Publications
2023
FP Weissenboeck, H Schepers, A Rentmeister (2023)
Optochemical control of mRNA translation in eukaryotes
Angewandte Chemie International Edition 62 (23), e202301778, https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202301778Lukas Gericke, Dipali Mhaindarkar, Lukas C Karst, Sören Jahn, Marco Kuge, Michael KF Mohr, Jana Gagsteiger, Nicolas V Cornelissen, Xiaojin Wen, Silja Mordhorst, Henning J Jessen, Andrea Rentmeister, Florian P Seebeck, Gunhild Layer, Christoph Loenarz, Jennifer N Andexer (2023)
Biomimetic S‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes
ChemBioChem 24 (9), e202300133, https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.202300133
NV Cornelissen, A Hoffmann, A Rentmeister (2023)
DNA Methyltransferases and AdoMet Analogs as Tools for Molecular Biology and Biotechnology
Chemie Ingenieur Technik 95 (4), 518-530 https://onlinelibrary.wiley.com/doi/full/10.1002/cite.202200174
A Hoffmann, KH Schülke, SC Hammer, A Rentmeister, NV Cornelissen (2023)
Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation
Chemical Communications 59 (36), 5463-5466 https://pubs.rsc.org/en/content/articlehtml/2023/cc/d3cc01036h
Dittmar, M., Weissenböck, F.P., Rentmeister, A. (2023)
Lichtgesteuerte Translation von mRNA in Eukaryoten.
BIOspektrum 2023, 29:31-34. https://doi.org/10.1007/s12268-023-1881-3Bollu, A., Klöcker, N., Špaček, P., Weissenböck, F.P., Hüwel, S., Rentmeister, A. (2023)
Light-Activated Translation of Different mRNAs in Cells via Wavelength-Dependent Photouncaging.
Angew Chem Int Ed Engl 2023, 62:e202209975.
Open Access Link: https://doi.org/10.1002/anie.202209975Klöcker, N., Anhäuser, L., Rentmeister, A. (2023)
Enzymatic Modification of the 5' Cap with Photocleavable ONB-Derivatives Using GlaTgs V34A.
Chembiochem 2023, 24:e202200522. https://doi.org/10.1002/cbic.202200522Muthmann, N., Albers, M., Rentmeister, A. (2023)
CAPturAM, a Chemo-Enzymatic Strategy for Selective Enrichment and Detection of Physiological CAPAM-Targets.
Angew Chem Int Ed Engl 2023, 62:e202211957. https://doi.org/10.1002/anie.2022119572022
Ergüven, M., Cornelissen, N.V., Peters, A., Karaca, E., Rentmeister, A. (2022)
Enzymatic Generation of Double-Modified AdoMet Analogues and Their Application in Cascade Reactions with Different Methyltransferases. ChemBioChem 2022, 23:e202200511. https://doi.org/10.1002/cbic.202200511Rösner, L., Reichert, D., Rau, K., Muthmann, N., Rentmeister, A. (2022)
Sequence-specific targeting of RNA
Methods 205, 73-82 https://doi.org/10.1016/j.ymeth.2022.06.007Muthmann, N., Špaček, P., Reichert, D., van Dülmen, M., Rentmeister, A. (2022)
Quantification of mRNA cap-modifications by means of LC-QqQ-MS
Methods 203, 196-206 https://doi.org/10.1016/j.ymeth.2021.05.018Klöcker, N., Weissenböck, F., van Dülmen, M., Špaček, P., Hüwel, S., and Rentmeister, A. (2022)
Photocaged 5′ cap analogues for optical control of mRNA translation in cells
Nat. Chem. (2022). https://doi.org/10.1038/s41557-022-00972-7Rösner, L., Konken, C.P., Depke, D.A., Rentmeister, A., Schäfers, M. (2022)
Covalent labeling of immune cells
Current Opinion in Chemical Biology 68, 102144 https://doi.org/10.1016/j.cbpa.2022.102144Bollu, A., Peters, A., Rentmeister, A. (2022)
Chemo-Enzymatic Modification of the 5′ Cap To Study mRNAs
Accounts of Chemical Research https://doi.org/10.1021/acs.accounts.2c00059Hartstock, K., Ovcharenko, A. , Kueck, N.A., Spacek, P., Cornelissen, N.V., Hüwel, S., Dieterich, C., Rentmeister, A. (2022)
MePMe-seq: Antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing
bioRxiv: https://doi.org/10.1101/2022.03.16.484494Peters, A., Herrmann, E., Cornelissen, N.V., Klöcker, N., Kümmel, D., Rentmeister, A. (2022)
Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
ChemBioChem 2022, 23:e202100437. https://doi.org/10.1002/cbic.2021004372021
Kueck, N.A., Ovcharenko, A., Hartstock, K., Cornelissen, N.V., Rentmeister, A. (2021)
Chapter Eight - Chemoenzymatic labeling of RNA to enrich, detect and identify methyltransferase-target sites.
