Veröffentlichungen

Original Articles, Review Articles and Patents

1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2006, 2007, 2009, 2010, 2011, 2012, 2014, 2016, 20172018

1984

  • K. Müller, A. Retzow, W. Wiegrebe;Drei Synthesemöglichkeiten für C-9-14C-Dithranol. Arch. Pharm. (Weinheim) 1984, 317, 120-126

1985

  • W. Wiegrebe, K. Müller, U. Runne;Topical pharmaceutical composition containing dithranol.Ger. Offen. DE 3338072 (CI. A61K31/05) 1985; Chem. Abstr. 1985, 103: P 76256d

1986

  • K. Müller, E. Eibler, K. K. Mayer, W. Wiegrebe, G. Klug; Dithranol, singlet oxygen and unsaturated fatty acids. Arch. Pharm. (Weinheim) 1986, 319, 2-9
  • K. Müller, K. K. Mayer, W. Wiegrebe; Dithranol and active oxygen species, II. 1O2-Oxidation of dithranol to chrysazin. Arch. Pharm. (Weinheim) 1986, 319, 1009-1018

1987

  • K. Müller, W. Wiegrebe, M. Younes; Formation of active oxygen species by dithranol, III. Dithranol, active oxygen species and lipid peroxidation in vivo. Arch. Pharm. (Weinheim) 1987, 320, 59-66

1988

  • H. J. Duchstein, K. Müller, G. Wurm; Zum Reaktionsmechanismus der Oxygenierung von Naphtholen mit dem System CuCl/O2.Arch. Pharm. (Weinheim) 1988, 321, 153-157
  • K. Müller; Active oxygen species and structure specificity of antipsoriatic anthrones. Arch. Pharm. (Weinheim) 1988, 321, 385-389
  • K. Müller; Aktive Sauerstoffspezies, Bedeutung für Krankheit und Gesundheit. Pharm. Unserer Zeit (VCH-Weinheim)1988, 17, 71-80
  • K. Müller, H. Kappus; Hydroxyl radical formation by dithranol. Biochem. Pharmacol. 1988, 37, 4277-4280

1989

  • K. Müller, H. J. Duchstein; Oxygenierung von Dithranol durch Übergangsmetallkomplexe. Arch. Pharm. (Weinheim) 1989, 322, 35-39

1990

  • K. Müller, R. C. Kanner, C. S. Foote; Kinetic studies on anthralin photooxidation. Photochem. Photobiol. 1990, 52, 445-450

1991

  • K. Müller, M. Seidel, C. Braun, K. Ziereis, W. Wiegrebe; Dithranol, glucose-6-phosphate dehydrogenase inhibition and active oxygen species. Arzneim.-Forsch. 1991, 41, 1176-1181

1992

  • K. Müller; Freie Radikale. Bedeutung in Pathophysiologie und Therapie. Dtsch. Apoth. Ztg. 1992, 132, 1473-1482
  • K. Müller, K. Ziereis; Naphthalenes as water-soluble singlet oxygen carriers and detectors: hydrophobic and kinetic properties. Arch. Pharm. (Weinheim) 1992, 325, 219-223

1993

  • K. Müller, K. Ziereis; Dimethyl 3,3’-(4-methyl-1,3-naphthylene)dipropionate as a singlet oxygen trap in biological systems. Arch. Pharm. (Weinheim) 1993, 326, 369-371
  • K. Müller, H. Tanzer, M. Seidel, D. Gürster, P. Leukel, H. Prinz, W. Wiegrebe; Interaction of antipsoriatic anthrone derivatives with the lipoxygenase system - a variety of problems. Chem. Listy 1993, 87 (Suppl.), 2-6
  • K. Müller, K. Ziereis; Effects of oxygen radicals, hydrogen peroxide and water-soluble singlet oxygen carriers on 5- and 12-lipoxygenase. Arch. Pharm. (Weinheim) 1993, 326, 819-821
  • K. Müller, D. Gürster; Hydroxyl radical damage to DNA sugar and model membranes induced by anthralin (dithranol. Biochem. Pharmacol. 1993, 46, 1695-1704
  • K. Müller, D. Gürster, S. Piwek, W. Wiegrebe; Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5 lipoxygenase. J. Med. Chem. 1993, 36, 4099-4107

