Topics of Research

Focus of our research is to investigate the pathophysiology of type 2 diabetes mellitus. In our projects we aim to develop innovative strategies to prevent progression of the disease and we search for new targets potentiating insulin release.

© Düfer
© Düfer

Areas of interest

  • Regulation of Ca2+ homeostasis of pancreatic islets by ion channels (e. g. Ca2+-activated K+ channels, TRPM5 channels, NMDA receptors)
  • Protection of beta-cells against glucolipotoxicity by modulators of redox balance
  • Significance of mitochondrial networks and mitochondrial heterogeneity for cellular physiology
  • Interplay of bile acids and the endocrine pancreas, cytosolic functions of the nuclear receptor FXR

© Düfer

We use a broad range of electrophysiological techniques (patch-clamp, microelectrode arrays), fluorescence imaging (high resolution real-time imaging, confocal and TIRF microscopy), hormone assays, immunohistology and biochemical assays, that are applied to in vitro and in vivo models of type 2 diabetes mellitus.