In Methods in Enzymology. Edited by Jackman JE: Academic Press; 2021:161-190. vol 658.Depke, D.A., Konken, C.P., Rösner, L., Hermann, S., Schäfers, M., Rentmeister, A. (2021)
A novel 18F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo. Chemical Communications 2021, 57:9850-9853. https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc03871k
https://www.uni-muenster.de/Cells-in-Motion/de/newsviews/2021/09-30.htmlRickhoff, J.; Cornelissen, N. V.; Beuse, T.; Rentmeister, A.; Jan Ravoo, B. (2021)
Multiresponsive hydrogels and organogels based on photocaged cysteine.
Chem Commun (Camb), 57 (48), 5913-5916. doi: 10.1039/D1CC01363GPottanam Chali, S.; Hüwel, S.; Rentmeister, A.; Ravoo, B. J. (2021)
Self-Assembled Cationic Polypeptide Supramolecular Nanogels for Intracellular DNA Delivery.
Chemistry 2021, 27, 12198-12206. DOI:10.1002/chem.202101924Muthmann, N.; Špaček, P.; Reichert, D.; van Dülmen, M.; Rentmeister, A. (2021)
Quantification of mRNA cap-modifications by means of LC-QqQ-MS.
Methods, DOI:https://doi.org/10.1016/j.ymeth.2021.05.018 Open access link: https://www.sciencedirect.com/science/article/pii/S104620232100150XReichert, D.; Schepers, H.; Simke, J.; Lechner, H.; Dörner, W.; Höcker, B.; Ravoo, B. J.; Rentmeister, A. (2021)
Computational design and experimental characterization of a photo-controlled mRNA-cap guanine-N7 methyltransferase.
RSC Chemical Biology 2021, 2:1484-1490. Open access link: https://pubs.rsc.org/en/content/articlehtml/2021/cb/d1cb00109dvan Dülmen, M., N. Muthmann and A. Rentmeister (2021)
Chemo-enzymatic modification of the 5' cap maintains translation and increases immunogenic properties of mRNA.
Angewandte Chemie International Edition, 60, 13280-13286. Open Access LinkMichailidou, F. and Rentmeister, A. (2021)
Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions.
Organic & Biomolecular Chemistry, 19, 3756-3762, DOI: 10.1039/D1OB00354BMattay, J., M. Dittmar and A. Rentmeister (2021)
Chemoenzymatic strategies for RNA modification and labeling.
Current Opinion in Chemical Biology, 63:46-56. doi: 10.1016/j.cbpa.2021.01.008Ovcharenko, A., Weissenboeck, F.P., and Rentmeister, A. (2021)
Tag-Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases.
Angew. Chem. Int. Ed., 60(8):4098-4103. Open Access LinkReichert, D., Mootz, H.D., and Rentmeister, A. (2021)
Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1.
Chem. Sci., 2021, 12, 4383-4388. DOI: 10.1039/D1SC00159K (Edge Article)Michailidou, F., N. Klöcker, N. Cornelissen, R. K. Singh, A. Peters, A. Ovcharenko, D. Kümmel and A. Rentmeister (2021)
Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions.
Angew. Chem. Int. Ed., 60:480-485. Open Access Link2020
Andexer, J. N. and A. Rentmeister (2020)
Challenging nature's preference for methylation.
Nature Chemistry 12(9): 791-792, https://www.nature.com/articles/s41557-020-0533-1van Dülmen, M. and A. Rentmeister (2020)
mRNA Therapies: New Hope in the Fight against Melanoma.
Biochemistry 59(17): 1650-1655. doi: 10.1021/acs.biochem.0c00181Klöcker, N., F. P. Weissenboeck and A. Rentmeister (2020)
Covalent labeling of nucleic acids.
Chemical Society Reviews. Open Access LinkWesterich, K.J.*, Chandrasekaran, K.S*., Gross-Thebing, T., Kück, N., Raz, E.+, Rentmeister, A.+ (2020)
Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos.
