International CiM Symposium 2017
Cells in Motion: Pattern formation in space and time
Münster, 4–6 September 2017
Meeting venue: lecture hall GEO1, Heisenbergstraße 2
When an organism develops, cells arrange themselves into three-dimensional structures and form patterns. Within cells too, the individual cell components produce patterns which then lead to certain functions. But what are the processes behind this? This was the question that international researchers discussed at the University of Münster in September 2017. At the symposium being hosted by the Cells-in-Motion (CiM) Cluster of Excellence, speakers from the fields of chemistry, mathematics, physics, biology and medicine presented their current research results.
The topics they talked about ranged from molecular self-organisation and membrane organisation as well as cell-matrix and cell-cell interactions to tissue morphogenesis and mechanobiology. Another focus of the symposium was on various imaging technologies which researchers use to visualize the patterns and the processes being investigated. The symposium provided a platform not only for the speakers who had been invited from all over the world and for the CiM group leaders, but also for junior researchers from the Cluster of Excellence to present their research.
International CiM Symposium 2017 | Cells in Motion: Pattern formation in space and time | 4-6 September 2017
Meeting venue: lecture hall GEO1, Heisenbergstraße 2
Free Childcare Available: Your children will be looked after during the afternoon session on site or at your home by the Zauberfrau. Toys will also be available. To make use of this offer please contact the CiM Office until Friday 2:00 p.m via e-mail.
Monday, 4 September 2017
11:00 Registration 13:00 Welcome
Session 1: Membrane Organisation
(Chair: Volker Gerke)
13:10 Matthias Röger, TU Dortmund University
Interaction of membrane localized reactions and transport-diffusion processes in cells
13:40 Milos Galic, University of Münster
Nanoscale membrane deformations control lamellipodia re-initiation, cell shape and migration pattern
14:00 Patricia Bassereau, Institute Curie, Paris
Coupling curved membranes to cytoskeleton: I-BAR proteins and Ezrin
14:30 Coffee break
Session 2: Visualising and Manipulating Processes in Living Cells
(Chair: Andrea Rentmeister)
15:00 Nathan Luedtke, University of Zurich
Harnessing bioorthogonal chemistry to visualize embryogenesis and drug metabolism
15:30 Benjamin Schumann, Stanford University
Glycosyltransferase bump-hole engineering to dissect mucin-type O-glycosylation in living cells
15:45 Markus Affolter, University of Basel
Angiogenesis live: new insights and new tools
16:15 Coffee break
Session 3: Young Investigator Talks
(Chairs: Milos Galic & Sebastian Rumpf)
16:45 Johannes Fels, University of Münster
Acute hydrostatic pressure activates apical acto-myosin in endothelial cells
17:00 Robert Meissner, University of Münster
In vivo shear stress development and blood flow manipulation
17:15 Maniraij Bhagawati, University of Münster
Traceless fluorescent labeling of cell-surface receptors using a novel split intein
17:30 Kathleen Hübner, University of Münster
Wnt signaling regulates vascular pattern formation and anastomosis in the CNS
17:45 Sargon Yigit, University of Münster
Characterization of cell-environment interactions affecting single-cell migration in vivo
18:00 short break to change session
(Chair: Erez Raz)
18:10 Benny Shilo, Weizmann Institute of Science
from 19:00 Reception & poster presentations
Tuesday, 5 September 2017
Session 4: Cell-Cell Interaction
(Chair: Ryan Gilmour)
9:00 Arndt Siekmann, University of Münster
Endothelial Notch signaling limits angiogenesis via control of artery formation
9:20 Peter A. Markowich, University of Cambridge
First principle modeling of biological transportation networks
9:50 Nick A. Meanwell, Bristol-Myers Squibb
Modulators of hepatitis C virus NS5A
10:20 Coffee break
Session 5: Mechanobiology
(Chair: Timo Betz)
10:50 Michel Labouesse, Institut de Biologie Paris-Seine
Tissue viscoplasticity in morphogenesis
11:20 Maja Matis, University of Münster
Control of the tissue mechanics via the atypical cadherins Fat and Dachsous
11:40 Matthieu Piel, Institute Curie, Paris
Squeezing the nucleus
12:10 Lunch break
Session 6: Cellular Communication
(Chair: Stefan Luschnig)
13:40 Stephan Sigrist, Freie Universität Berlin
Pre-post-synaptic communication patterns synaptic terminals in Drosophila
14:10 Jon Clardy, Harvard Medical School, Boston
Cellular communications in a two-kingdom symbiosis
14:40 Kerstin Bartscherer, University of Münster
Go ahead, grow a head! Mechanisms of regeneration initiation
15:00 Jan-Frederik Pietschmann, University of Münster
Phase separation in a model with non-local interactions
15:20 Coffee break
Session 7: Frontiers in Imaging
(Chair: Michael Schäfers)
15:50 David O'Hagan, University of St Andrews
Forming 18F-C bonds with an enzyme, for PET
