Participation in “Cells in Motion”

  • Member of the Research and Careers Committee
  • Management Board member of the CiM-IMPRS Graduate Programme
  • Project FF-2016-11: Effects of newly generated, peripherally-selective, anti-inflammatory kappa-opioid receptor agonists in the treatment of progressive CNS inflammation and neurodegeneration (Karin Loser, Bernhard Wünsch, Sonja Ständer, project time: 07/2016 - 10/2018)
  • Project FF-2014-03: In vivo intratumoral accumulation of cytotoxic drugs by tumor vascular infarction with retargeted tissue factor tTF-NGR (Wolfgang Berdel, Carsten Höltke, Stefan Wagner, Bernhard Wünsch, project time: 04/2014 - 03/2015)
© CiM - Peter Grewer

“Sigma receptors are pretty unusual!” – an interview

Prof Bernhard Wünsch is passionate about medicinal chemistry. He is investigating novel receptor ligands. Furthermore, he aims to support junior researchers. His happiest moment as a scientist was the appointment of one of his habilitands to get a professorship.

  • Papers in the research focus “cell dynamics and imaging”

    2019

    Tangherlini G, Kalinin DV, Schepmann D, Che T, Mykicki N, Stander S, Loser K, Wunsch B. Development of Novel Quinoxaline-Based kappa-Opioid Receptor Agonists for the Treatment of Neuroinflammation. J Med Chem 2019;62: 893-907. Abstract

    2018

    Butsch V, Borgel F, Galla F, Schwegmann K, Hermann S, Schafers M, Riemann B, Wunsch B, Wagner S. Design, (Radio)Synthesis, and in Vitro and in Vivo Evaluation of Highly Selective and Potent Matrix Metalloproteinase 12 (MMP-12) Inhibitors as Radiotracers for Positron Emission Tomography. J Med Chem 2018;61: 4115-4134. Abstract

    2017

    Ortmeyer CP, Haufe G, Schwegmann K, Hermann S, Schafers M, Borgel F, Wunsch B, Wagner S, Hugenberg V. Synthesis and evaluation of a [18F]BODIPY-labeled caspase-inhibitor. Bioorg Med Chem 2017;25: 2167-2176. Abstract

    2016

    Hugenberg V, Hermann S, Galla F, Schafers M, Wunsch B, Kolb HC, Szardenings K, Lebedev A, Walsh JC, Mocharla VP, Gangadharmath UB, Kopka K, Wagner S. Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability. Nucl Med Biol 2016;43: 424-437. Abstract
    Stucke-Ring J, Ronnacker J, Brand C, Holtke C, Schliemann C, Kessler T, Schmidt LH, Harrach S, Mantke V, Hintelmann H, Hartmann W, Wardelmann E, Lenz G, Wunsch B, Muller-Tidow C, Mesters RM, Schwoppe C, Berdel WE. Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction. Oncotarget 2016;7: 82458-82472. Abstract
    Weber F, Brune S, Borgel F, Lange C, Korpis K, Bednarski PJ, Laurini E, Fermeglia M, Pricl S, Schepmann D, Wunsch B. Rigidity versus Flexibility: Is This an Issue in sigma1 Receptor Ligand Affinity and Activity?. J Med Chem 2016;59: 5505-5519. Abstract
    Wiese C, Grosse Maestrup E, Galla F, Schepmann D, Hiller A, Fischer S, Ludwig F-A, Deuther-Conrad W, Donat CK, Brust P, Buter L, Karst U, Wunsch B. Comparison of in Silico, Electrochemical, in Vitro and in Vivo Metabolism of a Homologous Series of (Radio)fluorinated σ1 Receptor Ligands Designed for Positron Emission Tomography. ChemMedChem 2016;11: 2445–2458. Abstract

    2015

    Junker A, Kokornaczyk AK, Zweemer AJM, Frehland B, Schepmann D, Yamaguchi J, Itami K, Faust A, Hermann S, Wagner S, Schafers M, Koch M, Weiss C, Heitman LH, Kopka K, Wunsch B. Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists. Org Biomol Chem 2015;13: 2407-2422. Abstract
    Quick MP, Frohlich R, Schepmann D, Wunsch B. Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines. Org Biomol Chem 2015;13: 7265-7281. Abstract
    Strunz AK, Zweemer AJM, Weiss C, Schepmann D, Junker A, Heitman LH, Koch M, Wunsch B. Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2). Bioorg Med Chem 2015;23: 4034-4049. Abstract

