Beteiligung am Exzellenzcluster

CiM-Professor für Chemische Biologie
Mitglied der CiM-IMPRS Graduiertenschule

© CiM - Peter Grewer

„Wissenschaftler haben die Pflicht, Humboldts zentrale Idee hochzuhalten“

Prof. Ryan Gilmour behält gern das große Ganze im Blick. Daher begeistert ihn auch Humboldts zentrale Idee einer allumfassenden Weltanschauung. Seine „molekularen Designs“ gehören für ihn selbstverständlich dazu. Das sind Biomoleküle, die alle Aspekte des Zellverhaltens steuern. Interview

CiM-Publikationen

alle Publikationen von Ryan Gilmour

Accepted for publication

Metternich JB, Mudd RJ, Gilmour R. Flavins in Photochemistry. Science of Synthesis: accepted for publication.
Metternich JB, Sagebiel S, Lückener A, Lamping S, Ravoo BJ, Gilmour R. Covalent Immobilization of (–)-Riboflavin on Polymer Functionalized Silica Particles: Application in the Photocatalytic E→Z Isomerization of Polarized Alkenes. Chem. Eur. J.: accepted for publication.
Morack T, Metternich JB, Gilmour R. Vitamin Catalysis: Direct, Photocatalytic Synthesis of Benzocoumarins via (–)-Riboflavin-Mediated Electron Transfer. Org. Lett.: accepted for publication.
Teschers CS, Daniliuc CG, Kehr G, Gilmour R. Conformational Control Enabled by the Fluorine Gauche Effect in a Model of the β2-AR Agonist Salbutamol (VentolinTM). J. Fluorine Chem.: accepted for publication.

2018

Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schafers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. ChemMedChem 2018;13: 241-250. Abstract
Fassbender SI, Metternich JB, Gilmour R. Spatiotemporal Control of Pre-existing Alkene Geometry: A Bio-Inspired Route to 4-Trifluoromethyl-2H-chromenes. Org Lett 2018;20: 724-727. Abstract
Kieser T, Santschi N, Nowack L, Kehr G, Kuhlmann T, Albrecht S, Gilmour R. Single Site Fluorination of the GM4 Ganglioside Epitope Upregulates Oligodendrocyte Differentiation. ACS Chem Neurosci 2018: epub. Abstract
Molloy J, Metternich J, Watson A, Gilmour R. Contra-Thermodynamic, Photocatalytic E-->Z Isomerization of Styrenyl Boron Species: Vectors to Facilitate Exploration of 2D Chemical Space. Angew Chem Int Ed Engl 2018: epub. Abstract
Sadurni A, Kehr G, Ahlqvist M, Wernevik J, Sjogren HP, Kankkonen C, Knerr L, Gilmour R. Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes. Chemistry 2018: epub. Abstract

2017

Metternich JB, Artiukhin DG, Holland MC, von Bremen-Kuhne M, Neugebauer J, Gilmour R. Photocatalytic E --> Z Isomerization of Polarized Alkenes Inspired by the Visual Cycle: Mechanistic Dichotomy and Origin of Selectivity. J Org Chem 2017;82: 9955-9977. Abstract
Rey YP, Abradelo DG, Santschi N, Strassert CA, Gilmour R. Quantitative Profiling of the Heavy-Atom Effect in BODIPY Dyes: Correlating Initial Rates, Atomic Numbers, and[super:1]O[sub:2]Quantum Yields: Quantitative Profiling of the Heavy-Atom Effect in BODIPY Dyes: Correlating Initial Rates, Atomic Numbers, and[super:1]O[sub:2]Quantum Yields. Eur. J. Org. Chem. 2017;2017: 2170-2178. Abstract
Sarie JC, Thiehoff C, Mudd RJ, Daniliuc CG, Kehr G, Gilmour R. Deconstructing the Catalytic, Vicinal Difluorination of Alkenes: HF-Free Synthesis and Structural Study of p-TolIF2. J Org Chem 2017;82: 11792-11798. Abstract
Scheidt F, Selter P, Santschi N, Holland MC, Dudenko DV, Daniliuc C, Muck-Lichtenfeld C, Hansen MR, Gilmour R. Emulating Natural Product Conformation by Cooperative, Non-Covalent Fluorine Interactions. Chemistry 2017;23: 6142-6149. Abstract
Thiehoff C, Rey YP, Gilmour R. The Fluorine_Gauche_Effect: A Brief History. Isr. J. Chem. 2017;57: 92-100. Abstract

