Dr. Dagmar Aichele

Oberstudienrätin i.H.

 

© Dr. Dziemba












 

 

Kontakt:

PharmaCampus der Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
Corrensstraße 48
48149 Münster

Tel.: +49 (0)251 83-32204
Raum: A 110.110
E-Mail

 

Tätigkeiten am Institut

Lehraufgaben/ Praktikumsbetreuung

  • Praktikumsleiterin des Praktikums „Quantitative Bestimmung von Arznei-, Hilfs- und Schadstoffen“ (2. Semester)
  • Seminare und Übungen zum Praktikum „Quantitative Bestimmung von Arznei-, Hilfs- und Schadstoffen“ (2. Semester)
     

Weitere Aufgaben / Qualifikationen

  • Strahlenschutzbeauftragte
  • Leitung der Analysenausgabe
  • Qualifikation für Projektleiter gentechnischer Anlagen gemäß §15 Gentechniksicherheitsverordnung

  • Dezentrale Gleichstellungsbeauftragte des Fachbereichs

  • Mitglied im Prüfungsausschuss Pharmazie

  • Ansprechperson für Studentinnen des Studienganges Pharmazie, die dem Mutterschutzgesetz unterliegen

  • Leitung des Zellkulturlabors im AK Jose


Forschungsschwerpunkte

  • Reversible protein phosphorylation
  • Protein Kinase CK2: regulation and inhibition

  • Effects of CK2 inhibitors on tumor celllines

  • Lipid kinase PIPK1α: regulation and inhibition


Publikationen

 Dissertation

  • Protein phosphatase from bovine retinae – purification, characterization, cloning and expression. Universität Tübingen 1995


