Prof. Dr. Christos Gatsogiannis

• 2024
• 2023
• 2022
• 2021
• 2020
• 2019
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2010
• 2009
• 2007

2024

• Klink BU; Alavizargar A; Kalyankumar KS; Chen M; Heuer A; Gatsogiannis C. 2024. ‘Structural basis of α-latrotoxin transition to a cation-selective pore.’ Nature Communications 15, Nr. 1: 8551. doi: 10.1038/s41467-024-52635-5.
• Bohnert M; Gatsogiannis C; Herrmann JM. 2024. ‘The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria.’ Trends in Cell Biology 34, Nr. 9: 698–699. doi: 10.1016/j.tcb.2024.07.007.
• Dodd DO; Mechaussier S; Yeyati PL; McPhie F; Anderson JR; Khoo CJ; Shoemark A; Gupta DK; Attard T; Zariwala MA; Legendre M; Bracht D; Wallmeier J; Gui M; Fassad MR; Parry DA; Tennant PA; Meynert A; Wheway G; Fares-Taie L; Black HA; Mitri-Frangieh R; Faucon C; Kaplan J; Patel M; McKie L; Megaw R; Gatsogiannis C; Mohamed MA; Aitken S; Gautier P; Reinholt FR; Hirst RA; O'Callaghan C; Heimdal K; Bottier M; Escudier E; Crowley S; Descartes M; Jabs EW; Kenia P; Amiel J; Bacci GM; Calogero C; Palazzo V; Tiberi L; Blümlein U; Rogers A; Wambach JA; Wegner DJ; Fulton AB; Kenna M; Rosenfeld M; Holm IA; Quigley A; Hall EA; Murphy LC; Cassidy DM; von Kriegsheim A; Scottish Genomes Partnership16; Genomics England Research Consortium45; Undiagnosed Diseases Network46; Papon JF; Pasquier L; Murris MS; Chalmers JD; Hogg C; Macleod KA; Urquhart DS; Unger S; Aitman TJ; Amselem S; Leigh MW; Knowles MR; Omran H; Mitchison HM; Brown A; Marsh JA; Welburn JPI; Ti SC; Horani A; Rozet JM; Perrault I; Mill P. 2024. ‘Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules.’ Science 384, Nr. 6694: eadf5489. doi: 10.1126/science.adf5489.

2023

• Gomes P.A.; Bodo C.; Nogueras-Ortiz C.; Samiotaki M.; Chen M.; Soares-Cunha C.; Silva J.M.; Coimbra B.; Stamatakis G.; Santos L.; Panayotou G.; Tzouanou F.; Waites C.L.; Gatsogiannis C.; Sousa N.; Kapogiannis D.; Costa-Silva B.; Sotiropoulos I. 2023. ‘A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology.’ Cell Communication and Signaling 21, Nr. 1. doi: 10.1186/s12964-023-01045-z.
• Bürgi J.; Lill P.; Giannopoulou E.A.; Jeffries C.M.; Chojnowski G.; Raunser S.; Gatsogiannis C.; Wilmanns M. 2023. ‘Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase.’ Biological Chemistry 404: 195–207. doi: 10.1515/hsz-2022-0273.
• Borsdorf L.; Herkert L.; Bäumer N.; Rubert L.; Soberats B.; Korevaar P.A.; Bourque C.; Gatsogiannis C.; Fernández G. 2023. ‘Pathway-Controlled Aqueous Supramolecular Polymerization via Solvent-Dependent Chain Conformation Effects.’ Journal of the American Chemical Society 145, Nr. 16: 8882–8895. doi: 10.1021/jacs.2c12442.
• Rüttermann M.; Koci M.; Lill P.; Geladas E.D.; Kaschani F.; Klink B.U.; Erdmann R.; Gatsogiannis C. 2023. ‘Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.’ Nature Communications 14, Nr. 1. doi: 10.1038/s41467-023-41640-9.

