Publications

  • 2022

    Rösner, L., Reichert, D., Rau, K., Muthmann, N., Rentmeister, A.
    Sequence-specific targeting of RNA
    Methods 205, 73-82  https://doi.org/10.1016/j.ymeth.2022.06.007

    Muthmann, N., Špaček, P., Reichert, D., van Dülmen, M., Rentmeister, A.
    Quantification of mRNA cap-modifications by means of LC-QqQ-MS
    Methods 203, 196-206  https://doi.org/10.1016/j.ymeth.2021.05.018

    Klöcker, N., Weissenböck, F., van Dülmen, M., Špaček, P., Hüwel, S., and Rentmeister, A.
    Photocaged 5′ cap analogues for optical control of mRNA translation in cells
    Nat. Chem. (2022). https://doi.org/10.1038/s41557-022-00972-7

    Rösner, L., Konken, C.P., Depke, D.A., Rentmeister, A., Schäfers, M.
    Covalent labeling of immune cells
    Current Opinion in Chemical Biology 68, 102144 https://doi.org/10.1016/j.cbpa.2022.102144

    Bollu, A., Peters, A., Rentmeister, A.
    Chemo-Enzymatic Modification of the 5′ Cap To Study mRNAs
    Accounts of Chemical Research https://doi.org/10.1021/acs.accounts.2c00059

    Hartstock, K., Ovcharenko, A. , Kueck, N.A.,  Spacek, P., Cornelissen, N.V.,  Hüwel, S., Dieterich, C., Rentmeister, A.
    MePMe-seq: Antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing
    bioRxiv: https://doi.org/10.1101/2022.03.16.484494

    Peters, A., Herrmann, E., Cornelissen, N.V., Klöcker, N., Kümmel, D., Rentmeister, A.
    Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
    ChemBioChem 2022, 23:e202100437. https://doi.org/10.1002/cbic.202100437

  • 2021

    Kueck, N.A., Ovcharenko, A., Hartstock, K., Cornelissen, N.V., Rentmeister, A. (2021)
    Chapter Eight - Chemoenzymatic labeling of RNA to enrich, detect and identify methyltransferase-target sites.
    In Methods in Enzymology. Edited by Jackman JE: Academic Press; 2021:161-190. vol 658.

    Depke, D.A., Konken, C.P., Rösner, L., Hermann, S., Schäfers, M., Rentmeister, A. (2021)
    A novel 18F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo. Chemical Communications 2021, 57:9850-9853. https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc03871k
    https://www.uni-muenster.de/Cells-in-Motion/de/newsviews/2021/09-30.html

    Rickhoff, J.; Cornelissen, N. V.; Beuse, T.; Rentmeister, A.; Jan Ravoo, B. (2021)
    Multiresponsive hydrogels and organogels based on photocaged cysteine.
    Chem Commun (Camb), 57 (48), 5913-5916. doi: 10.1039/D1CC01363G

    Pottanam Chali, S.; Hüwel, S.; Rentmeister, A.; Ravoo, B. J. (2021)
    Self-Assembled Cationic Polypeptide Supramolecular Nanogels for Intracellular DNA Delivery.
    Chemistry 2021, 27, 12198-12206.  DOI:10.1002/chem.202101924

    Muthmann, N.; Špaček, P.; Reichert, D.; van Dülmen, M.; Rentmeister, A. (2021)
    Quantification of mRNA cap-modifications by means of LC-QqQ-MS.
    Methods, DOI:https://doi.org/10.1016/j.ymeth.2021.05.018 Open access link: https://www.sciencedirect.com/science/article/pii/S104620232100150X

    Reichert, D.; Schepers, H.; Simke, J.; Lechner, H.; Dörner, W.; Höcker, B.; Ravoo, B. J.; Rentmeister, A. (2021)
    Computational design and experimental characterization of a photo-controlled mRNA-cap guanine-N7 methyltransferase.
    RSC Chemical Biology 2021, 2:1484-1490. Open access link: https://pubs.rsc.org/en/content/articlehtml/2021/cb/d1cb00109d

    van Dülmen, M., N. Muthmann and A. Rentmeister (2021)
    Chemo-enzymatic modification of the 5' cap maintains translation and increases immunogenic properties of mRNA.
    Angewandte Chemie International Edition, 60, 13280-13286.  Open Access Link

