Prof. Dr. Christos Gatsogiannis

• 2024
• 2023
• 2022
• 2021
• 2020
• 2019
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2010
• 2009
• 2007

2024

• Klink, BU, Alavizargar, A, Kalyankumar, KS, Chen, M, Heuer, A, and Gatsogiannis, C. 2024. “Structural basis of α-latrotoxin transition to a cation-selective pore.” Nature Communications, № 15 (1): 8551–8551. doi: 10.1038/s41467-024-52635-5.
• Bohnert, M, Gatsogiannis, C, and Herrmann, JM. 2024. “The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria.” Trends in Cell Biology, № 34 (9): 698–699. doi: 10.1016/j.tcb.2024.07.007.
• DO, Dodd, S, Mechaussier, PL, Yeyati, F, McPhie, JR, Anderson, CJ, Khoo, A, Shoemark, DK, Gupta, T, Attard, MA, Zariwala, M, Legendre, D, Bracht, J, Wallmeier, M, Gui, MR, Fassad, DA, Parry, PA, Tennant, A, Meynert, G, Wheway, L, Fares-Taie, HA, Black, R, Mitri-Frangieh, C, Faucon, J, Kaplan, M, Patel, L, McKie, R, Megaw, C, Gatsogiannis, MA, Mohamed, S, Aitken, P, Gautier, FR, Reinholt, RA, Hirst, C, O'Callaghan, K, Heimdal, M, Bottier, E, Escudier, S, Crowley, M, Descartes, EW, Jabs, P, Kenia, J, Amiel, GM, Bacci, C, Calogero, V, Palazzo, L, Tiberi, U, Blümlein, A, Rogers, JA, Wambach, DJ, Wegner, AB, Fulton, M, Kenna, M, Rosenfeld, IA, Holm, A, Quigley, EA, Hall, LC, Murphy, DM, Cassidy, A, von Kriegsheim, Partnership16, Scottish Genomes, Consortium45, Genomics England Research, Network46, Undiagnosed Diseases, JF, Papon, L, Pasquier, MS, Murris, JD, Chalmers, C, Hogg, KA, Macleod, DS, Urquhart, S, Unger, TJ, Aitman, S, Amselem, MW, Leigh, MR, Knowles, H, Omran, HM, Mitchison, A, Brown, JA, Marsh, JPI, Welburn, SC, Ti, A, Horani, JM, Rozet, I, Perrault, and P, Mill. 2024. “Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules.” Science, № 384 (6694): eadf5489–eadf5489. doi: 10.1126/science.adf5489.

2023

• Gomes, P.A., Bodo, C., Nogueras-Ortiz, C., Samiotaki, M., Chen, M., Soares-Cunha, C., Silva, J.M., Coimbra, B., Stamatakis, G., Santos, L., Panayotou, G., Tzouanou, F., Waites, C.L., Gatsogiannis, C., Sousa, N., Kapogiannis, D., Costa-Silva, B., and Sotiropoulos, I. 2023. “A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology.” Cell Communication and Signaling, № 21 (1) doi: 10.1186/s12964-023-01045-z.
• Bürgi, J., Lill, P., Giannopoulou, E.A., Jeffries, C.M., Chojnowski, G., Raunser, S., Gatsogiannis, C., and Wilmanns, M. 2023. “Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase.” Biological Chemistry, № 404: 195–207. doi: 10.1515/hsz-2022-0273.
• Borsdorf, L., Herkert, L., Bäumer, N., Rubert, L., Soberats, B., Korevaar, P.A., Bourque, C., Gatsogiannis, C., and Fernández, G. 2023. “Pathway-Controlled Aqueous Supramolecular Polymerization via Solvent-Dependent Chain Conformation Effects.” Journal of the American Chemical Society, № 145 (16): 8882–8895. doi: 10.1021/jacs.2c12442.
• Rüttermann M.; Koci M.; Lill P.; Geladas E.D.; Kaschani F.; Klink B.U.; Erdmann R.; Gatsogiannis C.. 2023. “Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.” Nature Communications, № 14 (1) doi: 10.1038/s41467-023-41640-9.

