Participation in the Cluster of Excellence

CiM Principal Investigator
Educational Steering Committee Member
CiM-IMPRS Graduate School Member

  • Research Area A.4: Cell Programming and Mobility of Bone Marrow-Derived Cells
  • Research Area B.4: The Epidermal Barrier in the Inflammatory Response of the Skin
  • Research Area C.3: Bone Marrow-Derived Cells in Atherosclerosis
  • Project FF-2017-17 – Combining myeloid precursor immortalization, genome editing and genetic reporter systems for imaging of monocyte trafficking in inflammation and ischemia (Johannes Roth, Michael Schäfers; project time: 11/2017 - 12/2018)
  • Project FF-2013-24: Monitoring molecular mechanisms of monocyte migration during inflammatory processes in vivo (Michael Schäfers, Johannes Roth, project time: 07/2013 - 06/2015)

“We do research to benefit patients”

Prof. Johannes Roth is investigating the causes of inflammatory reactions at the Cells-in-Motion Cluster of Excellence. For many years he worked as a basic researcher and a paediatrician at the same time. His greatest aim is to discover basic mechanisms which can lead to diagnostic or therapeutic processes. Read the interview

CiM Papers


Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schafers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for improved in vivo Stability in Tracer Design. ChemMedChem 2017: epub. Abstract
Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schoning J, Schreek S, Pfeifer S, Reuner F, Vollger L, Stanulla M, von Kockritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D. S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol 2017;18: 622-632. Abstract
Voeller T, Faust A, Roth J, Schafers M, Vogl T, Hermann S. A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo. Mol Imaging Biol 2017: epub. Abstract


Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck A-K, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion. Acta Neuropathol 2016;132: 413-431. Abstract
Wales P, Schuberth CE, Aufschnaiter R, Fels J, Garcia-Aguilar I, Janning A, Dlugos CP, Schafer-Herte M, Klingner C, Walte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstadt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Soldner R. Calcium-mediated actin reset (CaAR) mediates acute cell adaptations. Elife 2016;5: e19850. Abstract


Choi IY, Gerlag DM, Herenius MJ, Thurlings RM, Wijbrandts CA, Foell D, Vogl T, Roth J, Tak PP, Holzinger D. MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Ann Rheum Dis 2015;74: 499-505. Abstract
Faust A, Voller T, Busch F, Schafers M, Roth J, Hermann S, Vogl T. Development and evaluation of a non-peptidic ligand for the molecular imaging of inflammatory processes using S100A9 (MRP14) as a novel target. Chem Commun (Camb) 2015;51: 15637-15640. Abstract


Borgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S. Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem 2014;289: 13-27. Abstract
Vogl T, Eisenblatter M, Voller T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schafers M, Bremer C, Roth J. Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 2014;5: 4593. Abstract


Achouiti A, Foll D, Vogl T, van Till JWO, Laterre P-F, Dugernier T, Wittebole X, Boermeester MA, Roth J, van der Poll T, van Zoelen MAD. S100A12 and soluble receptor for advanced glycation end products levels during human severe sepsis. Shock 2013;40: 188-194. Abstract
Foell D, Wittkowski H, Kessel C, Luken A, Weinhage T, Varga G, Vogl T, Wirth T, Viemann D, Bjork P, van Zoelen MAD, Gohar F, Srikrishna G, Kraft M, Roth J. Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4. Am J Respir Crit Care Med 2013;187: 1324-1334. Abstract
Friesenhagen J, Viemann D, Borgeling Y, Schmolke M, Spiekermann C, Kirschnek S, Ludwig S, Roth J. Highly Pathogenic Influenza Viruses Inhibit Inflammatory Response in Monocytes via Activation of Rar-Related Orphan Receptor RORalpha. J Innate Immun 2013;5: 505-518. Abstract
Hildebrand DG, Alexander E, Hörber S, Lehle SPD, Obermayer K, Münck N-A, Rothfuss O, Frick J-S, Schmitz I, Roth J, Ehrchen JM, Essmann F, Schulze-Osthoff K. IkBz Is a Transcriptional Key Regulator of CCL2/MCP-1. J Immunol 2013;190: 4812-4820. Abstract
Petersen B, Wolf M, Austermann J, van Lent P, Föll D, Ahlmann M, Kupas V, Loser K, Sorg C, Roth J, Vogl T. The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J 2013;32: 100-111. Abstract
Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PLEM, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. Doxycycline-induced expression of transgenic human tumor necrosis factor alpha in adult mice results in psoriasis-like arthritis. Arthritis Rheum 2013;65: 2290-2300. Abstract