© WWU - Laura Grahn

„Qualität ist die oberste Priorität“ – ein Interview mit Andrea Rentmeister

Prof. Andrea Rentmeister markiert Biomoleküle, insbesondere RNA. Die dafür notwendigen chemischen Reaktionen müssen hochselektiv und besonders schonend sein, denn sie werden an lebenden Zellen durchgeführt. Besonders wichtig ist ihr, immer akkurat zu arbeiten. So lässt sich nämlich auch herausfinden, woran es liegt, wenn einmal etwas nicht klappt.

  • Beteiligung an „Cells in Motion“

    • Cells-in-Motion-Professorin für Biomolekulare Markierungschemie
    • Vorstandsmitglied des Cells in Motion Interfaculty Centres
    • Mitglied im Graduiertenprogramm CiM-IMPRS
    • Forschungsinteressen: biomolecular label chemistry, RNA biochemistry, bioorthogonal chemistry, RNA modifications, nucleic acid chemistry, chemical biology, mRNA
    • Projekt FF-2016-09: A chemo-enzymatic approach for posttranscriptional RNA-labeling in living zebrafish (Sebastian Leidel, Andrea Rentmeister, Projektlaufzeit: 07/2016 - 10/2018)
    • Projekt FF-2016-13: Novel tools for mRNA labeling in Drosophila (Sebastian Rumpf, Andrea Rentmeister, Projektlaufzeit: 07/2016 - 10/2018)

  • Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“

    alle Publikationen von Andrea Rentmeister


    Michailidou F, Klocker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kummel D, Rentmeister A. Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew Chem Int Ed Engl 2021;60: 480-485. Abstract


    Anhauser L, Klocker N, Muttach F, Masing F, Spacek P, Studer A, Rentmeister A. A Benzophenone-Based Photocaging Strategy for the N7 Position of Guanosine. Angew Chem Int Ed Engl 2020;59: 3161-3165. Abstract
    Cornelissen NV, Michailidou F, Muttach F, Rau K, Rentmeister A. Nucleoside-modified AdoMet analogues for differential methyltransferase targeting. Chem Commun (Camb) 2020;56: 2115-2118. Abstract
    Kurmayer R, Entfellner E, Weisse T, Offterdinger M, Rentmeister A, Deng L. Chemically labeled toxins or bioactive peptides show a heterogeneous intracellular distribution and low spatial overlap with autofluorescence in bloom-forming cyanobacteria. Sci Rep 2020;10: 2781. Abstract
    Leiter J, Reichert D, Rentmeister A, Micura R. Practical Synthesis of Cap-4 RNA. Chembiochem 2020;21: 265-271. Abstract
    Muthmann N, Hartstock K, Rentmeister A. Chemo-enzymatic treatment of RNA to facilitate analyses. Wiley Interdiscip Rev RNA 2020;11: e1561. Abstract
    Westerich KJ, Chandrasekaran KS, Gross-Thebing T, Kueck N, Raz E, Rentmeister A. Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos. Chem. Sci. 2020;11: 3089-3095. Abstract


    Anhauser L, Huwel S, Zobel T, Rentmeister A. Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells. Nucleic Acids Res 2019;47: e42. Abstract
    Anhauser L, Teders M, Rentmeister A, Glorius F. Bio-additive-based screening: toward evaluation of the biocompatibility of chemical reactions. Nat Protoc 2019;14: 2599-2626. Abstract
    Chandrasekaran KS, Rentmeister A. Clicking a Fish: Click Chemistry of Different Biomolecules in Danio rerio. Biochemistry 2019;58: 24-30. Abstract
    Hartstock K, Rentmeister A. Mapping N(6) -Methyladenosine (m(6) A) in RNA: Established Methods, Remaining Challenges, and Emerging Approaches. Chemistry 2019;25: 3455-3464. Abstract
    Mauer J, Sindelar M, Despic V, Guez T, Hawley BR, Vasseur J-J, Rentmeister A, Gross SS, Pellizzoni L, Debart F, Goodarzi H, Jaffrey SR. FTO controls reversible m(6)Am RNA methylation during snRNA biogenesis. Nat Chem Biol 2019;15: 340-347. Abstract
    Muthmann N, Guez T, Vasseur J-J, Jaffrey SR, Debart F, Rentmeister A. Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5' Caps. Chembiochem 2019;20: 1693-1700. Abstract
    Muthmann N, Muttach F, Rentmeister A. Enzymatic Transfer of Photo-Cross-Linkers for RNA-Protein Photo-Cross-Linking at the mRNA 5'-Cap. Methods Mol Biol 2019;2008: 131-146. Abstract
    Rau K, Rosner L, Rentmeister A. Sequence-specific m(6)A demethylation in RNA by FTO fused to RCas9. Rna 2019;25: 1311-1323. Abstract


    Anhauser L, Muttach F, Rentmeister A. Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups. Chem Commun 2018;54: 449-451. Abstract
    Hartstock K, Nilges BS, Ovcharenko A, Cornelissen NV, Pullen N, Lawrence-Dorner A-M, Leidel SA, Rentmeister A. Enzymatic or In Vivo Installation of Propargyl Groups in Combination with Click Chemistry for the Enrichment and Detection of Methyltransferase Target Sites in RNA. Angew Chem Int Ed Engl 2018;57: 6342-6346. Abstract
    Ovcharenko A, Rentmeister A. Emerging approaches for detection of methylation sites in RNA. Open Biol 2018;8: pii: 180121. Abstract
    Rode S, Ohm H, Anhauser L, Wagner M, Rosing M, Deng X, Sin O, Leidel SA, Storkebaum E, Rentmeister A, Zhu S, Rumpf S. Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila. Cell Rep 2018;24: 2287-2299.e4. Abstract
    Teders M, Henkel C, Anhauser L, Strieth-Kalthoff F, Gomez-Suarez A, Kleinmans R, Kahnt A, Rentmeister A, Guldi D, Glorius F. The energy-transfer-enabled biocompatible disulfide-ene reaction. Nat Chem 2018;10: 981-988. Abstract


