© EIMI/P. Leßmann

Technologie & Medizinische Physik (Prof. Klaus Schäfers)

Wir entwickeln neue bildgebende Technologien für die hochpräzise molekulare Bildgebung. Unsere Forschung konzentriert sich überwiegend auf hochauflösende, hochempfindliche PET-Bildgebungsverfahren in drei Projekten:

  • Beseitigung von Bewegungsartefakten in der PET/CT und PET/MRT über Verfahren der Bewegungsdetektion und -korrektur
  • Verbesserung der räumlichen Auflösung und Empfindlichkeit von Kleintier-PET durch Nutzung der Vieldraht-Proportional-Kammer-Technologie
  • Entwicklung neuer Detektoren für verbesserte time-of-flight-PET mittels Flüssig-TMBi und Cherenkov-Lichtauslesung
  • News & Themen aus der Forschung

  • Projekte

  • Team

  • Publikationen

    2019

    Rigie D, Vahle T, Zhao T, Czekella B, Frohwein LJ, Schafers K, Boada FE. Cardiorespiratory motion-tracking via self-refocused rosette navigators. Magn Reson Med 2019;81: 2947-2958. Abstract

    2018

    Bolwin K, Czekalla B, Frohwein LJ, Büther F, Schäfers KP. Anthropomorphic thorax phantom for cardio-respiratory motion simulation in tomographic imaging. Phys Med Biol 2018;63: 035009. Abstract
    Büther F, Ernst I, Frohwein LJ, Pouw J, Schafers KP, Stegger L. Data-driven gating in PET: Influence of respiratory signal noise on motion resolution. Med Phys 2018;45: 3205-3213. Abstract
    Cal-Gonzalez J, Li X, Heber D, Rausch I, Moore SC, Schafers K, Hacker M, Beyer T. Partial volume correction for improved PET quantification in (18)F-NaF imaging of atherosclerotic plaques. J Nucl Cardiol 2018;25: 1742-1756. Abstract
    Cal-González J, Tsoumpas C, Lassen ML, Rasul S, Koller L, Hacker M, Schäfers K, Beyer T. Impact of motion compensation and partial volume correction for[super:18]F-NaF PET/CT imaging of coronary plaque. Phys. Med. Biol. 2018;63: 015005. Abstract
    Frohwein LJ, Hess M, Schlicher D, Bolwin K, Büther F, Jiang X, Schäfers KP. PET attenuation correction for flexible MRI surface coils in hybrid PET/MRI using a 3D depth camera. Phys Med Biol 2018;63: 025033. Abstract
    Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith D-M, Fricke IB, Just N, Doblas S, Sinkus R, Doring C, Schafers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH. Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-(18)F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model. J Nucl Med 2018;59: 1063-1069. Abstract
    Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Muller J, Seebohm G, Paul M, Schafers K, Stallmeyer B, Schafers M, Schulze-Bahr E. Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography. Heart 2018;104: 332-339. Abstract

    2017

    Bolwin K, Vernekohl D, Lühder J, Czekalla B, Wessels JP, Schäfers KP. Development of a clear sub-millimeter small animal PET scanner by reducing the influence of the non-collinearity effect. J. Inst. 2017;12: C03006-C03006. Abstract
    Cal-Gonzalez J, Li X, Heber D, Rausch I, Moore SC, Schafers K, Hacker M, Beyer T. Partial volume correction for improved PET quantification in 18F-NaF imaging of atherosclerotic plaques. J Nucl Cardiol 2017: 1–15. Abstract
    Hess M, Buther F, Schafers KP. Data-Driven Methods for the Determination of Anterior-Posterior Motion in PET. IEEE Trans Med Imaging 2017;36: 422-432. Abstract