    2014

    Bourgeois C, Werfel E, Galla F, Lehmkuhl K, Torres-Gomez H, Schepmann D, Kogel B, Christoph T, Strassburger W, Englberger W, Soeberdt M, Huwel S, Galla H-J, Wunsch B. Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted kappa-opioid receptor agonists. J Med Chem 2014;57: 6845-6860. Abstract
    Brust P, Deuther-Conrad W, Lehmkuhl K, Jia H, Wunsch B. Molecular imaging of sigma1 receptors in vivo: current status and perspectives. Curr Med Chem 2014;21: 35-69. Abstract
    Gawaskar S, Schepmann D, Bonifazi A, Wunsch B. Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines. Bioorg Med Chem 2014;22: 6638-6646. Abstract
    Hasebein P, Frehland B, Lehmkuhl K, Frohlich R, Schepmann D, Wunsch B. Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the alpha-substituted benzyl moiety in the 5-position. Org Biomol Chem 2014;12: 5407-5426. Abstract
    Hasebein P, Frehland B, Schepmann D, Wunsch B. Synthesis, sigma receptor affinity, and pharmacological evaluation of 5-phenylsulfanyl- and 5-benzyl-substituted tetrahydro-2-benzazepines. ChemMedChem 2014;9: 1697-1703. Abstract
    Holl K, Schepmann D, Fischer S, Ludwig F-A, Hiller A, Donat CK, Deuther-Conrad W, Brust P, Wunsch B. Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of sigma1 Receptors in the Brain. Pharmaceuticals (Basel) 2014;7: 78-112. Abstract
    Holla K, Schepmann D, Daniliuc CG, Wünsch B. Sharpless asymmetric dihydroxylation as the key step in the enantioselective synthesis of spirocyclic σ1 receptor ligands. Tetrahedron Asymmetry 2014;25: 268–277. Abstract
    Junker A, Kokornaczyk AK, Strunz AK, Wünsch B. Selective and Dual Targeting of CCR2 and CCR5 Receptors: A Current Overview. Chemokines 2014: 1-55. Abstract
    Junker A, Schepmann D, Yamaguchi J, Itami K, Faust A, Kopka K, Wagner S, Wünsch B. Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling. Org Biomol Chem 2014;12: 177-186. Abstract
    Miyata K, Moller G, Schepmann D, Wunsch B. Pyridine analogues of spirocyclic sigma(1) receptor ligands. Bioorg Med Chem 2014;22: 4277-4284. Abstract
    Miyata K, Schepmann D, Wunsch B. Synthesis and sigma receptor affinity of regioisomeric spirocyclic furopyridines. Eur J Med Chem 2014;83: 709-716. Abstract
    Schulte A, Saito S, Wünsch B. Stereoselective Synthesis of_cis_,_cis_-Configured Vicinal Triamines: Stereoselective Synthesis of_cis_,_cis_-Configured Vicinal Triamines. Eur J Org Chem 2014;2014: 5749-5756. Abstract
    Weber F, Brune S, Korpis K, Bednarski PJ, Laurini E, Dal Col V, Pricl S, Schepmann D, Wunsch B. Synthesis, pharmacological evaluation, and sigma1 receptor interaction analysis of hydroxyethyl substituted piperazines. J Med Chem 2014;57: 2884-2894. Abstract

    2013

    Brune S, Pricl S, Wunsch B. Structure of the sigma1 receptor and its ligand binding site. J Med Chem 2013;56: 9809-9819. Abstract
    Harel D, Schepmann D, Prinz H, Brun R, Schmidt TJ, Wunsch B. Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives. J Med Chem 2013;56: 7442-7448. Abstract
    Holl K, Falck E, Kohler J, Schepmann D, Humpf H-U, Brust P, Wunsch B. Synthesis, characterization, and metabolism studies of fluspidine enantiomers. ChemMedChem 2013;8: 2047-2056. Abstract
    Junker A, Yamaguchi J, Itami K, Wunsch B. Synthesis of thiophene-based TAK-779 analogues by C-H arylation. J Org Chem 2013;78: 5579-5586. Abstract
    Lueg C, Schepmann D, Gunther R, Brust P, Wunsch B. Development of fluorinated CB(2) receptor agonists for PET studies. Bioorg Med Chem 2013;21: 7481-7498. Abstract