Prof. Dr. Christos Gatsogiannis

• 2024
• 2023
• 2022
• 2021
• 2020
• 2019
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2010
• 2009
• 2007

2024

• Klink, BU, Alavizargar, A, Kalyankumar, KS, Chen, M, Heuer, A, and Gatsogiannis, C. 2024. “Structural basis of α-latrotoxin transition to a cation-selective pore.” Nature Communications 15 (1): 8551–8551. doi: 10.1038/s41467-024-52635-5.
• Bohnert, M, Gatsogiannis, C, and Herrmann, JM. 2024. “The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria.” Trends in Cell Biology 34 (9): 698–699. doi: 10.1016/j.tcb.2024.07.007.
• DO, Dodd, S, Mechaussier, PL, Yeyati, F, McPhie, JR, Anderson, CJ, Khoo, A, Shoemark, DK, Gupta, T, Attard, MA, Zariwala, M, Legendre, D, Bracht, J, Wallmeier, M, Gui, MR, Fassad, DA, Parry, PA, Tennant, A, Meynert, G, Wheway, L, Fares-Taie, HA, Black, R, Mitri-Frangieh, C, Faucon, J, Kaplan, M, Patel, L, McKie, R, Megaw, C, Gatsogiannis, MA, Mohamed, S, Aitken, P, Gautier, FR, Reinholt, RA, Hirst, C, O'Callaghan, K, Heimdal, M, Bottier, E, Escudier, S, Crowley, M, Descartes, EW, Jabs, P, Kenia, J, Amiel, GM, Bacci, C, Calogero, V, Palazzo, L, Tiberi, U, Blümlein, A, Rogers, JA, Wambach, DJ, Wegner, AB, Fulton, M, Kenna, M, Rosenfeld, IA, Holm, A, Quigley, EA, Hall, LC, Murphy, DM, Cassidy, A, von Kriegsheim, Partnership16, Scottish Genomes, Consortium45, Genomics England Research, Network46, Undiagnosed Diseases, JF, Papon, L, Pasquier, MS, Murris, JD, Chalmers, C, Hogg, KA, Macleod, DS, Urquhart, S, Unger, TJ, Aitman, S, Amselem, MW, Leigh, MR, Knowles, H, Omran, HM, Mitchison, A, Brown, JA, Marsh, JPI, Welburn, SC, Ti, A, Horani, JM, Rozet, I, Perrault, and P, Mill. 2024. “Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules.” Science 384 (6694): eadf5489–eadf5489. doi: 10.1126/science.adf5489.

2023

• Gomes, P.A., Bodo, C., Nogueras-Ortiz, C., Samiotaki, M., Chen, M., Soares-Cunha, C., Silva, J.M., Coimbra, B., Stamatakis, G., Santos, L., Panayotou, G., Tzouanou, F., Waites, C.L., Gatsogiannis, C., Sousa, N., Kapogiannis, D., Costa-Silva, B., and Sotiropoulos, I. 2023. “A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology.” Cell Communication and Signaling 21 (1). doi: 10.1186/s12964-023-01045-z.
• Bürgi, J., Lill, P., Giannopoulou, E.A., Jeffries, C.M., Chojnowski, G., Raunser, S., Gatsogiannis, C., and Wilmanns, M. 2023. “Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase.” Biological Chemistry 404: 195–207. doi: 10.1515/hsz-2022-0273.
• Borsdorf, L., Herkert, L., Bäumer, N., Rubert, L., Soberats, B., Korevaar, P.A., Bourque, C., Gatsogiannis, C., and Fernández, G. 2023. “Pathway-Controlled Aqueous Supramolecular Polymerization via Solvent-Dependent Chain Conformation Effects.” Journal of the American Chemical Society 145 (16): 8882–8895. doi: 10.1021/jacs.2c12442.
• Rüttermann M.; Koci M.; Lill P.; Geladas E.D.; Kaschani F.; Klink B.U.; Erdmann R.; Gatsogiannis C.. 2023. “Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.” Nature Communications 14 (1). doi: 10.1038/s41467-023-41640-9.

