In this project, we aim at a novel multimodal imaging approach using BODIPY-based nanostructures to investigate endothelial permeability upon inflammatory stimuli in vivo. The tunable size (ranging from few nanometers to several micrometers) and shape (spherical, 1D, 2D) of the nanostructures will allow for a quantitative assessment of endothelial barrier function using the entire range of multiscale imaging modalities applied in this CRC (1, 2).
We will evaluate our BODIPY-based approach in inflammatory pathologies associated with changes in endothelial permeability such as ischemia-reperfusion (I/R; heart, kidney) and sepsis (3).
The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.
2023
Hoffmann E, Gerwing M, Krahling T, Hansen U, Kronenberg K, Masthoff M, Geyer C, Holtke C, Wachsmuth L, Schinner R, Hoerr V, Heindel W, Karst U, Eisenblatter M, Maus B, Helfen A, Faber C, Wildgruber M. Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy. Breast Cancer Res 2023;25: 56. Abstract
2022
Gerwing M, Hoffmann E, Kronenberg K, Hansen U, Masthoff M, Helfen A, Geyer C, Wachsmuth L, Höltke C, Maus B, Hoerr V, Krähling T, Hiddeßen L, Heindel W, Karst U, Kimm MA, Schinner R, Eisenblätter M, Faber C, Wildgruber M. Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer. Front. Oncol. 2022;12Abstract
2021
Masthoff M, Freppon FN, Zondler L, Wilken E, Wachsmuth L, Niemann S, Schwarz C, Fredrich I, Havlas A, Block H, Gerwing M, Helfen A, Heindel W, Zarbock A, Wildgruber M, Faber C. Resolving immune cells with patrolling behaviour by magnetic resonance time-lapse single cell tracking. EBioMedicine 2021;73: 103670. Abstract
2020
Helmers I, Shen B, Kartha KK, Albuquerque RQ, Lee M, Fernandez G. Impact of Positional Isomerism on Pathway Complexity in Aqueous Media. Angew Chem Int Ed Engl 2020;59: 5675-5682. Abstract
2019
Masthoff M, Buchholz R, Beuker A, Wachsmuth L, Kraupner A, Albers F, Freppon F, Helfen A, Gerwing M, Holtke C, Hansen U, Rehkamper J, Vielhaber T, Heindel W, Eisenblatter M, Karst U, Wildgruber M, Faber C. Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining (57)Fe-Based MRI and Mass Spectrometry. Nano Lett 2019;19: 7908-7917. Abstract
2018
Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblatter M, Wildgruber M, Faber C. Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI. Sci Rep 2018;8: 9563. Abstract
Masthoff M, Helfen A, Claussen J, Karlas A, Markwardt NA, Ntziachristos V, Eisenblatter M, Wildgruber M. Use of Multispectral Optoacoustic Tomography to Diagnose Vascular Malformations. JAMA Dermatol 2018;154: 1457-1462. Abstract
Sampedro A, Ramos-Torres A, Schwoppe C, Muck-Lichtenfeld C, Helmers I, Bort A, Diaz-Laviada I, Fernandez G. Hierarchical Self-Assembly of BODIPY Dyes as a Tool to Improve the Antitumor Activity of Capsaicin in Prostate Cancer. Angew Chem Int Ed Engl 2018;57: 17235-17239. Abstract
2017
Rödle A, Lambov M, Mück-Lichtenfeld C, Stepanenko V, Fernández G. Cooperative nanoparticle H-type self-assembly of a bolaamphiphilic BODIPY derivative in aqueous medium. Polymer 2017;128: 317-324. Abstract
2016
Rodle A, Ritschel B, Muck-Lichtenfeld C, Stepanenko V, Fernandez G. Influence of Ester versus Amide Linkers on the Supramolecular Polymerization Mechanisms of Planar BODIPY Dyes. Chemistry 2016;22: 15772-15777. Abstract
2015
Reifschneider O, Wentker KS, Strobel K, Schmidt R, Masthoff M, Sperling M, Faber C, Karst U. Elemental bioimaging of thulium in mouse tissues by laser ablation-ICPMS as a complementary method to heteronuclear proton magnetic resonance imaging for cell tracking experiments. Anal Chem 2015;87: 4225-4230. Abstract
2014
Allampally NK, Florian A, Mayoral MJ, Rest C, Stepanenko V, Fernandez G. H-aggregates of oligophenyleneethynylene (OPE)-BODIPY systems in water: guest size-dependent encapsulation mechanism and co-aggregate morphology. Chemistry 2014;20: 10669-10678. Abstract
Schmidt R, Nippe N, Strobel K, Masthoff M, Reifschneider O, Castelli DD, Holtke C, Aime S, Karst U, Sunderkotter C, Bremer C, Faber C. Highly Shifted Proton MR Imaging: Cell Tracking by Using Direct Detection of Paramagnetic Compounds. Radiology 2014;272: 785-795. Abstract