16:20 Wolfram Pernice, University of Münster
Photonic nanostructures for imaging applications
16:40 Erik Sahai, The Francis Crick Institute, London
Cancer cell invasion in complex environments
19:00 Speakers' Dinner
Wednesday, 6 September 2017
Session 8: Cell Matrix Interaction
(Chair: Roland Wedlich-Söldner)
9:00 Zena Werb, University of California, San Francisco
Intravital imaging reveals cell-matrix interactions during breast development and cancer progression
9:30 Peter Seeberger, Max Planck Institute of Colloids and Interfaces, Potsdam
Automated glycan assembly as basis for chemical glycobiology and vaccine development
10:00 Britta Trappmann, University of Münster
Regulation of cell fate by extracellular matrix stiffness
10:20 Martin A. Schwartz, Yale Cardiovascular Research Center, New Haven
Cell responses to forces applied through integrins
10:50 Coffee break
Session 9: Tissue Morphogenesis
(Chair: Stefan Schulte-Merker)
11:20 Katie Bentley, Uppsala University, Sweden
The temporal basis of angiogenesis
11:50 Sebastian Rumpf, University of Münster
Spatiotemporal control of dendrite pruning in Drosophila
12:10 Julien Vermot, University of Strasbourg
Endocardial morphogenesis: from mechanical forces to cell behaviors
12:40 Closing remarks 12:45 Snacks
Travel and Hotel Information
GEO I (Institute of Geography)
Heisenbergstraße 2, D-48149 Münster
Directions by plane
From Münster-Osnabrück Airport (FMO)
- Via public transport (about 35 minutes): Take bus line S50, R51 or D50. Alight at Münster Central Station (Münster Hauptbahnhof). Please follow the directions by train and bus.
From Dortmund Airport (DTM), Düsseldorf Airport (DUS), Cologne Bonn Airport (CGN), Frankfurt Airport (FRA)
- Via public transport (about 1.5-2 hours from DTM/DUS/CGN, about 3-3.5 hours from FRA): Take a train (ICE/IC/RE) to Münster Central Station (Münster Hauptbahnhof). Please follow the directions by train and bus.
Directions by train
ICE, IC and EC trains arrive at Münster Central Station (Münster Hauptbahnhof).
Directions by bus
All registered symposium participants will receive a ‘Welcome! Münster Ticket’ for free public transport in Münster for the time of the conference. The tickets will be handed out on site at the registration for the symposium.
Bus options A (from Münster Central Station to Mendelstraße):
- City bus 2 (gate C1 in front of the train station), direction Alte Sternwarte
- City bus 13 (gate B2 in front of the train station), direction Technologiepark
You find the meeting venue right opposite of the bus stop Mendelstraße.
Bus options B (from Münster Central Station to Schreiberstraße):
- City bus 5 (gate B2 in front of the train station), direction Hannaschweg
- City bus 11 (gate C1 in front of the train station), direction Dieckmannstraße
From the bus stop please turn right into Schreiberstraße and proceed to Heisenbergstraße. The meeting venue is about 8 min walking distance (directions with Google Maps).
Directions by car
Address for your navigation system: Domagkstraße 61, D-48149 Münster
Please use the free parking garage at P+R Coesfelder Kreuz that is located about 8 minutes walking distance from the meeting venue (directions with Google Maps). There are no parking slots available at the meeting venue.
You can book your hotel in Münster here.
International CiM Symposium | Cells in Motion: Pattern formation in space and time | Münster, 4–6 September 2017
In a true testament to interdisciplinary research, the 2017 International CiM Symposium was recently held at the WWU Münster and brought together experts from the fields of biomedicine, biology, chemistry, biophysics, mathematics and computer science. The organising committee (T. Betz, R. Gilmour, G. Lenz, S. Luschnig, A. Rentmeister, S. Schulze-Merker, R. Wedlich-Söldner, B. Wirth - all WWU Münster) decided on the alluring conference theme “Patterns in space and time” and left the interpretation entirely up to a veritable who’s who of leading experts. The challenge for each speaker was to effectively convey sophisticated, cutting edge science to a mixed audience of clinicians and natural scientists. The end result was a 3-day tour-de-force in manipulating, studying and understanding cell behaviour.
Following a general introduction to the Cluster of Excellence “Cells in Motion” by Lydia Sorokin (WWU Münster), the opening session (Chair: Volker Gerker, WWU Münster) on membrane organisation began with a thoughtful discussion of membrane-localised interactions and transport diffusion processes in cells by Mathias Röger (TU Dortmund). From mathematics, the programme then switched to biophysics and a lecture by Milos Galic (WWU Münster) on nanoscale membrane deformations and their effects on lamellipodia re-initiation, cell shape and migration pattern. The session concluded with a lecture from Patricia Bassereau (Institut Cuire, Paris) on I-BAR proteins and Ezrin in the context of curved membranes.
