Dr. Dmitrii V. Kalinin

since 2018 Group Leader at the Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany
2017-2018 Postdoc at the University of Southern Denmark (group of Prof. T. Ulven), Denmark
2015 Research Stay (Molecular Modelling) at the Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg (group of Prof. W. Sippl), Germany
2013-2017 Ph.D. Fellow of the International “Cells in Motion” Graduate School, University of Münster (group of Prof. B. Wünsch and Prof. R. Holl), Germany
Dissertation: Amino Acid- and Triazole-Based Hydroxamates Targeting Zn2+-dependent Enzymes (LpxC, MMPs, and smHDAC8): Synthesis, Biological Evaluation, Docking Studies, and PET Tracer Development, 477 pages, Münster, 2016.
2012 Research Associate at the School of Pharmacy, Curtin University of Technology (group of Prof. A. Dolzhenko), Australia
2010-2012 Organic Chemistry Assistant at the Perm State Pharmaceutical Academy and work as a Pharmacist, Russia
2004-2009 Study of Pharmacy, Perm State Pharmaceutical Academy, Russia

Awards and Honors

2017 “Cells-in-Motion Bridging Grant” (short-lasting Post-doc position, CiM, WWU)
2015 “Pilot Project Grant” (start-up financing for research project, CiM, WWU)
2016 Best poster prize, Symposium on Medicinal Chemistry EFMC-ISMC 2016, Manchester, UK
2014 Best poster prize, 7th Summer school "Medicinal Chemistry", University of Regensburg, Germany
2013 Ph.D. Fellowship of the “Cells in motion” Graduate School
2013 Endeavour Postgraduate Scholarship in Australia (declined in a favor of “CIM Fellowship”)
2012 Scholarship of the President of the Russian Federation for Traineeship Abroad
2011 Research Grant “START” (Fund for Assistance to Small Innovative Enterprises in Science and Technology)
2010 Research Grant “UMNIK” – the pre-seed funding program
(Fund for Assistance to Small Innovative Enterprises in Science and Technology)
2008 Best poster and presentation prize, National Congress “Man and Medicine”, Moscow
2008, 2009 Scholarship of the President of the Russian Federation
2006 Scholarship of the Head of the City of Perm



Topics of Research

Blood Coagulation
Synthesis of Small Molecules Targeting Thrombosis
Blood Coagulation Factors and Neuroinflammation

Our research activities lay in the field of Medicinal Chemistry and Drug Design. We are mainly focused on the development of new chemical entities aiming to address blood coagulation factors to find their application as anticoagulant agents. For this purpose, we utilize a computational approach to design new molecules followed by their synthesis and analytical characterization. Additional emphasis is placed on the drug-like characteristics of compounds, e.g. lipophilicity, solubility, stability etc. Newly synthesized potential anticoagulants are subjected to enzymatic assays and in vitro coagulation tests.

This Project is supported by the Deutsche Forschungsgemeinschaft (DFG)