• Beteiligung an „Cells in Motion“

    • Forschungsinteressen: mass spectrometric based bioimaging; spatially resolved elemental and molecular information in tissues by e.g., µXRF, LA-ICP-MS, MALDI

            Projekt FF-2013-17: Massenspektrometrische Bildgebung als komplementäre Methode zur MRT (Uwe Karst,
                 Cornelius Faber, Projektlaufzeit: 07/2013 - 06/2015)

  • Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“


    Backhaus P, Buther F, Wachsmuth L, Frohwein L, Buchholz R, Karst U, Schafers K, Hermann S, Schafers M, Faber C. Toward precise arterial input functions derived from DCE-MRI through a novel extracorporeal circulation approach in mice. Magn Reson Med 2020;84: 1404-1415. Abstract


    Brangsch J, Reimann C, Kaufmann JO, Adams LC, Onthank DC, Thone-Reineke C, Robinson SP, Buchholz R, Karst U, Botnar RM, Hamm B, Makowski MR. Concurrent Molecular Magnetic Resonance Imaging of Inflammatory Activity and Extracellular Matrix Degradation for the Prediction of Aneurysm Rupture. Circ Cardiovasc Imaging 2019;12: e008707. Abstract
    Clases D, Fingerhut S, Jeibmann A, Sperling M, Doble P, Karst U. LA-ICP-MS/MS improves limits of detection in elemental bioimaging of gadolinium deposition originating from MRI contrast agents in skin and brain tissues. J Trace Elem Med Biol 2019;51: 212-218. Abstract
    Crone B, Schlatt L, Nadar RA, van Dijk NWM, Margiotta N, Sperling M, Leeuwenburgh S, Karst U. Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS. J Trace Elem Med Biol 2019;54: 98-102. Abstract
    Einer C, Leitzinger C, Lichtmannegger J, Eberhagen C, Rieder T, Borchard S, Wimmer R, Denk G, Popper B, Neff F, Polishchuk EV, Polishchuk RS, Hauck SM, von Toerne C, Muller J-C, Karst U, Baral BS, DiSpirito AA, Kremer AE, Semrau J, Weiss KH, Hohenester S, Zischka H. A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats. Cell Mol Gastroenterol Hepatol 2019;7: 571-596. Abstract
    Masthoff M, Buchholz R, Beuker A, Wachsmuth L, Kraupner A, Albers F, Freppon F, Helfen A, Gerwing M, Holtke C, Hansen U, Rehkamper J, Vielhaber T, Heindel W, Eisenblatter M, Karst U, Wildgruber M, Faber C. Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining (57)Fe-Based MRI and Mass Spectrometry. Nano Lett 2019;19: 7908-7917. Abstract
    Muller J-C, Horstmann M, Traeger L, Steinbicker AU, Sperling M, Karst U. muXRF and LA-ICP-TQMS for quantitative bioimaging of iron in organ samples of a hemochromatosis model. J Trace Elem Med Biol 2019;52: 166-175. Abstract
    Radbruch A, Richter H, Fingerhut S, Martin LF, Xia A, Henze N, Paulus W, Sperling M, Karst U, Jeibmann A. Gadolinium Deposition in the Brain in a Large Animal Model: Comparison of Linear and Macrocyclic Gadolinium-Based Contrast Agents. Invest Radiol 2019;54: 531-536. Abstract
    van der Bent SAS, Berg T, Karst U, Sperling M, Rustemeyer T. Allergic reaction to a green tattoo with nickel as a possible allergen. Contact Dermatitis 2019;81: 64-66. Abstract


    Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schafers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. ChemMedChem 2018;13: 241-250. Abstract
    de Vega RG, Sanchez MLF, Eiro N, Vizoso FJ, Sperling M, Karst U, Medel AS. Multimodal laser ablation/desorption imaging analysis of Zn and MMP-11 in breast tissues. Anal Bioanal Chem 2018;410: 913-922. Abstract
    Kroger S, Niehoff A-C, Jeibmann A, Sperling M, Paulus W, Stummer W, Karst U. Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery. Anal Chem 2018;90: 12253-12260. Abstract
    Lohofer F, Hoffmann L, Buchholz R, Huber K, Glinzer A, Kosanke K, Feuchtinger A, Aichler M, Feuerecker B, Kaissis G, Rummeny EJ, Holtke C, Faber C, Schilling F, Botnar RM, Walch AK, Karst U, Wildgruber M. Molecular imaging of myocardial infarction with Gadofluorine P - A combined magnetic resonance and mass spectrometry imaging approach. Heliyon 2018;4: e00606. Abstract


    Aschner M, Palinski C, Sperling M, Karst U, Schwerdtle T, Bornhorst J. Imaging metals in Caenorhabditis elegans. Metallomics 2017;9: 357-364. Abstract
    Clases D, Birka M, Sperling M, Faust A, Karst U. Isobaric dilution analysis as a calibration tool for long lived radionuclides in ICP-MS. J Trace Elem Med Biol 2017;40: 97-103. Abstract
    Hachmoeller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Investigating the influence of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry. J Trace Elem Med Biol 2017;44: 71-75. Abstract
    Hachmoeller O, Zibert A, Zischka H, Sperling M, Groba SR, Grunewald I, Wardelmann E, Schmidt HH-J, Karst U. Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS. J Trace Elem Med Biol 2017;44: 26-31. Abstract
    Niehoff A-C, Klasen T, Schmidt R, Palmes D, Faber C, Karst U, Hadrian R. Investigating the Lymphatic System by Dual-Color Elemental Mass Spectrometry Imaging. Contrast Media & Molecular Imaging 2017;2017: 1-8. Abstract
    Thyssen GM, Holtkamp M, Kaulfurst-Soboll H, Wehe CA, Sperling M, von Schaewen A, Karst U. Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles. Metallomics 2017;9: 676-684. Abstract


    Hachmoeller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Element bioimaging of liver needle biopsy specimens from patients with Wilson's disease by laser ablation-inductively coupled plasma-mass spectrometry. J Trace Elem Med Biol 2016;35: 97-102. Abstract
    Hachmoller O, Buzanich AG, Aichler M, Radtke M, Dietrich D, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U. Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using muXRF and XANES. Metallomics 2016;8: 648-653. Abstract
    Niehoff A-C, Grunebaum J, Moosmann A, Mulac D, Sobbing J, Niehaus R, Buchholz R, Kroger S, Wiehe A, Wagner S, Sperling M, von Briesen H, Langer K, Karst U. Quantitative bioimaging of platinum group elements in tumor spheroids. Anal Chim Acta 2016;938: 106-113. Abstract
    Niehoff A-C, Schulz J, Soltwisch J, Meyer S, Kettling H, Sperling M, Jeibmann A, Dreisewerd K, Francesconi KA, Schwerdtle T, Karst U. Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster. Anal Chem 2016;88: 5258-5263. Abstract
    Niehoff  A-C, Wachsmuth L, Schmid F, Sperling M, Faber C, Karst U. Quantification of Manganese Enhanced Magnetic Resonance Imaging based on Spatially Resolved Elemental Mass Spectrometry. ChemistrySelect 2016;1: 264-266. Abstract
    Wiese C, Grosse Maestrup E, Galla F, Schepmann D, Hiller A, Fischer S, Ludwig F-A, Deuther-Conrad W, Donat CK, Brust P, Buter L, Karst U, Wunsch B. Comparison of in Silico, Electrochemical, in Vitro and in Vivo Metabolism of a Homologous Series of (Radio)fluorinated σ1 Receptor Ligands Designed for Positron Emission Tomography. ChemMedChem 2016;11: 2445–2458. Abstract


