Buchbeiträge und sonstige Veröffentlichungen


Originalarbeiten, Reviews

2024, 2023, 20222021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000,


  • Dombovski, A., Steigerwald, R., Ritter, N., Disse, P., Goerges, G., Osthues, J., Aymanns, I., Dilkaute, C., Schreiber, J., Düfer, M., Seebohm, G., Wünsch, B., Jose, J. (2024) A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening. J. Pharm. Anal., accepted
  • Todesca, L. M., Gerke, M., Bulk, E. E., Bachmann, M., Rudersdorf, A., Antonuzzo, L., Pillozzi, S., Düfer, M., Szabo, I., Schwab, A. (2024) Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells. Cell Death Discov., 10(1):2.


  • Noguera Hurtado, H. , Gresch, A., Düfer, M. (2023) NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells. Biol. Chem., 404:311-324,


  • Soret, B., Hense, J., Lüdtke, S., Thale, I., Schwab, A., Düfer, M. (2022) Pancreatic KCa3.1 channels in health and disease. Biol. Chem., 404:339-353,

  • Pajaziti, B., Yosy, K., Steinberg, O.V., Düfer, M. (2022) FGF-23 protects cell function and viability in murine pancreatic islets challenged by glucolipotoxicity. Pfügers Archiv - European Journal of Physiology, 475:309-322,

  • Schreiber, J.A., Düfer, M., Seebohm, G. (2022) The Special One: Architecture, Physiology and Pharmacology of the TRESK Channel. Cell. Physiol. Biochem., 56(6):663-684.

  • Hake, A., Begrow, F., Spiegler, V., Symma, N., Hensel, A., Düfer, M. (2022) Effects of extracts and flavonoids from Drosera rotundifolia L. on ciliary beat frequency and murine airway smooth muscle. Molecules., Oct 5;27(19):6622.

  • Hake, A., Symma, N., Esch, S., Hensel, A., Düfer, M. (2022) Alkaloids from lime flower (Tiliae flos) exert spasmodic activity on murine airway smooth muscle involving acetylcholinesterase. Planta Med., Jul;88(8):639-649.

  • Schreiber, J.A., Möller, M., Zaydman, M., Zhao, L., Beller, Z., Becker, S., Ritter, N., Hou, P., Shi, J., Silva, J., Wrobel, E., Strutz-Seebohm, N., Decher, N., Schmitt, N., Meuth, S.G., Düfer, M., Wünsch, B., Cui, J., Seebohm, G. (2022) A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling. Commun. Biol. Apr 1;5(1):301.

  • Hüwel, J.D., Gresch, A., Berger, T., Düfer, M., Beecks, C. (2022) Analysis of Extracellular Potential Recordings by High-Density Micro-electrode Arrays of Pancreatic Islets. In: Strauss, C., Cuzzocrea, A., Kotsis, G., Tjoa, A.M., Khalil, I. (eds) Database and Expert Systems Applications. DEXA 2022. Lecture Notes in Computer Science, vol 13427. Springer, Cham.


  • Gresch, A., Noguera Hurtado, H., Wörmeyer, L., De Luca, V., Wiggers, R., Seebom, G., Wünsch, B., Düfer, M. (2021) Selective Inhibition of NMDA receptors with GluN2B subunit protects beta cells against stress-induced apoptotic cell death. J. Pharmacol. Exp. Ther.,
  • Guzmán, T., Düfer, M., Wiedemann, M., Olguín-Alor, R., Soldevila, G., Gurrola-Díaz, C. (2021) Lupin γ-conglutin protects against cell death induced by oxidative stress and lipotoxicity, but transiently inhibits in vitro insulin secretion by increasing KATP channel currents. Int. J. Biol. Macromol., 187:76-90,
  • Symma, N., Bütegerds, M., Senker, J., Petereit, F., Hake, A., Düfer, M., Hensel, A. (2021) Novel piperidine and 3,4-dihydro-2H-pyrrole alkaloids from tilia platyphyllos and tilia cordata flowers. Planta Med.,


  • Sikimic, J., Hoffmeister, T., Gresch, A., Kaiser, J., Barthlen, W., Wolke, C., Wieland, I., Lendeckel, U., Krippeit-Drews, P., Düfer, M., Drews, G. (2020) Possible new strategies for the treatment of congenital hyperinsulinism. Front. Endocrinol., 11:545638
  • Gresch, A., Düfer, M. (2020) Dextromethorphan and dextrorphan influence insulin secretion by interacting with KATP and L-type Ca2+ channels in pancreatic β-cells. J. Pharmacol. Exp. Ther., 375:10-20 doi:10.1124/jpet.120.265835
  • Hoffmeister, T., Kaiser, J., Lüdtke, S., Drews, G., Düfer, M. (2020) Interactions between atorvastatin and the farnesoid X receptor impair insulinotropic effects of bile acids and modulate diabetogenic risk. Mol. Pharmacol., 97:202-211
  • Schepmann, D., Neue, C., Westphälinger, S., Müller, C., Bracer, F., Lange, C., Bednarski, P., Almansa, C., Friedland, K., Räbiger, V., Düfer, M., Wünsch, B. (2020) Pharmacological characterization of high-affinity σ1 receptor ligands with spirocyclic thienopyran and thienofuran scaffold. J. Pharm. Pharmacol., 72:236-248


  • Schultheis, J., Beckmann, D., Mulac, D., Müller, L., Esselen, M., Düfer, M. (2019) Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance. Oxid. Med. Cell. Longev., 2019:7518510,
  • Maczewsky, J., Kaiser, J., Gresch, A., Gerst, F., Düfer, M., Krippeit-Drews, P., Drews, G. (2019) TGR5 activation promotes stimulus-secretion coupling of pancreatic beta-cells via a PKA-dependent pathway. Diabetes, 68:324-336,
  • Bauer, C., Kaiser, J., Sikimic, J., Krippeit-Drews, P., Düfer, M., Drews, G. (2019) ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic beta-cells. Endocrine, 63(2):270-283,


  • Brouwer, S., Hoffmeister, T., Gresch, A., Schönhoff, L., Düfer, M. (2018) Resveratrol influences pancreatic islets by opposing effects on electrical activity and insulin release. Mol. Nutr. Food Res.,


  • Undank, S., Kaiser, J., Sikimic, J., Düfer, M., Krippeit-Drews, P., Drews, G. (2017) Atrial natriuretic peptide (ANP) affects stimulus-secretion coupling of pancreatic beta-cells. Diabetes, 66:2840-2848,


  • Gonnissen, D., Qu, Y., Langer, K., Öztürk, C., Zhao, Y., Chen, C., Seeboom, G., Düfer, M., Fuchs, H., Galla, H.J., Riehemann, K. (2016) Comparison of cellular effects of starch-coated SPIONs and poly(lactic-co-glycolic acid) matrix nanoparticles on human monocytes. Int. J. Nanomedicine, 11:5221-5236,


  • Wiedemann, M., Gurrola-Díaz, C., Vargas-Guerrero, B., Wink, M., Garcia-Lopez, P. M., Düfer, M. (2015) Lupanine improves glucose homeostasis by influencing KATP channels and insuline gene expression. Molecules, 20:19085-19100,
  • Drews, G., Bauer, C., Edalat, A., Düfer M., Krippeit-Drews, P. (2015) Evidence against a Ca2+-induced potentiation of dehydrogenase activity in pancreatic beta-cells. Pfügers Arch., 467:2389-2397,
  • Edalat, A., Schulte-Mecklenbeck, P., Bauer, C., Undank, S., Krippeit-Drews, P., Drews, G., Düfer, M. (2015) Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells. Diabetologia,
  • Schittenhelm, B., Wagner, R., Kähny, V., Peter, A., Krippeit-Drews, P., Düfer, M., Drews, G. (2015) Role of FXR in beta-cells of lean and obese mice. Endocrinology, 156:1263-1271,
  • Lautenschläger, M., Sendker, J., Hüwel, S., Galla, H.J., Brandt, S., Düfer, M., Riehemann, K., Hensel, A. (2015) Intestinal formation of trans-crocetin from saffron extract (Crocus Sativus L.) and in vitro permeation trough intestinal and blood brain barrier. Phytomedicine, 22:36-44,


  • Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G. (2014) Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays. Integr Biol (Camb). Apr 22; 6: 540-544,


  • Düfer, M., Noack, K., Edalat, A., Krippeit-Drews, P., Drews, G (2013) Glitazones exert multiple effects on beta-cell stimulus-secretion coupling. Mol Pharmacol. 83, 51-60,


  • Düfer, M., Hörth K., Krippeit-Drews, P., Drews, G. (2012) The significance of the nuclear farnesoid X receptor (FXR) in beta-cell function. Islets, 4:334-338,
  • Drews, G, Düfer, M. (2012) Role of KATP channels in beta-cell resistance to oxidative stress, Diabetes Obes Metab. 14 Suppl 3, 120-128    Review,
  • Düfer, M., Hörth, K., Wagner, R., Prowald, S., Schittenhelm, B., Wagner, T., Oberwinkler, J., Lukowski, R., Krippeit-Drews, P., Drews, G. (2012)
    Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and KATP channel inhibition. Diabetes 61, 1479-89,


  • Pfeiffer, T., Kraushaar, U., Düfer, M., Schönecker, S., Haspel, D., Günther, E., Drews, G., Krippeit-Drews P. (2011)
    Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays. Pflügers Arch. 462, 835-840,
  • Düfer, M., Neye, Y., Hörth, K., Krippeit-Drews, P., Hennige, A., Widmer, H., McClafferty, H., Shipston, M.J., Häring, H.-U., Ruth, P., Drews, G.  (2011)
    BK channels affect glucose homeostasis and cell viability of murine pancreatic beta-cells. Diabetologia 54, 423-32,


  • Drews G., Krippeit-Drews P., Düfer M. (2010)
    Oxidative stress and beta-cell function. Pflügers Arch.  460, 703-718 Review,
  • Düfer M., Noack K., Krippeit-Drews, P., Drews, G. (2010)
    Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion, Islets 2, 156-163,
  • Hennige, A. M., Ranta, F., Heinzelmann, I., Düfer, M., Michael, D., Braunmüller, H., Lutz, S., Lammers, R., Drews, G., Bosch, F., Häring, H.-U., Ullrich, S. (2010)
    Overexpression of kinase negative PKCdelta in pancreatic beta-cells protects from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes 59, 119-127,


  • Gier, B., Krippeit-Drews, P., Sheiko, T., Aguilar-Bryan, L., Bryan, J., Düfer, M., Drews, G. (2009)
    Suppression of KATP channel activity protects pancreatic beta cells against oxidative stress. J. Clin. Invest. 119, 3246-3256,
  • Düfer, M., Gier, B., Wolpers, D., Krippeit-Drews, P., Ruth, P., Drews, G. (2009)
    Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.
    Diabetes 58, 1835-1843,
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. (2009)
    Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells. Pflügers Arch. 457, 1351-1360,


  • Wagner, T. F. J., Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I.,  Düfer, M., Lis, A., Flockerzi, V., Philipp, S. E., Oberwinkler, J. (2008)
    Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta-cells. Nature Cell Biology 10, 1421-1430,
  • Ranta, F., Düfer, M., Stork, B., Wesselborg, S., Drews, G., Häring, H.-U., Lang, F., Ullrich, S. (2008)
    Regulation of  calcineurin activity in insulin secreting cells: Stimulation by Hsp90 during glucocorticoid-induced apoptosis. Cell. Signal. 20, 1780-1786,


  • Weigert, C., Düfer, M.,  Simon, P., Runge, H., Brodbeck, K., Häring, H. U., Schleicher, E. D. (2007)
    Upregulation of IL-6 mRNA by IL-6 via a Ca2+-dependent mechanism and IL-6 mRNA stabilization in skeletal muscle cells. Am. J. Physiol. Cell Physiol. 293, C1139-C1147,
  • Schulze, D U., Düfer, M., Krippeit-Drews, P., Drews, G. (2007)
    An adenylate kinase is involved in KATP channel regulation of mouse pancreatic beta cells. Diabetologia 50, 2126-2134,
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Kelm, M., Ranta, F., Nitschke, R., Ullrich, S., Aguilar-Bryan, L., Bryan, J., Drews, G. (2007)
    The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells. Cell. Physiol. Biochem. 20, 65-74,
  • Bryan, J., Munoz, A., Zhang, X., Düfer, M., Drews, G., Krippeit-Drews, P., Aguilar-Bryan, L. (2007)
    ABCC8 and ABCC9: ABC transporter that regulate K+ channels. Pflügers Arch. - Eur. J. Physiol. 453, 703-718   Review,


  • Ranta, F., Avram, D., Berchtold, S., Düfer, M., Drews, G., Lang, F., Ullrich, S. (2006)
    Dexamethasone-induced cell death in insulin secreting cells, an effect reversed by exendin-4. Diabetes 55, 1380-1390,
  • Neye, Y., Düfer, M., Drews, G., Krippeit-Drews, P. (2006)
    HIV protease inhibitors: Suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents. J. Pharmacol. Exp. Ther. 316, 106-112,


  • Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G., Düfer, M. (2005)
    Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice. Diabetologia 48, 913-921,


  • Düfer, M., Neye, Y., Krippeit-Drews, P., Drews, G. (2004)
    Direct interference of HIV protease inhibitors with pancreatic ß-cell function. Naunyn-Schmiedeberg´s Arch. Pharmacol. 369, 583-590,
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. (2004)
    Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1-/- beta cells. Diabetologia 47, 488-498,


  • Remizov, O., Jakubov, R., Düfer, M., Krippeit-Drews, P., Drews, G., Waring, M., Brabant, G., Wienbergen, A., Rustenbeck, I., Schöfl, C. (2003)
    Palmitate-induced Ca2+-signaling in pancreatic beta-cells. Mol. Cell. Endocrinol. 212, 1-9,
  • Krippeit-Drews, P., Bäcker, M., Düfer, M., Drews, G. (2003)
    Phosphocreatine as a determinant of KATP channel activity in pancreatic ß-cells. Pflügers Arch. - Eur. J. Physiol. 445, 556-562,


  • Düfer, M., Krippeit-Drews, P., Buntinas, L., Siemen, D., Drews, G. (2002)
    Methyl pyruvate stimulates pancreatic ß-cells by a direct effect on KATP channels and not as a mitochondrial substrate. Biochem. J. 368, 817-825,
  • Düfer, M., Krippeit-Drews, P., Drews, G. (2002)
    Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells. Pflügers Arch. - Eur. J. Physiol. 444, 236-243,


  • Düfer, M., Krippeit-Drews, P., Lembert, N., Idahl, L.- Å., Drews, G. (2001)
    Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol. Pharmacol. 60, 873-879,
  • Boden, S.E., Schweizer, S., Bertsche, T., Düfer, M., Drews, G., Safayhi H. (2001)
    Stimulation of leukotriene synthesis in intact polymorphnuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid. Mol. Pharmacol. 60, 267-273,


  • Drews, G., Krämer, C., Düfer, M., Krippeit-Drews, P. (2000)
    Contrasting effects of alloxan on islets and single mouse pancreatic ß-cells. Biochem. J. 352, 389-397,
  • Krippeit-Drews, P., Düfer, M., Drews, G. (2000)
    Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells. Biochem. Biophys. Res. Commun. 267, 179-183,





Buchbeiträge und sonstige Veröffentlichungen:


Düfer, M. (2018)
Gap junctional communication between beta- and delta-cells: another player for suppression of glucagon release. Perspectives. J. Physiol. 596:131-132



Düfer, M. (2011)
Strategies for protection of pancreatic beta-cells against oxidative stress. Editorial. Diabetologie und Stoffwechsel, 4, 213-215


Deutschsprachige Fachzeitschriften

Düfer, M., Maas, D. und Waltering, I. (2020) Medizin meets Pharmazie. Osteoporose: Basiswissen - Diagnostik - Therapie - Patientenfall. Med. Monatsschr. Pharm., 2020(03):83-101

Düfer, M. (2017) Gestörter Knochenstoffwechsel. Dt. Apotherker Zeitung, 2017/16

Düfer, M. (2016) Biologicals zur Behandlung der Osteoporose und anderer Knochenstoffwechselstörungen. Med. Monatsschr. Pharm., 39:247-253

Düfer, M. (2016) Die Gefäßneubildung unterdrücken: Angiogenesehemmung mit Biologicals. Dt. Apotheker Zeitung, 2016/42

Düfer, M. (2014) Benzodiazepine: Ein Angriffspunkt, viele Wirkungen, Dt. Apotheker Zeitung, 2014/16

Düfer, M., Düfer-Kinzinger A. (jährlich seit 2013) Insulintabelle & Kommentar zur Insulintabelle. Diab. Stoffw. Herz



Bendas, G. und Düfer, M. (2016) Update Biologicals. Update-Buchreihe, Deutscher Apotheker Verlag

Düfer, M. (2012) Ion channel function in beta cells. In "Animal Models of Diabetes" Hrsg. Joost, H.-G., Schürmann, A., Al-Hasani, H., Humana Press, Springer, 933:203-217


Drews, G., Krippeit-Drews, P., Düfer, M. (2010, aktualisierte Auflage: 2013) Electrophysiology of islet cells. In “The Islets of Langerhans”,
Hrsg. Islam, S. et al., Adv. Exp. Biol. Med., 654:115-163


Arzneimittelinformation und –beratung (2009)
Hrsg. Ammon, Mutschler, Scholz, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart; Antimykotika, COX-2 Inhibitoren, Kalium-sparende Diuretika


Kommentare zu pharmakologischen Eigenschaften folgender Arzneistoffe für die Ergänzungslieferungen 17 bis 22 zum Arzneibuch-Kommentar, Hrsg. Hartke et al., Wissenschaftliche Verlagsgesellschaft mbH Stuttgart: