Letters

 


 
Osorio Lopes Abath Neto, Leonardo Furtado Freitas, Martha Quezado, Zied Abdullaev, Kenneth Aldape
Free Neuropathol 5: 23 (2024)
 
Felix Leitner, Sigrid Klotz, Karoline Ornig, Serge Weis, Ellen Gelpi
Free Neuropathol 5: 22 (2024)
 
Gianna M. Fote, Kamran Urgun, Jordan Davies, Alexander S. Himstead, Kevin Gramajo-Aponte, Alexander Lopez, Frank P.K. Hsu, William H. Yong
Free Neuropathol 5: 17 (2024)
We describe a case of a young patient with a recurrent pleomorphic xanthoastrocytoma (PXA) showing unusual cell-in-cell (CiC) phenomena. We observed mostly viable but also necrotic neutrophils engulfed within tumor cells. The recurrent tumor was immunopositive for BRAFV600E mutant protein and showed CDKN2 homozygous deletions typical of PXA. Both genetic alterations were also reported in the original primary tumor. Unlike the original tumor that was GFAP and Olig-2 immunopositive, the recurrent neoplasm was largely negative for GFAP and Olig-2 suggesting dedifferentiation. The large malignant cells that contained the neutrophils were negative for histiocytic and lymphohematopoietic markers. Whereas CDKN2 homozygous deletion is common in PXA, its presence is rare in histiocytic neoplasms. Both reactive astrocytes and glial neoplasms very rarely may engulf neutrophils in a process resembling emperipolesis or cellular cannibalism. Future work may clarify which type of CiC pathway is involved.
 
Bilge Dundar, Busranur Agac, Eyas Alzayadneh, Randy Tashjian, Kyle S. Conway
Free Neuropathol 5: 13 (2024)
 
Herbert Budka, Daniele U. Risser, Fabio C. Monticelli
Free Neuropathol 5: 12 (2024)
 
Ilay Caliskan, Rufei Lu, Cristine Szu Lyn Ding, Francineide Sadala de Souza, Arie Perry, Tarik Tihan
Free Neuropathol 5: 6 (2024)
 


 
Comment on: Considering the myelin-centric hypothesis: insights from Budka's historical adrenomyeloneuropathy case report by E. Salsano and C. Benzoni
Herbert Budka
Free Neuropathol 4: 24 (2023)
 
Ettore Salsano, Chiara Benzoni
Free Neuropathol 4: 23 (2023)
 


 
Osamu Yokota, Tomoko Miki, Chikako Ikeda, Hideki Ishizu, Takashi Haraguchi, Akinori Miyashita, Takeshi Ikeuchi, Shintaro Takenoshita, Seishi Terada
Free Neuropathol 3: 18 (2022)
 
Arnault Tauziède-Espariat, Nicolas Macagno, Daniel Pissaloux, Dominique Figarella-Branger, Romain Appay, Dorian Bochaton, Sanaa Tazi, Paul Kauv, Lauren Hasty, Alice Métais, Fabrice Chrétien, Pascale Varlet
Free Neuropathol 3: 11 (2022)
 


 
Thibauld Oullier, Alice Prigent, Guillaume Chapelet, Michel Neunlist, Franck Letournel, Pascal Derkinderen
Free Neuropathol 1: 14 (2020)