Dr. rer. nat. Helge Prinz

Pharmacist

© Prinz

 

 

 

 

 

 

 

 

 

 

Laboratory Address

Institute of Pharmaceutical and Medicinal Chemistry
Westfälische Wilhelms-Universität Münster
Corrensstr. 48
D-48149 Münster

Office phone number: +49 (0) 251-83-32195
Lab phone number: +49 (0) 251-83-33352
Room BC.120.285 (office) / B.120.243 (lab)
E-Mail


Education and Employment

  • 1986-1990, study of pharmaceutical sciences, Johannes Gutenberg-University Mainz, Germany
  • October 1990-September 1991, pharmaceutical probationer, public pharmacy, Mainz
  • October 1991, licensed as a qualified pharmacist, Mainz
  • November 1991-December 1995, graduate research assistant and graduate teaching assistant, University of Regensburg, Pharmaceutical and Medicinal Chemistry I, Ph.D. in Pharmaceutical and Medicinal Chemistry, Title of the Ph.D. thesis: '2-Substituted hydroxamic acid derivatives of the antipsoriatic anthralin - Synthesis and biological activity', supervisor: Prof. Dr. K. Müller (Pharmaceutical Chemistry)
  • 1996, postgraduate studies at the Institute of Pharmaceutical Chemistry, Universität Regensburg, Germany
  • 1997-onwards, postgraduate studies at the Institute of Pharmaceutical and Medicinal Chemistry, WWU Münster, Germany
  • 1999, June-October, visiting scientist at Graduate School of Biomedical Engineering (Prof. Umezawa), Faculty of Science and Technology, Keio University, Yokohama, Japan.
  • 1999-onwards, postgraduate studies at WWU Münster, Germany, Institute of Pharmaceutical and Medicinal Chemistry
  • 2003-present, employed at WWU Münster, Germany, Institute of Pharmaceutical and Medicinal Chemistry

Primary Research Interests

  • novel inhibitors of tumor cell growth – synthesis and mechanism of action
  • inhibitors of tubulin polymerization
  • CK2 inhibitors

