Participation in the Cells-in-Motion Cluster of Excellence
Junior Research Group 'Developmental Neurodegeneration'
Neurodegenerative diseases are a major focus of biomedical research. However, neurodegenerative processes also occur physiologically during neuronal development. Here, the selective degeneration of axons or dendrites ('pruning') or of selected neurons (through apoptosis) contribute greatly to the specificity of neuronal connections. Knowledge about the underlying mechanisms of developmental neurodegeneration is still scarce. We are using Drosophila genetics and live imaging to study pruning, and we have a particular interest in components of the ubiquitin-proteasome system.
As a scientist Dr. Sebastian Rumpf likes to probe into questions that he finds interesting. With his Junior Research Group at the Cells-in-Motion Cluster of Excellence he studies how neuronal extensions atrophy. One of his main aims is to impart to other people the pleasure he derives from his research work. Read the interview
|Kraemer R, Rode S, Rumpf S. Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons. Dev Biol 2019;451: 68-78. Abstract|
|Rumpf S, Wolterhoff N, Herzmann S. Functions of Microtubule Disassembly during Neurite Pruning. Trends Cell Biol 2019;29: 291-297. Abstract|
|Herzmann S, Gotzelmann I, Reekers L-F, Rumpf S. Spatial regulation of microtubule disruption during dendrite pruning in Drosophila. Development 2018;145: dev156950. Abstract|
|Rode S, Ohm H, Anhauser L, Wagner M, Rosing M, Deng X, Sin O, Leidel SA, Storkebaum E, Rentmeister A, Zhu S, Rumpf S. Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila. Cell Rep 2018;24: 2287-2299.e4. Abstract|
|Herzmann S, Krumkamp R, Rode S, Kintrup C, Rumpf S. PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. EMBO J 2017;36: 1981-1991. Abstract|
|Rode S, Ohm H, Zipfel J, Rumpf S. The spliceosome-associated protein Mfap1 binds to VCP in Drosophila. PLoS One 2017;12: e0183733. Abstract|