2022

• Bourque, C, Klink, BU, and Gatsogiannis, C. 2022. “An AI-assisted cryo-EM pipeline for structural studies of cellular extracts.” Structure, № 30 (4): 532–534. doi: 10.1016/j.str.2022.03.016.
• Günther, P, Quentin, D, Ahmad, S, Sachar, K, Gatsogiannis, C, Whitney, JC, and Raunser, S. 2022. “Structure of a bacterial Rhs effector exported by the type VI secretion system.” PLoS Pathogens, № 18 (1): e1010182–e1010182. doi: 10.1371/journal.ppat.1010182.
• Klink, BU, Herrmann, E, Antoni, C, Langemeyer, L, Kiontke, S, Gatsogiannis, C, Ungermann, C, Raunser, S, and Kümmel, D. 2022. “Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.” Proceedings of the National Academy of Sciences of the United States of America, № 119 (6) doi: 10.1073/pnas.2121494119.
• Rüttermann, M, and Gatsogiannis, C. 2022. “Good things come to those who bait: the peroxisomal docking complex.” Biological Chemistry, № 404(2-3): 107–119. doi: 10.1515/hsz-2022-0161.
• Skoneczny, M, Francisco, T, Erdmann, R, and Gatsogiannis, C. 2022. “Editorial: Structural aspects of peroxisome biogenesis and functions.” Frontiers in cell and developmental biology, № 10: 1114759–1114759. doi: 10.3389/fcell.2022.1114759.
• Wagner, M, Blum, D, Raschka, SL, Nentwig, L, Gertzen, CGW, Chen, M, Gatsogiannis, C, Harris, A, Smits, SHJ, Wagner, R, and Schmitt, L. 2022. “A New Twist in ABC Transporter Mediated Multidrug Resistance - Pdr5 is a Drug/proton Co-transporter.” Journal of Molecular Biology, № 434 (14): 167669–167669. doi: 10.1016/j.jmb.2022.167669.

2021

• Saha, S, Chen, YT, Ganta, S, Gilles, M, Holzapfel, B, Lill, P, Rehage, H, Gatsogiannis, C, and Clever, GH. 2021. “Coordination cage-based emulsifiers: templated formation of metal oxide microcapsules monitored by in situ LC-TEM.” Chemistry - A European Journal, № 2021 doi: 10.1002/chem.202103406.
• Chen, M, Blum, D, Engelhard, L, Raunser, S, Wagner, R, and Gatsogiannis, C. 2021. “Molecular architecture of black widow spider neurotoxins.” Nature Communications, № 12 (1): 6956. doi: 10.1038/s41467-021-26562-8.
• Dudziak, A, Engelhard, L, Bourque, C, Klink, BU, Rombaut, P, Kornakov, N, Jänen, K, Herzog, F, Gatsogiannis, C, and Westermann, S. 2021. “Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore.” The EMBO Journal, № 40 (18): e108004. doi: 10.15252/embj.2021108004.
• Kudruk, S, Pottanam, Chali S, Linard, Matos AL, Bourque, C, Dunker, C, Gatsogiannis, C, Ravoo, BJ, and Gerke, V. 2021. “Biodegradable and Dual-Responsive Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo.” Advanced Science, № 8: 2100694. doi: 10.1002/advs.202100694.

2020

• Lill, P, Hansen, T, Wendscheck, D, Klink, BU, Jeziorek, T, Vismpas, D, Miehling, J, Bender, J, Schummer, A, Drepper, F, Girzalsky, W, Warscheid, B, Erdmann, R, and Gatsogiannis, C. 2020. “Towards the molecular architecture of the peroxisomal receptor docking complex.” Proceedings of the National Academy of Sciences of the United States of America, № 2020 doi: 10.1073/pnas.2009502117.
• Klink, BU, Gatsogiannis, C, Hofnagel, O, Wittinghofer, A, and Raunser, S. 2020. “Structure of the human BBSome core complex.” eLife, № 9 doi: 10.7554/eLife.53910.
• Stabrin, M, Schoenfeld, F, Wagner, T, Pospich, S, Gatsogiannis, C, and Raunser, S. 2020. “TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM.” Nature Communications, № 11 (1): 5716. doi: 10.1038/s41467-020-19513-2.
• Antoni, C, Quentin, D, Lang, AE, Aktories, K, Gatsogiannis, C, and Raunser, S. 2020. “Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.” PLoS Pathogens, № 16 (8): e1008530. doi: 10.1371/journal.ppat.1008530.