Session two entitled “Visualising cells and manipulating processes in living cells” (Chair: Andrea Rentmeister, WWU Münster) focussed on the important role of chemistry. The importance of bio-orthogonal reactions in visualising drug metabolism and embryogenesis was emphasised by Nathan Leudtke (University of Zürich). In a switch to glycochemistry, Benjamin Schumann from Stanford University spoke about glycosyltransferase bump-hole engineering to dissect mucin-type O-glycosylation in living cells. The session was rounded off by Markus Affolter (University of Basel) who delivered a lecture entitled “Angiogenesis live: new insights and new tools”.
Session three, chaired by Milos Galic and Sebastian Rumpf, provided a platform for young investigators funded through the CiM Cluster to share their latest results. Speakers included Johannes Fels, Robert Meissner, Maniraij Bhagawati, Kathleen Hübner and Sargon Yigit (all WWU Münster).
The evening lecture, chaired by Erez Raz (WWU Münster), was delivered by Benny Shilo from the Weizmann Institute of Science. Entitled “Life’s Blueprint”, this talk was a beautiful balance between scientific complexity and everyday occurrences. Peppered with photographs and images from Shilo’s own collection, the lecture was both accessible and expressive. The first day of the meeting concluded with a reception and poster presentations.
The first session on Tuesday 5th September (Session 4. Chair: Ryan Gilmour, WWU Münster) kicked off with Arndt Siekmann’s (WWU Münster) lecture entitled “Endothelial notch signalling limits angiogenesis via controlled artery formation”. This was followed by a change in pace to mathematics and a presentation on modelling biological transport mechanisms by Peter Markowich from the University of Cambridge. The session concluded with the sole industrial speaker, Nick Meanwell (Bristol-Myers Squibb) who gave an account of BMS’s development of modulators of hepatitis C virus NS5A.
Session 5 focussed on the theme of mechanobiology (Chair: Timo Betz, WWU Münster), beginning with the subject of tissue viscoplasticity in a lecture by Michel Labouesse (Institut de Biologie Paris-Seine). Maja Matis (WWU Münster) addressed the control of tissue mechanics, before handing the floor to Matthieu Piel (Institut Curie, Paris) for lecture intriguingly entitled “Squeezing the nucleus”.
Central to the CiM initiative is cellular communication, the subject of session 6 chaired by Stefan Lusching. Commencing with a lecture by Stefan Sigrist (FU Berlin) on pre-post-synaptic communication patterns, the session then moved to chemical ecology and explored cellular communications in a two-kingdom symbiosis (Jon Clardy, Harvard University). Regeneration was the subject of the next lecture by Kerstin Bartscherer (MPI for Molecular Biomedicine), specifically understanding the mechanism of this process in flatworms. The final talk of this session moved to mathematics, and was given by Jan-Frederik Pietschmann (WWU Münster) on the development of a phase separation model with non-local interactions.
Following a short break, the second day concluded with session 6 entitled “Frontiers in imaging” chaired by Michael Schäfers (WWU Münster). David O’Hagan (St Andrews) demonstrated how an enzyme can be harnessed to form 18F-C bonds for application in positron emission tomography. Wolfram Pernice (WWU Münster) shared his lab’s latest results in the field of photonic nanostructures for imaging, and the session concluded with a lecture from Erik Sahai (The Francis Crick Institute, London) on cancer cell invasion in complex environments. The programme concluded with a Speakers Dinner held in the Picasso Museum, Münster (Restaurant La Californie) and a convivial evening was had by all.
The final day (Session 8, Chair: Roland Wedlich-Söldner, WWU Münster) was opened by Zena Werb from the University of California, San Francisco who discussed cancer progression and the importance of intravital imaging in revealing cell-matrix interactions. Peter Seeberger (MPI Potsdam) then discussed the importance of chemical glycobiology as a platform for vaccine development, and demonstrated how automated glycan assembly can facilitate this process. The penultimate lecture of the session was delivered by Britta Trappmann from the bioactive materials lab at the MPI in Münster entitled “Regulation of cell fate by extracellular matrix stiffness”. The finale to session 8 was provided by Martin Schwartz (Yale Cardiovascular Research Group) who lectured on the response of cells to forces applied through integrins.
Session 9 was devoted to tissue morphogenesis and chaired by Stefan Schulte-Merker (WWU Münster). The temporal basis of angiogenesis was addressed by Katie Bentley (Uppsala University) before a switch in themes to spatiotemporal control of dendrite pruning in Drosophila by Sebastian Rumpf (WWU Münster).
The 2017 International CiM Symposium was a huge success thanks to the 31 national and international speakers who were so very generous in sharing both their time and expertise. On behalf of the organising committee, we would like to express our deepest gratitude. Of course, a meeting of this complexity would not have been possible without the organisational support of our very dedicated CiM Office team, and in particular Ann-Christin Dietrich and Christel Marx.
The symposium was an excellent way to celebrate the Cluster’s success in Münster, but perhaps more importantly it provided inspiration and motivation for the future. We look forward to welcoming you to the next meeting in 2019!
Christiane Natsch and Ryan Gilmour