2022

• Bourque, C, Klink, BU, and Gatsogiannis, C. 2022. “An AI-assisted cryo-EM pipeline for structural studies of cellular extracts.” Structure 30 (4): 532–534. doi: 10.1016/j.str.2022.03.016.
• Günther, P, Quentin, D, Ahmad, S, Sachar, K, Gatsogiannis, C, Whitney, JC, and Raunser, S. 2022. “Structure of a bacterial Rhs effector exported by the type VI secretion system.” PLoS Pathogens 18 (1): e1010182–e1010182. doi: 10.1371/journal.ppat.1010182.
• Klink, BU, Herrmann, E, Antoni, C, Langemeyer, L, Kiontke, S, Gatsogiannis, C, Ungermann, C, Raunser, S, and Kümmel, D. 2022. “Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.” Proceedings of the National Academy of Sciences of the United States of America 119 (6). doi: 10.1073/pnas.2121494119.
• Rüttermann, M, and Gatsogiannis, C. 2022. “Good things come to those who bait: the peroxisomal docking complex.” Biological Chemistry 404(2-3): 107–119. doi: 10.1515/hsz-2022-0161.
• Skoneczny, M, Francisco, T, Erdmann, R, and Gatsogiannis, C. 2022. “Editorial: Structural aspects of peroxisome biogenesis and functions.” Frontiers in cell and developmental biology 10: 1114759–1114759. doi: 10.3389/fcell.2022.1114759.
• Wagner, M, Blum, D, Raschka, SL, Nentwig, L, Gertzen, CGW, Chen, M, Gatsogiannis, C, Harris, A, Smits, SHJ, Wagner, R, and Schmitt, L. 2022. “A New Twist in ABC Transporter Mediated Multidrug Resistance - Pdr5 is a Drug/proton Co-transporter.” Journal of Molecular Biology 434 (14): 167669–167669. doi: 10.1016/j.jmb.2022.167669.

2021

• Saha, S, Chen, YT, Ganta, S, Gilles, M, Holzapfel, B, Lill, P, Rehage, H, Gatsogiannis, C, and Clever, GH. 2021. “Coordination cage-based emulsifiers: templated formation of metal oxide microcapsules monitored by in situ LC-TEM.” Chemistry - A European Journal 2021. doi: 10.1002/chem.202103406.
• Chen, M, Blum, D, Engelhard, L, Raunser, S, Wagner, R, and Gatsogiannis, C. 2021. “Molecular architecture of black widow spider neurotoxins.” Nature Communications 12 (1): 6956.. doi: 10.1038/s41467-021-26562-8.
• Dudziak, A, Engelhard, L, Bourque, C, Klink, BU, Rombaut, P, Kornakov, N, Jänen, K, Herzog, F, Gatsogiannis, C, and Westermann, S. 2021. “Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore.” The EMBO Journal 40 (18): e108004.. doi: 10.15252/embj.2021108004.
• Kudruk, S, Pottanam, Chali S, Linard, Matos AL, Bourque, C, Dunker, C, Gatsogiannis, C, Ravoo, BJ, and Gerke, V. 2021. “Biodegradable and Dual-Responsive Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo.” Advanced Science 8: 2100694.. doi: 10.1002/advs.202100694.

2020

• Lill, P, Hansen, T, Wendscheck, D, Klink, BU, Jeziorek, T, Vismpas, D, Miehling, J, Bender, J, Schummer, A, Drepper, F, Girzalsky, W, Warscheid, B, Erdmann, R, and Gatsogiannis, C. 2020. “Towards the molecular architecture of the peroxisomal receptor docking complex.” Proceedings of the National Academy of Sciences of the United States of America 2020. doi: 10.1073/pnas.2009502117.
• Klink, BU, Gatsogiannis, C, Hofnagel, O, Wittinghofer, A, and Raunser, S. 2020. “Structure of the human BBSome core complex.” eLife 9. doi: 10.7554/eLife.53910.
• Stabrin, M, Schoenfeld, F, Wagner, T, Pospich, S, Gatsogiannis, C, and Raunser, S. 2020. “TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM.” Nature Communications 11 (1): 5716.. doi: 10.1038/s41467-020-19513-2.
• Antoni, C, Quentin, D, Lang, AE, Aktories, K, Gatsogiannis, C, and Raunser, S. 2020. “Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.” PLoS Pathogens 16 (8): e1008530.. doi: 10.1371/journal.ppat.1008530.