1994

  • K. Müller; 5-Lipoxygenase and 12-lipoxygenase: attractive targets for the development of novel antipsoriatic drugs. Arch. Pharm. (Weinheim) 1994, 327, 3-19
  • K. Müller, K. Ziereis; The antipsoriatic Mahonia aquifolium and its active constituents; I. Pro- and antioxidant properties and inhibition of 5-lipoxygenase. Planta Med. 1994, 60, 421-424
  • K. Müller, P. Leukel, K. Ziereis, I. Gawlik; Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin — antiproliferative activity and 5-lipoxygenase inhibition. J. Med. Chem. 1994, 37, 1660-1669
  • H.-S. Huang, K. K. Mayer, K. Müller, W. Wiegrebe; A convenient synthesis of 14C-anthralin. Arch. Pharm. (Weinheim) 1994, 327, 743-744

1995

  • K. Müller, W. Wiegrebe, D. Gürster, S. Peters; 10-Substituted 1,8-dihydroxy-9-(10H)-anthracenones as redox and non-redox inhibitors of 5-lipoxygenase. U. S. Patent Appl. 92,854, 1993; Pat. No. 5,426,197, 1995
  • K. Müller, K. Ziereis, I. Gawlik; The antipsoriatic Mahonia aquifolium and its active constituents; II. Antiproliferative activity against cell growth of human keratinocytes. Planta Med. 1995, 61, 74-75
  • S. Pecar, M. Schara, K. Müller, W. Wiegrebe; Reduction of nitroxides by anthralin and some of its derivatives. Free Radic. Biol. Med. 1995, 18, 459-465
  • W. Wiegrebe, K. Müller; Treatment of psoriasis with anthrones - chemical principles, biochemical aspects, and approaches to the design of novel derivatives. Skin Pharmacol. 1995, 8, 1-24
  • K. Müller, I. Gawlik, W. Wiegrebe; Acidity and stability of 10-substituted 1,8-dihydroxy-9(10H)-anthracenones. Arch. Pharm. (Weinheim) 1995, 328, 359-362
  • K. Müller, P. Leukel, K. K. Mayer, W. Wiegrebe; Modification of DNA bases by anthralin and related compounds. Biochem. Pharmacol. 1995, 49, 1607-1613
  • K. Müller, I. Gawlik; Novel 10-substituted antipsoriatic anthrones as inhibitors of epidermal 12-lipoxygenase and lipid peroxidation. Biochem. Pharmacol. 1995, 50, 2077-2083
  • K. Müller, W. Wiegrebe, D. Gürster, S. Peters; Preparation of 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as allergy inhibitors and antiinflammatories. PCT Int. Appl. WO 95 03,266 (Cl. C07C49/747) 1995; Chem. Abstr. 1995, 122 P 290472g

1996

  • H. Prinz, W. Wiegrebe, K. Müller; Syntheses of anthracenones. 1. Sodium dithionite reduction of peri-substituted anthracenediones. J. Org. Chem. 1996, 61, 2853-2856
  • H. Prinz, T. Burgemeister, W. Wiegrebe, K. Müller; Syntheses of anthracenones. 2. Preparation of 1,8-dimethoxy- (dimethylanthralin) and 4,5-dihydroxy-9(10H)-anthracenone (isoanthralin): a vision. J. Org. Chem. 1996, 61, 2857-2860
  • H. Prinz, W. Wiegrebe, K. Müller; Syntheses of anthracenones. 3. Revised preparative route to 10-benzoyl-1,8-dihydroxy-9(10H)-anthracenones. J. Org. Chem. 1996, 61, 2861-2864
  • K. Müller, I. Gawlik; Inactivation of mouse epidermal 12-lipoxygenase by anthralin – implications for the role of oxygen radicals. Biochem. Pharmacol. 1996, 51, 1173-1179
  • K. Müller; Antipsoriatic anthrones: aspects of oxygen radical formation, challenges and prospects. Gen. Pharmacol. 1996, 27, 1325-1335
  • H. Prinz, K. Müller; 2-Anthracenonyl acetic acids as 5-lipoxygenase inhibitors. Arch. Pharm. Pharm. Med. Chem. 1996, 329, 262-266
  • K. Müller, H.-S. Huang, W. Wiegrebe; Antipsoriatic anthrones with modulated redox properties. 3. 10-Thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis. J. Med. Chem. strong>1996, 39, 3132-3138
  • C. Vavrecková, I. Gawlik, K. Müller; Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism. Planta Med. 1996, 62, 397-401
  • K. Müller, K. Ziereis, W. Wiegrebe; The monograph dithranol in the European pharmacopoeia - comments and amendments. Pharmazie 1996, 51, 980-981
  • K. Müller, H.-S. Huang; Development of novel antipsoriatic anthrones. Chin. Pharm. J. 1996, 48, 337-354
  • C. Vavrecková, I. Gawlik, K. Müller; Benzophenanthridine alkaloids of Chelidonium majus; II. Potent inhibitory action against the growth of human keratinocytes. Planta Med. 1996, 62, 491-494