2022

• Bourque C; Klink BU; Gatsogiannis C. 2022. ‘An AI-assisted cryo-EM pipeline for structural studies of cellular extracts.’ Structure 30, Nr. 4: 532–534. doi: 10.1016/j.str.2022.03.016.
• Günther P; Quentin D; Ahmad S; Sachar K; Gatsogiannis C; Whitney JC; Raunser S. 2022. ‘Structure of a bacterial Rhs effector exported by the type VI secretion system.’ PLoS Pathogens 18, Nr. 1: e1010182. doi: 10.1371/journal.ppat.1010182.
• Klink BU; Herrmann E; Antoni C; Langemeyer L; Kiontke S; Gatsogiannis C; Ungermann C; Raunser S; Kümmel D. 2022. ‘Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.’ Proceedings of the National Academy of Sciences of the United States of America 119, Nr. 6. doi: 10.1073/pnas.2121494119.
• Rüttermann M; Gatsogiannis C. 2022. ‘Good things come to those who bait: the peroxisomal docking complex.’ Biological Chemistry 404(2-3): 107–119. doi: 10.1515/hsz-2022-0161.
• Skoneczny M; Francisco T; Erdmann R; Gatsogiannis C. 2022. ‘Editorial: Structural aspects of peroxisome biogenesis and functions.’ Frontiers in cell and developmental biology 10: 1114759. doi: 10.3389/fcell.2022.1114759.
• Wagner M; Blum D; Raschka SL; Nentwig L; Gertzen CGW; Chen M; Gatsogiannis C; Harris A; Smits SHJ; Wagner R; Schmitt L. 2022. ‘A New Twist in ABC Transporter Mediated Multidrug Resistance - Pdr5 is a Drug/proton Co-transporter.’ Journal of Molecular Biology 434, Nr. 14: 167669. doi: 10.1016/j.jmb.2022.167669.

2021

• Saha S, Chen YT, Ganta S, Gilles M, Holzapfel B, Lill P, Rehage H, Gatsogiannis C, Clever GH. 2021. ‘Coordination cage-based emulsifiers: templated formation of metal oxide microcapsules monitored by in situ LC-TEM.’ Chemistry 2021. doi: 10.1002/chem.202103406.
• Chen M, Blum D, Engelhard L, Raunser S, Wagner R, Gatsogiannis C. 2021. ‘Molecular architecture of black widow spider neurotoxins.’ Nature Communications 12, Nr. 1: 6956. doi: 10.1038/s41467-021-26562-8.
• Dudziak A, Engelhard L, Bourque C, Klink BU, Rombaut P, Kornakov N, Jänen K, Herzog F, Gatsogiannis C, Westermann S. 2021. ‘Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore.’ EMBO Journal 40, Nr. 18: e108004. doi: 10.15252/embj.2021108004.
• Kudruk S, Pottanam Chali S, Linard Matos AL, Bourque C, Dunker C, Gatsogiannis C, Ravoo BJ, Gerke V. 2021. ‘Biodegradable and Dual-Responsive Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo.’ Advanced Science 8: 2100694. doi: 10.1002/advs.202100694.

2020

• Lill P, Hansen T, Wendscheck D, Klink BU, Jeziorek T, Vismpas D, Miehling J, Bender J, Schummer A, Drepper F, Girzalsky W, Warscheid B, Erdmann R, Gatsogiannis C. 2020. ‘Towards the molecular architecture of the peroxisomal receptor docking complex.’ Proceedings of the National Academy of Sciences of the United States of America 2020. doi: 10.1073/pnas.2009502117.
• Klink BU, Gatsogiannis C, Hofnagel O, Wittinghofer A, Raunser S. 2020. ‘Structure of the human BBSome core complex.’ eLife 9. doi: 10.7554/eLife.53910.
• Stabrin M, Schoenfeld F, Wagner T, Pospich S, Gatsogiannis C, Raunser S. 2020. ‘TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM.’ Nature Communications 11, Nr. 1: 5716. doi: 10.1038/s41467-020-19513-2.
• Antoni C, Quentin D, Lang AE, Aktories K, Gatsogiannis C, Raunser S. 2020. ‘Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.’ PLoS Pathogens 16, Nr. 8: e1008530. doi: 10.1371/journal.ppat.1008530.