2019

• Wagner, T, Merino, F, Stabrin, M, Moriya, T, Antoni, C, Apelbaum, A, Hagel, P, Sitsel, O, Raisch, T, Prumbaum, D, Quentin, D, Roderer, D, Tacke, S, Siebolds, B, Schubert, E, Shaikh, TR, Lill, P, Gatsogiannis, C, and Raunser, S. 2019. “SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM.” Communications biology 2: 218.. doi: 10.1038/s42003-019-0437-z.
• Gatsogiannis, C, Balogh, D, Merino, F, Sieber, SA, and Raunser, S. 2019. “Cryo-EM structure of the ClpXP protein degradation machinery.” Nature structural {&} molecular biology 26 (10): 946–954. doi: 10.1038/s41594-019-0304-0.
• Leidreiter, F, Roderer, D, Meusch, D, Gatsogiannis, C, Benz, R, and Raunser, S. 2019. “Common architecture of Tc toxins from human and insect pathogenic bacteria.” Science advances 5 (10): eaax6497.. doi: 10.1126/sciadv.aax6497.
• Tanaka, Y, Kato, S, Stabrin, M, Raunser, S, Matsui, T, and Gatsogiannis, C. 2019. “Cryo-EM reveals the asymmetric assembly of squid hemocyanin.” IUCrJ 6 (Pt 3): 426–437. doi: 10.1107/S205225251900321X.

2018

• Vinayagam, D, Mager, T, Apelbaum, A, Bothe, A, Merino, F, Hofnagel, O, Gatsogiannis, C, and Raunser, S. 2018. “Electron cryo-microscopy structure of the canonical TRPC4 ion channel.” eLife 7. doi: 10.7554/eLife.36615.
• Gatsogiannis, C, Merino, F, Roderer, D, Balchin, D, Schubert, E, Kuhlee, A, Hayer-Hartl, M, and Raunser, S. 2018. “Tc toxin activation requires unfolding and refolding of a \textgreekb-propeller.” Nature 563 (7730): 209–213. doi: 10.1038/s41586-018-0556-6.
• Kato, S, Matsui, T, Gatsogiannis, C, and Tanaka, Y. 2018. “Molluscan hemocyanin: structure, evolution, and physiology.” Biophysical Reviews 10 (2): 191–202. doi: 10.1007/s12551-017-0349-4.
• Pfeifer, W, Lill, P, Gatsogiannis, C, and Sacc{à}, B. 2018. “Hierarchical Assembly of DNA Filaments with Designer Elastic Properties.” ACS Nano 12 (1): 44–55. doi: 10.1021/acsnano.7b06012.
• Saha, S, Holzapfel, B, Chen, Y, Terlinden, K, Lill, P, Gatsogiannis, C, Rehage, H, and Clever, GH. 2018. “Rational Design of an Amphiphilic Coordination Cage-Based Emulsifier.” Journal of the American Chemical Society 140 (50): 17384–17388. doi: 10.1021/jacs.8b10991.

2017

• Chen, M, Kato, K, Kubo, Y, Tanaka, Y, Liu, Y, Long, F, Whitman, WB, Lill, P, Gatsogiannis, C, Raunser, S, Shimizu, N, Shinoda, A, Nakamura, A, Tanaka, I, and Yao, M. 2017. “Structural basis for tRNA-dependent cysteine biosynthesis.” Nature Communications 8 (1): 1521.. doi: 10.1038/s41467-017-01543-y.
• Efremov, RG, Gatsogiannis, C, and Raunser, S. 2017. “Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM.” Methods in Enzymology 594: 1–30. doi: 10.1016/bs.mie.2017.05.007.
• Moriya, T, Saur, M, Stabrin, M, Merino, F, Voicu, H, Huang, Z, Penczek, PA, Raunser, S, and Gatsogiannis, C. 2017. “High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE.” Journal of visualized experiments : JoVE 2017 (123). doi: 10.3791/55448.
• Sprengel, A, Lill, P, Stegemann, P, Bravo-Rodriguez, K, Schönewei{ß}, E, Merdanovic, M, Gudnason, D, Aznauryan, M, Gamrad, L, Barcikowski, S, Sanchez-Garcia, E, Birkedal, V, Gatsogiannis, C, Ehrmann, M, and Sacc{à}, B. 2017. “Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions.” Nature Communications 8: 14472.. doi: 10.1038/ncomms14472.

