• Participation in “Cells in Motion”

    • Research interests: membrane lipid dynamics, membrane trafficking, membrane-cytoskeleton interactions, Ca2+ signalling, Ca2+ binding proteins
    • Executive Board member of the Cells in Motion Interfaculty Centre
    • Member of the Research and Careers Committee
    • Supervisor in the CiM-IMPRS Graduate Programme
    • Member of the Imaging Network – Microscopy
  • News & views

  • Papers in the research focus “cell dynamics and imaging”

    Accepted for publication

    Schwietzer MF†, Thölmann S†, Kummer D, Kaschler A, Greune L, Thüring EM, Schmidt MA, Gerke V, Ebnet K. Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfments. iScience: accepted for publication.


    Ebnet K, Gerke V. Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells. Front Cell Dev Biol 2022;10: 948013. Abstract
    Hartmann C, Thuring E-M, Greune L, Michels BE, Pajonczyk D, Leussink S, Brinkmann F, Glaesner-Ebnet M, Wardelmann E, Zobel T, Schmidt MA, Janssen K-P, Gerke V, Ebnet K. Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex. Sci Signal 2022;15: eabm2449. Abstract
    Kummer D, Steinbacher T, Tholmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B, Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V, Ebnet K. A JAM-A-tetraspanin-alphavbeta5 integrin complex regulates contact inhibition of locomotion. J Cell Biol 2022;221Abstract
    Russo A, Schurmann H, Brandt M, Scholz K, Matos ALL, Grill D, Revenstorff J, Rembrink M, von Wulffen M, Fischer-Riepe L, Hanley PJ, Hacker H, Prunster M, Sanchez-Madrid F, Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J. Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. Adv Sci (Weinh) 2022: e2201505. Abstract
    Tholmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K. JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Cell Mol Life Sci 2022;79: 88. Abstract


    Fitzian K, Bruckner A, Brohee L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kummel D. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol Cell 2021;81: 2705-2721.e8. Abstract
    Kudruk S, Pottanam Chali S, Linard Matos AL, Bourque C, Dunker C, Gatsogiannis C, Ravoo BJ, Gerke V. Biodegradable and Dual-Responsive Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo. Adv Sci (Weinh) 2021: e2100694. Abstract


    Hartmann C, Schwietzer YA, Kummer D, Kirschnick N, Hoppe E, Thuring E-M, Glaesner-Ebnet M, Brinkmann F, Gerke V, Reuter S, Nakayama M, Ebnet K. The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria. BMC Mol Cell Biol 2020;21: 30. Abstract
    Matos ALL, Kudruk S, Moratz J, Heflik M, Grill D, Ravoo BJ, Gerke V. Membrane Binding Promotes Annexin A2 Oligomerization. Cells 2020;9: 1169. Abstract


    Begemann I, Saha T, Lamparter L, Rathmann I, Grill D, Golbach L, Rasch C, Keller U, Trappmann B, Matis M, Gerke V, Klingauf J, Galic M. Mechanochemical self-organization determines search pattern in migratory cells. Nat. Phys. 2019;15: 848-857. Abstract
    de Vries WC, Kudruk S, Grill D, Niehues M, Matos ALL, Wissing M, Studer A, Gerke V, Ravoo BJ. Controlled Cellular Delivery of Amphiphilic Cargo by Redox‐Responsive Nanocontainers. Adv. Sci. 2019: 1901935. Abstract
    Mietkowska M, Schuberth C, Wedlich-Soldner R, Gerke V. Actin dynamics during Ca(2+)-dependent exocytosis of endothelial Weibel-Palade bodies. Biochim Biophys Acta Mol Cell Res 2019;1866: 1218-1229. Abstract
    Viplav A, Saha T, Huertas J, Selenschik P, Ebrahimkutty MP, Grill D, Lehrich J, Hentschel A, Biasizzo M, Mengoni S, Ahrends R, Gerke V, Cojocaru V, Klingauf J, Galic M. ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis. J Cell Sci 2019;132: pii: jcs226530. Abstract