    Michailidou, F. and Rentmeister, A.  (2021)
    Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions.
    Organic & Biomolecular Chemistry, 19, 3756-3762, DOI: 10.1039/D1OB00354B

    Mattay, J., M. Dittmar and A. Rentmeister (2021)
    Chemoenzymatic strategies for RNA modification and labeling.
    Current Opinion in Chemical Biology, 63:46-56. doi: 10.1016/j.cbpa.2021.01.008

    Ovcharenko, A., Weissenboeck, F.P., and Rentmeister, A. (2021)
    Tag-Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases.
    Angew. Chem. Int. Ed., 60(8):4098-4103. Open Access Link

    Reichert, D., Mootz, H.D., and Rentmeister, A. (2021)
    Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1.
    Chem. Sci., 2021, 12, 4383-4388.  DOI: 10.1039/D1SC00159K (Edge Article)

    Michailidou, F., N. Klöcker, N. Cornelissen, R. K. Singh, A. Peters, A. Ovcharenko, D. Kümmel and A. Rentmeister (2021)
    Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions.
    Angew. Chem. Int. Ed., 60:480-485. Open Access Link

  • 2020

    Andexer, J. N. and A. Rentmeister (2020)
    Challenging nature's preference for methylation.
    Nature Chemistry 12(9): 791-792, https://www.nature.com/articles/s41557-020-0533-1

    van Dülmen, M. and A. Rentmeister (2020)
    mRNA Therapies: New Hope in the Fight against Melanoma.
    Biochemistry 59(17): 1650-1655. doi: 10.1021/acs.biochem.0c00181

    Klöcker, N., F. P. Weissenboeck and A. Rentmeister (2020)
    Covalent labeling of nucleic acids.
    Chemical Society Reviews. Open Access Link

    Westerich, K.J.*, Chandrasekaran, K.S*., Gross-Thebing, T., Kück, N., Raz, E.+, Rentmeister, A.+ (2020)
    Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos.
    Chemical Science, 11, 3089, * Equal contribution, + co-corresponding authors Open access link

    Anhäuser, L., Klöcker, N., Muttach, F., Mäsing, F., Spacek, P., Studer, A., Rentmeister, A. (2020)
    A benzophenone-based photocaging strategy for the n7 position of guanosine.
    Angew Chem, 59(8):3161-3165. Open Access Link

    Kurmayer, R., Entfellner, E., Weisse, T., Offterdinger, M., Rentmeister, A., Deng, L. (2020)
    Chemically labeled toxins or bioactive peptides show a heterogeneous intracellular distribution and low spatial overlap with autofluorescence in bloom-forming cyanobacteria.
    Scientific Reports, 10(1):2781. Open Access Link

    Cornelissen, N.V., Michailidou, F., Muttach, F., Rau, K., Rentmeister, A. (2020)
    Nucleoside-modified adomet analogues for differential methyltransferase targeting.
    ChemCommun. Open Access Link

    Muthmann, N., Hartstock, K., Rentmeister, A. (2020)
    Chemo-enzymatic treatment of RNA to facilitate analyses.
    WIREs RNA, 11(1):e1561. Open Access Link

    Leiter, J., Reichert, D., Rentmeister, A., Micura, R. (2020)
    Practical synthesis of cap-4 RNA.
    Chembiochem, 21(1-2):265-271 doi: 10.1002/cbic.201900590

  • 2019

    Rau, K., Rösner, L., and A. Rentmeister (2019)
    Sequence-specific m6A demethylation in RNA by FTO fused to RCas9
    RNA, 25(10):1311-1323; https://rnajournal.cshlp.org/citmgr?gca=rna%3Brna.070706.119v1

    Muthmann, N., Muttach, F., Rentmeister, A. (2019)
    Enzymatic transfer of photo-cross-linkers for rna-protein photo-cross-linking at the mRNA 5'-cap.
    In: Proximity labeling: Methods and protocols. Sunbul M, Jäschke A (Eds)
    Springer New York, New York, NY (2019):131-146. 

