Top ten discoveries of the year: Neurooncology

  • Pieter Wesseling Department of Pathology, Amsterdam University Medical Centers, location VUmc, Brain Tumor Center Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands
Keywords: Brain tumor, Neuropathology, Molecular diagnostics, Glioma, Medulloblastoma, Methylome analysis


This article briefly discusses 10 topics that were selected by the author as top 10 discoveries published in 2019 in the broader field of neuro-oncological pathology (so including neurosciences as well as clinical neuro-oncology but with implications for neuro-oncological pathology). Some topics concern new information on immunohistochemical and molecular markers that enable improved diagnosis of particular tumors of the central nervous system (CNS) and information on a refined classification of medulloblastomas. Subsequently, several papers are discussed that further elucidate some pathobiological aspects of especially medulloblastomas (histogenesis, molecular evolution) and diffuse gliomas (mechanisms involved in CNS infiltration, role of cancer stem(-like) cells, longitudinal molecular evolution). The remaining topics concern progress made in vaccination therapy for glioblastomas and in using cerebrospinal fluid for liquid biopsy diagnosis of gliomas. Clearly, substantial, and sometimes even amazing progress has been made in increasing our understanding in several areas of neuro-oncological pathology. At the same time, almost every finding raises new questions, and translation of new insights in improving the outcome for patients suffering from CNS tumors remains a huge challenge.

How to Cite
Wesseling, P. (2020). Top ten discoveries of the year: Neurooncology. Free Neuropathology, 1, 8.