Beteiligung am Exzellenzcluster

CiM-Gruppenleiter

  • Forschungsgebiet A.5: Verfolgung Individueller Zellen In Vivo über Oberflächenzielstrukturen
  • Forschungsgebiet B.1: Ausbildung und Eigenschaften von epithelialen und endothelialen Zellbarrieren
  • Projekt FF-2013-17: Massenspektrometrische Bildgebung als komplementäre Methode zur MRT (Uwe Karst, Cornelius Faber, Projektlaufzeit: 07/2013 - 06/2015)

CiM-Publikationen

2018

Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schafers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. ChemMedChem 2018;13: 241-250. Abstract
de Vega RG, Sanchez MLF, Eiro N, Vizoso FJ, Sperling M, Karst U, Medel AS. Multimodal laser ablation/desorption imaging analysis of Zn and MMP-11 in breast tissues. Anal Bioanal Chem 2018;410: 913-922. Abstract

2017

Aschner M, Palinski C, Sperling M, Karst U, Schwerdtle T, Bornhorst J. Imaging metals in Caenorhabditis elegans. Metallomics 2017;9: 357-364. Abstract
Clases D, Birka M, Sperling M, Faust A, Karst U. Isobaric dilution analysis as a calibration tool for long lived radionuclides in ICP-MS. J Trace Elem Med Biol 2017;40: 97-103. Abstract
Hachmoeller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Investigating the influence of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry. J Trace Elem Med Biol 2017;44: 71-75. Abstract
Hachmoeller O, Zibert A, Zischka H, Sperling M, Groba SR, Grunewald I, Wardelmann E, Schmidt HH-J, Karst U. Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS. J Trace Elem Med Biol 2017;44: 26-31. Abstract
Niehoff A-C, Klasen T, Schmidt R, Palmes D, Faber C, Karst U, Hadrian R. Investigating the Lymphatic System by Dual-Color Elemental Mass Spectrometry Imaging. Contrast Media & Molecular Imaging 2017;2017: 1-8. Abstract
Thyssen GM, Holtkamp M, Kaulfurst-Soboll H, Wehe CA, Sperling M, von Schaewen A, Karst U. Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles. Metallomics 2017;9: 676-684. Abstract

2016

Hachmoeller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Element bioimaging of liver needle biopsy specimens from patients with Wilson's disease by laser ablation-inductively coupled plasma-mass spectrometry. J Trace Elem Med Biol 2016;35: 97-102. Abstract
Hachmoller O, Buzanich AG, Aichler M, Radtke M, Dietrich D, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using muXRF and XANES. Metallomics 2016;8: 648-653. Abstract
Niehoff A-C, Grunebaum J, Moosmann A, Mulac D, Sobbing J, Niehaus R, Buchholz R, Kroger S, Wiehe A, Wagner S, Sperling M, von Briesen H, Langer K, Karst U. Quantitative bioimaging of platinum group elements in tumor spheroids. Anal Chim Acta 2016;938: 106-113. Abstract
Niehoff A-C, Schulz J, Soltwisch J, Meyer S, Kettling H, Sperling M, Jeibmann A, Dreisewerd K, Francesconi KA, Schwerdtle T, Karst U. Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster. Anal Chem 2016;88: 5258-5263. Abstract
Niehoff  A-C, Wachsmuth L, Schmid F, Sperling M, Faber C, Karst U. Quantification of Manganese Enhanced Magnetic Resonance Imaging based on Spatially Resolved Elemental Mass Spectrometry. ChemistrySelect 2016;1: 264-266. Abstract
Wiese C, Grosse Maestrup E, Galla F, Schepmann D, Hiller A, Fischer S, Ludwig F-A, Deuther-Conrad W, Donat CK, Brust P, Buter L, Karst U, Wunsch B. Comparison of in Silico, Electrochemical, in Vitro and in Vivo Metabolism of a Homologous Series of (Radio)fluorinated σ1 Receptor Ligands Designed for Positron Emission Tomography. ChemMedChem 2016;11: 2445–2458. Abstract