    Chandrasekaran, K.S., Rentmeister, A. (2019)
    Clicking a fish: Click chemistry of different biomolecules in Danio rerio.
    Biochemistry, 58(1):24-30;  doi:10.1021/acs.biochem.8b00934

    Anhäuser, L., Teders, M., Rentmeister, A., Glorius, F. (2019)
    Bio-additive-based screening: Toward evaluation of the biocompatibility of chemical reactions.
    Nature Protocols, 14(9):2599-2626  doi: 10.1038/s41596-019-0190-2

    Mauer, J., Sindelar, M., Despic, V., Guez, T., Hawley, B.R., Vasseur, J.-J., Rentmeister, A., Gross, S.S., Pellizzoni, L., Debart, F., Goodarzi, H., and Jaffrey, S.R. (2019)
    FTO controls reversible m6Am RNA methylation during snRNA biogenesis
    Nature Chemical Biology, 15(4):340-347; doi: 10.1038/s41589-019-0231-8

    Muthmann, N., Guez, T., Vasseur, J.-J., Jaffrey, S., Debart, F., and Rentmeister, A. (2019)
    Combining chemical synthesis and enzymatic methylation to access short RNAs with various 5' caps
    ChemBioChem, 20(13):1693-1700; doi: 10.1002/cbic.201900037

    Anhäuser, L., Hüwel, S., Zobel, T., and Rentmeister, A.(2019)
    Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells
    Nucleic Acids Research, 47(7):e42-e42; doi: 10.1093/nar/gkz084

    Hartstock, K., Rentmeister, A. (2019)
    Mapping m6A in RNA: Established methods, remaining challenges and emerging approaches.
    Chemistry - A European Journal (2019) 25(14):3455-3464  doi: 10.1002/chem.201804043

  • 2018

    Hartstock, K., and Rentmeister, A. (2018)
    Mapping m6A in RNA: Established methods, remaining challenges and emerging approaches.
    Chemistry - A European Journal, in press, doi:10.1002/chem.201804043

    Rentmeister, A. (2018)
    Nobelpreise 2018: Frances H. Arnold.
    Nachrichten aus der Chemie 66, 1038-1040, doi:10.1002/nadc.20184081521

    Ovcharenko, A., and Rentmeister, A. (2018)
    Emerging approaches for detection of methylation sites in RNA
    Open Biol., 8:180121; http://dx.doi.org/10.1098/rsob.180121

    Teders, M., Henkel, C., Anhäuser, L., Strieth-Kalthoff, F., Gómez-Suárez, A., Kleinmans, R., Kahnt, A., Rentmeister, A., Guldi, D., and Glorius, F. (2018)
    The energy-transfer-enabled biocompatible disulfide-ene reaction.
    Nature Chemistry, 10(9):981-988.

    Schiefelbein, S.H.H., Kamal, A., She, Z., Rentmeister, A., and Kraatz, H.-B. (2018)
    Direct bisulfite-free detection of 5-methylcytosine by using electrochemical measurements aided by a monoclonal antibody.
    ChemElectroChem, 5(13):1631-1635.

    Rode, S., Ohm, H., Anhäuser, L., Wagner, M., Rosing, M., Deng, X., Sin, O, Leidel, S.A., Storkebaum, E., Rentmeister, A., Zhu, S., and Rumpf, S. (2018)
    Differential requirement for translation initiation factor pathways during ecdysone-dependent neuronal remodeling in drosophila.
    Cell Reports, 24(9):2287-2299.e2284.