1997

  • K. Müller, H. Prinz, W. Wiegrebe; Preparation of 1,8-dihydroxy-9-oxoanthracene-2-alkanoates and analogs as antiproliferatives and 5-lipoxygenase inhibitors. PCT Int. Appl. WO 96 40,623 (Cl. C07C259/06) 1996, Chem. Abstr. 1997, 126, 131258h
  • K. Müller, H.-S. Huang, W. Wiegrebe; Preparation of 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones for use in the treatment of inflammatory conditions. PCT Int. Appl. WO 96 40,632 (Cl. C07C323/52) 1996, Chem. Abstr. 1997, 126, 131259j
  • K. Müller, W. Wiegrebe; Psoriasis und Antipsoriatika. Pathobiochemische Grundlagen und Wirkmechanismen. Dtsch. Apoth. Ztg. 1997, 137, 1893-1902
  • K. Müller, I. Gawlik; Effects of reactive oxygen species on the biosynthesis of 12(S)-hydroxyeicosatetraenoic acid in mouse epidermal homogenate. Free Radic. Biol. Med. 1997, 23, 321-330
  • K. Müller; Antipsoriatic and proinflammatory action of anthralin – implications for the role of oxygen radicals. Biochem. Pharmacol. 1997, 53, 1215-1221
  • D. H. Paper, K. Müller, G. Franz; Frauenmantel, Schachtelhalm und Stechpalme. Die entzündungshemmende Wirkung der Urtinkturen. in: Rheumatherapie mit Phytopharmaka (S. Chrubasik, M. Wink, Ed.), Hippokrates Verlag, Stuttgart, 145-148, 1997
  • K. Müller, W. Wiegrebe; Schuppen auf der kranken Haut – Entwicklung neuer Wirkstoffe. Blick in die Wissenschaft (Forschungsmagazin der Universität Regensburg)1997, 9, 34-40
  • S. Kumar KC, K. Müller; Antiproliferative activity of selected Nepalese medicinal plants against the growth of human keratinocytes. Pharm. Pharmacol. Lett. 1997, 7, 63-65
  • K. Müller, H. Prinz; Antipsoriatic anthrones with modulated redox properties. 4. Synthesis and biological activity of novel 9,10-dihydro-1,8-dihydroxy-9-oxo-2-anthracenecarboxylic and -hydroxamic acids. J. Med. Chem. 1997, 40, 2780-2787
  • K. Müller, W. Wiegrebe, D. Gürster, S. Peters; 10-Substituted 1,8-dihydroxy-9(10H)-anthracenone pharmaceuticals. U. S. Patent Appl. 400,209, 1995; Pat. No. 5,661,187, 1997
  • K. Müller, A. Sellmer, H. Prinz; 10-Aminomethylene-1,8-dihydroxy-9(10H)-anthracenones: inhibitory action against 5-lipoxygenase and the growth of HaCaT cells. Eur. J. Med. Chem. 1997, 32, 895-900
  • K. Müller, H. Prinz, I. Gawlik, K. Ziereis, H.-S. Huang; Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J. Med. Chem. 1997, 40, 3773-3780
  • K. Müller; Vitamin D – Anwendung bei Psoriasis, Wirkmechanismus und Analoga, T&E Dermatologie, KOMPAKT Psoriasis, Dez. 1997, 11-12