2019

• Wagner T, Merino F, Stabrin M, Moriya T, Antoni C, Apelbaum A, Hagel P, Sitsel O, Raisch T, Prumbaum D, Quentin D, Roderer D, Tacke S, Siebolds B, Schubert E, Shaikh TR, Lill P, Gatsogiannis C, Raunser S. 2019. ‘SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM.’ Communications biology 2: 218. doi: 10.1038/s42003-019-0437-z.
• Gatsogiannis C, Balogh D, Merino F, Sieber SA, Raunser S. 2019. ‘Cryo-EM structure of the ClpXP protein degradation machinery.’ Nature structural {&} molecular biology 26, Nr. 10: 946–954. doi: 10.1038/s41594-019-0304-0.
• Leidreiter F, Roderer D, Meusch D, Gatsogiannis C, Benz R, Raunser S. 2019. ‘Common architecture of Tc toxins from human and insect pathogenic bacteria.’ Science advances 5, Nr. 10: eaax6497. doi: 10.1126/sciadv.aax6497.
• Tanaka Y, Kato S, Stabrin M, Raunser S, Matsui T, Gatsogiannis C. 2019. ‘Cryo-EM reveals the asymmetric assembly of squid hemocyanin.’ IUCrJ 6, Nr. Pt 3: 426–437. doi: 10.1107/S205225251900321X.

2018

• Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S. 2018. ‘Electron cryo-microscopy structure of the canonical TRPC4 ion channel.’ eLife 7. doi: 10.7554/eLife.36615.
• Gatsogiannis C, Merino F, Roderer D, Balchin D, Schubert E, Kuhlee A, Hayer-Hartl M, Raunser S. 2018. ‘Tc toxin activation requires unfolding and refolding of a \textgreekb-propeller.’ Nature 563, Nr. 7730: 209–213. doi: 10.1038/s41586-018-0556-6.
• Kato S, Matsui T, Gatsogiannis C, Tanaka Y. 2018. ‘Molluscan hemocyanin: structure, evolution, and physiology.’ Biophysical Reviews 10, Nr. 2: 191–202. doi: 10.1007/s12551-017-0349-4.
• Pfeifer W, Lill P, Gatsogiannis C, Sacc{à} B. 2018. ‘Hierarchical Assembly of DNA Filaments with Designer Elastic Properties.’ ACS Nano 12, Nr. 1: 44–55. doi: 10.1021/acsnano.7b06012.
• Saha S, Holzapfel B, Chen Y, Terlinden K, Lill P, Gatsogiannis C, Rehage H, Clever GH. 2018. ‘Rational Design of an Amphiphilic Coordination Cage-Based Emulsifier.’ Journal of the American Chemical Society 140, Nr. 50: 17384–17388. doi: 10.1021/jacs.8b10991.

2017

• Chen M, Kato K, Kubo Y, Tanaka Y, Liu Y, Long F, Whitman WB, Lill P, Gatsogiannis C, Raunser S, Shimizu N, Shinoda A, Nakamura A, Tanaka I, Yao M. 2017. ‘Structural basis for tRNA-dependent cysteine biosynthesis.’ Nature Communications 8, Nr. 1: 1521. doi: 10.1038/s41467-017-01543-y.
• Efremov RG, Gatsogiannis C, Raunser S. 2017. ‘Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM.’ Methods in Enzymology 594: 1–30. doi: 10.1016/bs.mie.2017.05.007.
• Moriya T, Saur M, Stabrin M, Merino F, Voicu H, Huang Z, Penczek PA, Raunser S, Gatsogiannis C. 2017. ‘High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE.’ Journal of visualized experiments : JoVE 2017, Nr. 123. doi: 10.3791/55448.
• Sprengel A, Lill P, Stegemann P, Bravo-Rodriguez K, Schönewei{ß} E, Merdanovic M, Gudnason D, Aznauryan M, Gamrad L, Barcikowski S, Sanchez-Garcia E, Birkedal V, Gatsogiannis C, Ehrmann M, Sacc{à} B. 2017. ‘Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions.’ Nature Communications 8: 14472. doi: 10.1038/ncomms14472.

