaiyama Prize.
Glorius | 01.09.2016
European Research Council Awards Prof. Armido Studer with an “Advanced Grant”
(available in )
Münster (upm) | 10.05.2016