1998

  • K. Müller, H.-S. Huang, W. Wiegrebe; 10-Thio-substituted 1,8-dihydroxy-9(10H)-anthracenone pharmaceuticals. U. S. Patent Appl. 487,344, 1995; Pat. No. 5,705,533, 1998
  • K. Müller, R. Altmann, H. Prinz; 10-Benzoyl-1,8-dihydroxy-9(10H)-anthracenones: synthesis and biological properties. Eur. J. Med. Chem. 1998, 33, 209-214
  • A. Krbavcic, S. Pecar, M. Schara, K. Müller, W. Wiegrebe; Anthranoid free radicals found in pseudomelanosis coli. Pharmazie 1998, 53, 336-338
  • K. Müller, K. Ziereis, D. H. Paper; Ilex aquifolium: protection against enzymatic and non-enzymatic lipid peroxidation. Planta Med. 1998, 64, 536-540
  • K. Müller; Psoriasis: Was gibt es Neues in der lokalen Therapie? Apotheken J. 1998, 20, 178-182, Ärztl. J. 1998, 5, 158-163
  • K. Müller; Gezielte Wirkstoffabwandlung in der Optimierung dermatischer Wirkstoffe am Beispiel von Dithranol-Derivaten; Pharm. Ztg. 1998, 143, 2945-2952
  • S. Kumar KC, K. Müller; Inhibition of leukotriene biosynthesis and lipid peroxidation in biological models by the extract of Cassia fistula. Phytother. Res. 1998, 12, 526-528
  • K. Müller, K. Breu; 10-?-Phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties. Bioorg. Med. Chem. Lett. 1998, 8, 3211-3216
  • K. Müller, H. Prinz; Strategies for the design and synthesis of antipsoriatic anthracenones. Recent Res. Dev. Org. Chem. 1998, 2, 745-751
  • K. Müller; Formelfest bei freien Radikalen und Fapy-Basen. Pharm. Ztg. 1998, 143, 3953-3955
  • K. Müller, W. Wiegrebe, D. Gürster, S. Peters; 10-Substituted 1,8-dihydroxy-9(10H)-anthracenone pharmaceuticals. U. S. Patent Appl. 825,075, 1997; Pat. No. 5,844,004, 1998
  • K. Müller, H. Reindl, I. Gawlik; 10-Hydrocinnamoyl- and 10-cinnamoyl-1,8-dihydroxy-9(10H)-anthracenones as inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. Eur. J. Med. Chem. 1998, 33, 969-973

1999

  • K. Müller, K. Breu; 10-alpha-Aminoacyl-9(10H)-anthracenones: inhibition of 12(S)-HETE biosynthesis and HaCaT cell growth. Arch. Pharm. Pharm. Med. Chem. 1999, 332, 31-35
  • S. Kumar KC, K. Müller; Medicinal plants from Nepal, II. Evaluation as inhibitors of lipid peroxidation in biological membranes. J. Ethnopharmacol. 1999, 64, 135-139
  • S. Kumar KC, K. Müller; Inhibition of keratinocyte growth by different Nepalese Zanthoxylum species. Phytother. Res. 1999, 13, 214-217
  • S. Kumar KC, K. Müller; Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism. J. Nat. Prod. 1999, 62, 817-820
  • S. Kumar KC, K. Müller; Lichen metabolites. 2. Antiproliferative and cytotoxic activity of gyrophoric, usnic, and diffractaic acid on human keratinocyte growth. J. Nat. Prod. 1999, 62, 821-823
  • K. Müller, W. Wiegrebe, H. Reindl; 10-Substituted 1,8-dihydroxy-9(10H)-anthracenone pharmaceuticals. U. S. Patent Appl. 075,314, 1998; Pat. No. 5,952,390, 1999
  • S. Kumar KC, K. Müller; Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogs of barbatic and diffractaic acid. Eur. J. Med. Chem. 1999, 34, 1035-1042
  • K. Müller, A. Sellmer, W. Wiegrebe; Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. J. Nat. Prod. 1999, 62, 1134-1136
  • K. Müller, H. Prinz, W. Wiegrebe; 2-Substituted 1,8-dihydroxy-9(10H)-anthracenone pharmaceuticals. U. S. Patent Appl. 08/933,926, 1997; Pat. No. 5,922,891, 1999

2000

  • S. Kumar KC, K. Ziereis, W. Wiegrebe, K. Müller; Medicinal plants from Nepal: evaluation as inhibitors of leukotriene biosynthesis. J. Ethnopharmacol. 2000, 70, 191-195
  • K. Müller; Current status and recent developments in anthracenone antipsoriatic agents. Curr. Pharm. Design 2000, 6, 1041-1057
  • S. Kumar KC, K. Müller; Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 2. Novel analogs of obtusatic acid. Eur. J. Med. Chem. 2000, 35, 405-411
  • K. Müller, W. Wiegrebe, D. Gürster, S. Peters; 10-Substituted 1,8-dihydroxy-(10H)-anthracenone pharmaceuticals. U. S. Patent Appl. 09/196,282, 1998; Pat. No. 6,127,426, 2000

