Beteiligung an „Cells in Motion“

  • Mitglied im Graduiertenprogramm CiM-IMPRS
  • Forschungsinteressen: virology, molecular cell biology, virus-host cell interaction, intracellular signal transduction, innate immunity

© CiM - Peter Grewer

„Wissenschaft ist kein Selbstzweck“ – ein Interview

Prof. Stephan Ludwig erforscht, wie Viren in eine Zelle gelangen, sich vermehren und dadurch ganze Organismen krank machen. Sein Wunsch ist es, dass sich aus seinen grundlegenden Ergebnissen eines Tages neue Therapien gegen Viruserkrankungen entwickeln lassen.

  • Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“

    alle Publikationen von Stephan Ludwig

    2018

    Masemann D, Köther K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S. Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages. OncoImmunology 2018: e1423171. Abstract
    Schräder T, Dudek SE, Schreiber A, Ehrhardt C, Planz O, Ludwig S. The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression. Antiviral Res 2018;157: 80-92. Abstract
    Vogl T, Stratis A, Wixler V, Voller T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Frohling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schafers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, Konig S, Pap T, Roth J. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest 2018;128: 1852-1866. Abstract

    2017

    Klemm C, Bruchhagen C, van Kruchten A, Niemann S, Loffler B, Peters G, Ludwig S, Ehrhardt C. Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection. Sci Rep 2017;7: 42473. Abstract
    Nacken W, Wixler V, Ehrhardt C, Ludwig S. Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked. Cell Microbiol 2017;19: e12721. Abstract

    2016

    Dudek SE, Nitzsche K, Ludwig S, Ehrhardt C. Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. Sci Rep 2016;6: 27275. Abstract

    2015

    Boergeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, Ludwig S. Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. PLoS Pathog 2015;11: e1004924. Abstract
    Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Duran FJ, Caro MSB, Rapp UR, Wixler V, Schenkel EP, Simoes CMO, Ludwig S. In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PLoS One 2015;10: e0117794. Abstract

    2014

    Borgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S. Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem 2014;289: 13-27. Abstract
    Liedmann S, Hrincius ER, Anhlan D, McCullers JA, Ludwig S, Ehrhardt C. New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant. J Infect Dis 2014;209: 532-541. Abstract
    Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green DR, Wolff T, McCullers JA, Ludwig S, Ehrhardt C. Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nat Commun 2014;5: 5645. Abstract
    Nacken W, Anhlan D, Hrincius ER, Mostafa A, Wolff T, Sadewasser A, Pleschka S, Ehrhardt C, Ludwig S. Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1. J Virol 2014;88: 8843-8852. Abstract

    2013

    Friesenhagen J, Viemann D, Borgeling Y, Schmolke M, Spiekermann C, Kirschnek S, Ludwig S, Roth J. Highly Pathogenic Influenza Viruses Inhibit Inflammatory Response in Monocytes via Activation of Rar-Related Orphan Receptor RORalpha. J Innate Immun 2013;5: 505-518. Abstract
    Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest 2013;123: 206-214. Abstract
    Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U. Annexin A6-balanced late endosomal cholesterol controls influenza a replication and propagation. MBio 2013;4: e00608-13. Abstract
    Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PLEM, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. Doxycycline-induced expression of transgenic human tumor necrosis factor alpha in adult mice results in psoriasis-like arthritis. Arthritis Rheum 2013;65: 2290-2300. Abstract