Alexander Gast

Ph.D. Student

© Werner














Kontakt:

PharmaCampus der Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
Corrensstraße 48
48149 Münster

Tel.: +49 (0)251 83-32206
Raum: A.110.106
E-Mail

 

Current Research Topic:

Variants of Protein Kinase CK2 found in neurodevelopmental disease

Teaching:

  • 2. Semester Quantitative Bestimmung von Arznei-, Hilfs- und Schadstoffen

Papers:

  • Gast A, Schreiber S, Jose J (2025), Rapid method for evaluation of CK2 enzymatic activity and CK2α/CK2β-interaction from Escherichia coli cell lysates, Biol Chem., 406(2-3), 117-124 https://doi.org/10.1515/hsz-2024-0159, IF: 2.9

  • Marminon C, Werner C, Gast A, Herfindal L, Charles J, Lindenblatt D, Aichele D, Mularoni A, Døskeland SO, Jose J, Niefind K, Le Borgne M (2025) Exploring the biological potential of the brominated indenoindole MC11 and its interaction with protein kinase CK2. Biol Chem.,406(3-4), 125-138 https://doi.org/10.1515/hsz-2024-0160, IF: 2.9

  • Cruz-Gamero JM, Ballardin D, Lecis B, Zhang C-L, Cobret L, Gast A, Morisset-Lopez S, Piskorowski R, Langui D, Jose J, Chevreux G, Rebholz H (2024) Missense mutation in the activation segment of the kinase CK2 models Okur Chung neurodevelopmental disorder and alters the hippocampal glutamatergic synapse. Mol Psychiatry, published online. 
    https://doi.org/10.1038/s41380-024-02762-8, IF: 9.6
  • Cruz-Gamero JM, Ballardin D, Lecis B, Zhang C-L, Cobret L, Gast A, Morisset-Lopez S, Piskorowski R, Langui D, Jose J, Chevreux G, Rebholz H (2024) Missense mutation in the activation segment of the kinase CK2 models Okur Chung neurodevelopmental disorder and alters the hippocampal glutamatergic synapse. bioRxiv
    https://doi.org/10.1101/2024.04.04.588084
  • Werner C, Gast A, Lindenblatt D, Nickelsen A, Niefind K, Jose J, Hochscherf J (2022) Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg. Front Mol Biosci, 9:831693.
    https://doi.org/10.3389/fmolb.2022.831693, IF: 6.113

Poster:

  • Gast A, Schreiber S, Werner C, Niefind K, Jose J (2025), Rapid method for evaluation of CK2 enzymatic activity and CK2α/CK2β-interaction in Escherichia coli cell lysates, CSNK2A1 Foundation Connect + Collaborate 2025 Scientific & Family Conference, Denver, USA, 17-20.07.2025
  • Werner C, Gast A, Jordan S, Meyer S, Buchwald L, Than TL, Jose J, Niefind K (2025), Investigation of the structure-disfunction relationship of various OCNDS-related CK2α mutants, CSNK2A1 Foundation Connect + Collaborate 2025 Scientific & Family Conference, Denver, USA, 17-20.07.2025
  • Jordan S, Werner C, Gast A, Jose J, Niefind K (2025), Characterization of four POBINDS-related CK2β-mutants, CSNK2A1 Foundation Connect + Collaborate 2025 Scientific & Family Conference, Denver, USA, 17-20.07.2025
  • Gast A, Schreiber S, Jose J (2025) Rapid Determination of Human Protein Kinase CK2 Enzymatic Activity and CK2α/CK2β-Interaction in Recombinant E. coli Cell Lysates, DPhG DoktorandInnentagung, Graz, 26.-28.02.2025
  • Gast A, Werner C, Meyer S, Than TL, Harasimowicz H, Buchwald L, Niefind K, Jose J (2024) Investigating the substrate specificity of CK2α-variants found in Okur-Chung Neurodevelopmental Syndrome. 9th International Conference on Protein Kinase CK2, Münster, 09.-12.09.2024
  • Gast A, Cruz-Gamero J, Rebholz H, Jose J (2024) Investigating the substrate specificity of CK2α-variants found in Okur-Chung Neurodevelopmental Syndrome. 5th Chembion Symposium, Münster, 16.02.2024
  • Gast A, Cruz-Gamero J, Rebholz H, Jose J (2023) Molecular Characterization of variant of CK2α found in Okur-Chung Neurodevelopmental Syndrome. DPhG-Jahrestagung 2023, Tübingen, 07.-10.10.2023
    Posterpreis
  • Gast A, Werner C, Lindenblatt D, Nickelsen A, Niefind K, Hochscherf J, Jose J (2023) Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg; structural and enzymological evidence. Frontiers in Medicinal Chemistry 2023, Vienna, 03.-05.04.2023

Oral Presentations:

  • Gast A, Werner C, Meyer S, Than TL, Harasimowicz H, Buchwald L, Niefind K, Jose J (2024) Investigating the substrate specificity of CK2α-variants found in Okur-Chung Neurodevelopmental Syndrome. 9th International Conference on Protein Kinase CK2, Münster, 09.-12.09.2024
  • Gast A, Jose J, Birus R, Aichele D, Nickelsen A (2021) Characterization of CSNK2A1 variants in Okur-Chung Neurodevelopmental Syndrome, CSNK2A1 Scientific Workshop (online), 27.05.2021
  • Gast A, Jose J (2022) Molecular characterization of protein kinase CK2α-variants identified in Okur-Chung Neurodevelopmental Syndrome, Simons Searchlight Family and Research Conference, Baltimore ML, USA, 04.-07.08.2022