• Participation in “Cells in Motion”

    • Research interests: calcium and pH signaling, ion transport in neutrophil chemotaxis and cancer progression
    • Supervisor in the CiM-IMPRS Graduate Programme

  • Papers in the research focus “cell dynamics and imaging”

    2023

    Thale I, Maskri S, Grey L, Todesca LM, Budde T, Maisuls I, Strassert CA, Koch O, Schwab A, Wunsch B. Imaging of K(Ca) 31 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes. ChemMedChem 2023;18: e202200551. Abstract

    2021

    Brömmel K, Konken CP, Börgel F, Obeng-Darko H, Schelhaas S, Bulk E, Budde T, Schwab A, Schäfers M, Wünsch B. Synthesis and biological evaluation of PET tracers designed for imaging of calcium activated potassium channel 31 (K[sub:Ca]31) channels_in vivo_. RSC Adv. 2021;11: 30295-30304. Abstract

    2020

    Brömmel K, Maskri S, Maisuls I, Konken CP, Rieke M, Petho Z, Strassert CA, Koch O, Schwab A, Wunsch B. Synthesis of Small-Molecule Fluorescent Probes for the In Vitro Imaging of Calcium-Activated Potassium Channel KCa 31. Angew Chem Int Ed Engl 2020;59: 8277-8284. Abstract
    Lindemann O, Rossaint J, Najder K, Schimmelpfennig S, Hofschroer V, Walte M, Fels B, Oberleithner H, Zarbock A, Schwab A. Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels. J Mol Med (Berl) 2020;98: 349-360. Abstract

    2019

    Koch A, Schwab A. Cutaneous pH landscape as a facilitator of melanoma initiation and progression. Acta Physiol (Oxf) 2019;225: e13105. Abstract
    Manoli S, Coppola S, Duranti C, Lulli M, Magni L, Kuppalu N, Nielsen N, Schmidt T, Schwab A, Becchetti A, Arcangeli A. The Activity of Kv 111 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel) 2019;11: 135. Abstract
    Petho Z, Najder K, Bulk E, Schwab A. Mechanosensitive ion channels push cancer progression. Cell Calcium 2019;80: 79-90. Abstract

    2018

    Fels B, Bulk E, Petho Z, Schwab A. The Role of TRP Channels in the Metastatic Cascade. Pharmaceuticals (Basel) 2018;11Abstract
    Gromnitza S, Lepa C, Weide T, Schwab A, Pavenstadt H, George B. Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation. Faseb J 2018;32: 1665-1676. Abstract
    Najder K, Musset B, Lindemann O, Bulk E, Schwab A, Fels B. The function of TRP channels in neutrophil granulocytes. Pflugers Arch 2018;470: 1017-1033. Abstract
    Olschewski DN, Hofschroer V, Nielsen N, Seidler DG, Schwab A, Stock C. The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior. Cell Physiol Biochem 2018;45: 2560-2576. Abstract

    2017

    Bulk E, Kramko N, Liashkovich I, Glaser F, Schillers H, Schnittler H-J, Oberleithner H, Schwab A. KCa31 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells. Oncotarget 2017;8: 112268-112282. Abstract
    Hofschroer V, Koch KA, Ludwig FT, Friedl P, Oberleithner H, Stock C, Schwab A. Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells. Sci Rep 2017;7: 42369. Abstract
    Nielsen N, Kondratska K, Ruck T, Hild B, Kovalenko I, Schimmelpfennig S, Welzig J, Sargin S, Lindemann O, Christian S, Meuth SG, Prevarskaya N, Schwab A. TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia. Pflugers Arch 2017;469: 1567-1577. Abstract
    Pedersen SF, Novak I, Alves F, Schwab A, Pardo LA. Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer. Bioessays 2017;39Abstract
    Storck H, Hild B, Schimmelpfennig S, Sargin S, Nielsen N, Zaccagnino A, Budde T, Novak I, Kalthoff H, Schwab A. Ion channels in control of pancreatic stellate cell migration. Oncotarget 2017;8: 769-784. Abstract

    2016

    Bzymek R, Horsthemke M, Isfort K, Mohr S, Tjaden K, Muller-Tidow C, Thomann M, Schwerdtle T, Bahler M, Schwab A, Hanley PJ. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep 2016;6: 25016. Abstract

    2015

    Bulk E, Ay A-S, Hammadi M, Ouadid-Ahidouch H, Schelhaas S, Hascher A, Rohde C, Thoennissen NH, Wiewrodt R, Schmidt E, Marra A, Hillejan L, Jacobs AH, Klein H-U, Dugas M, Berdel WE, Muller-Tidow C, Schwab A. Epigenetic dysregulation of KCa 31 channels induces poor prognosis in lung cancer. Int J Cancer 2015;137: 1306-1317. Abstract
    Lindemann O, Strodthoff C, Horstmann M, Nielsen N, Jung F, Schimmelpfennig S, Heitzmann M, Schwab A. TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes. Biochim Biophys Acta 2015;1853: 2122-2130. Abstract

    2014

    Nielsen N, Lindemann O, Schwab A. TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol 2014;171: 5524-5540. Abstract
    Schwab A, Stock C. Ion channels and transporters in tumour cell migration and invasion. Philos Trans R Soc Lond B Biol Sci 2014;369: 20130102. Abstract

    2013

    Christensen ST, Veland IR, Schwab A, Cammer M, Satir P. Analysis of primary cilia in directional cell migration in fibroblasts. Methods Enzymol 2013;525: 45-58. Abstract
    Clement DL, Mally S, Stock C, Lethan M, Satir P, Schwab A, Pedersen SF, Christensen ST. PDGFRalpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways. J Cell Sci 2013;126: 953-965. Abstract
    Lindemann O, Umlauf D, Frank S, Schimmelpfennig S, Bertrand J, Pap T, Hanley PJ, Fabian A, Dietrich A, Schwab A. TRPC6 Regulates CXCR2-Mediated Chemotaxis of Murine Neutrophils. J Immunol 2013;190: 5496-5505. Abstract
    Ludwig FT, Schwab A, Stock C. The Na+ /H+ -exchanger (NHE1) generates pH nanodomains at focal adhesions. J Cell Physiol 2013;228: 1351-1358. Abstract
    Stock C, Ludwig FT, Hanley PJ, Schwab A. Roles of ion transport in control of cell motility. Compr Physiol 2013;3: 59-119. Abstract
    Veland IR, Montjean R, Eley L, Pedersen LB, Schwab A, Goodship J, Kristiansen K, Pedersen SF, Saunier S, Christensen ST. Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. PLoS One 2013;8: e60193. Abstract

    2012

    Bulk E, Yu J, Hascher A, Koschmieder S, Wiewrodt R, Krug U, Timmermann B, Marra A, Hillejan L, Wiebe K, Berdel WE, Schwab A, Muller-Tidow C. Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer. PLoS One 2012;7: e44591. Abstract
    Haanes KA, Schwab A, Novak I. The P2X7 receptor supports both life and death in fibrogenic pancreatic stellate cells. PLoS One 2012;7: e51164. Abstract