    Holstein JM, Muttach F, Schiefelbein SHH, Rentmeister A. Dual 5' Cap Labeling Based on Regioselective RNA Methyltransferases and Bioorthogonal Reactions. Chemistry 2017;23: 6165-6173. Abstract
    Kellermann SJ, Rentmeister A. A FACS-based screening strategy to assess sequence-specific RNA-binding of Pumilio protein variants in E coli. Biol Chem 2017;398: 69-75. Abstract
    Muttach F, Masing F, Studer A, Rentmeister A. New AdoMet Analogues as Tools for Enzymatic Transfer of Photo-Cross-Linkers and Capturing RNA-Protein Interactions. Chemistry 2017;23: 5988-5993. Abstract
    Muttach F, Muthmann N, Reichert D, Anhäuser L, Rentmeister A. A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation. Chem. Sci. 2017;8: 7947-7953. Abstract
    Muttach F, Muthmann N, Rentmeister A. Chemo-enzymatic modification of eukaryotic mRNA. Org Biomol Chem 2017;15: 278-284. Abstract
    Rau K, Rentmeister A. Making the Message Clear: Concepts for mRNA Imaging. ACS Cent Sci 2017;3: 701-707. Abstract


    Holstein JM, Anhauser L, Rentmeister A. Modifying the 5'-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells. Angew Chem Int Ed Engl 2016;55: 10899-10903. Abstract
    Holstein JM, Rentmeister A. Current covalent modification methods for detecting RNA in fixed and living cells. Methods 2016;98: 18-25. Abstract
    Holstein JM, Stummer D, Rentmeister A. Enzymatic Modification of 5'-Capped RNA and Subsequent Labeling by Click Chemistry. Methods Mol Biol 2016;1428: 45-60. Abstract
    Kellermann SJ, Rentmeister A. A Genetically Encodable System for Sequence-Specific Detection of RNAs in Two Colors. Chembiochem 2016;17: 895-899. Abstract
    Mannack LVJC, Eising S, Rentmeister A. Current techniques for visualizing RNA in cells. F1000Res 2016;5: F1000 Faculty Rev-775. Abstract
    Muttach F, Rentmeister A. A Biocatalytic Cascade for Versatile One-Pot Modification of mRNA Starting from Methionine Analogues. Angew Chem Int Ed Engl 2016;55: 1917-1920. Abstract
    Muttach F, Rentmeister A. One-pot modification of 5'-capped RNA based on methionine analogs. Methods 2016;107: 3-9. Abstract
    Rau K, Rentmeister A. CRISPR/Cas9: A New Tool for RNA Imaging in Live Cells. Chembiochem 2016;17: 1682-1684. Abstract
    Rentmeister A, Kellermann S. Manipulation von RNA mit Designerproteinen. Nachr. Chem. 2016;64: 297-301. Abstract


    Holstein JM, Stummer D, Rentmeister A. Engineering Giardia lamblia trimethylguanosine synthase (GlaTgs2) to transfer non-natural modifications to the RNA 5'-cap. Protein Eng Des Sel 2015;28: 179-186. Abstract
    Holstein JM, Stummer D, Rentmeister A. Enzymatic modification of 5′-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels–Alder reaction. Chem. Sci. 2015;6: 1362-1369. Abstract
    Kaljunen H, Schiefelbein SHH, Stummer D, Kozak S, Meijers R, Christiansen G, Rentmeister A. Structural Elucidation of the Bispecificity of A Domains as a Basis for Activating Non-natural Amino Acids. Angew Chem Int Ed Engl 2015;54: 8833-8836. Abstract
    Rath AK, Rentmeister A. Genetically encoded tools for RNA imaging in living cells. Curr Opin Biotechnol 2015;31: 42-49. Abstract
    Rentmeister A. CRISPR craze conquers the RNA world: precise manipulation of DNA and RNA based on a bacterial defense system. Angew Chem Int Ed Engl 2015;54: 4710-4712. Abstract
    Stummer D, Herrmann C, Rentmeister A. Quantum Chemical Calculations and Experimental Validation of the Photoclick Reaction for Fluorescent Labeling of the 5' cap of Eukaryotic mRNAs. ChemistryOpen 2015;4: 295-301. Abstract


    Holstein JM, Schulz D, Rentmeister A. Bioorthogonal site-specific labeling of the 5'-cap structure in eukaryotic mRNAs. Chem Commun (Camb) 2014;50: 4478-4481. Abstract
    Kellermann SJ, Rentmeister A. Current Developments in Cellulase Engineering. ChemBioEng Reviews 2014;1: 6-13. Abstract
    Rath AK, Kellermann SJ, Rentmeister A. Programmable design of functional ribonucleoprotein complexes. Chem Asian J 2014;9: 2045-2051. Abstract
    Schulz D, Rentmeister A. Current approaches for RNA labeling in vitro and in cells based on click reactions. Chembiochem 2014;15: 2342-2347. Abstract
    Schulz D, Rentmeister A. Chemo-enzymatic Strategies to Modify RNA in vitro or in Living Cells. In: Erdmann VA, Markiewicz WT, Barciszewski J. Chemical Biology of Nucleic Acids 2014;Springer Berlin Heidelberg: 409-421. Abstract