05.1998 – 06.1999

Postdoc Studium (Biologische Massenspektrometrie): Prof. Dr. J. Peter-Katalinic (Inst. f. Medizinische Physik und Biophysik); Centro Internationale di Servizi di Spettrometria di Massa (CISeSMa, Neapel, Consiglio Nationale delle Ricerche); Prof. Dr. Peter (Institut für Organische Chemie und Strukturanalytik der Universität Potsdam)

10.1994 – 02.1998

Promotionsarbeit (H. J. Schäfer) WWU Münster: „Studien zur diastereselektiven Kupplung anodisch erzeugter Radikale in Hetero- und Homokupplungen“

10.1989 – 09.1994

Chemiestudium WWU Münster. Diplomarbeit (H. J. Schäfer) „Auxiliarkontrollierte Dimerisierung von 2-tert.-Butylmalonsäureamid- zu 2,3-Di-tert.-butylbernsteinsäurederivaten durch Kolbe-Elektrolyse“

seit 07.2012

Leiter der Massenspektrometrie am Organisch-Chemischen Institut der Universität Münster

01. – 07.2012

Stellv. Leiter der Massenspektrometrie am Organisch-Chemischen Institut der Westf. Wilhelms-Universität Münster

07.1999 – 12.2011

Leiter der Massenspektrometrie (Universität Bielefeld, Fakultät für Chemie)

01.2017 – 12.2024

Schatzmeister und Vorstandsmitglied der Deutschen Gesellschaft für Massenspektrometrie e.V. (Schatzmeister)

seit 2005

Mitglied der ASMS - Amerikanische Gesellschaft für Massenspektrometrie

seit 2004

Mitglied der DGMS - Deutsche Gesellschaft für Massenspektrometrie

• 2023
• 2021
• 2020
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2011
• 2010
• 2009
• 2008
• 2007
• 2006
• 2005
• 2004
• 2003
• 2002
• 2001
• 2000
• 1995

2023

• Mo, Boris, Scharf, Birte, Gutheil, Christian, Letzel, Matthias C., und Hensel, Andreas. 2023. „Tamm-Horsfall protein in humane urine: sex-dependent differences in the excretion and N-glycosylation pattern.“ Scientific Reports, Nr. 13 (1) doi: 10.1038/s41598-023-44650-1.

2021

• Fraschetti, C., Letzel, M.C., Paletta, M., Mattay, J., Crestoni, M.E., Chiavarino, B., und Filippi, A. 2021. „Unprotected Galactosamine as a Dynamic Key for a Cyclochiral Lock.“ Journal of The American Society for Mass Spectrometry, Nr. 2021 (24): 736–743. doi: 10.1021/jasms.0c00437.

2020

• Watanabe, Kohei, Ueno, Atsushi, Tao, Xin, Skoch, Karel, Jie, Xiaoming, Vagin, Sergei, Rieger, Bernhard, Daniliuc, Constantin G., Letzel, Matthias C., Kehr, Gerald, und Erker, Gerhard. 2020. „Reactions of an anionic chelate phosphane/borata-alkene ligand with [Rh(nbd)Cl]2, [Rh(CO)2Cl]2and [Ir(cod)Cl]2.“ Chemical science, Nr. 11 (28) doi: 10.1039/d0sc02223c.
• Jansen, Dennis, Gramueller, Johannes, Niemeyer, Felix, Schaller, Torsten, Letzel, Matthias C., Grimme, Stefan, Zhu, Hui, Gschwind, Ruth M., und Niemeyer, Jochen. 2020. „What is the role of acid-acid interactions in asymmetric phosphoric acid organocatalysis? A detailed mechanistic study using interlocked and non-interlocked catalysts.“ Chemical science, Nr. 11 (17) doi: 10.1039/d0sc01026j.

2018

• Kuck, D., Heitkamp, S., Letzel, M., Ahmed, I., und Krohn, K. 2018. „Consecutive loss of two benzyl radicals from the [M + Na]+ adduct ions of pyrogallol tribenzyl ether and its derivatives.“ European Journal of Mass Spectrometry, Nr. 24 (1): 23–32. doi: 10.1177/1469066717729300.