Chemical Science, 11, 3089, * Equal contribution, + co-corresponding authors Open access linkAnhäuser, L., Klöcker, N., Muttach, F., Mäsing, F., Spacek, P., Studer, A., Rentmeister, A. (2020)
A benzophenone-based photocaging strategy for the n7 position of guanosine.
Angew Chem, 59(8):3161-3165. Open Access LinkKurmayer, R., Entfellner, E., Weisse, T., Offterdinger, M., Rentmeister, A., Deng, L. (2020)
Chemically labeled toxins or bioactive peptides show a heterogeneous intracellular distribution and low spatial overlap with autofluorescence in bloom-forming cyanobacteria.
Scientific Reports, 10(1):2781. Open Access LinkCornelissen, N.V., Michailidou, F., Muttach, F., Rau, K., Rentmeister, A. (2020)
Nucleoside-modified adomet analogues for differential methyltransferase targeting.
ChemCommun. Open Access LinkMuthmann, N., Hartstock, K., Rentmeister, A. (2020)
Chemo-enzymatic treatment of RNA to facilitate analyses.
WIREs RNA, 11(1):e1561. Open Access LinkLeiter, J., Reichert, D., Rentmeister, A., Micura, R. (2020)
Practical synthesis of cap-4 RNA.
Chembiochem, 21(1-2):265-271 doi: 10.1002/cbic.2019005902019
Rau, K., Rösner, L., and A. Rentmeister (2019)
Sequence-specific m6A demethylation in RNA by FTO fused to RCas9
RNA, 25(10):1311-1323; https://rnajournal.cshlp.org/citmgr?gca=rna%3Brna.070706.119v1Muthmann, N., Muttach, F., Rentmeister, A. (2019)
Enzymatic transfer of photo-cross-linkers for rna-protein photo-cross-linking at the mRNA 5'-cap.
In: Proximity labeling: Methods and protocols. Sunbul M, Jäschke A (Eds)
Springer New York, New York, NY (2019):131-146.Chandrasekaran, K.S., Rentmeister, A. (2019)
Clicking a fish: Click chemistry of different biomolecules in Danio rerio.
Biochemistry, 58(1):24-30; doi:10.1021/acs.biochem.8b00934Anhäuser, L., Teders, M., Rentmeister, A., Glorius, F. (2019)
Bio-additive-based screening: Toward evaluation of the biocompatibility of chemical reactions.
Nature Protocols, 14(9):2599-2626 doi: 10.1038/s41596-019-0190-2Mauer, J., Sindelar, M., Despic, V., Guez, T., Hawley, B.R., Vasseur, J.-J., Rentmeister, A., Gross, S.S., Pellizzoni, L., Debart, F., Goodarzi, H., and Jaffrey, S.R. (2019)
FTO controls reversible m6Am RNA methylation during snRNA biogenesis
Nature Chemical Biology, 15(4):340-347; doi: 10.1038/s41589-019-0231-8Muthmann, N., Guez, T., Vasseur, J.-J., Jaffrey, S., Debart, F., and Rentmeister, A. (2019)
Combining chemical synthesis and enzymatic methylation to access short RNAs with various 5' caps
ChemBioChem, 20(13):1693-1700; doi: 10.1002/cbic.201900037Anhäuser, L., Hüwel, S., Zobel, T., and Rentmeister, A.(2019)
Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells
Nucleic Acids Research, 47(7):e42-e42; doi: 10.1093/nar/gkz084Hartstock, K., Rentmeister, A. (2019)
Mapping m6A in RNA: Established methods, remaining challenges and emerging approaches.
Chemistry - A European Journal (2019) 25(14):3455-3464 doi: 10.1002/chem.2018040432018
Hartstock, K., and Rentmeister, A. (2018)
Mapping m6A in RNA: Established methods, remaining challenges and emerging approaches.
Chemistry - A European Journal, in press, doi:10.1002/chem.201804043Rentmeister, A. (2018)
Nobelpreise 2018: Frances H. Arnold.
Nachrichten aus der Chemie 66, 1038-1040, doi:10.1002/nadc.20184081521Ovcharenko, A., and Rentmeister, A. (2018)
Emerging approaches for detection of methylation sites in RNA
Open Biol., 8:180121; http://dx.doi.org/10.1098/rsob.180121Teders, M., Henkel, C., Anhäuser, L., Strieth-Kalthoff, F., Gómez-Suárez, A., Kleinmans, R., Kahnt, A., Rentmeister, A., Guldi, D., and Glorius, F. (2018)
The energy-transfer-enabled biocompatible disulfide-ene reaction.