    Anhäuser, L., Muttach, F., and Rentmeister, A. (2018)
    Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups
    Chem. Commun., 54, 449-451; doi: 10.1039/C7CC08300A

    Hartstock, K., Nilges, B. S., Ovcharenko, A., Cornelissen, N. V., Püllen, N., Lawrence-Dörner, A., Leidel, S. A., and Rentmeister, A. (2018)
    Enzymatic or in vivo installation of propargyl groups in combination with click chemistry for the enhancement and detection of methyltransferase target sites in RNA
    Angew. Chem. Int. Ed.,57(21):6342-6346, doi:10.1002/anie.201803995

  • 2017

    F. Muttach, N. Muthmann, D. Reichert, L. Anhäuser and A. Rentmeister (2017)
    A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation
    Chem. Sci., DOI: 10.1039/C7SC03631K

    K. Rau and A. Rentmeister (2017)
    Making the message clear: Concepts for mRNA imaging
    ACS Cent. Sci., DOI:10.1021/acscentsci.7b00251

    L. Anhäuser and A. Rentmeister (2017)
    Enzyme-mediated tagging of RNA
    Curr. Opin. Biotechnol., DOI:10.1016/j.copbio.2017.03.013

    S. Besztejan, S. Keskin, S. Manz, G. Kassier, R. Bücker, D. Venegas-Rojas, H.K. Trieu, A. Rentmeister and R.J.D. Miller (2017)
    Visualization of cellular components in a mammalian cell with liquid-cell transmission electron microscopy.
    Microsc. Microanal., 23(1):46-55. DOI: https://doi.org/10.1017/S1431927616012708

    J.M. Holstein, F. Muttach, S.H.H. Schiefelbein, A. Rentmeister (2017)
    Dual 5' cap labeling based on regioselective RNA methyltransferases and bioorthogonal reactions
    Chemistry, DOI:10.1002/chem.201604816

    F. Muttach, F. Mäsing, A. Studer, A. Rentmeister (2017)
    New AdoMet analogues as tools for enzymatic transfer of photo-crosslinkers and capturing RNA-protein interactions
    Chemistry, 2017, DOI: 10.1002/chem.201605663

    F. Muttach, N. Muthmann and A. Rentmeister (2017)
    Chemo-enzymatic modification of eukaryotic mRNA
    Org. Biomol. Chem., 15, 278-284, DOI: 10.1039/C6OB02144A.

    F. Muttach, N. Muthmann and A. Rentmeister (2017)
    Synthetic mRNA capping
    Beilstein J. Org. Chem., 13, 2819-2832, DOI:10.3762/bjoc.13.274

    S. Kellermann and A. Rentmeister (2017)
    A FACS-based screening strategy to assess sequence-specific RNA-binding of Pumilio protein variants in E. coli
    Biol. Chem., 398(1), 69-75, DOI: 10.1515/hsz-2016-0214

  • 2016

    J. Holstein, L. Anhäuser, and A. Rentmeister (2016)
    Modifying the 5'-cap to click eukaryotic mRNA and tune translation efficiency in living cells
    Angew. Chem. Int. Ed. Engl., DOI:10.1002/anie.201604107/abstract

    J. Holstein, and A. Rentmeister (2016)
    Current covalent modification methods for detecting RNA in fixed and living cells
    Methods, 98, 18-25

    J. Holstein, D. Stummer, and A. Rentmeister (2016)
    Enzymatic modification of 5'-capped RNA and subsequent labeling by click chemistry
    Methods Mol. Biol. 1428, 45-60

    S. Kellermann, and A. Rentmeister (2016)
    A genetically encodable system for sequence-specific detection of RNAs in two Colors
    ChemBioChem 17, 895-899

    L. Mannack, S. Eising, and A.Rentmeister (2016)
    Current techniques for visualizing RNA in cells
    F1000Research 2016, 5

    F. Muttach, and A. Rentmeister (2016)
    A biocatalytic cascade for versatile one-pot modification of mRNA starting from methionine analogues
    Angew. Chem. Int. Ed. 55, 1917-1920 (german version: see below)

    F. Muttach, and A. Rentmeister (2016)
    Eine biokatalytische Kaskade für die vielseitige Eintopf-Modifizierung von mRNA ausgehend von Methioninanaloga
    Angew. Chem. 128, 1951-1954.

