Finkemeier, Iris, Prof. Dr rer. nat.
Westfälische Wilhelms-Universität Münster
Dekanat des Fachbereichs Biologie
Schlossplatz 4
D-48149 Münster
Tel. +49 (0)251 / 83-2 30 12
dekanat.bio@uni-muenster.de
Vice Dean
Wissenschaftlicher Werdegang
Professor, Plant Physiology, Institute for Plant Biology and Biotechnology, 2015 - present
Research Group Leader, Plant Proteomics, Max-Planck-Institute for Plant Breeding Research, Cologne, 2013-2015
Habilitation in Botany, LMU Munich, 2014
Emmy Noether Research Group Leader, Ludwig Maximilians University Munich, 2010-2013
Junior Research Fellow for Biology, Christ Church College, University of Oxford, 2007 – 2011
Feodor-Lynen Research Fellow, Department of Plant Sciences, University of Oxford, 2006 – 2009
Postdoctoral Researcher, Bielefeld University, 2005
PhD in Plant Physiology and Biochemistry, Bielefeld University, 2005
Diploma (equ. to MSc) in Biology, Bielefeld University, 2001
Lehrschwerpunkte
- Plant Physiology and Biochemistry
- Plant Proteomics
Forschungsschwerpunkte
- Mitochondria and Chloroplasts
- Adaptation to abiotic stress
- Metabolite and energy signalling
- Post-translational modifications
- Metabolic pathways
- Plant proteomics
Ausgewählte Projekte
- Exploring the role of lysine acetylation in the regulation of plant metabolism
- Retrograde regulation of plant organellar functions
Publications
- . . ‘The interplay of post‐translational protein modifications in Arabidopsis leaves during photosynthesis induction.’ The Plant journal 2023. doi: 10.1111/tpj.16406.
- . . ‘Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation.’ Nature Chemistry 2023. doi: 10.1038/s41557-023-01388-7.
- . . ‘Glutamate 1-semialdehyde aminotransferase is connected to GluTR by GluTR-binding protein and contributes to the rate-limiting step of 5-aminolevulinic acid synthesis.’ The Plant cell 34. doi: 10.1093/plcell/koac237.
- . . ‘Eukaryote-specific assembly factor DEAP2 mediates an early step of photosystem II assembly in Arabidopsis.’ Plant Physiology 2023. doi: 10.1093/plphys/kiad446.
- 10.1111/tpj.16206. . ‘Proteome-wide lysine acetylation profiling to investigate the involvement of histone deacetylase HDA5 in the salt stress response of Arabidopsis leaves.’ The Plant journal 115, No. 1: 275–292. doi:
- . . ‘Light acclimation interacts with thylakoid ion transport to govern the dynamics of photosynthesis in Arabidopsis.’ New Phytologist 2022. doi: 10.1111/nph.18534.
- 10.1016/bs.mie.2022.09.005. . ‘Peptide CoA conjugates for in situ proteomics profiling of acetyltransferase activities.’ Methods in Enzymology 684: 209–252. doi:
- . . ‘Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.’ New Phytologist 238, No. 1. doi: 10.1111/nph.18657.
- . . ‘Differential proteome profiling of bacterial culture supernatants reveals candidates for the induction of oral immune priming in the red flour beetle.’ Biology Letters 19, No. 11. doi: 10.1098/rsbl.2023.0322.
- . . ‘Mass Spectrometry-Based Quantitative Cysteine Redox Proteome Profiling of Isolated Mitochondria Using Differential iodoTMT Labeling.’ Methods in Molecular Biology 2363: 215–234. doi: 10.1007/978-1-0716-1653-6_16.
- . . ‘Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum.’ Frontiers in Plant Science 13: 909624. doi: 10.3389/fpls.2022.909624.
- . . ‘Investigating Peptide‐Coenzyme A Conjugates as Chemical Probes for Proteomic Profiling of N‐Terminal and Lysine Acetyltransferases.’ ChemBioChem 23. doi: 10.1002/cbic.202200255.
- . . ‘Acetylation of conserved lysines fine-tunes mitochondrial malate dehydrogenase activity in land plants.’ The Plant journal 109, No. 1: 92–111. doi: 10.1111/tpj.15556.
- . . ‘Dynamic light‐ and acetate‐dependent regulation of the proteome and lysine acetylome of Chlamydomonas.’ The Plant journal 109, No. 1: 261–277. doi: 10.1111/tpj.15555.
- 10.1111/tpj.15924. . ‘Lysine acetylation regulates moonlighting activity of the E2 subunit of the chloroplast pyruvate dehydrogenase complex in Chlamydomonas.’ The Plant journal 111, No. 6: 1780–1800. doi:
- 10.1016/j.molp.2021.11.006. . ‘Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling.’ Molecular Plant 15, No. 4: 651–670. doi:
- . . ‘Functional characterization of protonantiport regulation in the thylakoid membrane.’ Plant Physiology 187. doi: 10.1093/plphys/kiab135.
