Participation in the Cells-in-Motion Cluster of Excellence

Junior Research Group 'Developmental Neurodegeneration'

Neurodegenerative diseases are a major focus of biomedical research. However, neurodegenerative processes also occur physiologically during neuronal development. Here, the selective degeneration of axons or dendrites ('pruning') or of selected neurons (through apoptosis) contribute greatly to the specificity of neuronal connections. Knowledge about the underlying mechanisms of developmental neurodegeneration is still scarce. We are using Drosophila genetics and live imaging to study pruning, and we have a particular interest in components of the ubiquitin-proteasome system.

  • Research Area A.1: Cellular Polarization and Changes in Cell Shape
  • Research area A.3: Functional membrane domains in neuronal and non-neuronal compartmentalization
  • Project FF-2016-13: Novel tools for mRNA labeling in Drosophila (Sebastian Rumpf, Andrea Rentmeister, project time: 07/2016 - 10/2018)
© CiM - Peter Grewer

“Science is like a jigsaw puzzle”

As a scientist Dr. Sebastian Rumpf likes to probe into questions that he finds interesting. With his Junior Research Group at the Cells-in-Motion Cluster of Excellence he studies how neuronal extensions atrophy. One of his main aims is to impart to other people the pleasure he derives from his research work. Read the interview

CiM Papers

2019

Kraemer R, Rode S, Rumpf S. Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons. Dev Biol 2019;451: 68-78. Abstract
Rumpf S, Wolterhoff N, Herzmann S. Functions of Microtubule Disassembly during Neurite Pruning. Trends Cell Biol 2019;29: 291-297. Abstract

2018

Herzmann S, Gotzelmann I, Reekers L-F, Rumpf S. Spatial regulation of microtubule disruption during dendrite pruning in Drosophila. Development 2018;145: dev156950. Abstract
Rode S, Ohm H, Anhauser L, Wagner M, Rosing M, Deng X, Sin O, Leidel SA, Storkebaum E, Rentmeister A, Zhu S, Rumpf S. Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila. Cell Rep 2018;24: 2287-2299.e4. Abstract

2017

Herzmann S, Krumkamp R, Rode S, Kintrup C, Rumpf S. PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. EMBO J 2017;36: 1981-1991. Abstract
Rode S, Ohm H, Zipfel J, Rumpf S. The spliceosome-associated protein Mfap1 binds to VCP in Drosophila. PLoS One 2017;12: e0183733. Abstract