2017

• Thierbach, Sven, Birmes, Franziska S., Letzel, Matthias C., Hennecke, Ulrich, und Fetzner, Susanne. 2017. „Chemical Modification and Detoxification of the <i>Pseudomonas</i> <i>aeruginosa</i> Toxin 2-Heptyl-4-hydroxyquinoline <i>N</i>-Oxide by Environmental and Pathogenic Bacteria.“ ACS Chemical Biology, Nr. 12 (9): 2305–2312. doi: 10.1021/acschembio.7b00345.
• Thierbach, S., Birmes, F., Letzel, M., Hennecke, U., und Fetzner, S. 2017. „Chemical Modification and Detoxification of the Pseudomonas aeruginosa Toxin 2-Heptyl-4-hydroxyquinoline N-Oxide by Environmental and Pathogenic Bacteria.“ ACS Chemical Biology, Nr. 12 (9): 2305–2312. doi: 10.1021/acschembio.7b00345.
• Tesch, M, Kudruk, S, Letzel, M, und Studer, A. 2017. „Orthogonal Click Postfunctionalization of Alternating Copolymers Prepared by Nitroxide-Mediated Polymerization.“ Chemistry - A European Journal, Nr. 23 (25): 5915–5919. doi: 10.1002/chem.201605639.
• Letzel, MC, Schäfer, H-J, und Fröhlich, R. 2017. „Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates.“ Beilstein Journal of Organic Chemistry, Nr. 13 (null): 33–42. doi: 10.3762/bjoc.13.5.

2016

• Elghamry, I., El-Ayaan, U., Youssef, M., Al-Shihry, S., Letzel, M., und Mattay, J. 2016. „Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products.“ Chemical Monthly / Monatshefte für Chemie, Nr. 2016: 1–6. doi: 10.1007/s00706-016-1765-z.
• Mitra, R., Thiele, M., Octa-Smolin, F., Letzel, M., und Niemeyer, J. 2016. „A bifunctional chiral [2]catenane based on 1,1′-binaphthyl-phosphates.“ Chemical communications, Nr. 52 (35): 5977–5980. doi: 10.1039/c6cc01980c.
• Hickert, S., Cramer, B., Letzel, M., und Humpf, H.-U. 2016. „Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging of ochratoxin A and fumonisins in mold-infected food.“ Rapid Communications in Mass Spectrometry, Nr. 30 (23): 2508–2516. doi: 10.1002/rcm.7733.

2015

• Radunsky, C, Kösters, J, Letzel, MC, Yogendra, S, Schwickert, C, Manck, S, Sarkar, B, Pöttgen, R, Weigand, JJ, Neugebauer, J, und Müller, J. 2015. „Dioxygen Activation by an in situ Reduced Cu^II Hydrazone Complex.“ European Journal of Inorganic Chemistry, Nr. 2015: 4006–4012. doi: 10.1002/ejic.201500556.
• Tesch, M., Hepperle, J., Klaasen, H., Letzel, M., und Studer, A. 2015. „Alternating copolymerization by nitroxide-mediated polymerization and subsequent orthogonal functionalization.“ Angewandte Chemie International Edition, Nr. 54 (17): 5054–5059. doi: 10.1002/anie.201412206.
• Kuck, D., Heitkamp, S., Sproß, J., Letzel, M., Ahmed, I., Krohn, K., Parker, R., Wang, Y., Robbins, V., Ames, W., Schettler, P., und Hark, R. 2015. „Consecutive losses of two benzyl radicals from the [M+Na]⁺ adduct ions of di- and tri(benzyloxy)benzenes under ESI/CID conditions.“ International Journal of Mass Spectrometry, Nr. 377 (1): 23–38. doi: 10.1016/j.ijms.2014.06.013.
• Volkenhoff, A., Weiler, A., Letzel, M., Stehling, M., Klämbt, C., und Schirmeier, S. 2015. „Glial glycolysis is essential for neuronal survival in drosophila.“ Cell Metabolism, Nr. 22 (3): 437–447. doi: 10.1016/j.cmet.2015.07.006.

2014

• Kuck, D., Salameh, L., Onwuka, K., und Letzel, M. 2014. „Unidirectional triple hydrogen rearrangement in the radical cations of electron-rich 3-aryl-1-propanols: Further evidence and limitation.“ European Journal of Mass Spectrometry, Nr. 20 (1): 51–61. doi: 10.1255/ejms.1239.
• Pirkl, A., Meier, M., Popkova, Y., Letzel, M., Schnapp, A., Schiller, J., und Dreisewerd, K. 2014. „Analysis of free fatty acids by ultraviolet laser desorption ionization mass spectrometry using insect wings as hydrophobic sample substrates.“ Analytical Chemistry, Nr. 86 (21): 10763–10771. doi: 10.1021/ac5020047.