    2016

    Buther F, Vehren T, Schafers KP, Schafers M. Impact of Data-driven Respiratory Gating in Clinical PET. Radiology 2016: 152067. Abstract
    Fricke IB, Viel T, Worlitzer MM, Collmann FM, Vrachimis A, Faust A, Wachsmuth L, Faber C, Dolle F, Kuhlmann MT, Schafers K, Hermann S, Schwamborn JC, Jacobs AH. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. Eur J Neurosci 2016;43: 1352-1365. Abstract
    Hermann S, Kuhlmann MT, Starsichova A, Eligehausen S, Schafers K, Stypmann J, Tiemann K, Levkau B, Schafers M. Imaging Reveals the Connection Between Spontaneous Coronary Plaque Ruptures, Atherothrombosis, and Myocardial Infarctions in HypoE/SRBI-/- Mice. J Nucl Med 2016;57: 1420-1427. Abstract
    Range FT, Kies P, Schafers KP, Breithardt G, Schober O, Wichter T, Schafers MA. Sex differences in absolute myocardial perfusion Non-invasive H2(15)O-PET in young healthy adults. Nuklearmedizin 2016;55: 196-202. Abstract
    Reinartz G, Haverkamp U, Wullenkord R, Lehrich P, Kriz J, Buther F, Schafers K, Schafers M, Eich HT. 4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma : Determination of intra- and interfractional gastric motion. Strahlenther Onkol 2016;192: 322-332. Abstract

    2015

    Ersepke T, Buther F, Hess M, Schafers KP. A contactless approach for respiratory gating in PET using continuous-wave radar. Med Phys 2015;42: 4911. Abstract
    Frohwein LJ, Hoerr V, Faber C, Schäfers KP. Correction of MRI-induced geometric distortions in whole-body small animal PET-MRI. Med. Phys. 2015;42: 3848-3858. Abstract
    Heß M, Büther F, Gigengack F, Dawood M, Schäfers KP. A dual-Kinect approach to determine torso surface motion for respiratory motion correction in PET. Med. Phys. 2015;42: 2276-2286. Abstract
    Reilmann R, Lippross V, Holzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lucke M, Riess O, Nguyen HP, Von Horsten S, Schafers K, Schafers M, Jacobs AH, Hermann S. FDG muPET Fails to Detect a Disease-Specific Phenotype in Rats Transgenic for Huntington's Disease - A 15 Months Follow-up Study. J Huntingtons Dis 2015;4: 37-47. Abstract
    Schmid S, Jiang X, Schafers K. Puzzle Approach to Pose Tracking of a Rigid Object in a Multi Camera System. Lect Notes Comput Sc 2015;9256: 337-349. Abstract

    2014

    Fieseler M, Gigengack F, Jiang X, Schafers KP. Motion correction of whole-body PET data with a joint PET-MRI registration functional. Biomed Eng Online 2014;13 Suppl 1: S2. Abstract
    Kesner AL, Schleyer PJ, Buther F, Walter MA, Schafers KP, Koo PJ. On transcending the impasse of respiratory motion correction applications in routine clinical imaging - a consideration of a fully automated data driven motion control framework. EJNMMI Phys 2014;1: 8. Abstract
    Lamare F, Le Maitre A, Dawood M, Schafers KP, Fernandez P, Rimoldi OE, Visvikis D. Evaluation of respiratory and cardiac motion correction schemes in dual gated PET/CT cardiac imaging. Med Phys 2014;41: 072504. Abstract
    Schäfers KP, Bolwin K, Büther F, Hermann S, Jacobs AH, Kösters T, Kuhlmann M, Schäfers M, Viel T. High-Resolution Small Animal Imaging. In: Comprehensive Biomedical Physics 2014;Elsevier, Oxford: 181-211. Abstract