2015

Birka M, Wentker KS, Lusmoller E, Arheilger B, Wehe CA, Sperling M, Stadler R, Karst U. Diagnosis of nephrogenic systemic fibrosis by means of elemental bioimaging and speciation analysis. Anal Chem 2015;87: 3321-3328. Abstract
Koeppen C, Reifschneider O, Castanheira I, Sperling M, Karst U, Ciarimboli G. Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin. Metallomics 2015;7: 1595-1603. Abstract
Niehaus R, Sperling M, Karst U. Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS. J. Anal. At. Spectrom. 2015;30: 2056-2065. Abstract
Niehoff A-C, Bauer OB, Kroger S, Fingerhut S, Schulz J, Meyer S, Sperling M, Jeibmann A, Schwerdtle T, Karst U. Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster. Anal Chem 2015;87: 10392-10396. Abstract
Reifschneider O, Schutz CL, Brochhausen C, Hampel G, Ross T, Sperling M, Karst U. Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy. Anal Bioanal Chem 2015;407: 2365-2371. Abstract
Reifschneider O, Wentker KS, Strobel K, Schmidt R, Masthoff M, Sperling M, Faber C, Karst U. Elemental bioimaging of thulium in mouse tissues by laser ablation-ICPMS as a complementary method to heteronuclear proton magnetic resonance imaging for cell tracking experiments. Anal Chem 2015;87: 4225-4230. Abstract
Wehe CA, Thyssen GM, Herdering C, Raj I, Ciarimboli G, Sperling M, Karst U. Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry. J Am Soc Mass Spectrom 2015;26: 1274-1282. Abstract

2014

Blaske F, Reifschneider O, Gosheger G, Wehe CA, Sperling M, Karst U, Hauschild G, Holl S. Elemental bioimaging of nanosilver-coated prostheses using X-ray fluorescence spectroscopy and laser ablation-inductively coupled plasma-mass spectrometry. Anal Chem 2014;86: 615-620. Abstract
Grosse Brinkhaus S, Bornhorst J, Chakraborty S, Wehe CA, Niehaus R, Reifschneider O, Aschner M, Karst U. Elemental bioimaging of manganese uptake in C elegans. Metallomics 2014;6: 617-621. Abstract
Niehoff A-C, Moosmann A, Sobbing J, Wiehe A, Mulac D, Wehe CA, Reifschneider O, Blaske F, Wagner S, Sperling M, von Briesen H, Langer K, Karst U. A palladium label to monitor nanoparticle-assisted drug delivery of a photosensitizer into tumor spheroids by elemental bioimaging. Metallomics 2014;6: 77-81. Abstract
Schmidt R, Nippe N, Strobel K, Masthoff M, Reifschneider O, Castelli DD, Holtke C, Aime S, Karst U, Sunderkotter C, Bremer C, Faber C. Highly Shifted Proton MR Imaging: Cell Tracking by Using Direct Detection of Paramagnetic Compounds. Radiology 2014;272: 785-795. Abstract
Wehe CA, Beyer G, Sperling M, Ciarimboli G, Karst U. Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation. J Trace Elem Med Biol 2014;28: 166-172. Abstract
Wehe CA, Niehoff A-C, Thyssen GM, Sperling M, Karst U. Rapid cell mode switching and dual laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging. Rapid Commun Mass Spectrom 2014;28: 2627-2635. Abstract

2013

Herdering C, Reifschneider O, Wehe CA, Sperling M, Karst U. Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 2013;27: 2595-2600. Abstract
Herdering C, Wehe CA, Reifschneider O, Raj I, Ciarimboli G, Diebold K, Becker C, Sperling M, Karst U. Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis. Rapid Commun Mass Spectrom 2013;27: 2588-2594. Abstract
Hoerr V, Tuchscherr L, Huve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkotter C, Karst U, Klingauf J, Peters G, Loffler B, Faber C. Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol 2013;11: 63. Abstract