Buchbeiträge und sonstige Veröffentlichungen

Originalarbeiten, Reviews

2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000


  • Gresch, A., Düfer, M. (2020) Dextromethorphan and dextrorphan influence insulin secretion by interacting with KATP and L-type Ca2+ channels in pancreatic β-cells. J. Pharmacol. Exp. Ther., doi:10.1124/jpet.120.265835
  • Hoffmeister, T., Kaiser, J., Lüdtke, S., Drews, G., Düfer, M. (2020) Interactions between atorvastatin and the farnesoid X receptor impair insulinotropic effects of bile acids and modulate diabetogenic risk. Mol. Pharmacol., 97:202-211
  • Schepmann, D., Neue, C., Westphälinger, S., Müller, C., Bracer, F., Lange, C., Bednarski, P., Almansa, C., Friedland, K., Räbiger, V., Düfer, M., Wünsch, B. (2020) Pharmacological characterization of high-affinity σ1 receptor ligands with spirocyclic thienopyran and thienofuran scaffold. J. Pharm. Pharmacol., 72:236-248


  • Schultheis, J., Beckmann, D., Mulac, D., Müller, L., Esselen, M., Düfer, M. (2019) Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance. Oxid. Med. Cell. Longev., 2019:7518510, doi:10.1155/2019/7518510
  • Maczewsky, J., Kaiser, J., Gresch, A., Gerst, F., Düfer, M., Krippeit-Drews, P., Drews, G. (2019) TGR5 activation promotes stimulus-secretion coupling of pancreatic beta-cells via a PKA-dependent pathway. Diabetes, 68:324-336
  • Bauer, C., Kaiser, J., Sikimic, J., Krippeit-Drews, P., Düfer, M., Drews, G. (2019) ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic beta-cells. Endocrine, 63(2):270-283


  • Brouwer, S., Hoffmeister, T., Gresch, A., Schönhoff, L., Düfer, M. (2018) Resveratrol influences pancreatic islets by opposing effects on electrical activity and insulin release. Mol. Nutr. Food Res., doi: 10.1002/mnfr.201700902


  • Undank, S., Kaiser, J., Sikimic, J., Düfer, M., Krippeit-Drews, P., Drews, G. (2017) Atrial natriuretic peptide (ANP) affects stimulus-secretion coupling of pancreatic beta-cells. Diabetes, 66:2840-2848


  • Gonnissen, D., Qu, Y., Langer, K., Öztürk, C., Zhao, Y., Chen, C., Seeboom, G., Düfer, M., Fuchs, H., Galla, H.J., Riehemann, K. (2016) Comparison of cellular effects of starch-coated SPIONs and poly(lactic-co-glycolic acid) matrix nanoparticles on human monocytes. Int. J. Nanomedicine, 11:5221-5236


  • Wiedemann, M., Vargas-Guerrero, B., Wink, M., Garcia-Lopez, P. M., Düfer, M. (2015) Lupanine improves glucose homeostasis by influencing KATP channels and insuline gene expression. Molecules, 20:19085-19100
  • Drews, G., Bauer, C., Edalat, A., Düfer M., Krippeit-Drews, P. (2015) Evidence against a Ca2+-induced potentiation of dehydrogenase activity in pancreatic beta-cells. Pfügers Arch., 467:2389-2397
  • Edalat, A., Schulte-Mecklenbeck, P., Bauer, C., Undank, S., Krippeit-Drews, P., Drews, G., Düfer, M. (2015) Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells. Diabetologia, doi 10.1007/s00125-015-3577-9
  • Schittenhelm, B., Wagner, R., Kähny, V., Peter, A., Krippeit-Drews, P., Düfer, M., Drews, G. (2015) Role of FXR in beta-cells of lean and obese mice. Endocrinology, 156:1263-1271
  • Lautenschläger, M., Sendker, J., Hüwel, S., Galla, H.J., Brandt, S., Düfer, M., Riehemann, K., Hensel, A. (2015) Intestinal formation of trans-crocetin from saffron extract (Crocus Sativus L.) and in vitro permeation trough intestinal and blood brain barrier. Phytomedicine, 22:36-44


  • Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G. (2014) Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays. Integr Biol (Camb). Apr 22; 6: 540-544


  • Düfer, M., Noack, K., Edalat, A., Krippeit-Drews, P., Drews, G (2013) Glitazones exert multiple effects on beta-cell stimulus-secretion coupling. Mol Pharmacol. 83, 51-60