    2013

    Buther F, Ernst I, Hamill J, Eich HT, Schober O, Schafers M, Schafers KP. External radioactive markers for PET data-driven respiratory gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2013;40: 602-614. Abstract
    Dawood M, Gigengack F, Jiang X, Schäfers KP. A mass conservation-based optical flow method for cardiac motion correction in 3D-PET. Med Phys 2013;40: 012505. Abstract
    Fieseler M, Kugel H, Gigengack F, Kösters T, Büther F, Quick HH, Faber C, Jiang X, Schäfers KP. A dynamic thorax phantom for the assessment of cardiac and respiratory motion correction in PET/MRI: A preliminary evaluation. Nucl Instrum Methods Phys Res A 2013;702: 59-63. Abstract
    Gigengack F, Ruthotto L, Jiang X, Modersitzki J, Burger M, Hermann S, Schäfers KP. Atlas-Based Whole-Body PET-CT Segmentation using a Passive Contour Distance. Lect Notes Comput Sc 2013;7766: 82-92. Abstract
    Gottschlag H, Kösters T, Vernekohl D, Reygers K, Schäfers KP, Wübbeling F, Wessels JP. Towards Quantitative Image Reconstruction Using Monte-Carlo Simulations in Multi-Wire Proportional Chamber-Based Small Animal PET. IEEE Trans Nucl Sci 2013;60: 3343-3354. Abstract
    Jiang X, Dawood M, Gigengack F, Risse B, Schmid S, Tenbrinck D, Schäfers K. Biomedical imaging: A computer vision perspective. Lect Notes Comput Sc 2013;8047: 1-19. Abstract
    Schmid S, Jiang X, Schäfers K. High-precision lens distortion correction using smoothed thin plate splines. Lect Notes Comput Sc 2013;8048: 432-439. Abstract
    Tenbrinck D, Schmid S, Jiang X, Schäfers K, Stypmann J. Histogram-based Optical Flow for Motion Estimation in Ultrasound Imaging. J Math Imaging Vision 2013;47(1): 138-150.
    Waerzeggers Y, Viel T, Schäfers S, Wagner S, Faust A, Riemann B, Kopka K, Schober O, Schäfers K, Jacobs AH. Positron Emission Tomography (PET)-based Molecular Imaging. Part 5 - Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism 2013;Neuromethods; 77: 301-327.

    2012

    Gigengack F, Ruthotto L, Burger M, Wolters C, Jiang X, Schäfers K. Motion Correction in Dual Gated Cardiac PET using Mass-Preserving Image Registration. IEEE Trans Med Imaging 2012;31: 698-712. Abstract
    Gigengack F, Ruthotto L, Kösters T, Jiang X, Modersitzki J, Burger M, Hermann S, Schäfers KP. Atlas-Based Segmentation Using Passive Contours. IEEE NSS/MIC 2012: 3015-3016.
    Gigengack F, Ruthotto L, Kösters T, Jiang X, Modersitzki J, Burger M, Wolters CH, Schäfers KP. Pipeline for Motion Correction in Dual Gated PET. IEEE NSS/MIC 2012: 2983-2984. Abstract
    Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M. Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Eur J Nucl Med Mol Imaging 2012;39: 416-420. Abstract
    Ruthotto L, Gigengack F, Burger M, Wolters CH, Jiang X, Schäfers KP, Modersitzki J. A Simplified Pipeline for Motion Correction in Dual Gated Cardiac PET. In: Bildverarbeitung für die Medizin 2012: 51-56. Abstract

    2011

    Engbers R, Benning M, Heins P, Schäfers K, Burger M. Sparse recovery in myocardial blood flow quantification via PET. IEEE NSS/MIC 2011: 3742-3744.
    Fieseler M, Kosters T, Gigengack F, Braun H, Quick HH, Schäfers KP, Jiang X. Motion correction in PET-MRI: A human torso phantom study. IEEE NSS/MIC 2011: 3586-3588.
    Gigengack F, Ruthotto L, Burger M, Wolters CH, Jiang X, Schäfers KP. Mass-preserving motion correction of PET: Displacement field vs spline transformation. IEEE NSS/MIC 2011: 3088-3090.
    Gigengack F, Ruthotto L, Burger M, Wolters CH, Jiang X, Schäfers KP. Mass-preserving motion correction of dual gated cardiac PET. IEEE NSS/MIC 2011: 3206-3208.
    Kösters T, Schäfers KP, Wübbeling F. EMRECON: An expectation maximization based image reconstruction framework for emission tomography data. IEEE NSS/MIC 2011: 4365-4368.
    Muller J, Brune C, Sawatzky A, Kosters T, Schäfers KP, Burger M. Reconstruction of short time PET scans using Bregman iterations. IEEE NSS/MIC 2011: 2383-2385.
    Schellmann M, Gorlatch S, Meiländer D, Kösters T, Schäfers K, Wübbeling F, Burger M. Parallel medical image reconstruction: from graphics processing units (GPU) to grids. J Supercomp 2011;52: 151-160. Abstract
    Schmid S, Tenbrinck D, Jiang X, Schäfers K, Tiemann K, Stypmann J. Histogram-Based Optical Flow for Functional Imaging in Echocardiography. Lect Notes Comput Sc 2011;6854/2011: 477-485. Abstract
    Seidler DG, Mohamed NA, Bocian C, Stadtmann A, Hermann S, Schäfers K, Schäfers M, Iozzo RV, Zarbock A, Götte M. The role for decorin in delayed-type hypersensitivity. J Immunol 2011;187: 6108-6119. Abstract

