"I like to look at questions from new angles" – an interview with Erez Raz

What allows a cell migrate from A to B? This is something that Prof Erez Raz would like to find out. In doing so, he likes to try out new paths and always likes being surprised. And there is one thing he is sure about: it is the combination of various fields that characterizes good science.

  • Participation in “Cells in Motion”

    • Management Board member of the CiM-IMPRS Graduate Programme
    • Research interests: mechanisms controlling cell migration, cell-fate maintenance and organogenesis in the context of the live vertebrate embryo
    • Project FF-2017-14 – Characterization of cell-environment interactions affecting single-cell motility in vivo (Erez Raz, Martin Burger, Daniel Tenbrinck; project time: 11/2017 - 12/2018)
    • Project FF-2014-09: The impact of cellular and tissue viscoelasticity on cell migration and morphogenesis (Cornelia Denz, Erez Raz, project time: 07/2014 - 06/2016)

  • Papers in the research focus “cell dynamics and imaging”

    all papers by Erez Raz


    Grimaldi C, Raz E. Germ cell migration-Evolutionary issues and current understanding. Semin Cell Dev Biol 2020;100: 152-159. Abstract
    Gross-Thebing T, Raz E. Dead end and Detour: The function of the RNA-binding protein Dnd in posttranscriptional regulation in the germline. Curr Top Dev Biol 2020;140: 181-208. Abstract
    Westerich KJ, Chandrasekaran KS, Gross-Thebing T, Kueck N, Raz E, Rentmeister A. Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos. Chem. Sci. 2020;11: 3089-3095. Abstract


    Goudarzi M, Boquet-Pujadas A, Olivo-Marin J-C, Raz E. Fluid dynamics during bleb formation in migrating cells in vivo. PLoS One 2019;14: e0212699. Abstract
    Lavi I, Goudarzi M, Raz E, Gov NS, Voituriez R, Sens P. Cellular Blebs and Membrane Invaginations Are Coupled through Membrane Tension Buffering. Biophys J 2019;117: 1485-1495. Abstract
    Olguin-Olguin A, Aalto A, Maugis B, Reichman-Fried M, Raz E. Chemokine-biased robust self-organizing polarization of migrating cells in vivo. bioRxiv 2019: epub. Abstract
    Skvortsova K, Tarbashevich K, Stehling M, Lister R, Irimia M, Raz E, Bogdanovic O. Retention of paternal DNA methylome in the developing zebrafish germline. Nat Commun 2019;10: 3054. Abstract


    Malhotra D, Shin J, Solnica-Krezel L, Raz E. Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. Elife 2018;7: e33574. Abstract
    Pfeiffer J, Tarbashevich K, Bandemer J, Palm T, Raz E. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Dev Biol 2018;436: 84-93. Abstract


    Cao J, Ehling M, März S, Seebach J, Tarbashevich K, Sixta T, Pitulescu ME, Werner A-C, Flach B, Montanez E, Raz E, Adams RH, Schnittler H. Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat Commun 2017;8Abstract
    Goudarzi M, Tarbashevich K, Mildner K, Begemann I, Garcia J, Paksa A, Reichman-Fried M, Mahabaleshwar H, Blaser H, Hartwig J, Zeuschner D, Galic M, Bagnat M, Betz T, Raz E. Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Dev Cell 2017;43: 577-587.e5. Abstract
    Gross-Thebing T, Yigit S, Pfeiffer J, Reichman-Fried M, Bandemer J, Ruckert C, Rathmer C, Goudarzi M, Stehling M, Tarbashevich K, Seggewiss J, Raz E. The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation. Developmental Cell 2017;43: 704-715.e5. Abstract
    Horner F, Meissner R, Polali S, Pfeiffer J, Betz T, Denz C, Raz E. Holographic optical tweezers-based in vivo manipulations in zebrafish embryos. J Biophotonics 2017;10: 1492-1501. Abstract


    Otten ABC, Theunissen TEJ, Derhaag JG, Lambrichs EH, Boesten IBW, Winandy M, van Montfoort APA, Tarbashevich K, Raz E, Gerards M, Vanoevelen JM, van den Bosch BJC, Muller M, Smeets HJM. Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells. Cell Rep 2016;16: 622-630. Abstract
    Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E. Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nat Commun 2016;7: 11288. Abstract


    Bussmann J, Raz E. Chemokine-guided cell migration and motility in zebrafish development. Embo J 2015;34: 1309-1318. Abstract
    Goudarzi M, Mildner K, Babatz F, Riedel D, Klambt C, Zeuschner D, Raz E. Correlative Light and Electron Microscopy of Rare Cell Populations in Zebrafish Embryos Using Laser Marks. Zebrafish 2015;12: 470-473. Abstract
    Meyen D, Tarbashevich K, Banisch TU, Wittwer C, Reichman-Fried M, Maugis B, Grimaldi C, Messerschmidt E-M, Raz E. Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. Elife 2015;4: e05279. Abstract
    Paksa A, Raz E. Zebrafish germ cells: motility and guided migration. Curr Opin Cell Biol 2015;36: 80-85. Abstract
    Stanganello E, Hagemann AIH, Mattes B, Sinner C, Meyen D, Weber S, Schug A, Raz E, Scholpp S. Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun 2015;6: 5846. Abstract
    Tarbashevich K, Reichman-Fried M, Grimaldi C, Raz E. Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Curr Biol 2015;25: 1096-1103. Abstract


    Gross-Thebing T, Paksa A, Raz E. Simultaneous high-resolution detection of multiple transcripts combined with localization of proteins in whole-mount embryos. BMC Biol 2014;12: 55. Abstract
    Hartwig J, Tarbashevich K, Seggewiss J, Stehling M, Bandemer J, Grimaldi C, Paksa A, Gross-Thebing T, Meyen D, Raz E. Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Proc Natl Acad Sci U S A 2014;111: 11389-11394. Abstract
    Reichman-Fried M, Raz E. Small proteins, big roles: The signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo. Bioessays 2014;36: 741-745. Abstract
    Xu C, Hasan SS, Schmidt I, Rocha SF, Pitulescu ME, Bussmann J, Meyen D, Raz E, Adams RH, Siekmann AF. Arteries are formed by vein-derived endothelial tip cells. Nat Commun 2014;5: 5758. Abstract


    Goudarzi M, Strate I, Paksa A, Lagendijk A-K, Bakkers J, Raz E. On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nat Genet 2013;45: 1264-1265. Abstract
    Paluch EK, Raz E. The role and regulation of blebs in cell migration. Curr Opin Cell Biol 2013;25: 582-590. Abstract