    Birka M, Wentker KS, Lusmoller E, Arheilger B, Wehe CA, Sperling M, Stadler R, Karst U. Diagnosis of nephrogenic systemic fibrosis by means of elemental bioimaging and speciation analysis. Anal Chem 2015;87: 3321-3328. Abstract
    Koeppen C, Reifschneider O, Castanheira I, Sperling M, Karst U, Ciarimboli G. Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin. Metallomics 2015;7: 1595-1603. Abstract
    Niehaus R, Sperling M, Karst U. Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS. J. Anal. At. Spectrom. 2015;30: 2056-2065. Abstract
    Niehoff A-C, Bauer OB, Kroger S, Fingerhut S, Schulz J, Meyer S, Sperling M, Jeibmann A, Schwerdtle T, Karst U. Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster. Anal Chem 2015;87: 10392-10396. Abstract
    Reifschneider O, Schutz CL, Brochhausen C, Hampel G, Ross T, Sperling M, Karst U. Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy. Anal Bioanal Chem 2015;407: 2365-2371. Abstract
    Reifschneider O, Wentker KS, Strobel K, Schmidt R, Masthoff M, Sperling M, Faber C, Karst U. Elemental bioimaging of thulium in mouse tissues by laser ablation-ICPMS as a complementary method to heteronuclear proton magnetic resonance imaging for cell tracking experiments. Anal Chem 2015;87: 4225-4230. Abstract
    Wehe CA, Thyssen GM, Herdering C, Raj I, Ciarimboli G, Sperling M, Karst U. Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry. J Am Soc Mass Spectrom 2015;26: 1274-1282. Abstract


    Blaske F, Reifschneider O, Gosheger G, Wehe CA, Sperling M, Karst U, Hauschild G, Holl S. Elemental bioimaging of nanosilver-coated prostheses using X-ray fluorescence spectroscopy and laser ablation-inductively coupled plasma-mass spectrometry. Anal Chem 2014;86: 615-620. Abstract
    Grosse Brinkhaus S, Bornhorst J, Chakraborty S, Wehe CA, Niehaus R, Reifschneider O, Aschner M, Karst U. Elemental bioimaging of manganese uptake in C elegans. Metallomics 2014;6: 617-621. Abstract
    Niehoff A-C, Moosmann A, Sobbing J, Wiehe A, Mulac D, Wehe CA, Reifschneider O, Blaske F, Wagner S, Sperling M, von Briesen H, Langer K, Karst U. A palladium label to monitor nanoparticle-assisted drug delivery of a photosensitizer into tumor spheroids by elemental bioimaging. Metallomics 2014;6: 77-81. Abstract
    Schmidt R, Nippe N, Strobel K, Masthoff M, Reifschneider O, Castelli DD, Holtke C, Aime S, Karst U, Sunderkotter C, Bremer C, Faber C. Highly Shifted Proton MR Imaging: Cell Tracking by Using Direct Detection of Paramagnetic Compounds. Radiology 2014;272: 785-795. Abstract
    Wehe CA, Beyer G, Sperling M, Ciarimboli G, Karst U. Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation. J Trace Elem Med Biol 2014;28: 166-172. Abstract
    Wehe CA, Niehoff A-C, Thyssen GM, Sperling M, Karst U. Rapid cell mode switching and dual laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging. Rapid Commun Mass Spectrom 2014;28: 2627-2635. Abstract


    Herdering C, Reifschneider O, Wehe CA, Sperling M, Karst U. Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 2013;27: 2595-2600. Abstract
    Herdering C, Wehe CA, Reifschneider O, Raj I, Ciarimboli G, Diebold K, Becker C, Sperling M, Karst U. Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis. Rapid Commun Mass Spectrom 2013;27: 2588-2594. Abstract
    Hoerr V, Tuchscherr L, Huve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkotter C, Karst U, Klingauf J, Peters G, Loffler B, Faber C. Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol 2013;11: 63. Abstract