2016

• Gatsogiannis C, Merino F, Prumbaum D, Roderer D, Leidreiter F, Meusch D, Raunser S. 2016. ‘Membrane insertion of a Tc toxin in near-atomic detail.’ Nature structural {&} molecular biology 23, Nr. 10: 884–890. doi: 10.1038/nsmb.3281.

2015

• Gatsogiannis C, Hofnagel O, Markl J, Raunser S. 2015. ‘Structure of mega-hemocyanin reveals protein origami in snails.’ Structure (London, England : 1993) 23, Nr. 1: 93–103. doi: 10.1016/j.str.2014.10.013.
• Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. 2015. ‘Determinants of amyloid fibril degradation by the PDZ protease HTRA1.’ Nature Chemical Biology 11, Nr. 11: 862–869. doi: 10.1038/nchembio.1931.
• Raunser S, Gatsogiannis C. 2015. ‘Deciphering the tubulin code.’ Cell 161, Nr. 5: 960–961. doi: 10.1016/j.cell.2015.05.004.

2014

• Erkelenz M, Bauer DM, Meyer R, Gatsogiannis C, Raunser S, Sacc{à} B, Niemeyer CM. 2014. ‘A facile method for preparation of tailored scaffolds for DNA-origami.’ Small (Weinheim an der Bergstrasse, Germany) 10, Nr. 1: 73–77. doi: 10.1002/smll.201300701.
• Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O, Vetter IR, Aktories K, Raunser S. 2014. ‘Mechanism of Tc toxin action revealed in molecular detail.’ Nature 508, Nr. 7494: 61–65. doi: 10.1038/nature13015.

2013

• Gatsogiannis C, Lang AE, Meusch D, Pfaumann V, Hofnagel O, Benz R, Aktories K, Raunser S. 2013. ‘A syringe-like injection mechanism in Photorhabdus luminescens toxins.’ Nature 495, Nr. 7442: 520–523. doi: 10.1038/nature11987.
• Sadian Y, Gatsogiannis C, Patasi C, Hofnagel O, Goody RS, Farkasovský M, Raunser S. 2013. ‘The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation.’ eLife 2: e01085. doi: 10.7554/eLife.01085.

2012

• Bröcker C, Kuhlee A, Gatsogiannis C, Balderhaar HJk, Hönscher C, Engelbrecht-Vandré S, Ungermann C, Raunser S. 2012. ‘Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.’ Proceedings of the National Academy of Sciences of the United States of America 109, Nr. 6: 1991–1996. doi: 10.1073/pnas.1117797109.

2010

• Lieb B, Gebauer W, Gatsogiannis C, Depoix F, Hellmann N, Harasewych MG, Strong EE, Markl J. 2010. ‘Molluscan mega-hemocyanin: an ancient oxygen carrier tuned by a {\~{}}}550 kDa polypeptide.’ Frontiers in Zoology 7: 14. doi: 10.1186/1742-9994-7-14.

2009

• Gatsogiannis C, Markl J. 2009. ‘Keyhole limpet hemocyanin: 9-A CryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional units.’ Journal of Molecular Biology 385, Nr. 3: 963–983. doi: 10.1016/j.jmb.2008.10.080.

2007

• Gatsogiannis C, Moeller A, Depoix F, Meissner U, Markl J. 2007. ‘Nautilus pompilius hemocyanin: 9 A cryo-EM structure and molecular model reveal the subunit pathway and the interfaces between the 70 functional units.’ Journal of Molecular Biology 374, Nr. 2: 465–486. doi: 10.1016/j.jmb.2007.09.036.
• Meissner U, Gatsogiannis C, Moeller A, Depoix F, Harris JR, Markl J. 2007. ‘Comparative 11A structure of two molluscan hemocyanins from 3D cryo-electron microscopy.’ Micron 38, Nr. 7: 754–765. doi: 10.1016/j.micron.2006.11.005.