2013

• Letzel, M., Barth, D., Kuck, D., Grützmacher, H., Kim, S., Yim, M., und Choe, J. 2013. „Unimolecular reactions of gaseous picoline radical cations. A new experimental and computational study.“ International Journal of Mass Spectrometry, Nr. 336 (null): 1–16. doi: 10.1016/j.ijms.2012.11.005.
• Rozhenko, A., Schoeller, W., Letzel, M., Decker, B., und Mattay, J. 2013. „Anion-π interactions in adducts of anionic guests with octahydroxy-pyridine[4]arene: Theoretical and experimental elucidation.“ New Journal of Chemistry, Nr. 37 (2): 356–365. doi: 10.1039/c2nj40670e.

2012

• Amick, A., Hoegg, E., Harrison, S., Houston, K., Hark, R., Reingold, I., Barth, D., Letzel, M., und Kuck, D. 2012. „Site-specific hydrogen exchange and hydrogen transfer processes preceding the fragmentation of long-lived radical cations of ethyl dihydrocinnamate and related arylalkanoates.“ International Journal of Mass Spectrometry, Nr. null (null): 206–215. doi: 10.1016/j.ijms.2012.01.005.
• Fraschetti, C., Letzel, M., Paletta, M., Mattay, J., Speranza, M., Filippi, A., Aschi, M., und Rozhenko, A. 2012. „Cyclochiral resorcin[4]arenes as effective enantioselectors in the gas phase.“ Journal of Mass Spectrometry, Nr. 47 (1): 72–78. doi: 10.1002/jms.2028.
• Fraschetti, C., Letzel, M., Filippi, A., Speranza, M., und Mattay, J. 2012. „Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system.“ Beilstein Journal of Organic Chemistry, Nr. 8 (null): 539–550. doi: 10.3762/bjoc.8.62.

2011

• Botta, B., Fraschetti, C., D'Acquarica, I., Sacco, F., Mattay, J., Letzel, M., und Speranza, M. 2011. „Unprecedented gas-phase chiroselective logic gates.“ Organic and Biomolecular Chemistry, Nr. 9 (6): 1717–1719. doi: 10.1039/c0ob00664e.
• Kuck, D., Matthias, C., Barth, D., und Letzel, M. 2011. „Isomerization of the constituents of ion/neutral complexes during the fragmentation of protonated dialkyl-substituted 1,3-diphenylpropanes.“ International Journal of Mass Spectrometry, Nr. 306 (null): 167–174. doi: 10.1016/j.ijms.2010.10.007.
• Kuck, D., Grützmacher, H., Barth, D., Heitkamp, S., und Letzel, M. 2011. „The role of ion/neutral complexes in the fragmentation of N-benzyl-(alkylpyridinium) ions.“ International Journal of Mass Spectrometry, Nr. 306 (null): 159–166. doi: 10.1016/j.ijms.2010.10.006.

2010

• Krohn, K., Ahmed, I., John, M., Letzel, M., und Kuck, D. 2010. „Stereoselective synthesis of benzylated prodelphinidins and their diastereomers with use of the mitsunobu reaction in the preparation of their gallocatechin precursors.“ European Journal of Organic Chemistry, Nr. null (13): 2544–2554. doi: 10.1002/ejoc.201000053.

2009

• Botta, B., Fraschetti, C., D'Acquarica, I., Speranza, M., Novara, F., Mattay, J., und Letzel, M. 2009. „Gas-Phase enantioselectivity of chiral N-Linked peptidoresorc[4]arene isomers toward dipeptides.“ Journal of Physical Chemistry A, Nr. 113 (52): 14625–14629. doi: 10.1021/jp904374h.
• Böcker, S., Letzel, M., Lipták, Z., und Pervukhin, A. 2009. „SIRIUS: Decomposing isotope patterns for metabolite identification.“ Bioinformatics, Nr. 25 (2): 218–224. doi: 10.1093/bioinformatics/btn603.
• Botta, B., Fraschetti, C., Novara, F., Tafi, A., Sacco, F., Mannina, L., Sobolev, A., Mattay, J., Letzel, M., und Speranza, M. 2009. „Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: A dynamic, kinetic, and spectroscopic study.“ Organic and Biomolecular Chemistry, Nr. 7 (9): 1798–1806. doi: 10.1039/b900735k.
• Sekiguchi, O., Meyer, V., Letzel, M., Kuck, D., und Uggerud, E. 2009. „Energetics and reaction mechanisms for the competitive losses of H 2, CH4 and C2H4 from protonated methylbenzenes-implications to the methanol-to-hydrocarbons (MTH) process.“ European Journal of Mass Spectrometry, Nr. 15 (2): 167–181. doi: 10.1255/ejms.953.

