Quantitative assessment of endothelial permeability by novel scalable BODIPY nanostructures

Principal investigators: Gustavo Fernandez Huertas, Max Masthoff
Project number: CRC 1450 B01
Project term: 01/2021–12/2028

In the first funding period, we have developed size-controllable aza-BODIPY nanostructures for optical and photoacoustic imaging. We will now utilize these to expand the platform to PET-MRI and to multimodally study endothelial permeability in vivo in local and systemic inflammation. We also aim to modulate the shape of the aza-BODIPY assemblies to rationalize the relationship between molecular design, aggregate morphology and associated cell labelling efficacy. We will ultimately in vivo track aza-BODIPY-labelled monocytes in inflammatory diseases as well as to the tumour microenvironment in a murine cancer model.

Team

Principal investigators

• Fernandez Huertas, Gustavo, Univ.-Prof. Dr. rer. nat.
  Institute for Organic Chemistry
• Masthoff, Max, Prof. Dr. med.
  Department of Radiology

Project members

• Emami, Sahar
  Department of Radiology
• Köyer, Max
  Institute for Organic Chemistry

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.