    Grill D, Matos ALL, de Vries WC, Kudruk S, Heflik M, Dorner W, Mootz HD, Jan Ravoo B, Galla H-J, Gerke V. Bridging of membrane surfaces by annexin A2. Sci Rep 2018;8: 14662. Abstract
    Matos ALL, Grill D, Kudruk S, Heitzig N, Galla H-J, Gerke V, Rescher U. Dissipative Microgravimetry to Study the Binding Dynamics of the Phospholipid Binding Protein Annexin A2 to Solid-supported Lipid Bilayers Using a Quartz Resonator. J Vis Exp 2018;141Abstract
    Rakers L, Grill D, Matos ALL, Wulff S, Wang D, Borgel J, Korsgen M, Arlinghaus HF, Galla H-J, Gerke V, Glorius F. Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes. Cell Chem Biol 2018;25: 952-961.e12. Abstract
    Schibilla F, Holthenrich A, Song B, Linard Matos AL, Grill D, Rota Martir D, Gerke V, Zysman-Colman E, Ravoo BJ. Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging. Chem Sci 2018;9: 7822-7828. Abstract


    Biesemann A, Gorontzi A, Barr F, Gerke V. Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies. J Biol Chem 2017;292: 11631-11640. Abstract
    Boye TL, Maeda K, Pezeshkian W, Sonder SL, Haeger SC, Gerke V, Simonsen AC, Nylandsted J. Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair. Nat Commun 2017;8: 1623. Abstract
    Chehab T, Santos NC, Holthenrich A, Koerdt SN, Disse J, Schuberth C, Nazmi AR, Neeft M, Koch H, Man KNM, Wojcik SM, Martin TFJ, van der Sluijs P, Brose N, Gerke V. A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells. Mol Biol Cell 2017;28: 1688-1700. Abstract
    de Vries WC, Grill D, Tesch M, Ricker A, Nusse H, Klingauf J, Studer A, Gerke V, Ravoo BJ. Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery. Angew Chem Int Ed Engl 2017;56: 9603-9607. Abstract
    Koerdt SN, Gerke V. Annexin A2 is involved in Ca2+-dependent plasma membrane repair in primary human endothelial cells. Biochim Biophys Acta 2017;1864: 1046-1053. Abstract
    Rieger S, Grill D, Gerke V, Fallnich C. Quantitative spontaneous Raman scattering spectroscopy in artificial binary lipid membranes: Quantitative Raman spectroscopy in lipid membranes. J Raman Spectrosc 2017;48: 1264-1269. Abstract


    Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell 2016;27: 2811-2821. Abstract
    Gerke V. Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis. Biol Chem 2016;397: 995-1003. Abstract


    Nammalwar RC, Heil A, Gerke V. Ezrin interacts with the scaffold protein IQGAP1 and affects its cortical localization. Biochim Biophys Acta 2015;1853: 2086-2094. Abstract
    Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun 2015;6: 8128. Abstract


    Drucker P, Pejic M, Grill D, Galla H-J, Gerke V. Cooperative binding of annexin A2 to cholesterol- and phosphatidylinositol-4,5-bisphosphate-containing bilayers. Biophys J 2014;107: 2070-2081. Abstract
    Quiskamp N, Poeter M, Raabe CA, Hohenester UM, Konig S, Gerke V, Rescher U. The tumor suppressor annexin A10 is a novel component of nuclear paraspeckles. Cell Mol Life Sci 2014;71: 311-329. Abstract
    Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. Mol Biol Evol 2014;31: 1710-1723. Abstract


    Brandherm I, Disse J, Zeuschner D, Gerke V. cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2. Blood 2013;122: 1042-1051. Abstract
    Drucker P, Pejic M, Galla H-J, Gerke V. Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2. J Biol Chem 2013;288: 24764-24776. Abstract
    Ghavampour S, Lange C, Bottino C, Gerke V. Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration. PLoS One 2013;8: e73981. Abstract
    Kluger MS, Clark PR, Tellides G, Gerke V, Pober JS. Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol 2013;33: 489-500. Abstract
    Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U. Annexin A6-balanced late endosomal cholesterol controls influenza a replication and propagation. MBio 2013;4: e00608-13. Abstract
    Peddibhotla SSD, Brinkmann BF, Kummer D, Tuncay H, Nakayama M, Adams RH, Gerke V, Ebnet K. Tetraspanin CD9 links junctional adhesion molecule-A to alphavbeta3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling. Mol Biol Cell 2013;24: 933-944. Abstract


    Iden S, Misselwitz S, Peddibhotla SSD, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K. aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol 2012;196: 623-639. Abstract
    Nazmi AR, Ozorowski G, Pejic M, Whitelegge JP, Gerke V, Luecke H. N-terminal acetylation of annexin A2 is required for S100A10 binding. Biol Chem 2012;393: 1141-1150. Abstract
    Tcatchoff L, Andersson S, Utskarpen A, Klokk TI, Skanland SS, Pust S, Gerke V, Sandvig K. Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. PLoS One 2012;7: e40429. Abstract