Tracking Cells in Motion: How Do Immune Cells Break Down Barriers When Migrating?
Tracking is known for example from online shopping: You can follow your order from where it is located in the delivery process to the time the postman will ring. Thus, tracking means following the movement of an object over a period of time. Mathematician Dr. Christoph Brune is modelling such motion sequences in order to simulate the next possible movement of an object. For biomedicine, these models are very helping – since there are many cells in our body ever in motion.
Prof. Dietmar Vestweber is interested in cells that migrate into tissue during inflammation. In order to reach the tissue, they first have to break down a barrier. By using tracking-methods, Dietmar Vestweber wants to gain knowledge on the pathway cells take in order to overcome the barrier and migrate into tissue. In applied mathematics, some tricks are utilized: The live images of the organism, taken by a fluorescence microscope, are optimized by methods like inpainting and de-blurring to sharpen the images. Sharper edges allow to segregate one cell from the other. The team also focuses on the inner forces a cell brings up to move forward.