© WWU - Peter Grewer
Univ.-Prof. Dr. rer. nat. Christian Klämbt
Institute for Neuro- and Behavioural Biology
Klämbt Lab
Tel: +49 251 83-21122

”My job isn’t ‘work’ – it’s my life!“ – an interview with Christian Klämbt

Prof Christian Klämbt is a scientist heart and soul. He studies glial cells, one of the main components of the brain. His overriding aim is to understand how the brain and all its wonders work. But he also knows that this is an aim that cannot be reached easily.

  • Participation in “Cells in Motion”

    • Member of the Research and Careers Committee
    • Supervisor in the CiM-IMPRS Graduate Programme
    • Member of the Imaging Network – Microscopy
    • Research interests: Drosophila glial cell development and function, receptor tyrosine kinase signalling and differentiation, neuron-glial interaction, larval locomotion, blood brain barrier
    • Projekt FF-2016-06: FIM4D: Automated FIM-based in-vial activity monitoring and tracking for locomotion analysis of Drosophila larvae (Xiaoyi Jiang, Christian Klämbt, project time: 07/2016 - 10/2018)
    • Project FF-2014-12: Metabolic crosstalk across the blood brain barrier (Christian Klämbt, Matthias Letzel, Stefanie Limmer, 07/2014 - 06/2016)

  • Patents in the research focus “cell dynamics and imaging”

    • Jiang X, Klämbt C, Risse B, Valkov D. Verfahren und Vorrichtung zur Erfassung wenigsten eines Tieres. DE 102012016122; 20/02/2014.
  • Papers in the research focus “cell dynamics and imaging”

    all papers by Christian Klämbt (PubMed)


    Berh D, Scherzinger A, Otto N, Jiang X, Klambt C, Risse B. Automatic non-invasive heartbeat quantification of Drosophila pupae. Comput Biol Med 2018;93: 189-199. Abstract
    Otto N, Marelja Z, Schoofs A, Kranenburg H, Bittern J, Yildirim K, Berh D, Bethke M, Thomas S, Rode S, Risse B, Jiang X, Pankratz M, Leimkuhler S, Klambt C. The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Nat Commun 2018;9: 3514. Abstract
    Schuermann S, Steffes G, Manikowski D, Kastl P, Malkus U, Bandari S, Ohlig S, Ortmann C, Rebollido-Rios R, Otto M, Nusse H, Hoffmann D, Klambt C, Galic M, Klingauf J, Grobe K. Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing. Elife 2018;7: e33033. Abstract


    Almeida-Carvalho MJ, Berh D, Braun A, Chen Y-C, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiang X, Kleber J, Klambt C, Konig C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Randel N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A, Zlatic M. The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae. J Exp Biol 2017;220: 2452-2475. Abstract
    Berh D, Risse B, Michels T, Otto N, Jiang X, Klambt C. An FIM-Based Long-Term In-Vial Monitoring System for Drosophila Larvae. IEEE Trans. Biomed. Eng. 2017;64: 1862-1874. Abstract
    Risse B, Berh D, Otto N, Klambt C, Jiang X. FIMTrack: An open source tracking and locomotion analysis software for small animals. PLoS Comput Biol 2017;13: e1005530. Abstract
    Risse B, Otto N, Berh D, Jiang X, Kiel M, Klambt C. FIM2c : A Multi-Colour, Multi-Purpose Imaging System to Manipulate and Analyse Animal Behaviour. IEEE Trans Biomed Eng 2017;64: 610-620. Abstract


    Otto N, Risse B, Berh D, Bittern J, Jiang X, Klambt C. Interactions among Drosophila larvae before and during collision. Sci Rep 2016;6: 31564. Abstract
    Sasse S, Klambt C. Repulsive Epithelial Cues Direct Glial Migration along the Nerve. Dev Cell 2016;39: 696-707. Abstract


    Goudarzi M, Mildner K, Babatz F, Riedel D, Klambt C, Zeuschner D, Raz E. Correlative Light and Electron Microscopy of Rare Cell Populations in Zebrafish Embryos Using Laser Marks. Zebrafish 2015;12: 470-473. Abstract
    Risse B, Berh D, Otto N, Jiang X, Klambt C. Quantifying subtle locomotion phenotypes of Drosophila larvae using internal structures based on FIM images. Comput Biol Med 2015;63: 269-276. Abstract
    Schirmeier S, Klambt C. The Drosophila blood-brain barrier as interface between neurons and hemolymph. Mech Dev 2015;138 Pt 1: 50-55. Abstract
    Volkenhoff A, Weiler A, Letzel M, Stehling M, Klambt C, Schirmeier S. Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. Cell Metab 2015;22: 437-447. Abstract


    Kim SN, Jeibmann A, Halama K, Witte HT, Walte M, Matzat T, Schillers H, Faber C, Senner V, Paulus W, Klambt C. ECM stiffness regulates glial migration in Drosophila and mammalian glioma models. Development 2014;141: 3233-3242. Abstract
    Lammel U, Bechtold M, Risse B, Berh D, Fleige A, Bunse I, Jiang X, Klambt C, Bogdan S. The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response. Development 2014;141: 1366-1380. Abstract
    Risse B, Otto N, Berh D, Jiang X, Klambt C. FIM imaging and FIMtrack: two new tools allowing high-throughput and cost effective locomotion analysis. J Vis Exp 2014: e52207. Abstract


    Risse B, Thomas S, Otto N, Lopmeier T, Valkov D, Jiang X, Klambt C. FIM, a novel FTIR-based imaging method for high throughput locomotion analysis. PLoS One 2013;8: e53963. Abstract