- 10.1016/j.bbabio.2021.148443. . ‘Protein interaction patterns in Arabidopsis thaliana leaf mitochondria change in dependence to light.’ Biochimica et Biophysica Acta - Bioenergetics 1862, No. 8. doi:
- 10.1016/j.ijbiomac.2021.10.192. . ‘The functionality of plant mechanoproteins (forisomes) is dependent on the dual role of conserved cysteine residues.’ International Journal of Biological Macromolecules 193: 1332–1339. doi:
- . . ‘Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation.’ Molecular Systems Biology 16, No. 7: e9464. doi: 10.15252/msb.20209464.
- . . ‘Single organelle function and organization as estimated from Arabidopsis mitochondrial proteomics.’ The Plant journal 1. doi: 10.1111/tpj.14534.
- . . ‘NAA50 is an enzymatically active Nα-acetyltransferase that is crucial for development and regulation of stress responses.’ Plant Physiology 183, No. 4: 1502–1516. doi: 10.1104/pp.20.00222.
- . . ‘Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination.’ Proceedings of the National Academy of Sciences of the United States of America (PNAS) 117, No. 1: 741–751. doi: 10.1073/pnas.1910501117.
- 10.1111/pce.13100. [online first] . ‘Oxidative stress-triggered interactions between the succinyl- and acetyl-proteomes of rice leaves.’ Plant, Cell and Environment 2018, No. null. doi:
- . . ‘Mitochondrial regulation in the photosynthetic cell: principles and concepts.’ In Annual Plant Reviews: Plant Mitochondria, edited by , 185–226. 2nd Ed. John Wiley & Sons.
- 10.1016/j.mito.2016.07.012. . ‘Lysine acetylation in mitochondria: From inventory to function.’ Mitochondrion 33, No. null: 58–71. doi:
- 10.15252/msb.20177819. . ‘Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis.’ Molecular Systems Biology 13, No. 10. doi:
- 10.1002/1873-3468.12692. . ‘Identification of the missing mitochondrial methyltransferase of citrate synthase.’ FEBS Letters 591, No. 12: 1653–1656. doi:
- 10.1007/978-1-4939-7225-8_5. . ‘Dimethyl-labeling-based quantification of the lysine acetylome and proteome of plants.’ In Photorespiration, Methods in Molecular Biology , edited by , 65–81. Humana Press. doi:
- 10.1038/s41467-017-00113-6. . ‘DELAY of GERMINATION1 requires PP2C phosphatases of the ABA signalling pathway to control seed dormancy /631/449/2679/2683 /631/449/2653 article.’ Nature Communications 8, No. 1. doi:
- 10.3389/fpls.2016.00820. . ‘Obligate biotroph pathogens of the genus albugo are better adapted to active host defense compared to niche competitors.’ Frontiers in Plant Science 7, No. null. doi:
- 10.1104/pp.16.00525. . ‘Sequence polymorphisms at the REDUCED DORMANCY5 pseudophosphatase underlie natural variation in Arabidopsis dormancy.’ Plant Physiology 171, No. 4: 2659–2670. doi:
- 10.1002/psc.2875. . ‘Probing the structure-activity relationship of endogenous histone deacetylase complexes with immobilized peptide-inhibitors.’ Journal of Peptide Science 22, No. 5: 352–359. doi:
- 10.1111/mmi.13528. . ‘The SAGA complex in the rice pathogen Fusarium fujikuroi: structure and functional characterization.’ Molecular Microbiology 102, No. 6: 951–974. doi:
- 10.1002/anie.201508174. . ‘Interrogating substrate selectivity and composition of endogenous histone deacetylase complexes with chemical probes.’ Angewandte Chemie - International Edition 55, No. 3: 1192–1195. doi:
- 10.1007/978-1-4939-2639-8_7. . ‘Identification of lysine-acetylated mitochondrial proteins and their acetylation sites.’ In Plant Mitochondria, edited by , 107–121. Humana Press. doi:
- 10.1007/978-1-4939-2639-8_7. . ‘Identification of lysine-acetylated mitochondrial proteins and their acetylation sites.’ In Plant Mitochondria: Methods and Protocols, edited by , 107–121. Springer. doi:
- 10.1105/tpc.15.00509. . ‘The EF-hand Ca2+ binding protein MICU choreographs mitochondrial Ca2+ dynamics in arabidopsis.’ The Plant cell 27, No. 11: 3190–3212. doi:
- 10.1016/j.mito.2014.03.004. . ‘The mitochondrial lysine acetylome of Arabidopsis.’ Mitochondrion 19, No. null: 252–260. doi:
- 10.1016/j.mito.2014.02.006. . ‘The life of plant mitochondrial complex I.’ Mitochondrion 19, No. null: 295–313. doi:
- 10.1104/pp.113.232496. . ‘The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism.’ Plant Physiology 164, No. 3: 1401–1414. doi:
- . ‘Redox regulation of Arabidopsis mitochondrial citrate synthase.’ Molecular Plant 7, No. 1: 156–169.