    2010

    Buscher K, Judenhofer MS, Kuhlmann MT, Hermann S, Wehrl HF, Schäfers KP, Schäfers M, Pichler BJ, Stegger L. Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI. J Nucl Med 2010;51: 1277-1284. Abstract
    Büther F, Ernst I, Dawood M, Kraxner P, Schäfers M, Schober O, Schäfers KP. Detection of respiratory tumour motion using intrinsic list mode-driven gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2010;37: 2315-2327. Abstract
    Dawood M, Brune C, Büther F, Jiang X, Burger M, Schober O, Schäfers M, Schäfers KP. A continuity equation based optical flow method for cardiac motion correction in 3 D PET data. Lect Notes Comput Sc 2010;6326: 88-97. Abstract
    Ernst L, Büther F, Dawood M, Moustakis C, Willich N, Schäfers K, Boelling T. Listmode based PET/CT planning for motion detection in high precision radiotherapy. Strahlenther Onkol 2010;186: 13-14.
    Gigengack F, Ruthotto L, Burger M, Wolters CH, Jiang X, Schäfers K. Motion correction of cardiac PET using mass-preserving registration. IEEE NSS/MIC 2010: 3317-3319.
    Law MP, Schäfers K, Kopka K, Wagner S, Schober O, Schäfers M. Molecular imaging of cardiac sympathetic innervation by 11C-mHED and PET: from man to mouse?. J Nucl Med 2010;51: 1269-1276. Abstract
    Schnöckel U, Hermann S, Stegger L, Law M, Kuhlmann M, Schober O, Schäfers K, Schäfers M. Small-animal PET: a promising, non-invasive tool in pre-clinical research. Eur J Pharm Biopharm 2010;74: 50-54. Abstract
    Tenbrinck D, Dawood M, Gigengack F, Fieseler M, Jiang X, Schäfers K. Motion correction in Positron Emission Tomography considering Partial Volume Effects in optical flow estimation. IEEE ISBI 2010: 1233-1236. Abstract

    2009

    Büther F, Dawood M, Stegger L, Wübbeling F, Schäfers M, Schober O, Schäfers KP. List mode-driven cardiac and respiratory gating in PET. J Nucl Med 2009;50: 674-681. Abstract
    Dawood M, Büther F, Schober O, Schäfers M, Schäfers KP. Wieviele respiratorische Gates? Einfluss der Anzahl an Gates auf atemgetriggerte PET Aufnahmen. Nuklearmedizin 2009;48: A23.
    Dawood M, Büther F, Stegger L, Jiang X, Schober O, Schäfers M, Schäfers KP. Optimal number of respiratory gates in positron emission tomography: a cardiac patient study. Med Phys 2009;36: 1775-1784. Abstract
    Ernst I, Büther F, Dawood M, Kraxner P, Moustakis C, Bolling T, Schober O, Schäfers K, Willich N. PET/CT for movement detection in high precision radiotherapy. Strahlenther Onkol 2009;185: 35-36.
    Range FT, Paul M, Schäfers KP, Acil T, Kies P, Hermann S, Schober O, Breithardt G, Wichter T, Schäfers MA. Myocardial perfusion in nonischemic dilated cardiomyopathy with and without atrial fibrillation. J Nucl Med 2009;50: 390-396. Abstract
    Schellmann M, Gorlatch S, Meiländer D, Kösters T, Schäfers K, Wübbeling F, Burger M. Parallel Medical Image Reconstruction: From Graphics Processors to Grids. Lect Notes Comput Sc 2009;5698: 457-473. Abstract
    Stegger L, Heijman E, Schäfers KP, Nicolay K, Schäfers MA, Strijkers GJ. Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI. J Nucl Med 2009;50: 132-138. Abstract