  • Düfer, M., Hörth K., Krippeit-Drews, P., Drews, G. (2012) The significance of the nuclear farnesoid X receptor (FXR) in beta-cell function. Islets, 4:334-338
  • Drews, G, Düfer, M. (2012) Role of KATP channels in beta-cell resistance to oxidative stress, Diabetes Obes Metab. 14 Suppl 3, 120-128    Review
  • Düfer, M., Hörth, K., Wagner, R., Prowald, S., Schittenhelm, B., Wagner, T., Oberwinkler, J., Lukowski, R., Krippeit-Drews, P., Drews, G. (2012)
    Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and KATP channel inhibition. Diabetes 61, 1479-89


  • Pfeiffer, T., Kraushaar, U., Düfer, M., Schönecker, S., Haspel, D., Günther, E., Drews, G., Krippeit-Drews P. (2011)
    Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays. Pflügers Arch. 462, 835-840
  • Düfer, M., Neye, Y., Hörth, K., Krippeit-Drews, P., Hennige, A., Widmer, H., McClafferty, H., Shipston, M.J., Häring, H.-U., Ruth, P., Drews, G.  (2011)
    BK channels affect glucose homeostasis and cell viability of murine pancreatic beta-cells. Diabetologia 54, 423-32


  • Drews G., Krippeit-Drews P., Düfer M. (2010)
    Oxidative stress and beta-cell function. Pflügers Arch.  460, 703-718 Review
  • Düfer M., Noack K., Krippeit-Drews, P., Drews, G. (2010)
    Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion, Islets 2, 156-163
  • Hennige, A. M., Ranta, F., Heinzelmann, I., Düfer, M., Michael, D., Braunmüller, H., Lutz, S., Lammers, R., Drews, G., Bosch, F., Häring, H.-U., Ullrich, S. (2010)
    Overexpression of kinase negative PKCdelta in pancreatic beta-cells protects from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes 59, 119-127


  • Gier, B., Krippeit-Drews, P., Sheiko, T., Aguilar-Bryan, L., Bryan, J., Düfer, M., Drews, G. (2009)
    Suppression of KATP channel activity protects pancreatic beta cells against oxidative stress. J. Clin. Invest. 119, 3246-3256
  • Düfer, M., Gier, B., Wolpers, D., Krippeit-Drews, P., Ruth, P., Drews, G. (2009)
    Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.
    Diabetes 58, 1835-1843
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. (2009)
    Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells. Pflügers Arch. 457, 1351-1360


  • Wagner, T. F. J., Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I.,  Düfer, M., Lis, A., Flockerzi, V., Philipp, S. E., Oberwinkler, J. (2008)
    Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta-cells. Nature Cell Biology 10, 1421-1430
  • Ranta, F., Düfer, M., Stork, B., Wesselborg, S., Drews, G., Häring, H.-U., Lang, F., Ullrich, S. (2008)
    Regulation of  calcineurin activity in insulin secreting cells: Stimulation by Hsp90 during glucocorticoid-induced apoptosis. Cell. Signal. 20, 1780-1786


  • Weigert, C., Düfer, M.,  Simon, P., Runge, H., Brodbeck, K., Häring, H. U., Schleicher, E. D. (2007)
    Upregulation of IL-6 mRNA by IL-6 via a Ca2+-dependent mechanism and IL-6 mRNA stabilization in skeletal muscle cells. Am. J. Physiol. Cell Physiol. 293, C1139-C1147
  • Schulze, D U., Düfer, M., Krippeit-Drews, P., Drews, G. (2007)
    An adenylate kinase is involved in KATP channel regulation of mouse pancreatic beta cells. Diabetologia 50, 2126-2134
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Kelm, M., Ranta, F., Nitschke, R., Ullrich, S., Aguilar-Bryan, L., Bryan, J., Drews, G. (2007)
    The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells. Cell. Physiol. Biochem. 20, 65-74
  • Bryan, J., Munoz, A., Zhang, X., Düfer, M., Drews, G., Krippeit-Drews, P., Aguilar-Bryan, L. (2007)
    ABCC8 and ABCC9: ABC transporter that regulate K+ channels. Pflügers Arch. - Eur. J. Physiol. 453, 703-718   Review


  • Ranta, F., Avram, D., Berchtold, S., Düfer, M., Drews, G., Lang, F., Ullrich, S. (2006)
    Dexamethasone-induced cell death in insulin secreting cells, an effect reversed by exendin-4. Diabetes 55, 1380-1390
  • Neye, Y., Düfer, M., Drews, G., Krippeit-Drews, P. (2006)
    HIV protease inhibitors: Suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents. J. Pharmacol. Exp. Ther. 316, 106-112


  • Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G., Düfer, M. (2005)
    Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice. Diabetologia 48, 913-921