2016

Aiguabella N, Holland MC, Gilmour R. Fluorine-directed 1,2-trans glycosylation of rare sugars. Org Biomol Chem 2016;14: 5534-5538. Abstract
Holland MC, Gilmour R, Houk KN. Importance of Intermolecular Hydrogen Bonding for the Stereochemical Control of Allene-Enone (3+2) Annulations Catalyzed by a Bifunctional, Amino Acid Derived Phosphine Catalyst. Angew Chem Int Ed Engl 2016;55: 2022-2027. Abstract
Metternich J, Gilmour R. Photocatalytic E → Z Isomerization of Alkenes. Synlett 2016;27: 2541-2552. Abstract
Metternich JB, Gilmour R. One Photocatalyst, n Activation Modes Strategy for Cascade Catalysis: Emulating Coumarin Biosynthesis with (-)-Riboflavin. J Am Chem Soc 2016;138: 1040-1045. Abstract
Molnár I, Holland M, Daniliuc C, Houk K, Gilmour R. Organocatalysis Intermediates as Platforms to Study Noncovalent Interactions: Integrating Fluorine Gauche Effects in Iminium Systems to Facilitate Acyclic Conformational Control. Synlett 2016;27: 1051-1055. Abstract
Molnar IG, Gilmour R. Catalytic Difluorination of Olefins. J Am Chem Soc 2016;138: 5004-5007. Abstract
Molnár IG, Thiehoff C, Holland MC, Gilmour R. Catalytic, Vicinal Difluorination of Olefins: Creating a Hybrid, Chiral Bioisostere of the Trifluoromethyl and Ethyl Groups. ACS Catal. 2016;6: 7167-7173. Abstract
Santschi N, Thiehoff C, Holland MC, Daniliuc CG, Houk KN, Gilmour R. The Sulfur–Fluorine_Gauche_Effect in Coinage-Metal Complexes: Augmenting Conformational Equilibria by Complexation. Organometallics 2016;35: 3040-3044. Abstract
Thiehoff C, Schifferer L, Daniliuc CG, Santschi N, Gilmour R. The influence of electronic perturbations on the Sulfur–Fluorine Gauche Effect. Journal of Fluorine Chemistry 2016;182: 121-126. Abstract

2015

Holland MC, Gilmour R. Deconstructing covalent organocatalysis. Angew Chem Int Ed Engl 2015;54: 3862-3871. Abstract
Holland MC, Meemken F, Baiker A, Gilmour R. Chiral imidazolidinone and proline-derived surface modifiers for the Pt-catalysed asymmetric hydrogenation of activated ketones. Journal of Molecular Catalysis A: Chemical 2015;396: 335-345. Abstract
Holland MC, Metternich JB, Daniliuc C, Schweizer WB, Gilmour R. Aromatic Interactions in Organocatalyst Design: Augmenting Selectivity Reversal in Iminium Ion Activation. Chemistry 2015;21: 10031-10038. Abstract
Holland MC, Metternich JB, Muck-Lichtenfeld C, Gilmour R. Cation-pi interactions in iminium ion activation: correlating quadrupole moment & enantioselectivity. Chem Commun (Camb) 2015;51: 5322-5325. Abstract
Metternich JB, Gilmour R. A Bio-Inspired, Catalytic E --> Z Isomerization of Activated Olefins. J Am Chem Soc 2015;137: 11254-11257. Abstract
Sagamanova I, Rodríguez-Escrich C, Molnár IG, Sayalero S, Gilmour R, Pericàs MA. Translating the Enantioselective Michael Reaction to a Continuous Flow Paradigm with an Immobilized, Fluorinated Organocatalyst. ACS Catal. 2015;5: 6241-6248. Abstract
Santschi N, Aiguabella N, Lewe V, Gilmour R. Delineating the Physical Organic Profile of the 6-Fluoro Glycosyl Donor. J Flourine Chem 2015: 96-101.
Santschi N, Gilmour R. A Comparative Analysis of Fluorine-Directed Glycosylation Selectivity: Interrogating C2 [OH → F] Substitution in D-Glucose and D-Galactose. Eur J Org Chem 2015;32: 6983-6987.
Santschi N, Wagner S, Daniliuc C, Hermann S, Schafers M, Gilmour R. Synthesis of 2-[(18) F]Fluoro-2-deoxyisosorbide 5-mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET). ChemMedChem 2015;10: 1724-1732. Abstract
Thiehoff C, Holland MC, Daniliuc C, Houk KN, Gilmour R. Can acyclic conformational control be achieved via a sulfur–fluorine gauche effect?. Chem. Sci. 2015;6: 3565-3571. Abstract

2014

Holland MC, Berden G, Oomens J, Meijer AJHM, Schäfer M, Gilmour R. Infrared Multiphoton Dissociation Spectroscopic Analysis of Noncovalent Interactions in Organocatalysis: Analysis of Noncovalent Interactions in Organocatalysis. Eur J Org Chem 2014;2014: 5675-5680. Abstract
Molnar IG, Tanzer E-M, Daniliuc C, Gilmour R. Enantioselective aziridination of cyclic enals facilitated by the fluorine-iminium ion gauche effect. Chemistry 2014;20: 794-800. Abstract
Rey YP, Zimmer LE, Sparr C, Tanzer EM, Schweizer WB, Senn HM, Lakhdar S, Gilmour R. Molecular Design Exploiting a Fluorine gauche Effect as a Stereoelectronic Trigger. Eur J Org Chem 2014;2014: 1202-1211. Abstract
Santschi N, Gilmour R. The (not so) ephemeral trifluoromethanide anion. Angew Chem Int Ed Engl 2014;53: 11414-11415. Abstract

2013

Holland MC, Paul S, Schweizer WB, Bergander K, Muck-Lichtenfeld C, Lakhdar S, Mayr H, Gilmour R. Noncovalent interactions in organocatalysis: modulating conformational diversity and reactivity in the MacMillan catalyst. Angew Chem Int Ed Engl 2013;52: 7967-7971. Abstract
Paul S, Schweizer WB, Rugg G, Senn HM, Gilmour R. The fluorine-NHC gauche effect: a structural and computational study. Tetrahedron 2013;69: 5647-5659. Abstract
Rey YP, Gilmour R. Modulating NHC catalysis with fluorine. Beilstein J Org Chem 2013;9: 2812-2820. Abstract