Veröffentlichungen

  • Birus R, El-Awaad E, Ballentin L, Alchab F, Aichele D, Ettouati L, Götz C, Le Borgne M, Jose J (2022) 4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects, FEBS Open Bio 12:394-411 doi: 10.1002/2211-5463.13346
  • Haidar S, Jürgens FM, Aichele D, Jagels A, Humpf HU, Jose J (2021) Natural compounds isolates from Stachybotrys chartarum are potent inhibitors of human Protein kinase CK2, Molecules, 26: 4453. doi: 10.3390/molecules26154453
  • Haidar S, Jürgens F, Aichele D, Jose J (2021) In Silico and in vitro studies of natural comounds as Human CK2 inhibitors, Curr Comput Drug Des, 17: 323-331.
  • El-Awaad E, Birus R, Marminon C, Bouaziz Z, Ballentin L, Aichele D, Le Borgne M, Jose J (2021) Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Subsituted Ideno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor, Pharmaceuticals, 14: 542, https://doi.org/10.3390/ph14060542, IF: 5,863
  • Haidar S, Marminon C, Aichele D, Nacereddine A, Zeinyeh W, Bouzina A, Berredjem M, Ettouati L, Bouaziz Z, Le Borgne M, Jose J (2020) QSAR model of indeno[1,2-b]indole derivatives and identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide as potent CK2 inhibitor, molecules, 25: 97 doi: 10.3390/molecules 25010097, IF: 3.267
  • Oramas-Royo S, Haidar S, Amesty A, Martín-Acosta P, Feresin G, Tapia A, Aichele D, Jose J, Estévez-Braun A (2019) Design, synthesis and biological evaluation of new embelin derivatives as CK2 inhibitors, Bioorg Chem. 95:103520. doi: 10.1016/j.bioorg.2019.103520
  • Haidar S, Aichele D, Birus R, Hielscher J, Laitinen T, Poso A, Jose J (2019) In vitro and in silico evaluation of bikaverin as a potent inhibitor of human protein kinase CK2, Molecules, 24: 1380
  • Haidar S, Jabbour M, Al-Khayat MA, Aichele D, Jose J (2018) Synthesis and biological evaluation of novel 2(4'-hydroxynaphthyl)chrome-4-one as a CK2 inhibitor. Die Pharmazie, 73: 191-195.
  • Martin-Acosta P, Haidar S, Amesty A, Aichele D, Jose J, Estevez-Braun A (2018) A new family of highly functionalized pyranobenzoquinones as potent human protein kinase CK2 inhibitors. Eur J Med Chem, 144: 410-423.
  • Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K (2017) Unexpected binding mode of a potent indeno[1,2-b]indole-type inhibitor of protein kinase CK2 revealed by complex structures with the catalytic subunit CK2α and its paralog CK2α'. Pharmaceuticals, 10(4) 98.
  • Gozzi GJ, Bouaziz Z, Winter E, Daflon-Yunes N, Aichele D, Nacereddine A, Marminon C, Valdameri G, Zeinyeh W, Bollacke A, Guillon J, Lacoudre A, Pinaud N, Cadena S, Jose J, Le Borgne M, Di Pietro A (2014) Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2
  • into selective inhibitors of the breast cancer resistance protein ABCG2. J Med Chem, DOI:10.1021/jm500943z
  • Klumpp S, Mäurer A, Zhu Y, Aichele D, Pinna LA, Krieglstein J.: Protein kinase CK2 phosphorylates BAD at threonine-117. Neurochem Int., 2004, 45(5), 747-52
  • Krieglstein J., Selke D., Maassen A., Klumpp S: Activity of PP2C beta is increased by divalent cations and lipophilic compounds depending on the substrate. Methods Enzymol. 2003,366:282-9
  • Susanne Klumpp , Gunther Bechmann, Anette Mäurer, Dagmar Selke and Josef Krieglstein: ATP-citrate lyase as a substrate of protein histidine phosphatase in vertebrates. Biochem Biophys Res Comm., 2003, 306 (1), 110-5
  • Klumpp S, Selke D, Krieglstein J.: Protein phosphatase type 2C dephosphorylates BAD. Neurochem Int. 2003, 42(7): 555-60
  • Klumpp S, Selke D, Ahlemeyer B, Schaper C, Krieglstein J.: Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells. Neurochem Int. 2002; 41(4): 251-9
  • Klumpp S, Hermesmeier J, Selke D, Baumeister R, Kellner R, Krieglstein J.: Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling J Cereb Blood Flow Metab 2002; 22(12): 1420-4
  • Ahlemeyer B, Selke D, Schaper C, Klumpp S, Krieglstein J.: Ginkgolic acids induce neuronal death and activate protein phosphatase type-2C. Eur J Pharmacol. 2001, 26;430(1):1-7.
  • Kolberg A, Kirrlach S, Selke D and Schulze B: Oxidation of acceptor-substituted isothiazolium-2-imines to stable cyclic sulfin- and sulfonamides with 3-hydroperoxy function. J Prakt Chem 2000, 342(3), 291-6
  • Klumpp S, Selke D.: Purification and characterization of protein phosphatase type 2C in photoreceptors. Methods Enzymol. 2000;315:570-8.
  • Selke D, Klumpp S, Kaupp B, Baumann A.: Molecular cloning of protein phosphatase type 2C isoforms from retinal cDNA. Methods Mol Biol. 1998;93:243-50.
  • Klumpp S, Selke D.: Separation of protein phosphatase type 2C isozymes by chromatography on blue sepharose. Methods Mol Biol. 1998;93:213-8.
  • Klumpp S, Selke D, Fischer D, Baumann A, Müller F, Thanos S.: Protein phosphatase type-2C isozymes present in vertebrate retinae: purification, characterization, and localization in photoreceptors. J Neurosci Res. 1998 ;51(3):328-38.
  • Klumpp S, Selke D, Hermesmeier J.: Protein phosphatase type 2C active at physiological Mg2+: stimulation by unsaturated fatty acids. FEBS Lett. 1998,  23;437(3):229-32.
  • Selke D, Anton H, Klumpp S.: Serine/threonine protein phosphatases type 1, 2A and 2C in vertebrate retinae. Acta Anat (Basel). 1998;162(2-3):151-6.
  • Schulze B, Mütze K, Selke D, Kempe R: Synthesis of novel N-Aroyl- and N-Arylsulfonylisothiazole-2-imines by cyclization of Thiocyanatovinylaldehyde hydrazones. Tetrahedron Lett. 1993, 34(12), 1909-12


Posterbeiträge

  • Aichele D, Pataillot J, Le Borgne M, Jose J (2016) Effects of Indeno[1,2-b]indol inhibitors of human protein kinase CK2 on different tumor cell lines. 8th International Conference on Protein Kinase CK2, Homburg, 6.-9.9.2016.
  • Haidar S, Aichele D, Popp R, Meyers A, Jose J (2016) Design and development of 9,10-dihydrophenanthrene derivatives as inhibitors of human protein kinase CK2. Frontiers in Medicinal Chemistry, Bonn, 13.-16.3.2016. P90.