Selected Publications

  • Prinz*, H.; Ishii, Y.; Hirano, T.; Stoiber, T.; Camacho Gomez, J. A.; Schmidt, P.; Düßmann, H.; Burger, A. M.; Prehn, J. H.; Günther, E. G.; Unger, E.; Umezawa, K. Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J. Med. Chem. 2003, 46, 3382-3394.
  • Zuse, A.; Schmidt, P.; Baasner, S.; Böhm, K. J.; Müller, K.; Gerlach, M.; Günther, E. G.; Unger, E.; Prinz*, H. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J. Med. Chem. 2006, 49, 7816-7825.
  • Zuse, A.; Schmidt, P.; Baasner, S.; Böhm, K. J.; Müller, K.; Gerlach, M.; Günther, E. G.; Unger, E.; Prinz*, H. Sulfonate derivatives of Naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)Anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J. Med. Chem. 2007, 50, 6059-6066.
  • Preparation of 10-phenacylidenylanthrones and related compounds for treatment of benign and malignant tumors diseases. Gerlach, Matthias; Günther, Eckhard; Schmidt, Peter; Prinz, Helge; Böhm, Konrad; Unger, Eberhard. PCT Int. Appl. (2008), 104 pp., WO 2008015265 A1 20080207 CAN 148:238891
  • Prinz* H., Schmidt P., Böhm K. J., Baasner S., Müller K., Unger E., Gerlach M., Günther E. G., 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization, J. Med. Chem., 2009, 52, 1284-1294.
  • Putic A., Stecher L., Prinz H., Müller K., Structure-activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth, Eur. J. Med. Chem., 2010, 45(8), 3299-3310
  • Surkau G., Böhm K. J., Müller K., Prinz* H., Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives, Eur. J. Med. Chem., 2010, 45(8), 3354-3364
  • Nickel H., Schmidt P., Böhm K. J., Baasner S., Müller K., Gerlach M., Unger E., Günther E. G., Prinz* H., Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety, Eur. J. Med. Chem., 2010, 45(8), 3420-3438
  • Kratz U., Prinz H., Müller K., Synthesis and biological evaluation of novel 10-benzyl-substituted 4,5-dichloro-10H-anthracen-9-ones, Eur. J. Med. Chem., 2010, 45, 5278-5285
  • Putic A., Stecher L., Prinz H., Müller K., Structure-activity relationship studies of acridones as potential antipsoriatic agents. 2. Synthesis and antiproliferative activity of 10-substituted hydroxy-10H-acridin-9-ones against human keratinocyte growth, Eur. J. Med. Chem., 2010, 45, 5345-5352
  • Prinz* H., Böhm K., Müller K., Synthesis of 2,6-aceanthrylenedione, a cyclic vinylog of anthraquinone, J. Org. Chem., 2010, 75(11), 3867-3870
  • Prinz* H., Chamasmani B., Vogel K., Böhm K. J., Aicher B., Gerlach M., Günther E. G., Amon P., Ivanov I., Müller K., N-Benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity and inhibition of tubulin polymerization, J. Med. Chem., 2011, 54, 4247-4263
  • Prinz* H., Schmidt P., Böhm K. J., Baasner S., Müller K., Gerlach M. E., Günther G.,  Unger E., Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents - Synthesis, antiproliferative activity and inhibition of tubulin polymerization, Bioorgan. Med. Chem., 2011, 19, 4183-4191
  • A. Reichstein, S. Vortherms, S. Bannwitz, J. Tentrop, H. Prinz, K. Müller; Synthesis and Structure-activity relationships of Lapacho Analogues 1. Suppression of Human Keratinocyte Hyperproliferation by 2-Substituted Naphtho[2,3-b]furan-4,9-diones, Activation by Enzymatic One- and Two-Electron Reduction, and Intracellular Generation of Superoxide , J. Med. Chem. 2012, 55, 7273-7281
  • H. Li, M. DH Hassona, N. A. Lack, P. Axerio-Cilies, E. Leblanc, N. Kanaan, K. Frewin, K. Singh, H. Adomat, K. J. Böhm, H. Prinz, E. Tomlinson Guns, P. S. Rennie, A. Cherkasov; Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer, Mol. Cancer Ther. 2013, Published Online first August 12, 2013, DOI: 10.1158/1535-7163.MCT-13-0267
  • D. Harel, D. Schepmann, H. Prinz, R. Brun, T. J. Schmidt, Wünsch B.; Natural product derived antiprotozoal agents: Synthesis, biological evaluation and structure-activity relationships of novel chromene and chromane derivatives, J. Med. Chem. 2013, Accepted, DOI: 10.1021/jm401007p
  • S. Bannwitz, D. Krane, S. Vortherms, T. Kalin, C. Lindenschmidt, N. Zahedi Golpayegani, J. Tentrop, H. Prinz, K. Mueller; Synthesis and Structure-​Activity Relationships of Lapacho Analogues. 2. Modification of the Basic Naphtho[2,​3-​b]​furan-​4,​9-​dione, Redox Activation, and Suppression of Human Keratinocyte Hyperproliferation by 8-​Hydroxynaphtho[2,​3-​b]​thiophene-​4,​9-​diones, J. Med. Chem. 2014, 57, 6226-6239
  • A. Marcu, U. Schurigt, K. Müller, H. Moll, R. L. Krauth-Siegel, H. Prinz*, Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase, Eur. J. Med. Chem. 2016, 108, 436-443
  • C. Lindenschmidt, D. Krane, S. Vortherms, L. Hilbig, H. Prinz, K. Müller, 8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties, Eur. J. Med. Chem. 2016, 110, 280-290
  • H. Prinz*, A.-K. Ridder, K. Vogel, K. J. Böhm, I. Ivanov, J. B. Ghasemi, E. Aghaee, K. Müller, N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization, J. Med. Chem. 2017, 60, 749-766
  • A. Basoglu, S. Dirkmann, N. Zahedi Golpayegani, S. Vortherms, J. Tentrop, D. Nowottnik, H. Prinz, R. Fröhlich, K. Müller, Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent, Eur. J. Med. Chem. 2017, 134, 119-132
  • K. Dalal, H. Morin, F. Ban, A. Shepherd, M. Fernandez, K. J. Tam, H. Li, E. LeBlanc, N. Lack, H. Prinz, P. S. Rennie, A. Cherkasov; Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor, Eur. J. Med. Chem. 2018, 157, 1164-1173
  • Waltemate, J.; Ivanov, I.; Ghasemi, J. B.; Aghaee, E.; Daniliuc, C. G.; Muller, K.; Prinz*, H. 10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorganic Med. Chem. Lett. 2021, 32, doi.org/10.1016/j.bmcl.2020.127687.

Seminars and Lab Courses

  • Course management and implementation of the lab course (AAppO) on general and analytical chemistry of inorganic drugs, excipients and harmful substances (including pharmacopoeial methods), Prinz, H. / Koch, O.

Lectures

  • Pharmaceutical/Medicinal Chemistry II (Vorl.), Prinz, H. / Jose, J.

Further

  • Teaching and education of (chemical) laboratory assistant trainees

  • Textbook "Pharmazeutische/Medizinische Chemie Arzneistoffe - von der Struktur zur Wirkung"
    Klaus Müller, Helge Prinz, Matthias Lehr
    Wissenschaftliche Verlagsgesellschaft; First Edition (October 6, 2022), 1720 pages