Dr. Dmitrii V. Kalinin |
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| 2004 – 2009 | Diploma in Pharmacy, Perm State Pharmaceutical Academy, Russia |
| 2009 | Internship in Pharmaceutical Holding STADA CIS and Biotech Company, "Biocad", Moscow, Russia |
| 2010 – 2012 | Organic Chemistry assistant (Perm State Pharmaceutical Academy) and work as a pharmacist, Russia |
| 02/2012 – 11/2012 | Research associate in the laboratory of Dr. A. V. Dolzhenko, School of Pharmacy, Curtin University of Technology, Australia |
| 2013 – 2017 | Ph.D thesis (International “Cells in Motion” Graduate School) under the supervision of Prof. Dr. R. Holl in the group of Prof. Dr. B. Wünsch, University of Münster, Germany |
| 2015 | Short research stay (Molecular Modelling) in the group of Prof. Dr. W. Sippl, Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg, Germany |
| 2017 – 2018 | Post-doc with Prof. Dr. Trond Ulven, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Denmark |
| Since 2018 | Project Leader at the Institute of Pharmaceutical and Medicinal Chemistry University of Münster, Germany |
Awards and Honors |
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| 2017 | “Cells-in-Motion Bridging Grant” (short-lasting Post-doc position, CiM, WWU) |
| 2015 | “Pilot Project Grant” (start-up financing for research project, CiM, WWU) |
| 2016 | Best poster prize, Symposium on Medicinal Chemistry EFMC-ISMC 2016, Manchester, UK |
| 2014 | Best poster prize, 7th Summer school "Medicinal Chemistry", University of Regensburg, Germany |
| 2013 | Ph.D. Fellowship of the “Cells in motion” Graduate School |
| 2013 | Endeavour Postgraduate Scholarship in Australia (declined in a favor of “CIM Fellowship”) |
| 2012 | Scholarship of the President of the Russian Federation for Traineeship Abroad |
| 2011 | Research Grant “START” (Fund for Assistance to Small Innovative Enterprises in Science and Technology) |
| 2010 | Research Grant “UMNIK” – the pre-seed funding program (Fund for Assistance to Small Innovative Enterprises in Science and Technology) |
| 2008 | Best poster and presentation prize, National Congress “Man and Medicine”, Moscow |
| 2008, 2009 | Scholarship of the President of the Russian Federation |
| 2006 | Scholarship of the Head of the City of Perm |
| Topics of Research |
| Blood Coagulation Synthesis of Small Molecules Targeting Thrombosis Blood Coagulation Factors and Neuroinflammation |
| Our research activities lay in the field of Medicinal Chemistry and Drug Design. We are mainly focused on the development of new chemical entities aiming to address blood coagulation factors to find their application as anticoagulant agents. For this purpose, we utilize a computational approach to design new molecules followed by their synthesis and analytical characterization. Additional emphasis is placed on the drug-like characteristics of compounds, e.g. lipophilicity, solubility, stability etc. Newly synthesized potential anticoagulants are subjected to enzymatic assays and in vitro coagulation tests. |
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| Synthetic approach: heterocyclic chemistry, Pd-catalyzed cross-coupling reactions, carbonylative reactions, stereoselective synthesis, microwave-assisted synthesis etc. Molecular modeling: computer-aided drug design, docking studies; Bioassays: we utilize and develop in vitro coagulation assays and study the inhibitory activity of novel compounds towards the human blood coagulation factors utilizing chromogenic substrates. |