Nature Chemistry, 10(9):981-988.Schiefelbein, S.H.H., Kamal, A., She, Z., Rentmeister, A., and Kraatz, H.-B. (2018)
Direct bisulfite-free detection of 5-methylcytosine by using electrochemical measurements aided by a monoclonal antibody.
ChemElectroChem, 5(13):1631-1635.Rode, S., Ohm, H., Anhäuser, L., Wagner, M., Rosing, M., Deng, X., Sin, O, Leidel, S.A., Storkebaum, E., Rentmeister, A., Zhu, S., and Rumpf, S. (2018)
Differential requirement for translation initiation factor pathways during ecdysone-dependent neuronal remodeling in drosophila.
Cell Reports, 24(9):2287-2299.e2284.Anhäuser, L., Muttach, F., and Rentmeister, A. (2018)
Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups
Chem. Commun., 54, 449-451; doi: 10.1039/C7CC08300AHartstock, K., Nilges, B. S., Ovcharenko, A., Cornelissen, N. V., Püllen, N., Lawrence-Dörner, A., Leidel, S. A., and Rentmeister, A. (2018)
Enzymatic or in vivo installation of propargyl groups in combination with click chemistry for the enhancement and detection of methyltransferase target sites in RNA
Angew. Chem. Int. Ed.,57(21):6342-6346, doi:10.1002/anie.2018039952017
F. Muttach, N. Muthmann, D. Reichert, L. Anhäuser and A. Rentmeister (2017)
A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation
Chem. Sci., DOI: 10.1039/C7SC03631KK. Rau and A. Rentmeister (2017)
Making the message clear: Concepts for mRNA imaging
ACS Cent. Sci., DOI:10.1021/acscentsci.7b00251L. Anhäuser and A. Rentmeister (2017)
Enzyme-mediated tagging of RNA
Curr. Opin. Biotechnol., DOI:10.1016/j.copbio.2017.03.013S. Besztejan, S. Keskin, S. Manz, G. Kassier, R. Bücker, D. Venegas-Rojas, H.K. Trieu, A. Rentmeister and R.J.D. Miller (2017)
Visualization of cellular components in a mammalian cell with liquid-cell transmission electron microscopy.
Microsc. Microanal., 23(1):46-55. DOI: https://doi.org/10.1017/S1431927616012708J.M. Holstein, F. Muttach, S.H.H. Schiefelbein, A. Rentmeister (2017)
Dual 5' cap labeling based on regioselective RNA methyltransferases and bioorthogonal reactions
Chemistry, DOI:10.1002/chem.201604816F. Muttach, F. Mäsing, A. Studer, A. Rentmeister (2017)
New AdoMet analogues as tools for enzymatic transfer of photo-crosslinkers and capturing RNA-protein interactions
Chemistry, 2017, DOI: 10.1002/chem.201605663F. Muttach, N. Muthmann and A. Rentmeister (2017)
Chemo-enzymatic modification of eukaryotic mRNA
Org. Biomol. Chem., 15, 278-284, DOI: 10.1039/C6OB02144A.F. Muttach, N. Muthmann and A. Rentmeister (2017)
Synthetic mRNA capping
Beilstein J. Org. Chem., 13, 2819-2832, DOI:10.3762/bjoc.13.274S. Kellermann and A. Rentmeister (2017)
A FACS-based screening strategy to assess sequence-specific RNA-binding of Pumilio protein variants in E. coli
Biol. Chem., 398(1), 69-75, DOI: 10.1515/hsz-2016-02142016
J. Holstein, L. Anhäuser, and A. Rentmeister (2016)
Modifying the 5'-cap to click eukaryotic mRNA and tune translation efficiency in living cells
Angew. Chem. Int. Ed. Engl., DOI:10.1002/anie.201604107/abstractJ. Holstein, and A. Rentmeister (2016)
Current covalent modification methods for detecting RNA in fixed and living cells
Methods, 98, 18-25J. Holstein, D. Stummer, and A. Rentmeister (2016)
Enzymatic modification of 5'-capped RNA and subsequent labeling by click chemistry
Methods Mol. Biol. 1428, 45-60S. Kellermann, and A. Rentmeister (2016)
A genetically encodable system for sequence-specific detection of RNAs in two Colors
ChemBioChem 17, 895-899L. Mannack, S. Eising, and A.Rentmeister (2016)
Current techniques for visualizing RNA in cells
F1000Research 2016, 5F. Muttach, and A. Rentmeister (2016)
A biocatalytic cascade for versatile one-pot modification of mRNA starting from methionine analogues
