The
Biomedical Analysis Group is almost thirty years leading in the field
of biological mass spectrometry, developments and applications to human
diseases. In the last 15 years the focus has been directed toward
structural systems biology, which encompasses structural analysis of
complex biological systems. Novel MALDI-TOF, ESI-QTOF and high field
FT-ICR mass spectrometry protocols and new MS fragmentation protocols
for
de-novo sequencing were developed and implemented to
proteomics and glycomics to achieve high confidence structural and
heterogeneity analysis. Novel technologies for biological sample
delivery, like hyphenated microanalysis, automatization and chip-MS,
were implemented for identification and validation of glycoconjugates
such as oligosaccharides, glycoproteins and glycolipids of biological
importance. The group carried out a number of research projects in
cooperation with German, European and US university groups. The group
is collaborating on specific topics and technologies with industrial
labs in a bilateral way. We are working strongly interdisciplinary
within an international network of (bio-)chemists, physicists,
biotechnologists and clinicians.