2008

• Letzel, M., Grützmacher, H., Stein, D., und Grützmacher, H. 2008. „Trends in the reactions of gaseous phenyl pnictogen radical cations C 6H5EH2̇+ (E = N, P, As).“ Dalton Transactions, Nr. null (25): 3282–3291. doi: 10.1039/b801970c.
• König, H., Marsmann, H., und Letzel, M. 2008. „Thioether Functionalized Octasilsesquioxanes.“ In Organosilicon Chemistry I: From Molecules to Materials, Bd. null , herausgegeben von Norbert Auner und Johann Weis. New York City: John Wiley & Sons. doi: 10.1002/9783527620777.ch69d.
• Igoli, J., Onyiriuka, S., Letzel, M., Nwaji, M., und Gray, A. 2008. „Cassane diterpenoids from Lonchocarpus laxiflorus.“ Natural Product Communications, Nr. 3 (1): 5–10.
• Schröder, T., Brodbeck, R., Letzel, M., Mix, A., Schnatwinkel, B., Tonigold, M., Volkmer, D., und Mattay, J. 2008. „A self-assembling metallosupramolecular cage based on cavitand-terpyridine subunits.“ Tetrahedron Letters, Nr. 49 (41): 5939–5942. doi: 10.1016/j.tetlet.2008.07.143.
• Letzel, M., Schäfer, C., Novara, F., Speranza, M., Rozhenko, A., Schoeller, W., und Mattay, J. 2008. „A kinetic study of guest displacement reactions on a host-guest complex with a photoswitchable calixarene.“ Journal of Mass Spectrometry, Nr. 43 (11): 1553–1564. doi: 10.1002/jms.1464.

2007

• Botta, B., D'Acquarica, I., Nevola, L., Sacco, F., Lopez, Z., Zappia, G., Fraschetti, C., Speranza, M., Tafi, A., Caporuscio, F., Letzel, M., und Mattay, J. 2007. „Bis(diamido)-bridged basket resorcin[4]arenes as enantioselective receptors for amino acids and amines.“ European Journal of Organic Chemistry, Nr. null (36): 5995–6002. doi: 10.1002/ejoc.200700829.

2006

• Schäfer, C., Decker, B., Letzel, M., Novara, F., Eckel, R., Ros, R., Anselmetti, D., und Mattay, J. 2006. „On the way to supramolecular photochemistry at the single-molecule level.“ Pure and Applied Chemistry, Nr. 78 (12): 2247–2259. doi: 10.1351/pac200678122247.
• Letzel, M., Kirchhoff, D., Grützmacher, H., Stein, D., und Grützmacher, H. 2006. „Isomerization and fragmentation reactions of gaseous phenylarsane radical cations and phenylarsanyl cations. A study by tandem mass spectrometry and theoretical calculations.“ Dalton Transactions, Nr. null (16): 2008–2016. doi: 10.1039/b514312h.
• Svelle, S., Bjørgen, M., Kolboe, S., Kuck, D., Letzel, M., Olsbye, U., Sekiguchi, O., und Uggerud, E. 2006. „Intermediates in the methanol-to-hydrocarbons (MTH) reaction: A gas phase study of the unimolecular reactivity of multiply methylated benzenium cations.“ Catalysis Letters, Nr. 109 (null): 25–35. doi: 10.1007/s10562-006-0052-8.
• Rozhenko, A., Schoeller, W., Letzel, M., Decker, B., Agena, C., und Mattay, J. 2006. „Calixarenes as hosts for ammonium cations: A quantum chemical study and mass-spectrometric investigations.“ Chemistry - A European Journal, Nr. 12 (35): 8995–9000. doi: 10.1002/chem.200501520.
• Böcker, S., Letzel, M., Lipták, Z., und Pervukhin, A. 2006. „Decomposing metabolomic isotope patterns.“ In Bd. null aus Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) Heidelberg: Springer.
• Sekiguchi, O., Letzel, M., Kuck, D., und Uggerud, E. 2006. „The unimolecular dissociation of protonated glyoxylic acid: Structure and dynamics of a step-by-step process.“ International Journal of Mass Spectrometry, Nr. null (null): 177–184. doi: 10.1016/j.ijms.2005.12.041.

2005

• Schulte, T, Siegenthaler, KO, Luftmann, H, Letzel, M, und Studer, A. 2005. „Nitroxide-mediated polymerization of N-isopropylacrylamide: Electrospray ionization mass spectrometry, matrix-assisted laser desorption ionization mass spectrometry, and multiple-angle laser light scattering studies on nitroxide-terminated poly-N-isopropylacrylamides.“ Macromolecules, Nr. 38 (16): 6833–6840. doi: 10.1021/ma050343n.
• Rozhenko, A., Schoeller, W., Letzel, M., Decker, B., Agena, C., und Mattay, J. 2005. „Conformational features of calix[4]arenes with alkali metal cations: A quantum chemical investigation with density functional theory.“ Journal of Molecular Structure: THEOCHEM, Nr. 732 (null): 7–20. doi: 10.1016/j.theochem.2005.06.041.

