Passion flower based food supplements

Passiflora incarnata
© IPBP
Passiflora incarnata
© IPBP

Products made from the above-ground plant material of Passiflora incarnata (passion flower) are often used to alleviate stress symptoms and promote sleep. In Europe, they are available either as authorised herbal medicinal products or as food supplements. For consumers, however, this difference is often not recognisable - with potentially significant consequences for product quality.

In this study, a total of 11 commercially available passionflower preparations were analysed. Six of these are marketed as dietary supplements, while the other five preparations are registered herbal medicinal products. The following parameters were used as quality markers:

  • Authenticity (DC and UHPLC; UV and MS detection)
  • Total flavone content (photometric and UHPLC; UV detection)

Conclusion: While the registered herbal medicinal products met the defined specifications and were all of very good quality, only one food supplement showed a positive identity. All other samples showed considerable deviations from the declaration.

Assessment of the products (incl. illustrations): The results obtained can be divided into the following categories (colours according to the traffic light principle). The results serve as an overview. A detailed tabular presentation of the products and results is provided.

 

Category 1: Products that fully comply with the declaration or that can be certified as being of very good overall quality (=high total flavone content)


Category 2: Products with the correct identity but not directly recommended overall


Category 3: Products that deviate from the declaration and whose authenticity could not be determined

P01
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P01

Declaration (per daily dose)

Passion flower extract 2250 mg
Of which flavones: 45mg
L-leucine: 90mg

Results
typical flavones from passionflower herb not detectable

Category 3

P02
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Declaration (per daily dose)

Passion flower extract: 375mg
(4% flavonoids)
Extract from water-ethanol extract (10:1)

Results
typical flavones from passionflower herb not detectable

 Category 3

P03
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P03

Declaration (per daily dose)

Passion flower extract 2250 mg
Of which flavones: 45mg


Results
typical flavones from passionflower herb not detectable

Category 3

P04
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P04

Declaration (per daily dose)

Passion flower extract (12:1) 750mg
Of which flavones: 15mg (2%)

Results
typical flavones from passionflower herb not detectable


Category 3

P05
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P05

Declaration (per daily dose)

Passion flower extract: 750mg (DEV: 5:1)

Results
typical flavones from passionflower herb not detectable

Category 3

P06
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P06

Declaration (per daily dose)

Passionflower Aerial Parts Extract: 500mg
standardised for 3.5% flavonoids as Vitexin


Results
photometric content determination: 9.2 ± 0.3 mg per capsule; 3.7 %
content determination via UHPLC: 8.1 ± 0.34 mg per capsule; 3.2 %
Daily dose of flavones [mg] when taken according to dosage recommendation: 16.2 mg

Category 1

P07
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P07

Declaration
100mL pressed juice from fresh passionflower herb (DEV: 1:0.7-0.9)


Results
photometric content determination: not performed
content determination via UHPLC: 1.7 ± 0.1 mg/mL
Daily dose of flavones [mg] when taken according to dosage recommendation: 52.2

Category 1

P08
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P08

Declaration
Passion flower extract: 425 mg
DER: 5-7:1

Results
photometric content determination: 27.2 ± 0.9 mg per tablet; 6.4 %
content determination via UHPLC: 25.6 ± 0.5 mg per tablet; 6.0 %
Daily dose of flavones [mg] when taken according to dosage recommendation: 51.1 mg

Category 1

P09
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P09

Declaration
Passionflower herb

Results
photometric content determination: 61 ± 1 mg; 3.1 %
content determination via UHPLC: 61.5 ± 1.5 mg; 3.1%


Category 1

P10
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P10

Declaration
Passiflora incarnata mother tincture, 65% (vol) ethanol

Results
photometric content determination: not performed
content determination via UHPLC: 3.4 ± 0.3 mg/mL
Daily dose of flavones [mg] when taken according to dosage recommendation: 0.3 - 1 mg

Category 2
(dosage recommendation based on basic homeopathic principles; clear distinction from herbal medicines)

P11
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P11

Declaration
Passion flower extract: 260 mg; DEV: (5-7:1)

Results
photometric content determination: 14.2 ± 0.2 mg per capsule; 5.5 %
content determination via UHPLC: 15.6 ± 0.1 mg per capsule; 6.0 %
Daily dose of flavones [mg] when taken according to dosage recommendation: 62.5 mg

Category 1