  • Düfer, M., Neye, Y., Krippeit-Drews, P., Drews, G. (2004)
    Direct interference of HIV protease inhibitors with pancreatic ß-cell function. Naunyn-Schmiedeberg´s Arch. Pharmacol. 369, 583-590
  • Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. (2004)
    Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1-/- beta cells. Diabetologia 47, 488-498


  • Remizov, O., Jakubov, R., Düfer, M., Krippeit-Drews, P., Drews, G., Waring, M., Brabant, G., Wienbergen, A., Rustenbeck, I., Schöfl, C. (2003)
    Palmitate-induced Ca2+-signaling in pancreatic beta-cells. Mol. Cell. Endocrinol. 212, 1-9
  • Krippeit-Drews, P., Bäcker, M., Düfer, M., Drews, G. (2003)
    Phosphocreatine as a determinant of KATP channel activity in pancreatic ß-cells. Pflügers Arch. - Eur. J. Physiol. 445, 556-562


  • Düfer, M., Krippeit-Drews, P., Buntinas, L., Siemen, D., Drews, G. (2002)
    Methyl pyruvate stimulates pancreatic ß-cells by a direct effect on KATP channels and not as a mitochondrial substrate. Biochem. J. 368, 817-825
  • Düfer, M., Krippeit-Drews, P., Drews, G. (2002)
    Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells. Pflügers Arch. - Eur. J. Physiol. 444, 236-243


  • Düfer, M., Krippeit-Drews, P., Lembert, N., Idahl, L.- Å., Drews, G. (2001)
    Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol. Pharmacol. 60, 873-879
  • Boden, S.E., Schweizer, S., Bertsche, T., Düfer, M., Drews, G., Safayhi H. (2001)
    Stimulation of leukotriene synthesis in intact polymorphnuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid. Mol. Pharmacol. 60, 267-273


  • Drews, G., Krämer, C., Düfer, M., Krippeit-Drews, P. (2000)
    Contrasting effects of alloxan on islets and single mouse pancreatic ß-cells. Biochem. J. 352, 389-397
  • Krippeit-Drews, P., Düfer, M., Drews, G. (2000)
    Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells. Biochem. Biophys. Res. Commun. 267, 179-183

Buchbeiträge und sonstige Veröffentlichungen:


Düfer, M. (2018)
Gap junctional communication between beta- and delta-cells: another player for suppression of glucagon release. Perspectives. J. Physiol. 596:131-132

Düfer, M. (2011)
Strategies for protection of pancreatic beta-cells against oxidative stress. Editorial. Diabetologie und Stoffwechsel, 4, 213-215

Deutschsprachige Fachzeitschriften

Düfer, M., Maas, D. und Waltering, I. (2020) Medizin meets Pharmazie. Osteoporose: Basiswissen - Diagnostik - Therapie - Patientenfall. Med. Monatsschr. Pharm., 2020(03):83-101

Düfer, M. (2017) Gestörter Knochenstoffwechsel. Dt. Apotherker Zeitung, 2017/16

Düfer, M. (2016) Biologicals zur Behandlung der Osteoporose und anderer Knochenstoffwechselstörungen. Med. Monatsschr. Pharm., 39:247-253

Düfer, M. (2016) Die Gefäßneubildung unterdrücken: Angiogenesehemmung mit Biologicals. Dt. Apotheker Zeitung, 2016/42

Düfer, M. (2014) Benzodiazepine: Ein Angriffspunkt, viele Wirkungen, Dt. Apotheker Zeitung, 2014/16

Düfer, M., Düfer-Kinzinger A. (jährlich seit 2013) Insulintabelle & Kommentar zur Insulintabelle. Diab. Stoffw. Herz


Bendas, G. und Düfer, M. (2016) Update Biologicals. Update-Buchreihe, Deutscher Apotheker Verlag

Düfer, M. (2012) Ion channel function in beta cells. In "Animal Models of Diabetes" Hrsg. Joost, H.-G., Schürmann, A., Al-Hasani, H., Humana Press, Springer, 933:203-217

Drews, G., Krippeit-Drews, P., Düfer, M. (2010, aktualisierte Auflage: 2013) Electrophysiology of islet cells. In “The Islets of Langerhans”,
Hrsg. Islam, S. et al., Adv. Exp. Biol. Med., 654:115-163

Arzneimittelinformation und –beratung (2009)
Hrsg. Ammon, Mutschler, Scholz, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart; Antimykotika, COX-2 Inhibitoren, Kalium-sparende Diuretika

Kommentare zu pharmakologischen Eigenschaften folgender Arzneistoffe für die Ergänzungslieferungen 17 bis 22 zum Arzneibuch-Kommentar, Hrsg. Hartke et al., Wissenschaftliche Verlagsgesellschaft mbH Stuttgart: