

Beteiligung an „Cells in Motion“
- Sprecherin des Cells in Motion Interfaculty Centres
- Mitglied der Kommission für Forschung und Karriere
- Mitglied im Graduiertenprogramm CiM-IMPRS
- Mitglied im Imaging Network – Mikroskopie
- Forschungsinteressen: cell-matrix interactions, leukocyte extravasation, blood vessels, secondary lymphoid organs
- Projekt FF-2015-03: CCR6 as a marker of CD4+Th17+ T cells in inflammation: development of specific imaging and therapeutic tools (Günter Haufe, Lydia Sorokin, Projektlaufzeit: 07/2015 - 06/2017)
- Projekt FF-2013-28: Entwicklung neuartiger, MOBSAM-basierter, spezifischer Inhibitoren von MMP-2/9 für die molekulare Bildgebung und zur Untersuchung ihrer Wirksamkeit bei entzündlichen Erkrankungen in vivo (Lydia Sorokin, Günter Haufe, Projektlaufzeit: 07/2013 - 06/2015)
Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“
alle Publikationen von Lydia Sorokin (PubMed)
2019
Hannocks M-J, Zhang X, Gerwien H, Chashchina A, Burmeister M, Korpos E, Song J, Sorokin L. The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes. Matrix Biol 2019;75-76: 102-113. Abstract Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergun S, Henke E, Nieswandt B. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood 2019;133: 2696-2706. Abstract 2018
Beutel B, Song J, Konken CP, Korpos E, Schinor B, Gerwien H, Vidyadharan R, Burmeister M, Li L, Haufe G, Sorokin L. New in Vivo Compatible Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitors. Bioconjug Chem 2018;29: 3715-3725. Abstract Breuer J, Korpos E, Hannocks M-J, Schneider-Hohendorf T, Song J, Zondler L, Herich S, Flanagan K, Korn T, Zarbock A, Kuhlmann T, Sorokin L, Wiendl H, Schwab N. Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus. J Neuroinflammation 2018;15: 236. Abstract Hannocks M-J, Pizzo ME, Huppert J, Deshpande T, Abbott NJ, Thorne RG, Sorokin L. Molecular characterization of perivascular drainage pathways in the murine brain. J Cereb Blood Flow Metab 2018;38: 669-686. Abstract Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblatter M, Wildgruber M, Faber C. Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI. Sci Rep 2018;8: 9563. Abstract Nascimento MA, Sorokin L, Coelho-Sampaio T. Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone. J Neurosci 2018;38: 3880-3889. Abstract Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks M-J, Abbott NJ, Meyerand ME, Sorokin L, Stanimirovic DB, Thorne RG. Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery. J Physiol 2018;596: 445-475. Abstract Samus M, Seelige R, Schafer K, Sorokin L, Vestweber D. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J Leukoc Biol 2018;104: 787-797. Abstract Susek KH, Korpos E, Huppert J, Wu C, Savelyeva I, Rosenbauer F, Muller-Tidow C, Koschmieder S, Sorokin L. Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow. Matrix Biol 2018;67: 47-62. Abstract Tuchscherr L, Korpos E, van de Vyver H, Findeisen C, Kherkheulidze S, Siegmund A, Deinhardt-Emmer S, Bach O, Rindert M, Mellmann A, Sunderkotter C, Peters G, Sorokin L, Loffler B. Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts. Int J Med Microbiol 2018;308: 761-769. Abstract 2017
Di Russo J, Hannocks M-J, Luik A-L, Song J, Zhang X, Yousif L, Aspite G, Hallmann R, Sorokin L. Vascular laminins in physiology and pathology. Matrix Biol 2017;57-58: 140-148. Abstract Di Russo J, Luik A-L, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker E NTP, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin L. Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J 2017;36: 183-201. Abstract Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 2017;19: 189-201. Abstract Polisetti N, Sorokin L, Okumura N, Koizumi N, Kinoshita S, Kruse FE, Schlotzer-Schrehardt U. Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells. Sci Rep 2017;7: 5152. Abstract Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lutke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep 2017;18: 1256-1269. Abstract 2016
Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lutke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J. Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun 2016;7: 10828. Abstract Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen Z-L, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol 2016;56: 42-56. Abstract Gerwien H, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schafers M, Sorokin L. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med 2016;8: 364ra152. Abstract Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L. Laminin alpha5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol 2016;56: 24-41. Abstract 2015
Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks M-J, Sorokin L. The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 2015;36: 54-61. Abstract Liu Z, Xu Y, Zhang X, Song J, Sorokin L, Bahler M. The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol 2015;282: 25-32. Abstract Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, Sorokin L. Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep 2015;10: 1040-1054. Abstract Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz H-J, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab 2015;35: 1711-1721. Abstract 2014
Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 2014;14: 552. Abstract Deak F, Mates L, Korpos E, Zvara A, Szenasi T, Kiricsi M, Mendler L, Keller-Pinter A, Ozsvari B, Juhasz H, Sorokin L, Dux L, Mermod N, Puskas LG, Kiss I. Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration. J Cell Sci 2014;127: 3240-3256. Abstract Schneider-Hohendorf T, Rossaint J, Mohan H, Boning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med 2014;211: 1833-1846. Abstract Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L. Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat Cell Biol 2014;16: 931-941. Abstract Spenle C, Lefebvre O, Lacroute J, Mechine-Neuville A, Barreau F, Blottiere HM, Duclos B, Arnold C, Hussenet T, Hemmerle J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P. The laminin response in inflammatory bowel disease: protection or malignancy?. PLoS One 2014;9: e111336. Abstract 2013
Enzmann G, Mysiorek C, Gorina R, Cheng Y-J, Ghavampour S, Hannocks M-J, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 2013;125: 395-412. Abstract Korpos E, Kadri N, Kappelhoff R, Wegner J, Overall CM, Weber E, Holmberg D, Cardell S, Sorokin L. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62: 531-542. Abstract Song J, Lokmic Z, Lämmermann T, Rolf J, Wu C, Zhang X, Hallmann R, Hannocks M-J, Horn N, Ruegg MA, Sonnenberg A, Georges-Labouesse E, Winkler TH, Kearney JF, Cardell S, Sorokin L. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proc Natl Acad Sci USA 2013;110: E2915-24. Abstract Song J, Wu C, Zhang X, Sorokin LM. In Vivo Processing of CXCL5 (LIX) by Matrix Metalloproteinase (MMP)-2 and MMP-9 Promotes Early Neutrophil Recruitment in IL-1beta-Induced Peritonitis. J Immunol 2013;190: 401-410. Abstract Yousif L, Di Russo J, Sorokin L. Laminin isoforms in endothelial and perivascular basement membranes. Cell Adh Migr 2013;7: 101-110. Abstract Zhang X, Wu C, Song J, Gotte M, Sorokin L. Syndecan-1, a Cell Surface Proteoglycan, Negatively Regulates Initial Leukocyte Recruitment to the Brain across the Choroid Plexus in Murine Experimental Autoimmune Encephalomyelitis. J Immunol 2013;191: 4551-4561. Abstract 2012
Steiner E, Enzmann GU, Lin S, Ghavampour S, Hannocks M-J, Zuber B, Ruegg MA, Sorokin L, Engelhardt B. Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia 2012;60: 1646-1659. Abstract