    2008

    Benning M, Kösters M, Wübbeling F, Schäfers K, Burger M. A nonlinear variational method for improved quantification of myocardial blood flow using dynamic H215O pET. IEEE NSS 2008: 4472-4477.
    Dawood M, Büther F, Jiang X, Schäfers KP. Respiratory motion correction in 3-D PET data with advanced optical flow algorithms. IEEE Trans.Med.Imaging 2008;27: 1164-1175. Abstract
    Dawood M, Kösters T, Fieseler M, Büther F, Jiang X, Schäfers KP. Motion Correction on Dual ECG and Respiratory Gated 0440 3D Cardiac PET/CT Data. lncs 2008: 155-162.
    Riemann B, Schäfers KP, Schober O, Schäfers M. Small animal PET in preclinical studies: opportunities and challenges. Q J Nucl Med Mol Imaging 2008;52: 215-221.
    Schafers KP, Stegger L. Combined imaging of molecular function and morphology with PET/CT and SPECT/CT: image fusion and motion correction. Basic Res Cardiol 2008;103: 191-199. Abstract
    Schnöckel U, Reuter S, Stegger L, Schlatter E, Schäfers KP, Hermann S, Schober O, Gabriels G, Schäfers M. Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats. Eur J Nucl Med Mol Imaging 2008;35: 2267-2274. Abstract

    2007

    Büther F, Stegger L, Dawood M, Range F, Schäfers M, Fischbach R, Wichter T, Schober O, Schäfers KP. Effective methods to correct contrast agent-induced errors in PET quantification in cardiac PET/CT. J Nucl Med 2007;48: 1060-1068. Abstract
    Dawood M, Büther F, Lang N, Schober O, Schäfers KP. Respiratory gating in positron emission tomography: a quantitative comparison of different gating schemes. Med Phys 2007;34: 3067-3076. Abstract
    Dawood M, Fieseler M, Büther F, Jiang X, Schäfers KP. A Multi-resolution Optical Flow Based Approach to Respiratory Motion Correction in 3D PET/CT Images. Lect Notes Comput Sc 2007: 314-322. Abstract
    Lang N, Hermann S, Hold S, Mienkina M, Stegger L, Stypmann J, Schober O, Schäfers M, Schäfers KP, Schmitz G. Hybrid 3D Sono/PET in a mouse. Eur J Nucl Med Mol Imaging 2007;34: 1706-1707. Abstract
    Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T. Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Eur Heart J 2007;28: 2223-2230. Abstract
    Stegger L, Schäfers K, Kopka K, Wagner S, Hermann S, Kies P, Law M, Schober O, Schäfers M. Molecular cardiovascular imaging using scintigraphic methods. Eur Radiol 2007;17: 1422-1432. Abstract

    2006

    Dawood M, Büther F, Lang N, Jiang X, Schäfers KP. Transforming Static CT in Gated PET/CT Studies to Multiple Respiratory Phases. ICPR 2006: 1026-1029. Abstract
    Dawood M, Lang N, Jiang X, Schäfers KP. Lung motion correction on respiratory gated 3-D PET/CT images. IEEE Trans Med Imaging 2006;25: 476-485. Abstract
    Schäfers KP, Lang N, Stegger L, Schober O, Schäfers M. Gated listmode acquisition with the quadHIDAC animal PET to image mouse hearts. Z Med Phys 2006;16: 60-66. Abstract
    Stegger L, Hoffmeier A-N, Schäfers KP, Hermann S, Schober O, Schäfers MA, Theilmeier G. Accurate noninvasive measurement of infarct size in mice with high-resolution PET. J Nucl Med 2006;47: 1837-1844. Abstract

    2005

    Stegger L, Schäfers KP, Flogel U, Livieratos L, Hermann S, Jacoby C, Keul P, Conway EM, Schober O, Schrader J, Levkau B, Schäfers M. Monitoring left ventricular dilation in mice with PET. J.Nucl.Med. 2005;46: 1516-1521.

    2004

    Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG. Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation 2004;110: 3017-3022. Abstract
    Schäfers M, Riemann B, Kopka K, Breyholz HJ, Wagner S, Schäfers KP, Law MP, Schober O, Levkau B. Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo. Circulation 2004;109: 2554-2559. Abstract

    2002

    Wichter T, Matheja P, Eckardt L, Kies P, Schäfers KP, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M. Cardiac autonomic dysfunction in Brugada syndrome. Circulation 2002;105: 702-706. Abstract
  • Patente

    Hayes C, Ladebeck R, Schäfers K. Method for motion correction of emission computed tomography data by way of magnetic resonance tomography data. US-20140357980; publication date: 04/12/2014.