2001

  • K. Müller, H. Reindl, K. Breu; Heterocyclic substituted anthralin derivatives as inhibitors of HaCaT keratinocyte growth and inducers of differentiation. Bioorg. Med. Chem. Lett. 2001, 11, 47-50
  • K. Müller, H. Reindl; Cornified envelope formation by anthralin, simple analogues and related anthracenones. Arch. Pharm. Pharm. Med. Chem. 2001, 334, 86-92
  • K. Müller, H. Reindl; 10-Phenylbutyryl-substituted anthracenones as inhibitors of keratinocyte growth and LTB4 biosynthesis. Eur. J. Med. Chem. 2001, 36, 179-184
  • K. Müller, H. Reindl, K. Breu; Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones. J. Med. Chem. 2001, 44, 814-821
  • Müller, R. Altmann, H. Prinz; 2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 1. Structure–activity relationships of the terminal phenyl ring. Eur. J. Med. Chem. 2001, 36, 569-575
  • K. Müller; Pharmaceutically relevant metabolites from lichens; Appl. Microbiol. Biotechnol. 2001, 56, 9-16

2002

  • K. Müller, R. Altmann, H. Prinz; 2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 2. Structure–activity relationships of the linker chain. Eur. J. Med. Chem. 2002, 37, 83-89
  • K. Müller, A. Sellmer; Novel lapacho compounds and methods of use thereof. U.S.S.N. 60/411,478, 2002

2003

  • K. Müller; Innovative anthralin derivatives, in: Clinico-Experimental Advances in Dermatological Diagnostics and Treatment (B. Bonnekoh, H. Gollnick, Hrsg.). Bibliomed – Medizinische Verlagsgesellschaft mbH, Melsungen, 2003
  • K. Müller, W. Wiegrebe; Schuppen auf der kranken Haut – Entwicklung neuer Wirkstoffe. Der Allgemeinarzt 2003, 25, 716-725

2004

  • H.M.T.B. Herath, K. Müller, H.V.K. Diyabalanage; Synthesis of acrimarins from 1,3,5-trioxygenated-9-acridone derivatives. J. Heterocycl. Chem. 2004, 41, 23-28
  • H. Prinz, A. Zuse, K. Müller, T. Stoiber, E. Unger; 9-Benzyliden-naphtho-[2,3-b]-thiophen-4-one als neue Inhibitoren der Tubulin-Polymerisation. Ger. Offen. DE 102 41 287 A1 2004.03.18 (AZ 102 41 287.1), 2004
  • K. Müller, A. Sellmer, J. Salvesen; Lapacho compounds, their preparation, and methods of use for the treatment of cell proliferative disorders, PCT. Int. App. 2004, WO 2004026253 A2 20040401.

2006

  • K. Müller, A. Sellmer, J. Salvesen, C. Li, Y. Li, X. Sun; Novel lapacho compounds and methods of use thereof. U. S. Patent Appl. 10/528,295, 2005; Pat. No. 2006/0142271 A1,2006
  • A. Zuse, P. Schmidt, S. Baasner, K. J. Böhm, K. Müller, M. Gerlach, E. G. Günther, E. Unger, H. Prinz; 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents – synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J. Med. Chem. 2006, 49, 7816-7825

2007

  • K. Müller; Moderne Behandlungsstrategien der Psoriasis. Pharm. Ztg. 2007, 152, 730-737
  • A. Zuse, H. Prinz, K. Müller, P. Schmidt, E. G. Günther, J. H. M. Prehn, M. Los; 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. Eur. J. Clin. Pharmacol. 2007, 575, 34-45
  • A. Zuse, P. Schmidt, S. Baasner, K. J. Böhm, K. Müller, M. Gerlach, E. G. Günther, E. Unger, H. Prinz; Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J. Med. Chem. 2007, 50, 6059-6066

2009

  • H. Prinz, P. Schmidt, K.J. Böhm, S. Baasner, K. Müller, E. Unger, M. Gerlach, E. G. Günther;  10-(2-oxo-2-Phenylethylidene-10H-anthracen-9-ones as highly active antimicrotubule agents: Synthesis, antiproliferative activity, and inhibition of tubulin polymerization, J. Med. Chem. 2009, 52, 1284-1294