    F. Muttach, and A. Rentmeister (2016)
    One-pot modification of 5'-capped RNA based on methionine analogs
    Methods, 107:3-9. doi: 10.1016/j.ymeth.2016.02.008

    K. Rau, and A. Rentmeister (2016)
    CRISPR/Cas9 - A new tool for RNA imaging in live cells
    ChemBioChem 17, 1682-1684, DOI: 10.1002/cbic.201600342

    A. Rentmeister, and S. Kellermann (2016)
    Manipulation von RNA mit Designerproteinen
    Nachr. Chem. 64, 297-301

  • 2015

    S. Keskin, S. Besztejan, G, Kassier, S. Manz, R. Bücker, S. Riekeberg, H.K. Trieu, A. Rentmeister, and R.J.D. Miller (2015)
    Visualization of multimerization and self-assembly of DNA-functionalized gold nanoparticles using in-liquid transmission electron microscopy
    The Journal of Physical Chemistry Letters, 4487-4492,
    DOI:10.1021/acs.jpclett.5b02075.

    D. Stummer, C. Herrmann, and A. Rentmeister (2015)
    Quantum chemical calculations and experimental validation of the photoclick reaction for fluorescent labeling of the 5' cap of eukaryotic mRNAs
    ChemistryOpen DOI: 10.1002/open.201402104.

    A. Rentmeister (2015)
    CRISPR craze conquers the RNA world: Precise manipulation of DNA and RNA based on a bacterial defense system
    Angewandte Chemie International Edition 54, 4710-4712.

    H. Kaljunen, S.H.H. Schiefelbein, D. Stummer, S. Kozak, R. Meijers, G. Christiansen, and A. Rentmeister (2015)
    Structural elucidation of the bispecificity of A domains as a basis for activating non-natural amino acids
    Angew. Chem. Int. Ed. Engl. 54, 8833-8836,
    DOI: 10.1002/anie.201503275.

    J. M. Holstein, D. Stummer, and A. Rentmeister (2015)
    Engineering Giardia lamblia trimethylguanosine synthase (GlaTgs2) to transfer non-natural modifications to the RNA 5'-cap
    Protein Engineering Design and Selection 28, 179-186.

    A.K. Rath, and A. Rentmeister (2015)
    Genetically encoded tools for RNA imaging in living cells.
    Current Opinion in Biotechnology, 31(0): p. 42-49.

    J.M. Holstein, D. Stummer, and A. Rentmeister (2015)
    Enzymatic modification of 5'-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels-Alder reaction.
    Chemical Science, Chemical Science 2015, 6, 1362-1369,
    https://pubs.rsc.org/en/Content/ArticleLanding/2015/SC/c4sc03182b#!divAbstract.

  • 2014

    D. Schulz and A. Rentmeister (2014)
    Current approaches for RNA labeling in vitro and in cells based on click reactions.
    Chembiochem, 15(16): p. 2342-7.

    D. Schulz and A. Rentmeister (2014)
    Chemo-enzymatic strategies to modify RNA in vitro or in living cells.
    in: Chemical Biology of Nucleic Acids, V.A. Erdmann, W.T. Markiewicz, and J. Barciszewski, Editors., Springer Berlin Heidelberg. p. 409-421.

    A.K. Rath, S.J. Kellermann, and A. Rentmeister (2014)
    Programmable design of functional ribonucleoprotein complexes.
    Chemistry - An Asian Journal, 9(8): p. 2045-2051.

    S.J. Kellermann, and A. Rentmeister (2014)
    Current developments in cellulase engineering.
    ChemBioEng Reviews, 2014. 1(1): p. 6-13.

    J.M. Holstein, D. Schulz, and A. Rentmeister (2014)
    Bioorthogonal site-specific labeling of the 5'-cap structure in eukaryotic mRNAs.
    Chemical Communications, 50(34): p. 4478-4481.
    https://pubs.rsc.org/en/content/articlepdf/2014/cc/c4cc01549e

  • 2013

    D. Schulz, J. M. Holstein and A. Rentmeister (2013)
    A chemo-enzymatic approach for site-specific modification of the RNA cap.
    Angew. Chem. Int. Ed., 52, 7874-7878.

    S. J. Kellermann, A. K. Rath and A. Rentmeister (2013)
    Tetramolecular fluorescence complementation for detection of specific RNAs in vitro.
    ChemBioChem., 14, 200-204.