Univ.-Prof. Dr. rer. nat. Cornelia Denz
Institute of Applied Physics
Denz Lab: Nonlinear Photonics
Tel: +49 251 83-33517

“I want to tailor light in all its features into novel applications“ – an interview with Cornelia Denz

Prof Cornelia Denz sculpts light and exploits it, for example, to investigate cells in living organisms, or to understand cell dynamics and migration in the inner cell. She is able to tailor light to tackle and answer many actual research challenges in cell science and nanotechnology – and most of all she would like to develop more applications using advanced structured light.

  • Participation in “Cells in Motion”

    • Member of the Research and Careers Committee
    • Supervisor in the CiM-IMPRS Graduate Programme
    • Research interests: biophysics and biophotonics in life sciences, micro- and optofluidics, soft and hard laser lithography, structured, tailored light, nanophotonics and information optics, nonlinear physics in photonics
    • Project FF-2014-09: The impact of cellular and tissue viscoelasticity on cell migration and morphogenesis (Cornelia Denz, Erez Raz, project time: 07/2014 - 06/2016)

  • Papers in the research focus “cell dynamics and imaging”

    all papers by Cornelia Denz


    Zannotti A, Denz C, Alonso MA, Dennis MR. Shaping caustics into propagation-invariant light. Nat Commun 2020;11: 3597. Abstract
    Zhang X, Wang Y, Song J, Gerwien H, Chuquisana O, Chashchina A, Denz C, Sorokin L. The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain. J Exp Med 2020;217: e20191339. Abstract


    Otte E, Tekce K, Lamping S, Ravoo BJ, Denz C. Polarization nano-tomography of tightly focused light landscapes by self-assembled monolayers. Nat Commun 2019;10: 4308. Abstract


    Meissner R, Oliver N, Denz C. Optical Force Sensing with Cylindrical Microcontainers. Part. Part. Syst. Charact. 2018;35: 1800062. Abstract


    Horner F, Meissner R, Polali S, Pfeiffer J, Betz T, Denz C, Raz E. Holographic optical tweezers-based in vivo manipulations in zebrafish embryos. J Biophotonics 2017;10: 1492-1501. Abstract
    Otte E, Tekce K, Denz C. Tailored intensity landscapes by tight focusing of singular vector beams. Opt Express 2017;25: 20194-20201. Abstract
    Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol 2017;19: 653-665. Abstract


    Barroso A, Landwerth S, Woerdemann M, Alpmann C, Buscher T, Becker M, Studer A, Denz C. Optical assembly of bio-hybrid micro-robots. Biomed Microdevices 2015;17: 26. Abstract
    Meißner R, Alpmann C, Barroso A, Denz C. Greifen ohne Berühren, Zelluntersuchungen mit der optischen Pinzette. labor&more 2015: 42-46. Abstract
    Otte E, Schlickriede C, Alpmann C, Denz C. Complex light fields enter a new dimension: holographic modulation of polarization in addition to amplitude and phase. Proc SPIE 2015;9379: 937908 (13 pp.). Abstract


    Woerdemann M, Hörner F, Denz C. Structured attachment of bacterial molecular motors for defined micro flow induction. Optofluidics, Microfluidics, and Nanofluidics 2014;1: 19-26. Abstract


    Barroso A, Woerdemann M, Vollmer A, von Bally G, Kemper B, Denz C. Three-dimensional exploration and mechano-biophysical analysis of the inner structure of living cells. Small 2013;9: 885-893. Abstract
    Kemper B, Barroso A, Denz C. Combined Holographic Optical Trapping and Imaging - Exploring the Inside of Cells and Modeling Infection. Imaging Microscopy 2013;15: 41-43. Abstract
    Kemper B, Barroso A, Woerdemann M, Dewenter L, Vollmer A, Schubert R, Mellmann A, von Bally G, Denz C. Towards 3D modelling and imaging of infection scenarios at the single cell level using holographic optical tweezers and digital holographic microscopy. J Biophotonics 2013;6: 260-266. Abstract
    Schafer S, Dekiff M, Plate U, Szuwart T, Denz C, Dirksen D. Quantitative analysis of dynamic behavior of osteoblasts during in vitro formation of micro-mass cell cultures. J Biophotonics 2013;6: 637-644. Abstract
    Woerdemann M, Alpmann C, Esseling M, Denz C. Advanced optical trapping by complex beam shaping. Laser Photonics Rev 2013;7: 839–854. Abstract


    Alpmann C, Esseling M, Rose P, Denz C. Dynamic Light Cages: Putting Absorbing Matter Behind Bars. Opt Photon News 2012;23: 48. Abstract
    Neugebauer U, Große C, Bauer M, Kemper B, Barroso-Pena A, Bauwens A, Glueder M, Woerdemann M, Dewenter L, Denz C, Kloß S, Rösch P, Sabat A, Schütze K, Friedrich A, Bally G von, Popp J, Mellmann A. From Infection to Detection: Imaging S aureus – host interactions. Biomed Tech (Berl) 2012;57: 503 -6. Abstract
    Woerdemann M, Veiga-Gutiérrez M, De Cola L, Denz C. Creating Functional Microstructures with an Optical-Tweezers Assembly-Line. Opt Photon News 2012;23: 47. Abstract