Angew. Chem. Int. Ed. 55, 1917-1920 (german version: see below)F. Muttach, and A. Rentmeister (2016)
Eine biokatalytische Kaskade für die vielseitige Eintopf-Modifizierung von mRNA ausgehend von Methioninanaloga
Angew. Chem. 128, 1951-1954.F. Muttach, and A. Rentmeister (2016)
One-pot modification of 5'-capped RNA based on methionine analogs
Methods, 107:3-9. doi: 10.1016/j.ymeth.2016.02.008K. Rau, and A. Rentmeister (2016)
CRISPR/Cas9 - A new tool for RNA imaging in live cells
ChemBioChem 17, 1682-1684, DOI: 10.1002/cbic.201600342A. Rentmeister, and S. Kellermann (2016)
Manipulation von RNA mit Designerproteinen
Nachr. Chem. 64, 297-3012015
S. Keskin, S. Besztejan, G, Kassier, S. Manz, R. Bücker, S. Riekeberg, H.K. Trieu, A. Rentmeister, and R.J.D. Miller (2015)
Visualization of multimerization and self-assembly of DNA-functionalized gold nanoparticles using in-liquid transmission electron microscopy
The Journal of Physical Chemistry Letters, 4487-4492,
DOI:10.1021/acs.jpclett.5b02075.D. Stummer, C. Herrmann, and A. Rentmeister (2015)
Quantum chemical calculations and experimental validation of the photoclick reaction for fluorescent labeling of the 5' cap of eukaryotic mRNAs
ChemistryOpen DOI: 10.1002/open.201402104.A. Rentmeister (2015)
CRISPR craze conquers the RNA world: Precise manipulation of DNA and RNA based on a bacterial defense system
Angewandte Chemie International Edition 54, 4710-4712.H. Kaljunen, S.H.H. Schiefelbein, D. Stummer, S. Kozak, R. Meijers, G. Christiansen, and A. Rentmeister (2015)
Structural elucidation of the bispecificity of A domains as a basis for activating non-natural amino acids
Angew. Chem. Int. Ed. Engl. 54, 8833-8836,
DOI: 10.1002/anie.201503275.J. M. Holstein, D. Stummer, and A. Rentmeister (2015)
Engineering Giardia lamblia trimethylguanosine synthase (GlaTgs2) to transfer non-natural modifications to the RNA 5'-cap
Protein Engineering Design and Selection 28, 179-186.A.K. Rath, and A. Rentmeister (2015)
Genetically encoded tools for RNA imaging in living cells.
Current Opinion in Biotechnology, 31(0): p. 42-49.J.M. Holstein, D. Stummer, and A. Rentmeister (2015)
Enzymatic modification of 5'-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels-Alder reaction.
Chemical Science, Chemical Science 2015, 6, 1362-1369,
https://pubs.rsc.org/en/Content/ArticleLanding/2015/SC/c4sc03182b#!divAbstract.2014
D. Schulz and A. Rentmeister (2014)
Current approaches for RNA labeling in vitro and in cells based on click reactions.
Chembiochem, 15(16): p. 2342-7.D. Schulz and A. Rentmeister (2014)
Chemo-enzymatic strategies to modify RNA in vitro or in living cells.
in: Chemical Biology of Nucleic Acids, V.A. Erdmann, W.T. Markiewicz, and J. Barciszewski, Editors., Springer Berlin Heidelberg. p. 409-421.A.K. Rath, S.J. Kellermann, and A. Rentmeister (2014)
Programmable design of functional ribonucleoprotein complexes.
Chemistry - An Asian Journal, 9(8): p. 2045-2051.S.J. Kellermann, and A. Rentmeister (2014)
Current developments in cellulase engineering.
ChemBioEng Reviews, 2014. 1(1): p. 6-13.J.M. Holstein, D. Schulz, and A. Rentmeister (2014)
Bioorthogonal site-specific labeling of the 5'-cap structure in eukaryotic mRNAs.
Chemical Communications, 50(34): p. 4478-4481.
https://pubs.rsc.org/en/content/articlepdf/2014/cc/c4cc01549e2013
D. Schulz, J. M. Holstein and A. Rentmeister (2013)
A chemo-enzymatic approach for site-specific modification of the RNA cap.
Angew. Chem. Int. Ed., 52, 7874-7878.S. J. Kellermann, A. K. Rath and A. Rentmeister (2013)
Tetramolecular fluorescence complementation for detection of specific RNAs in vitro.
ChemBioChem., 14, 200-204.