Publications |
| 1. Marek, M., Tajith, B. S., Heimburg, T., Chakrabarti, A., Lancelot, J., Ramos-Morales, E., Veiga, C.D., Kalinin, D.V., et. al. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 2018, 61 (22), 10000-10016. DOI: 10.1021/acs.jmedchem.8b01087 2. Tangherlini, G., Kalinin, D. V., Schepmann, D., Che, T., Mykicki, N., Ständer, S., ... & Wünsch, B. Development of novel quinoxaline-based kappa-opioid receptor (KOR) agonists for the treatment of neuroinflammation. J. Med. Chem., 2018 (Article ASAP). DOI: 10.1021/acs.jmedchem.8b01609 3. Kalinina, S. A.*, Kalinin, D. V.*, Hövelmann, Y., Daniliuc, C. G., Mück-Lichtenfeld, C., Cramer, B., & Humpf, H. U. Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity. J. Nat. Prod., 2018, 81(10), 2177-2186. *- contributed equally, DOI: 10.1021/acs.jnatprod.8b00187 4. Thum, S., Schepmann, D., Kalinin, D. V., Ametamey, S. M., & Wünsch, B. Replacement of the Benzylpiperidine Moiety with Fluorinated Phenylalkyl Side Chains for the Development of GluN2B Receptor Ligands. ChemMedChem 2018, 13.23: 2522-2529. DOI: https://doi.org/10.1002/cmdc.201800566 5. Kalinin, D.V. and Holl, R., LpxC inhibitors: a patent review (2010-2016). Expert Opin. Ther. Pat. 2017, 27 (11), 1227-1250. DOI: 10.1080/13543776.2017.1360282 6. Kalinin, D.V. Doctoral dissertation: “Amino Acid- and Triazole-Based Hydroxamates Targeting Zn2+-dependent Enzymes (LpxC, MMPs, and smHDAC8): Synthesis, Biological Evaluation, Docking Studies, and PET Tracer Development, 477 pages. University of Münster, 2016 7. Kalinin, D.V., Wagner, S., Riemann, B., Hermann, S., Schmidt, F., Becker-Pauly, C., Rose-John, S., Schäfers, M. and Holl, R. Novel Potent Proline-based Metalloproteinase Inhibitors: Design, (Radio)Synthesis and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography. J. Med. Chem., 2016, 59 (20), 9541–9559. DOI: 10.1021/acs.jmedchem.6b01291 8. Kalinin, D. V., Holl, R.. Insights into the zinc-dependent deacetylase LpxC: biochemical properties and inhibitor design. Curr Top Med Chem 2016, 16 (21), 2379-2430. DOI: 10.2174/1568026616666160413135835 9. Kalinina, S. A., Elkina, O. V., Kalinin, D. V., Syropyatov, B. Y., Dolzhenko, A. V. Diuretic activity and toxicity of some Verbascum nigrum extracts and fractions. Pharm Biol 2014, 52 (2), 191-8. DOI: 10.3109/13880209.2013.822001 10. Kalinin, D. V., Pantsurkin, V. I., Syropyatov, B. Y., Kalinina, S. A., Rudakova, I. P., Vakhrin, M. I., Dolzhenko, A. V. Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides. Eur J Med Chem 2013, 63, 144-50. DOI: 10.1016/j.ejmech.2013.02.003 11. Kalinina, S. A., Kalinin, D. V., Dolzhenko, A. V. A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1, 2, 4-triazolo [1,5-a][1,3,5] triazines. Tetrahedron Letters 2013, 54 (40), 5537-5540. DOI: http://dx.doi.org/10.1016/j.tetlet.2013.07.158 12. Dolzhenko, A. V., Kalinina, S. A., Kalinin, D. V. A novel multicomponent microwave-assisted synthesis of 5-aza-adenines. RSC Advances 2013, 3 (36), 15850-15855. DOI: 10.1039/C3RA41932K 13. Kalinin, D. V., Kalinina, S. A., Dolzhenko, A. V. A new synthesis of amino substituted azolo [1,3,5] triazines via reaction of N1, N1-dimethyl-N2-azolylformamidines with cyanamide. Heterocycles 2013, 87(1), 147-154. DOI: 10.3987/COM-12-12601 14. Kalinin, D.V., Kalinina, S.A., and Dolzhenko, A.V. Synthesis of novel trichloromethyl substituted azolo [1,3,5] triazines. Heterocycles 2012, 85(10), 2515-2522. DOI: 10.3987/COM-12-12542 |