• Beteiligung an „Cells in Motion“

    • Forschungsinteressen: membrane trafficking and signal transduction, regulatory protein complexes of small GTPases, mechanisms of membrane targeting, protein structure analysis, protein engineering and inhibitor design
    • Mitglied im Graduiertenprogramm CiM-IMPRS
  • News & Themen

  • Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“


    Klink BU, Herrmann E, Antoni C, Langemeyer L, Kiontke S, Gatsogiannis C, Ungermann C, Raunser S, Kümmel D. Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation. Proc Natl Acad Sci USA 2022;119: e2121494119. Abstract
    Peters A, Herrmann E, Cornelissen NV, Klocker N, Kummel D, Rentmeister A. Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases. Chembiochem 2022;23: e202100437. Abstract


    Fitzian K, Bruckner A, Brohee L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kummel D. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol Cell 2021;81: 2705-2721.e8. Abstract
    Michailidou F, Klocker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kummel D, Rentmeister A. Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew Chem Int Ed Engl 2021;60: 480-485. Abstract


    Hansmann P, Bruckner A, Kiontke S, Berkenfeld B, Seebohm G, Brouillard P, Vikkula M, Jansen FE, Nellist M, Oeckinghaus A, Kummel D. Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Structure 2020;28: 933-942.e4. Abstract


    Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kummel D. Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1. Nat Commun 2017;8: 14034. Abstract