2010

  • A. Putic, L.Stecher, H. Prinz, K. Müller; Structure-activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth, Eur. J. Med. Chem. 2010, 45, 3299-3310
  • G. Surkau, K. J. Böhm, K. Müller, H. Prinz; Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives, Eur. J. Med. Chem., 2010, 45, 3354-3364
  • H. Nickel, P. Schmidt, K. J. Böhm, S. Baasner, K. Müller, M. Gerlach, E. Unger, E. G. Günther, H. Prinz; Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety, Eur. J. Med. Chem., 2010, 45, 3420-3438
  • H. Prinz, K. J. Böhm, K. Müller; Synthesis of 2,6-aceanthrylenedione, a cyclic vinylog of anthraquinone, J. Org. Chem., 2010, 75, 3867-3870
  • U. Kratz, H. Prinz, K. Müller; Synthesis and biological evaluation of novel 10-benzyl-substituted 4,5-dichloro-10H-anthracen-9-ones as inhibitors of keratinocyte hyperproliferation, Eur. J. Med. Chem., 2010, 45, 5278-5285
  • A. Putic, L. Stecher, H. Prinz, K. Müller; Structure–activity relationship studies of acridones as potential antipsoriatic agents. 2. Synthesis and antiproliferative activity of 10-substituted hydroxy-10H-acridin-9-ones against human keratinocyte growth, Eur. J. Med. Chem., 2010, 45, 5345-5352

2011

  • H. Prinz, B. Chamasmani, K. Vogel, K. J. Böhm, B. Aicher, M. Gerlach, E. G. Günther, P. Amon, I. Ivanov, K. Müller; N-Benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity and inhibition of tubulin polymerization, J. Med. Chem., 2011, 54, 4247-4263
  • Prinz H., Schmidt P., Böhm K. J., Baasner S., Müller K., Gerlach M. E., Günther G.,  Unger E.; Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents - Synthesis, antiproliferative activity and inhibition of tubulin polymerization, Bioorgan. Med. Chem., 2011, 19, 4183-4191

2012

  • A. Reichstein, S. Vortherms, S. Bannwitz, J. Tentrop, H. Prinz, K. Müller; Synthesis and Structure-activity relationships of Lapacho Analogues 1. Suppression of Human Keratinocyte Hyperproliferation by 2-Substituted Naphtho[2,3-b]furan-4,9-diones, Activation by Enzymatic One- and Two-Electron Reduction, and Intracellular Generation of Superoxide , J. Med. Chem. 2012, 55, 7273-7281

2014

  • S. Bannwitz, D. Krane, S. Vortherms, T. Kalin, C. Lindenschmidt, N. Zahedi Golpayegani, J. Tentrop, H. Prinz, K. Mueller; Synthesis and Structure-​Activity Relationships of Lapacho Analogues. 2. Modification of the Basic Naphtho[2,​3-​b]​furan-​4,​9-​dione, Redox Activation, and Suppression of Human Keratinocyte Hyperproliferation by 8-​Hydroxynaphtho[2,​3-​b]​thiophene-​4,​9-​diones, J. Med. Chem. 2014, 57, 6226-6239

2016

  • C. Lindenschmidt, D. Krane, S. Vortherms, L. Hilbig, H. Prinz, K. Müller; 8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of Keratinocyte hyperproliferation with reduced membrane-damaging properties, Eur. J. Med. Chem. 2016, 110, 280-290
  • A. Marcu, U. Schurigt, K. Müller, H. Moll, R. L. Krauth-Siegel, H. Prinz; Inhibitory Effect of Phenothiazine- and Phenoxazine-Derived Chloroacetamides on Leishmania major Growth and Trypanosoma brucei Trypanothione Reductase, Eur. J. Med. Chem. 2016, 108, 436-443

2017

  • , , , , , , , N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization, J. Med. Chem. 2017, 60, 749-766
  • A. Basoglu, S. Dirkmann, N. Zahedi Golpayegani, S. Vortherms, J. Tentrop, D. Nowottnik, H. Prinz, R. Fröhlich, K. Müller; Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent, Eur. J. Med. Chem. 2017, 134, 119-132

2018

  • J. Acuna, J. Piermattey, D. Caro, S. Bannwitz, L. Barrios, J. Lopez, Y. Ocampo, R. Vivas-Reyes, F. Aristizabal, R. Gaitan, K. Müller, L. Franco; Synthesis, Anti-Proliferative Activity Evaluation and 3D-QSAR Study of Naphthoquinone Derivatives as Potential Anti-Colorectal Cancer Agents, Molecules 2018, 23, 186
  • H. Löcken, C. Clamor, K. Müller; Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells, J. Nat. Prod., 2018, 81, 1636-1644