2019

• Wagner, T, Merino, F, Stabrin, M, Moriya, T, Antoni, C, Apelbaum, A, Hagel, P, Sitsel, O, Raisch, T, Prumbaum, D, Quentin, D, Roderer, D, Tacke, S, Siebolds, B, Schubert, E, Shaikh, TR, Lill, P, Gatsogiannis, C, and Raunser, S. 2019. “SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM.” Communications biology, № 2: 218. doi: 10.1038/s42003-019-0437-z.
• Gatsogiannis, C, Balogh, D, Merino, F, Sieber, SA, and Raunser, S. 2019. “Cryo-EM structure of the ClpXP protein degradation machinery.” Nature structural {&} molecular biology, № 26 (10): 946–954. doi: 10.1038/s41594-019-0304-0.
• Leidreiter, F, Roderer, D, Meusch, D, Gatsogiannis, C, Benz, R, and Raunser, S. 2019. “Common architecture of Tc toxins from human and insect pathogenic bacteria.” Science advances, № 5 (10): eaax6497. doi: 10.1126/sciadv.aax6497.
• Tanaka, Y, Kato, S, Stabrin, M, Raunser, S, Matsui, T, and Gatsogiannis, C. 2019. “Cryo-EM reveals the asymmetric assembly of squid hemocyanin.” IUCrJ, № 6 (Pt 3): 426–437. doi: 10.1107/S205225251900321X.

2018

• Vinayagam, D, Mager, T, Apelbaum, A, Bothe, A, Merino, F, Hofnagel, O, Gatsogiannis, C, and Raunser, S. 2018. “Electron cryo-microscopy structure of the canonical TRPC4 ion channel.” eLife, № 7 doi: 10.7554/eLife.36615.
• Gatsogiannis, C, Merino, F, Roderer, D, Balchin, D, Schubert, E, Kuhlee, A, Hayer-Hartl, M, and Raunser, S. 2018. “Tc toxin activation requires unfolding and refolding of a \textgreekb-propeller.” Nature, № 563 (7730): 209–213. doi: 10.1038/s41586-018-0556-6.
• Kato, S, Matsui, T, Gatsogiannis, C, and Tanaka, Y. 2018. “Molluscan hemocyanin: structure, evolution, and physiology.” Biophysical Reviews, № 10 (2): 191–202. doi: 10.1007/s12551-017-0349-4.
• Pfeifer, W, Lill, P, Gatsogiannis, C, and Sacc{à}, B. 2018. “Hierarchical Assembly of DNA Filaments with Designer Elastic Properties.” ACS Nano, № 12 (1): 44–55. doi: 10.1021/acsnano.7b06012.
• Saha, S, Holzapfel, B, Chen, Y, Terlinden, K, Lill, P, Gatsogiannis, C, Rehage, H, and Clever, GH. 2018. “Rational Design of an Amphiphilic Coordination Cage-Based Emulsifier.” Journal of the American Chemical Society, № 140 (50): 17384–17388. doi: 10.1021/jacs.8b10991.

2017

• Chen, M, Kato, K, Kubo, Y, Tanaka, Y, Liu, Y, Long, F, Whitman, WB, Lill, P, Gatsogiannis, C, Raunser, S, Shimizu, N, Shinoda, A, Nakamura, A, Tanaka, I, and Yao, M. 2017. “Structural basis for tRNA-dependent cysteine biosynthesis.” Nature Communications, № 8 (1): 1521. doi: 10.1038/s41467-017-01543-y.
• Efremov, RG, Gatsogiannis, C, and Raunser, S. 2017. “Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM.” Methods in Enzymology, № 594: 1–30. doi: 10.1016/bs.mie.2017.05.007.
• Moriya, T, Saur, M, Stabrin, M, Merino, F, Voicu, H, Huang, Z, Penczek, PA, Raunser, S, and Gatsogiannis, C. 2017. “High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE.” Journal of visualized experiments : JoVE, № 2017 (123) doi: 10.3791/55448.
• Sprengel, A, Lill, P, Stegemann, P, Bravo-Rodriguez, K, Schönewei{ß}, E, Merdanovic, M, Gudnason, D, Aznauryan, M, Gamrad, L, Barcikowski, S, Sanchez-Garcia, E, Birkedal, V, Gatsogiannis, C, Ehrmann, M, and Sacc{à}, B. 2017. “Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions.” Nature Communications, № 8: 14472. doi: 10.1038/ncomms14472.