2004

• Mehdizadeh, A., Letzel, M., Klaes, M., Agena, C., und Mattay, J. 2004. „Chiral discrimination on the host-guest complexation of resorc[4]arenes with quarternary amines.“ European Journal of Mass Spectrometry, Nr. 10 (5): 649–655. doi: 10.1255/ejms.675.
• Oley, M., Letzel, M., und Ragg, H. 2004. „Inhibition of furin by serpin Spn4A from Drosophila melanogaster.“ FEBS Letters, Nr. 577 (null): 165–169. doi: 10.1016/j.febslet.2004.10.003.
• Letzel, M., Decker, B., Rozhenko, A., Schoeller, W., und Mattay, J. 2004. „Encapsulated guest molecules in the dimer of octahydroxypyridine[4]arene.“ Journal of the American Chemical Society, Nr. 126 (31): 9669–9674. doi: 10.1021/ja049128x.

2003

• Leitão, E., Bittencourt, V., Haido, R., Valente, A., Peter-Katalinic, J., Letzel, M., de Souza, L., und Barreto-Bergter, E. 2003. „β-Galactofuranose-containing O-linked oligosaccharides present in the cell wall peptidogalactomannan of Aspergillus fumigatus contain immunodominant epitopes.“ Glycobiology, Nr. 13 (10): 681–692. doi: 10.1093/glycob/cwg089.

2002

• Bahrke, S., Einarsson, J., Gislason, J., Haebel, S., Letzel, M., Peter-Katalinić, J., und Peter, M. 2002. „Sequence analysis of chitooligosaccharides by matrix-assisted laser desorption ionization postsource decay mass spectrometry.“ Biomacromolecules, Nr. 3 (4): 696–704. doi: 10.1021/bm020010n.
• Müller, A., Diemann, E., Shah, S., Kuhlmann, C., und Letzel, M. 2002. „Soccer-playing metal oxide giant spheres: A first step towards patterning structurally well defined nano-object collectives.“ Chemical communications, Nr. null (5): 440–441.
• Letzel, M., Agena, C., und Mattay, J. 2002. „Investigation of homo- and heterodimer alkali metal cation complexes of resorc[4]arenes by electrospray ionization mass spectrometry.“ Journal of Mass Spectrometry, Nr. 37 (1): 63–68. doi: 10.1002/jms.247.
• Letzel, M., Grützmacher, H., Fürst, T., Mayer, K., und Wiegrebe, W. 2002. „Functional group migration in benzaldoxime-O-n-propyl ether radical cation.“ International Journal of Mass Spectrometry, Nr. 217 (null): 153–168. doi: 10.1016/S1387-3806(02)00571-7.

2001

• Letzel, M., Agena, C., und Mattay, J. 2001. „Letter: Calibration of electrospray mass spectrometers with rccc-2,8,14,20-tetra-n-octyl-5,11,17,23- tetrahydroxyresorc[4]arene in the high mass range up to m/z 6000.“ European Journal of Mass Spectrometry, Nr. 7 (1): 35–38.
• Hollah, P, Hausberg, M, Kosch, M, Barenbrock, M, Letzel, M, Schlatter, E, und Rahn, KH. 2001. „A novel assay for determination of diadenosine polyphosphates in human platelets: studies in normotensive subjects and in patients with essential hypertension.“ Journal of Hypertension, Nr. 19 (2): 237–245. doi: 10.1097/00004872-200102000-00010.

2000

• Letzel, Matthias C., Synstad, B., Eijsink, V.G.H, Peter-Katalinić, Jasna, und Peter, Martin G. 2000. „Libraries of chito-oligosaccharides of mixed acetylation patterns and their interactions with chitinases.“ In Advan. Chitin Science 2000, Vol. IV, herausgegeben von G. Peter, R.A.A. Muzzarelli und A. Domard. N/A: unbekannt / n.a. / unknown.

1995

• Schäfer, H.J., Klotz-Berendes, B., Letzel, M., Zielinski, C., Schoo, N., und Lohl, T.Höweler U. 1995. „Diastereoselective and Enantioselective Conversions at the Anode and the Cathode.“ In Novel Trends in Electroorganic Synthesis, herausgegeben von Torii Sigeru. Okayama.