- 10.1093/mp/ssu042. . ‘Meta-analysis of retrograde signaling in Arabidopsis thaliana reveals a core module of genes embedded in complex cellular signaling networks.’ Molecular Plant 7, No. 7: 1167–1190. doi:
- 10.1093/mp/ssu034. . ‘Induced deactivation of genes encoding chlorophyll biosynthesis enzymes disentangles tetrapyrrole-mediated retrograde signaling.’ Molecular Plant 7, No. 7: 1211–1227. doi:
- 10.1104/pp.114.243824. . ‘FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis.’ Plant Physiology 166, No. 2: 808–828. doi:
- 10.1104/pp.113.214114. . ‘Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in arabidopsis leaves.’ Plant Physiology 162, No. 1: 239–253. doi:
- 10.1007/s12268-013-0392-z. . „Protein modification. Lysine acetylation: A well-known protein modification in new light.“ BIOspektrum 19, No. 7: 810–812. doi:
- 10.1089/ars.2012.5104. . ‘Mitochondrial energy and redox signaling in plants.’ Antioxidants and Redox Signaling 18, No. 16: 2122–2144. doi:
- 10.1093/jxb/err374. . ‘The impact of impaired mitochondrial function on retrograde signalling: A meta-analysis of transcriptomic responses.’ Journal of Experimental Botany 63, No. 4: 1735–1750. doi:
- 10.3389/fpls.2012.00253. . ‘Plant mitochondrial retrograde signaling: Post-translational modifications enter the stage.’ Frontiers in Plant Science 3, No. null. doi:
- 10.1104/pp.110.171595. . ‘Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.’ Plant Physiology 155, No. 4: 1779–1790. doi:
- . . ‘Plant Chloroplasts and Other Plastids .’ eLS na.
- . . ‘The role of malate in plant homeostasis.’ F1000 Biology Reports I, No. 47.
- 10.1104/pp.107.113613. . ‘Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis.’ Plant Physiology 147, No. 1: 101–114. doi:
- 10.1111/j.1399-3054.2006.00785.x. . ‘The mitochondrial type II peroxiredoxin from poplar.’ Physiologia Plantarum 129, No. 1: 196–206. doi:
- 10.1105/tpc.107.055061. . ‘S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration.’ The Plant cell 19, No. 12: 4120–4130. doi:
- 10.1016/j.plaphy.2007.07.017. . ‘Biochemical and molecular characterization of the mitochondrial peroxiredoxin PsPrxII F from Pisum sativum.’ Plant Physiology and Biochemistry 45, No. null: 729–739. doi:
- . . ‘The Role of Peroxiredoxins in Oxygenic Photosynthesis of Cyanobacteria and Higher Plants: Peroxide Detoxification or Redox Sensing? .’ In Photoprotection, photoinhibition, gene regulation, and environment, edited by , 303–319. Kluwer Academic.
- 10.1093/jxb/erj160. . ‘The function of peroxiredoxins in plant organelle redox metabolism.’ Journal of Experimental Botany 57, No. 8: 1697–1709. doi:
- 10.1111/j.1469-8137.2006.01805.x. . ‘Signalling in primary metabolism.’ New Phytologist 171, No. 3: 445–447. doi:
- 10.1016/j.febslet.2006.01.043. . ‘Redox regulation of peroxiredoxin and proteinases by ascorbate and thiols during pea root nodule senescence.’ FEBS Letters 580, No. 5: 1269–1276. doi:
- 10.1111/j.1365-313X.2006.02665.x. . ‘Peroxiredoxin Q of Arabidopsis thaliana is attached to the thylakoids and functions in context of photosynthesis.’ The Plant journal 45, No. 6: 968–981. doi:
- 10.1074/jbc.M413189200. . ‘The mitochondrial type II peroxiredoxin F is essential for redox homeostasis and root growth of Arabidopsis thaliana under stress.’ Journal of Biological Chemistry 280, No. 13: 12168–12180. doi:
- 10.1089/ars.2005.7.919. . ‘Identification of plant glutaredoxin targets.’ Antioxidants and Redox Signaling 7, No. null: 919–929. doi:
- 10.1111/j.0031-9317.2004.0272.x. . ‘The antioxidant status of photosynthesizing leaves under nutrient deficiency: Redox regulation, gene expression and antioxidant activity in Arabidopsis thaliana.’ Physiologia Plantarum 120, No. 1: 63–73. doi:
- 10.1016/j.plantsci.2004.01.006. . ‘Cadmium toxicity to barley (Hordeum vulgare) as affected by varying Fe nutritional status.’ Plant Science 166, No. 5: 1287–1295. doi:
- 10.1104/pp.102.018457. . ‘Salicylic acid alleviates the cadmium toxicity in barley seedlings.’ Plant Physiology 132, No. 1: 272–281. doi:
- 10.1104/pp.010017. . ‘Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis.’ Plant Physiology 131, No. 1: 317–325. doi:
- 10.1046/j.1365-3040.2003.01014.x. . ‘Alterations in Cd-induced gene expression under nitrogen deficiency in Hordeum vulgare.’ Plant, Cell and Environment 26, No. 6: 821–833. doi: