Participation in the Cluster of Excellence

CiM Professor of Biomolecular Label Chemistry
Vice Chairwoman of the Gender and Diversity Committee

  • Research Area A.5: Surface-Targeted Tracking of Individual Cells In Vivo
  • Project FF-2016-09: A chemo-enzymatic approach for posttranscriptional RNA-labeling in living zebrafish (Sebastian Leidel, Andrea Rentmeister, project time: 07/2016 - 06/2018)
  • Project FF-2016-13: Novel tools for mRNA labeling in Drosophila (Sebastian Rumpf, Andrea Rentmeister, project time: 07/2016 - 06/2018)
© CiM - Peter Grewer

“Quality is the top priority“

Prof. Andrea Rentmeister labels biomolecules, especially RNA. The chemical reactions necessary for this have to be highly selective and proceed under mild conditions as they are carried out on living cells. For Andrea Rentmeister it is especially important always to work accurately, because this is the way to find out the reason if something has gone wrong. Read the interview

CiM Papers

all papers by Andrea Rentmeister

Accepted for publication

Hartstock K, Nilges B, Ovcharenko A, Cornelissen N, Puellen N, Leidel S, Rentmeister A. Enzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA. Angew. Chem.: accepted for publication.


Holstein JM, Muttach F, Schiefelbein SHH, Rentmeister A. Dual 5' Cap Labeling Based on Regioselective RNA Methyltransferases and Bioorthogonal Reactions. Chemistry 2017;23: 6165-6173. Abstract
Kellermann SJ, Rentmeister A. A FACS-based screening strategy to assess sequence-specific RNA-binding of Pumilio protein variants in E coli. Biol Chem 2017;398: 69-75. Abstract
Muttach F, Masing F, Studer A, Rentmeister A. New AdoMet Analogues as Tools for Enzymatic Transfer of Photo-Cross-Linkers and Capturing RNA-Protein Interactions. Chemistry 2017;23: 5988-5993. Abstract
Muttach F, Muthmann N, Reichert D, Anhäuser L, Rentmeister A. A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation. Chem. Sci. 2017;8: 7947-7953. Abstract
Muttach F, Muthmann N, Rentmeister A. Chemo-enzymatic modification of eukaryotic mRNA. Org Biomol Chem 2017;15: 278-284. Abstract


Holstein JM, Anhauser L, Rentmeister A. Modifying the 5'-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells. Angew Chem Int Ed Engl 2016;55: 10899-10903. Abstract
Holstein JM, Rentmeister A. Current covalent modification methods for detecting RNA in fixed and living cells. Methods 2016;98: 18-25. Abstract
Holstein JM, Stummer D, Rentmeister A. Enzymatic Modification of 5'-Capped RNA and Subsequent Labeling by Click Chemistry. Methods Mol Biol 2016;1428: 45-60. Abstract
Kellermann SJ, Rentmeister A. A Genetically Encodable System for Sequence-Specific Detection of RNAs in Two Colors. Chembiochem 2016;17: 895-899. Abstract
Mannack LVJC, Eising S, Rentmeister A. Current techniques for visualizing RNA in cells. F1000Res 2016;5: epub. Abstract
Muttach F, Rentmeister A. A Biocatalytic Cascade for Versatile One-Pot Modification of mRNA Starting from Methionine Analogues. Angew Chem Int Ed Engl 2016;55: 1917-1920. Abstract
Muttach F, Rentmeister A. One-pot modification of 5'-capped RNA based on methionine analogs. Methods 2016;107: 3-9. Abstract
Rau K, Rentmeister A. CRISPR/Cas9: A New Tool for RNA Imaging in Live Cells. Chembiochem 2016;17: 1682-1684. Abstract
Rentmeister A, Kellermann S. Manipulation von RNA mit Designerproteinen. Nachr. Chem. 2016;64: 297-301. Abstract


Holstein JM, Stummer D, Rentmeister A. Enzymatic modification of 5′-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels–Alder reaction. Chem. Sci. 2015;6: 1362-1369. Abstract
Holstein JM, Stummer D, Rentmeister A. Engineering Giardia lamblia trimethylguanosine synthase (GlaTgs2) to transfer non-natural modifications to the RNA 5'-cap. Protein Eng Des Sel 2015;28: 179-186. Abstract
Kaljunen H, Schiefelbein SHH, Stummer D, Kozak S, Meijers R, Christiansen G, Rentmeister A. Structural Elucidation of the Bispecificity of A Domains as a Basis for Activating Non-natural Amino Acids. Angew Chem Int Ed Engl 2015;54: 8833-8836. Abstract
Rath AK, Rentmeister A. Genetically encoded tools for RNA imaging in living cells. Curr Opin Biotechnol 2015;31: 42-49. Abstract
Rentmeister A. CRISPR craze conquers the RNA world: precise manipulation of DNA and RNA based on a bacterial defense system. Angew Chem Int Ed Engl 2015;54: 4710-4712. Abstract
Stummer D, Herrmann C, Rentmeister A. Quantum Chemical Calculations and Experimental Validation of the Photoclick Reaction for Fluorescent Labeling of the 5' cap of Eukaryotic mRNAs. ChemistryOpen 2015;4: 295-301. Abstract


Holstein JM, Schulz D, Rentmeister A. Bioorthogonal site-specific labeling of the 5'-cap structure in eukaryotic mRNAs. Chem Commun (Camb) 2014;50: 4478-4481. Abstract
Kellermann SJ, Rentmeister A. Current Developments in Cellulase Engineering. ChemBioEng Reviews 2014;1: 6-13. Abstract
Rath AK, Kellermann SJ, Rentmeister A. Programmable design of functional ribonucleoprotein complexes. Chem Asian J 2014;9: 2045-2051. Abstract
Schulz D, Rentmeister A. Chemo-enzymatic Strategies to Modify RNA in vitro or in Living Cells. In: Erdmann VA, Markiewicz WT, Barciszewski J. Chemical Biology of Nucleic Acids 2014;Springer Berlin Heidelberg: 409-421. Abstract
Schulz D, Rentmeister A. Current approaches for RNA labeling in vitro and in cells based on click reactions. Chembiochem 2014;15: 2342-2347. Abstract