2016

• Gatsogiannis, C, Merino, F, Prumbaum, D, Roderer, D, Leidreiter, F, Meusch, D, and Raunser, S. 2016. “Membrane insertion of a Tc toxin in near-atomic detail.” Nature structural {&} molecular biology 23 (10): 884–890. doi: 10.1038/nsmb.3281.

2015

• Gatsogiannis, C, Hofnagel, O, Markl, J, and Raunser, S. 2015. “Structure of mega-hemocyanin reveals protein origami in snails.” Structure (London, England : 1993) 23 (1): 93–103. doi: 10.1016/j.str.2014.10.013.
• Poepsel, S, Sprengel, A, Sacca, B, Kaschani, F, Kaiser, M, Gatsogiannis, C, Raunser, S, Clausen, T, and Ehrmann, M. 2015. “Determinants of amyloid fibril degradation by the PDZ protease HTRA1.” Nature Chemical Biology 11 (11): 862–869. doi: 10.1038/nchembio.1931.
• Raunser, S, and Gatsogiannis, C. 2015. “Deciphering the tubulin code.” Cell 161 (5): 960–961. doi: 10.1016/j.cell.2015.05.004.

2014

• Erkelenz, M, Bauer, DM, Meyer, R, Gatsogiannis, C, Raunser, S, Sacc{à}, B, and Niemeyer, CM. 2014. “A facile method for preparation of tailored scaffolds for DNA-origami.” Small (Weinheim an der Bergstrasse, Germany) 10 (1): 73–77. doi: 10.1002/smll.201300701.
• Meusch, D, Gatsogiannis, C, Efremov, RG, Lang, AE, Hofnagel, O, Vetter, IR, Aktories, K, and Raunser, S. 2014. “Mechanism of Tc toxin action revealed in molecular detail.” Nature 508 (7494): 61–65. doi: 10.1038/nature13015.

2013

• Gatsogiannis, C, Lang, AE, Meusch, D, Pfaumann, V, Hofnagel, O, Benz, R, Aktories, K, and Raunser, S. 2013. “A syringe-like injection mechanism in Photorhabdus luminescens toxins.” Nature 495 (7442): 520–523. doi: 10.1038/nature11987.
• Sadian, Y, Gatsogiannis, C, Patasi, C, Hofnagel, O, Goody, RS, Farkasovský, M, and Raunser, S. 2013. “The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation.” eLife 2: e01085.. doi: 10.7554/eLife.01085.

2012

• Bröcker, C, Kuhlee, A, Gatsogiannis, C, Balderhaar, HJk, Hönscher, C, Engelbrecht-Vandré, S, Ungermann, C, and Raunser, S. 2012. “Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.” Proceedings of the National Academy of Sciences of the United States of America 109 (6): 1991–1996. doi: 10.1073/pnas.1117797109.

2010

• Lieb, B, Gebauer, W, Gatsogiannis, C, Depoix, F, Hellmann, N, Harasewych, MG, Strong, EE, and Markl, J. 2010. “Molluscan mega-hemocyanin: an ancient oxygen carrier tuned by a {\~{}}}550 kDa polypeptide.” Frontiers in Zoology 7: 14.. doi: 10.1186/1742-9994-7-14.

2009

• Gatsogiannis, C, and Markl, J. 2009. “Keyhole limpet hemocyanin: 9-A CryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional units.” Journal of Molecular Biology 385 (3): 963–983. doi: 10.1016/j.jmb.2008.10.080.

2007

• Gatsogiannis, C, Moeller, A, Depoix, F, Meissner, U, and Markl, J. 2007. “Nautilus pompilius hemocyanin: 9 A cryo-EM structure and molecular model reveal the subunit pathway and the interfaces between the 70 functional units.” Journal of Molecular Biology 374 (2): 465–486. doi: 10.1016/j.jmb.2007.09.036.
• Meissner, U, Gatsogiannis, C, Moeller, A, Depoix, F, Harris, JR, and Markl, J. 2007. “Comparative 11A structure of two molluscan hemocyanins from 3D cryo-electron microscopy.” Micron 38 (7): 754–765. doi: 10.1016/j.micron.2006.11.005.