2016

• Gatsogiannis, C, Merino, F, Prumbaum, D, Roderer, D, Leidreiter, F, Meusch, D, and Raunser, S. 2016. “Membrane insertion of a Tc toxin in near-atomic detail.” Nature structural {&} molecular biology, № 23 (10): 884–890. doi: 10.1038/nsmb.3281.

2015

• Gatsogiannis, C, Hofnagel, O, Markl, J, and Raunser, S. 2015. “Structure of mega-hemocyanin reveals protein origami in snails.” Structure (London, England : 1993), № 23 (1): 93–103. doi: 10.1016/j.str.2014.10.013.
• Poepsel, S, Sprengel, A, Sacca, B, Kaschani, F, Kaiser, M, Gatsogiannis, C, Raunser, S, Clausen, T, and Ehrmann, M. 2015. “Determinants of amyloid fibril degradation by the PDZ protease HTRA1.” Nature Chemical Biology, № 11 (11): 862–869. doi: 10.1038/nchembio.1931.
• Raunser, S, and Gatsogiannis, C. 2015. “Deciphering the tubulin code.” Cell, № 161 (5): 960–961. doi: 10.1016/j.cell.2015.05.004.

2014

• Erkelenz, M, Bauer, DM, Meyer, R, Gatsogiannis, C, Raunser, S, Sacc{à}, B, and Niemeyer, CM. 2014. “A facile method for preparation of tailored scaffolds for DNA-origami.” Small (Weinheim an der Bergstrasse, Germany), № 10 (1): 73–77. doi: 10.1002/smll.201300701.
• Meusch, D, Gatsogiannis, C, Efremov, RG, Lang, AE, Hofnagel, O, Vetter, IR, Aktories, K, and Raunser, S. 2014. “Mechanism of Tc toxin action revealed in molecular detail.” Nature, № 508 (7494): 61–65. doi: 10.1038/nature13015.

2013

• Gatsogiannis, C, Lang, AE, Meusch, D, Pfaumann, V, Hofnagel, O, Benz, R, Aktories, K, and Raunser, S. 2013. “A syringe-like injection mechanism in Photorhabdus luminescens toxins.” Nature, № 495 (7442): 520–523. doi: 10.1038/nature11987.
• Sadian, Y, Gatsogiannis, C, Patasi, C, Hofnagel, O, Goody, RS, Farkasovský, M, and Raunser, S. 2013. “The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation.” eLife, № 2: e01085. doi: 10.7554/eLife.01085.

2012

• Bröcker, C, Kuhlee, A, Gatsogiannis, C, Balderhaar, HJk, Hönscher, C, Engelbrecht-Vandré, S, Ungermann, C, and Raunser, S. 2012. “Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.” Proceedings of the National Academy of Sciences of the United States of America, № 109 (6): 1991–1996. doi: 10.1073/pnas.1117797109.

2010

• Lieb, B, Gebauer, W, Gatsogiannis, C, Depoix, F, Hellmann, N, Harasewych, MG, Strong, EE, and Markl, J. 2010. “Molluscan mega-hemocyanin: an ancient oxygen carrier tuned by a {\~{}}}550 kDa polypeptide.” Frontiers in Zoology, № 7: 14. doi: 10.1186/1742-9994-7-14.

2009

• Gatsogiannis, C, and Markl, J. 2009. “Keyhole limpet hemocyanin: 9-A CryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional units.” Journal of Molecular Biology, № 385 (3): 963–983. doi: 10.1016/j.jmb.2008.10.080.

2007

• Gatsogiannis, C, Moeller, A, Depoix, F, Meissner, U, and Markl, J. 2007. “Nautilus pompilius hemocyanin: 9 A cryo-EM structure and molecular model reveal the subunit pathway and the interfaces between the 70 functional units.” Journal of Molecular Biology, № 374 (2): 465–486. doi: 10.1016/j.jmb.2007.09.036.
• Meissner, U, Gatsogiannis, C, Moeller, A, Depoix, F, Harris, JR, and Markl, J. 2007. “Comparative 11A structure of two molluscan hemocyanins from 3D cryo-electron microscopy.” Micron, № 38 (7): 754–765. doi: 10.1016/j.micron.2006.11.005.